Neal Shore
Joan Carles
Ray McDermott3
Neeraj Agarwal
Bertrand Tombal- 1Carolina Urologic Research Center, Myrtle Beach, SC, United States
- 2Vall d'Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital, Barcelona, Spain
- 3St Vincent's University Hospital, Cancer Trials Ireland, Dublin, Ireland
- 4University of Utah Huntsman Cancer Institute (NCI-CCC), Salt Lake City, UT, United States
- 5Cliniques Universitaires Saint-Luc, Brussels, Belgium
Several life-prolonging therapies with diverse mechanisms of action (MoA) are available for the treatment of metastatic hormone-sensitive/castration-resistant prostate cancer, with many patients requiring multiple lines of therapy. Nevertheless, treatment optimization to further delay disease progression and improve overall survival remains an unmet need. Despite the number of agents with differing MoAs approved for advanced prostate cancer, many patients receive only one or two life-prolonging therapies. One strategy for enhancing the benefit of treatment for this aggressive disease is combining therapies with different MoAs (treatment intensification) early in the disease course, which may be more effective than administering therapies sequentially, yet still allow for subsequent sequential use of individual therapies to optimize patient outcomes. In this narrative review we discuss the rationale for combining 223radium dichloride (223Ra; an alpha-emitting radionuclide) with enzalutamide (an androgen receptor inhibitor) for treatment intensification, including their differing MoAs, their individual efficacy in this setting, and their largely non-overlapping tolerability profiles. We also summarize the preclinical and clinical data available for this combination to date, including interim safety data from the phase 3 EORTC 1333/PEACE III study which highlight the low fracture risk of 223Ra plus enzalutamide when administered concomitantly with bone health agents. Relevant data were sourced from clinical studies published by the authors and via searches of PubMed, clinical trial registries and congress abstracts.
Introduction
Prostate cancer pathogenesis is significantly influenced by abnormal androgen signaling. Consequently, patients with advanced prostate cancer often receive therapies to reduce androgen ligands and downregulate the androgen-androgen receptor axis which drives tumor proliferation. While localized disease may respond to active interventions (prostatectomy, radiation), it will ultimately progress from non-metastatic hormone-sensitive to non-metastatic castration-resistant prostate cancer (nmCRPC) after androgen deprivation therapy (ADT) or metastatic hormone-sensitive prostate cancer (mHSPC) in the absence of ADT (although for some patients, prostate cancer is first diagnosed at the mHSPC stage) (1, 2). Unfortunately, most advanced prostate cancer cases eventually progress to metastatic castration-resistant prostate cancer (mCRPC), a disease stage oftentimes characterized by bone metastases (3), meaning patients are at high risk of skeletal-related events that contribute to disease-related morbidity and mortality (4, 5). Data from the Surveillance Epidemiology and End Results (SEER) program from 2013 to 2019 indicate a 5-year relative survival rate of 34% for patients whose prostate cancer has metastasized (6).
The contemporary treatment landscape for mCRPC includes multiple life-prolonging therapies with diverse mechanisms of action (MoAs). These include androgen receptor pathway inhibitors (ARPIs; abiraterone acetate [hereafter referred to as abiraterone] and enzalutamide) (7–10), chemotherapy agents (docetaxel and cabazitaxel) (11–14), poly (adenosine diphosphate-ribose) polymerase inhibitors [olaparib (15, 16), rucaparib (17), niraparib (as a fixed-dose combination with abiraterone) (18, 19), and talazoparib (20)], and targeted radionuclide therapies (223radium dichloride [223Ra] and lutetium-177 vipivotide tetraxetan [177Lu-PSMA-617]) (21–24). Additionally, the immunotherapies pembrolizumab (for microsatellite instability-high or mismatch repair-deficient tumors) (25) and sipuleucel-T (26) are both approved in the US only.
With the various therapeutic options available, treatment decisions can be individualized based on factors such as comorbidities, life-expectancy, disease characteristics, patient preferences, quality of life (QoL), and prior therapies (27, 28). Due to the heterogenous nature of mCRPC (29), patients may require multiple lines of therapy. However, determining optimal treatment sequences to ensure patients derive the best overall survival (OS) benefit while maintaining QoL remains challenging.
Therapies combining ADT with an ARPI and/or docetaxel have shown improved survival relative to ADT monotherapy in patients with high-risk biochemical recurrence and mHSPC (30–36). Thus, intensifying treatment by combining therapies with different MoAs (simultaneously blocking different tumor growth pathways) may benefit patients with mCRPC, potentially offering more effective disease control than sequential therapy administration. Notably, as real-world data from the US show half of patients receive only one line of therapy after mCRPC diagnosis (37, 38), using combination therapy earlier rather than later may be appropriate. As some of the life-prolonging therapies for patients with mCRPC have distinct MoAs, combining therapies may be feasible, provided the safety profile is acceptable. 223Ra may be particularly useful in this regard for multiple reasons. First, as 223Ra is an alpha particle-emitting osteotropic calcium mimetic (39), its MoA (further discussed in section 2) is distinct from that of other life-prolonging therapies approved for patients with mCRPC. Second, data from the pivotal phase 3 ALSYMPCA study indicated that 223Ra can be used in conjunction with best supportive care treatments (e.g., local external-beam radiation therapy, glucocorticoids, antiandrogens, ketoconazole, or estrogens) without impacting its safety profile (40). Third, an early access program suggested enhanced survival benefit when 223Ra was used in combination with denosumab, abiraterone, or enzalutamide relative to 223Ra monotherapy (41).
However, potential treatment approaches combining 223Ra with other approved life-prolonging therapies must be explored carefully, as a phase 3 study in patients with mCRPC and bone metastases (ERA 223) demonstrated an increased incidence of non-pathological fractures with the combination of 223Ra with abiraterone plus prednisone/prednisolone versus abiraterone plus prednisone/prednisolone (42). Abiraterone must be administered concurrently with corticosteroids (7, 8), which are associated with an increased risk of fractures and bone loss (43). Moreover, preclinical data highlight the bone resorptive effects of abiraterone plus prednisone which, when combined with 223Ra, may impair bone remodeling and suppress bone formation (44).
Although the combination of 223Ra with abiraterone plus prednisone/prednisolone is not suitable for patients with mCRPC due to the fracture risk [combination contraindicated in EU (7) and not recommended in US (8)], it may be feasible to combine 223Ra with alternative ARPIs, such as enzalutamide. Unlike abiraterone, enzalutamide does not require administration with a corticosteroid (9, 10) and inhibits androgen receptor signaling in a more targeted fashion.
Rationale for combining 223Ra with enzalutamide in mCRPC
223Ra and enzalutamide have distinct yet complimentary MoAs (Figure 1). 223Ra is a calcium mimetic that is preferentially taken up into newly formed bone within metastatic lesions, where it emits high-energy alpha particles that induce double-stranded DNA breaks within both tumor cells and nearby cells of the tumor microenvironment that contribute to metastatic growth (39). Enzalutamide directly targets the androgen receptors that drive tumor pathogenesis, competing with native androgens for androgen receptor occupancy, and blocking nuclear translocation of the androgen receptor to prevent transcription of androgen-responsive genes (45). Blocking androgen receptor function via this mechanism is a more direct method of inhibiting the androgen receptor pathway than inhibiting androgen biosynthesis (as with abiraterone) (46). Notably, androgen receptor signaling plays a role in regulating DNA repair genes (47–49), and inhibiting this pathway downregulates DNA damage repair in prostate cancer (50–52). It has been suggested that enzalutamide-mediated downregulation of DNA damage repair could sensitize cells to the double-stranded DNA breaks caused by 223Ra (52), leading to enhanced cancer cell death.
Figure 1. Mechanism of action (MoA) of 223Ra and enzalutamide.
223Ra (40) and enzalutamide (53, 54) each improve survival outcomes in patients with mCRPC. In the ALSYMPCA study, 223Ra significantly improved median OS compared with placebo, when each was used in combination with best supportive care (14.9 vs. 11.3 months; hazard ratio [HR] 0.70; 95% confidence interval [CI] 0.58 to 0.83; p < 0.001) (40). Following the approval of 223Ra, various real-world studies have further supported the safety and effectiveness of 223Ra in patients with mCRPC (55–59). Regarding enzalutamide, the phase 3 AFFIRM study showed that, in patients who had previously received docetaxel, enzalutamide plus ADT significantly improved median OS versus placebo plus ADT (18.4 vs. 13.6 months; HR 0.63; 95% CI 0.53–0.75; p < 0.001) (53). This finding was supported by the phase 3 PREVAIL study, in which enzalutamide plus ADT provided significant improvements versus placebo plus ADT in progression-free survival (PFS) at 12 months (65% vs. 14%; HR 0.19; 95% CI 0.15–0.23; p < 0.001) and median OS (32.4 vs. 30.2 months; HR 0.71; 95% CI 0.60 to 0.84; p < 0.001) in chemotherapy-naïve patients (54).
223Ra and enzalutamide also have largely non-overlapping toxicity profiles, supporting the possibility of combining them without additive toxic events. The most common any-grade adverse events (AEs) with 223Ra in ALSYMPCA (occurring in ≥5% of patients) were bone pain, nausea and anemia. These AEs occurred at the same or higher rates with placebo and no clinically meaningful differences in the frequency of other hematologic AEs (thrombocytopenia and neutropenia) or grade 3/4 AEs were observed between 223Ra and placebo (40). A 3-year follow-up of ALSYMPCA indicated there were no second primary malignancies considered related to 223Ra and no other new safety concerns (60). In the PREVAIL (54) and AFFIRM (53) studies, the most common AEs with enzalutamide that occurred with an incidence >2% higher than with placebo included hot flashes, fatigue, gastrointestinal events and musculoskeletal events. Longer term, 5-year follow-up data from PREVAIL indicated a manageable toxicity profile for enzalutamide, although the rate of fatal treatment-emergent AEs was 1.8-fold greater with enzalutamide than placebo (6.9% vs. 3.8%) (61).
Data for 223Ra in combination with enzalutamide
Data supporting the combined use of 223Ra and enzalutamide in patients with mCRPC can be derived from a preclinical study, several clinical trials and real-world studies. These are summarized below and detailed in Table 1.
Table 1. Key safety and efficacy findings for 223Ra plus enzalutamide in clinical trials and real-world studies.
Preclinical data
Preclinical data indicate that 223Ra plus enzalutamide may provide enhanced antitumor activity versus either agent alone and could potentially be used without negatively impacting bone health (52). Furthermore, enzalutamide concurrent with 223Ra did not alter 223Ra uptake in bone or the ability of 223Ra to reduce osteoblast number and inhibit abnormal bone formation (52).
Clinical data
The efficacy and/or safety of 223Ra plus enzalutamide has been evaluated in several small (<50 patients) phase 2 clinical studies [with (62, 63) or without (64, 65) an enzalutamide comparator arm], as well as real-world studies (66–68); of these, some specify 223Ra and enzalutamide were administered concurrently (started within 30 days of one another) or in a layered fashion (second drug started ≥30 days after the first) (66, 68). Additionally, a randomized, multicenter, phase 3 study [EORTC 1333/PEACE III; NCT02194842 (69)] is ongoing to assess the safety and efficacy of 223Ra plus enzalutamide versus enzalutamide alone in patients with asymptomatic or mildly symptomatic mCRPC and bone metastases. All studies were primarily designed to assess safety (62–68), with one phase 2 trial also including change in serum levels of the bone metabolism marker N-telopeptide as a co-primary endpoint (62, 63).
Safety
223Ra plus enzalutamide had an acceptable safety profile in phase 2 trials (63–65), with the largest real-world study (REASSURE) finding no new safety signals (66). In the only comparative phase 2 study, several any-grade AEs were more common with 223Ra plus enzalutamide than with enzalutamide alone (incidence difference of ≥15%), including anemia (26% vs. 7%), constipation (29% vs. 0%), diarrhea (54% vs. 7%), fatigue (46% vs. 21%), flu-like symptoms (17% vs. 0%), lymphocyte count decrease (51% vs. 29%), nausea (46% vs. 7%), neutrophil count decrease (40% vs. 0%), platelet count decrease (20% vs. 0%), and white blood cell count decrease (57% vs. 0%). However, these were generally grade 1–2 in severity, except for lymphocyte count decrease (grade 3 in 20% of patients) (63). In the two non-comparative phase 2 studies, the most common AEs considered to be related to 223Ra plus enzalutamide were fatigue (25.6 and 55.5%) and nausea (17.9 and 46.7%) (64, 65).
Given the fracture risk associated with 223Ra plus abiraterone plus prednisone/prednisolone (42), fractures were included as a safety outcome in several studies of 223Ra plus enzalutamide (Supplementary Figure S1). In an interim safety analysis of the EORTC 1333/PEACE III study, for patients who did not receive concomitant bone health agents (BHAs), a two-fold increased risk of fractures was observed in the 223Ra plus enzalutamide group versus the enzalutamide group at 1.5 years; however, fracture risk was mostly eliminated in corresponding groups with concomitant BHA use (70). These findings are supported by a phase 2 study in which most (96%) patients received concomitant BHAs, with the fracture incidence being 5.7% with 223Ra plus enzalutamide versus 0% with enzalutamide (63).
Across other phase 2 (64, 65) and real-world (66–68) studies, BHA use and fracture data were variable (Supplementary Figure S1). In a phase 2 study in patients receiving concurrent 223Ra plus enzalutamide, in which 38.5% received BHAs, one patient experienced worsening of a pre-existing hip fracture during treatment (deemed unrelated to therapy) and another patient experienced a hip fracture 284 days after initiating treatment; neither patient was receiving a BHA (64). When fracture incidence was assessed both during and after completing 223Ra plus enzalutamide combination therapy in another phase 2 study (in which 57.8% of patients were receiving BHAs at entry), the incidence was 8.9 and 37.8%, respectively (65). However, the time to first fracture event ranged from 3 to 40 months after starting treatment (65), and disease progression over time may have weakened bones in some patients, leading to fractures. Across real-world studies, fracture incidence was 2–12% in patients who received 223Ra plus enzalutamide in a concurrent or layered fashion (66–68) versus 3–10% with any 223Ra regimen (66, 68). Of note, in real-world studies, patients may not be routinely assessed for fractures unless they experience bone pain or progressive disease, so asymptomatic fractures could go undetected. This contrasts with the EORTC 1333/PEACE III trial, which includes frequent, per protocol image assessment that may identify asymptomatic fractures that would otherwise go undetected. This, along with the variation in BHA use, highlights the difficulties in comparing fracture incidence across studies.
Efficacy
In a phase 2 study that compared 223Ra plus enzalutamide with enzalutamide, the combination regimen improved the pre-specified secondary endpoints of median OS (30.8 vs. 20.6 months), radiographic PFS (11.5 vs. 7.4 months) and prostate-specific antigen (PSA)-PFS (8.9 vs. 3.4 months), although the between-group differences did not reach statistical significance (63). Moreover, in a post hoc analysis of this trial, 223Ra plus enzalutamide significantly improved PSA-PFS2 (time from start of protocol therapy to PSA progression on subsequent therapy) relative to enzalutamide (18.7 vs. 8.4 months; p = 0.033) (63). The combination also showed promising efficacy [median OS (secondary endpoint) not reached; mean 34.8 months] (65) and improvements in QoL and pain (secondary objectives) (64) in non-comparative studies. Efficacy data for EORTC 1333/PEACE III are not yet available, although it has recently been announced that the study has met its primary endpoint (71).
In two real-world studies (66, 68) that report efficacy for 223Ra plus enzalutamide, median OS (from 223Ra initiation; secondary endpoint) was longer when the agents were administered concurrently than in a layered fashion [22.2 vs. 16.5 months (66); 19.1 vs. 15.2 months (68)]; however, these findings are limited by the small patient numbers in the concurrent groups and lack of a control group.
Discussion
The treatment landscape for mCRPC is continuously evolving based on evidence from clinical studies, including the integration of therapies to earlier treatment lines. 223Ra and enzalutamide are well-established, life-prolonging therapies with strong rationale for combined use. Emerging clinical efficacy and tolerability data highlight the promise of the combination as an option for treatment intensification in patients with mCRPC. Notably, interim safety data from the EORTC 1333/PEACE III study indicate that, when taken in combination with BHAs, 223Ra plus enzalutamide is associated with a low risk of fractures, similar to enzalutamide alone. A UK consensus guideline strongly recommends that BHAs should be considered for all patients with mCRPC to prevent fractures (72). Similar recommendations are made by a European consensus guideline (all patients with bone metastases are advised to receive BHAs upon developing castration resistance) (73) and American Urological Association/Society of Urologic Oncology guidelines (clinicians should prescribe BHAs to all patients with mCRPC and bone metastases to prevent skeletal-related events) (28).
When choosing a therapy for patients with mCRPC, an important factor to consider is prior treatment history. With this in mind, enzalutamide plus ADT is now approved for patients with non-metastatic hormone-sensitive prostate cancer with biochemical recurrence at high risk for metastasis (9), based on findings from the EMBARK trial (36). Furthermore, there have been significant additions to the treatments recommended for mHSPC, with a shift from ADT monotherapy to ADT in combination with other agents (e.g., enzalutamide, abiraterone, apalutamide, darolutamide, docetaxel) for most patients, based on the improvements in survival seen with combination therapies (27, 28, 74, 75). Similarly, the treatment landscape for nmCRPC is also evolving, with a number of ARPIs now approved for use in this setting (9, 10, 76–80). Consequently, patients with newly diagnosed mCRPC may now have received more therapies during treatment for mHSPC or nmCRPC. For patients with mCRPC, evidence does not support the efficacy of a second ARPI following progression on a previous ARPI (27, 81, 82) and, as such, this is not recommended by the European Society of Medical Oncology or American Urological Association/Society of Urologic Oncology (27, 28). Given this, it is unclear whether 223Ra plus enzalutamide would be suitable for patients who have previously received an ARPI for mHSPC or nmCRPC. Notably, EORTC 1333/PEACE III excluded patients with prior enzalutamide, apalutamide or darolutamide treatment; patients with prior abiraterone use for mCRPC were also excluded, but prior abiraterone use for mHSPC was permitted [providing patients had a response or stable disease for at least 1 year in this setting (69)].
Concerns over prior ARPI use may also apply when combining an ARPI with other therapies. One such combination is enzalutamide plus 177Lu-PSMA-617 (another radioligand therapy), which has recently been shown to significantly improve PSA-PFS versus enzalutamide alone (13.0 vs. 7.8 months; HR 0.43; 95% CI 0.29–0.63; p < 0.0001) in patients with mCRPC in a phase 2 trial (ENZA-p study) (83). Similar to EORTC 1333/PEACE III, patients with prior enzalutamide, apalutamide or darolutamide were excluded from ENZA-p, although prior abiraterone use was permitted (84). Prospective studies are therefore needed to determine any impact of prior ARPI use when using combination regimens that include an ARPI.
Despite some guidelines not recommending it (27, 28), use of back-to-back ARPIs is common in some countries (38, 85). Furthermore, the proportion of patients who still receive first-line ADT monotherapy for mHSPC varies by country/region according to recent real-world studies (86–88). For instance, in a retrospective analysis of oncology patient records (2018–2020) from five countries, ADT monotherapy was the most common treatment in Western countries (53.4–58.1%), while ADT plus older anti-hormonal therapies was the most common in Eastern countries (54.6–67.2%); overall, 76.1% of patients received non-guideline-concordant therapies (87). Such findings highlight the complexity of the treatment landscape and should be considered during treatment decision-making for patients with mCRPC.
Bone metastases are common in patients with mCRPC (3), with visceral metastases typically developing later in the disease course (89). As 223Ra is approved for the treatment of patients with mCRPC with bone metastases and no known visceral metastases (21, 22), and enzalutamide demonstrated greater OS benefit in patients without versus with visceral metastases in the AFFIRM (53) and PREVAIL (54) trials, the combined use of 223Ra plus enzalutamide may be a suitable early treatment option for patients with mCRPC. 223Ra is also being evaluated in combination with various other agents in patients with mCRPC whose disease is confined to the bones. These include docetaxel (phase 3 DORA trial) (90), olaparib (phase 1/2 COMRADE trial) (91), nivolumab (phase 1/2 Rad2Nivo trial) (92), and 177Lu-PSMA (phase 1/2 AlphaBet and DUET trials) (93, 94).
To conclude, the treatment landscape of mCRPC is continuously changing. The full efficacy and safety data from EORTC 1333/PEACE III are awaited with interest, as they will help to inform clinicians as to how the combination of 223Ra plus enzalutamide may be used to treat patients with mCRPC.
Author contributions
NS: Conceptualization, Writing – original draft, Writing – review & editing. JC: Conceptualization, Writing – original draft, Writing – review & editing. RM: Conceptualization, Writing – original draft, Writing – review & editing. NA: Conceptualization, Writing – original draft, Writing – review & editing. BT: Conceptualization, Writing – original draft, Writing – review & editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Acknowledgments
Chris Guise and Georgia Greaves, Bioscript Group, Cheshire, UK, provided medical writing assistance (funded by Bayer). Lila Adnane (Bayer) provided editorial assistance.
Conflict of interest
Neal Shore: Consulting or advisory role: AbbVie, Alessa, Amgen, Astellas Pharma, AstraZeneca, Bayer, Bristol-Myers Squibb, Clarity, Dendreon, Exact Imaging, Ferring, Foundation Medicine, Janssen, Lantheus, Lilly, Mdxhealth, Merck, Myovant, Myriad, Novartis, Pfizer, Photocure, Telix Tolmar, UroGen. Joan Carles: Consultant and scientific advisory board attendee: Amgen, Astellas, Bayer, Bristol-Myers Squibb, MSD, Johnson & Johnson, Sanofi, Pfizer, Novartis (AAA); Speaker bureau: Asofarma, Astellas, Bayer, Johnson & Johnson, Sanofi; Others: CAMDHA Agency Institutional Studies Collaborations: AB Science, Aragon Pharmaceuticals, Arog Pharmaceuticals, Astellas Pharma, AstraZeneca, Aveo Pharmaceuticals, Bayer, Blueprint Medicines Corporation, BN Immunotherapeutics, Boehringer Ingelheim España, Bristol-Myers Squibb, Clovis Oncology, Cougar Biotechnology, Deciphera Pharmaceuticals, Exelixis, F. Hoffmann-La Roche, Genentech, GlaxoSmithKline, Incyte, Janssen-Cilag International, Karyopharm Therapeutics, Laboratoires Leurquin Mediolanum, Eli Lilly, Medimmune, Millennium Pharmaceuticals, Nanobiotix, Novartis, Pfizer, Puma Biotechnology, Sanofi-Aventis, SFJ Pharma, Teva Pharma. Ray McDermott: Consulting or advisory role: Bayer, Janssen, Pfizer; Support for travel and/or accommodation: Celgene, Janssen, Pfizer; Research funding related to clinical trials: Clovis Oncology, Amgen, Bayer, Bristol-Myers Squibb, Merck. Neeraj Agarwal: Honorarium before May 2021 and during his lifetime for consulting: Astellas, AstraZeneca, Aveo, Bayer, Bristol-Myers Squibb, Calithera, Clovis, Eisai, Eli Lilly, EMD Serono, Exelixis, Foundation Medicine, Genentech, Gilead, Janssen, Merck, MEI Pharma, Nektar, Novartis, Pfizer, Pharmacyclics, Seattle Genetics; Research funding (during his lifetime, to NA’s institution): Arnivas, Astellas, AstraZeneca, Bavarian Nordic, Bayer, Bristol-Meyers Squibb, Calithera, Celldex, Clovis, CRISPR Therapeutics, Eisai, Eli Lilly, EMD Serono, Exelixis, Genentech, Gilead, GlaxoSmithKline, Immunomedics, Janssen, Lava, Medivation, Merck, Nektar, Neoleukin, New Link Genetics, Novartis, Oric, Pfizer, Prometheus, Rexahn, Roche, Sanofi, Seattle Genetics, Takeda, Tracon. Bertrand Tombal: Personal fees and nonfinancial support: Amgen, Astellas, Bayer, Ferring Pharmaceuticals, Janssen, Sanofi; Personal fees: Pfizer, Steba Biotech, Takeda; Grants: Ferring Pharmaceuticals.
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Supplementary material
The Supplementary material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmed.2024.1460212/full#supplementary-material
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Keywords: radium-223, metastatic castration-resistant prostate cancer, enzalutamide, treatment intensification, combination therapy
Citation: Shore N, Carles J, McDermott R, Agarwal N and Tombal B (2024) Treatment intensification with radium-223 plus enzalutamide in patients with metastatic castration-resistant prostate cancer. Front. Med. 11:1460212. doi: 10.3389/fmed.2024.1460212
Edited by:
James Nagarajah, Radboud University Medical Centre, NetherlandsReviewed by:
Bastiaan Privé, Radboud University Medical Centre, NetherlandsMotohiro Fujiwara, Japanese Foundation for Cancer Research, Japan
Copyright © 2024 Shore, Carles, McDermott, Agarwal and Tombal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Bertrand Tombal, bertrand.tombal@saintluc.uclouvain.be