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ORIGINAL RESEARCH article

Front. Med.
Sec. Hepatobiliary Diseases
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1503090
This article is part of the Research Topic Hot Topics in Diabetes and Steatotic Liver Disease View all 6 articles

Increased platelet aggregation in hepatic tissue of metabolic-associated fatty liver disease -an observational study

Provisionally accepted
Fan Rongshan Fan Rongshan 1*Yandong Li Yandong Li 2Zeng Du Zeng Du 1
  • 1 Department of Hepatology, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China
  • 2 Department of Pathology, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China

The final, formatted version of the article will be published soon.

    The study aimed to observe the quantity of platelet aggregation in the hepatic tissue of patients with metabolic-associated fatty liver disease (MAFLD) and its relationship with hepatic inflammation, fibrosis, and fatty degeneration. Methods: Clinical data of 55 patients with MAFLD and 25 patients without MAFLD, admitted to the Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine from December 2020 to May 2022, were retrospectively analyzed. Liver tissue obtained by liver biopsy underwent routine pathological examination. Immunohistochemical staining with CD63 antibody was performed to label platelets in the liver tissue. Clinical, liver pathology, and immunohistochemical staining data of the study subjects were statistically analyzed using unpaired t-test. Results: The quantity of platelet aggregation in the hepatic tissue was higher in MAFLD patients than in non-MAFLD patients and was related to the degree of hepatic inflammation but not to the degree of hepatic fibrosis or fatty degeneration.The quantity of platelet aggregation in hepatic tissue was increased in patients with MAFLD and was related to the degree of hepatic inflammation.

    Keywords: metabolic-associated fatty liver disease, Hepatic tissue, Platelet, Aggregation, Hepatic inflammation

    Received: 28 Sep 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Rongshan, Li and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Fan Rongshan, Department of Hepatology, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China

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