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ORIGINAL RESEARCH article

Front. Med.
Sec. Ophthalmology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1487981
This article is part of the Research Topic Biomedical Sensing in Assistive Devices View all 6 articles

A Bibliometric and Visualization Analysis of Electrochemical Biosensors for Early Diagnosis of Eye Diseases

Provisionally accepted
Fushen Zhang Fushen Zhang 1Weiye Xu Weiye Xu 1Zejun Deng Zejun Deng 2*Jufang Huang Jufang Huang 1*
  • 1 Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan Province, China
  • 2 State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan Province, China

The final, formatted version of the article will be published soon.

    Electrochemical biosensors can provide an economical, accurate and rapid method for early screening of disease biomarkers in clinical medicine due to their high sensitivity, selectivity, portability, low cost and easy manufacturing, and multiplexing capability. Tear, a fluid naturally secreted by the human body, is not only easily accessible but also contains a great deal of biological information. However, no bibliometric studies focus on applying electrochemical sensors in tear/eye diseases. Therefore, we utilized VOSviewer and CiteSpace, to perform a detailed bibliometric analysis of 114 papers in the field of research on the application of tear in electrochemical biosensors screened from Web of Science with the combination of Scimago Graphica and Microsoft Excel for visualization to show the current research hotspots and future trends. The results show that the research in this field started in 2008 and experienced an emerging period in recent years. Researchers from China and the USA mainly contributed to the thriving research areas, with 41 and 29 articles published, respectively. Joseph Wang from the University of California San Diego is the most influential author in the field, and Biosensors & Bioelectronics is the journal with the most published research and the most cited journal. The highest appearance keywords were "biosensor" and "tear glucose", while the most recent booming keywords "diagnosis" and "in-vivo" were. In conclusion, this study elucidates current trends, hotspots, and emerging frontiers, and provides future biomarkers of ocular and systemic diseases by electrochemical sensors in tear with new ideas and opinions.

    Keywords: electrochemical biosensors, Eye Diseases, Tears, Bibliometrics, VOSviewer, Citespace

    Received: 29 Aug 2024; Accepted: 27 Dec 2024.

    Copyright: © 2024 Zhang, Xu, Deng and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zejun Deng, State Key Laboratory of Powder Metallurgy, Central South University, Changsha, 130012, Hunan Province, China
    Jufang Huang, Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, 410083, Hunan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.