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ORIGINAL RESEARCH article

Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1513788
This article is part of the Research Topic Infectious Diseases and Hematology: Diagnosis and Management - Volume II View all 7 articles

Prognostic value of HSP27 in 28-Day Mortality in Septic ICU patients: a Retrospective Cohort Study

Provisionally accepted
Lihua Yao Lihua Yao 1Zaiwei Fan Zaiwei Fan 2*Fangyi Yao Fangyi Yao 3*Xiaozhong Wang Xiaozhong Wang 3*
  • 1 Affiliated Hospital of North Sichuan Medical College, Nanchong, China
  • 2 Department of Orthopedics, Nanchang University, Nanchang, Jiangxi, China., Nanchang, China
  • 3 Department of Clinical Laboratory, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    Background: This study aimed to investigate the association between serum heat shock protein 27 (HSP27) levels and 28-day mortality in patients with sepsis.Methods: This retrospective study analyzed the clinical data of 76 septic patients admitted to the intensive care unit (ICU). Fifty non-septic ICU patients and 50 healthy individuals served as control groups. Serum HSP27 levels were measured on the day of ICU admission and compared to sepsis severity and survival outcomes.Results: Median serum HSP27 levels in septic patients (4.70 ng/mL, IQR: 2.10-13.48 ng/mL) were significantly higher than those in both non-septic ICU controls and healthy controls (all p < 0.05). Moreover, non-survivors exhibited significantly higher median HSP27 levels (9.30 ng/mL, IQR: 3.62-25.91 ng/mL) compared to survivors (3.03 ng/mL, IQR: 1.48-7.39 ng/mL, p < 0.05). Multivariate logistic regression analysis confirmed the association between HSP27 levels and 28-day mortality in sepsis patients. Receiver operating characteristic (ROC) curve analysis revealed an area under the curve (AUC) of 0.720 (95% CI: 0.605-0.817, p < 0.001) for HSP27 in predicting sepsis prognosis. Survival analysis demonstrated that patients with high serum HSP27 levels (≥ 2.61 ng/mL) had a worse prognosis than those with low levels (< 2.61 ng/mL).Conclusions: HSP27 shows potential as a biomarker for the diagnosis and prognosis of sepsis, however, further research is necessary to solidify its clinical utility.

    Keywords: Hsp27, Sepsis, prognosis, Infection, Inflammatory

    Received: 19 Oct 2024; Accepted: 10 Dec 2024.

    Copyright: © 2024 Yao, Fan, Yao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zaiwei Fan, Department of Orthopedics, Nanchang University, Nanchang, Jiangxi, China., Nanchang, China
    Fangyi Yao, Department of Clinical Laboratory, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China
    Xiaozhong Wang, Department of Clinical Laboratory, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.