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BRIEF RESEARCH REPORT article

Front. Med.
Sec. Geriatric Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1499798
This article is part of the Research Topic From Crosstalk Among Cell Populations in the Microenvironment of Bone Degenerative Diseases to the Novel Therapeutic Approaches View all 4 articles

Analysis of ASAS Health Index and Its Influencing Factors in Ankylosing Spondylitis: A Prospective Study Based on the Population of Chaoshan Region

Provisionally accepted
Aikang Li Aikang Li 1Rongji Liang Rongji Liang 1Liangbin Wu Liangbin Wu 2*Cai Minghua Cai Minghua 1*Jiayou Chen Jiayou Chen 1Gong Yao Gong Yao 1,3*Zeng Shaoyin Zeng Shaoyin 1*
  • 1 College of Medicine, Shantou University, Shantou, China
  • 2 Shenzhen University, Shenzhen, Guangdong Province, China
  • 3 First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Objective: This study aimed to evaluate the health-related quality of life (HRQoL) in ankylosing spondylitis (AS) patients in the Chaoshan region and identify factors influencing the ASAS Health Index (ASAS-HI) to enhance comprehensive AS treatment strategies.Methods: A survey of ASAS-HI was conducted on 82 AS patients from the rheumatology outpatient department of the First Affiliated Hospital of Shantou University Medical College. The Bath Ankylosing Spondylitis Global Score (BAS-G) assessed overall health status, the Ankylosing Spondylitis Quality of Life Questionnaire (AS-QOL) evaluated quality of life, the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) measured disease activity, and the Bath Ankylosing Spondylitis Functional Index (BASFI) assessed functional difficulties. Inflammatory markers and patient data were collected, and univariate/multivariate logistic regression analyses were used to explore influencing factors of ASAS-HI.The mean ASAS-HI score was 3.52 ± 3.12. ASAS-HI was positively correlated with BASDAI (r=0.478, P<0.001), ASDAS-CRP (r=0.406, P<0.001), BASFI (r=0.338, P<0.002), and BAS-G (r=0.335, P<0.002). Patients with ASDAS-ESR ≥ 2.1, ASDAS-CRP ≥ 2.1, and spinal tenderness had significantly higher ASAS-HI scores than others (P<0.001). Spinal tenderness and radiographic grading were identified as key influencing factors.ASAS-HI is significantly impacted by disease activity and functional limitations. Early assessment of ASAS-HI is crucial for optimizing disease management in AS patients.

    Keywords: ankylosing spondylitis, Assessment of Spondyloarthritis international Society Health Index, Quality of Life, Influencing factors, Chaoshan

    Received: 21 Sep 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Li, Liang, Wu, Minghua, Chen, Yao and Shaoyin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Liangbin Wu, Shenzhen University, Shenzhen, 518060, Guangdong Province, China
    Cai Minghua, College of Medicine, Shantou University, Shantou, China
    Gong Yao, College of Medicine, Shantou University, Shantou, China
    Zeng Shaoyin, College of Medicine, Shantou University, Shantou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.