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ORIGINAL RESEARCH article

Front. Med.
Sec. Obstetrics and Gynecology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1436458
This article is part of the Research Topic Endometriosis: Updates on the Etiology, Pathophysiology, Measurements and Therapeutics View all 10 articles

Epidemiology of Endometriosis in Kazakhstan: A national population-based cohort analysis (2014-2019) using data from the National Electronic Healthcare System

Provisionally accepted
Gulzhanat Aimagambetova Gulzhanat Aimagambetova 1*Yesbolat Sakko Yesbolat Sakko 1Talshyn Ukybassova Talshyn Ukybassova 2Milan Terzic Milan Terzic 1Aizada Marat Aizada Marat 3Nazira Kamzayeva Nazira Kamzayeva 2Arnur Gusmanov Arnur Gusmanov 1Gulnur Zhakhina Gulnur Zhakhina 1Sauran Yerdessov Sauran Yerdessov 1Kamila Mussina Kamila Mussina 1Dmitriy Syssoyev Dmitriy Syssoyev 1Abduzhappar Gaipov Abduzhappar Gaipov 1
  • 1 Nazarbayev University, Nur-Sultan, Kazakhstan
  • 2 University Medical Center Astana, Nur-sultan, Kazakhstan
  • 3 Astana Medical University, Nur-Sultan, Akmola, Kazakhstan

The final, formatted version of the article will be published soon.

    Background: Endometriosis is a condition affecting reproductive-age women and associated with dysmenorrhea, pelvic organs dysfunction, pelvic pain, and infertility. The real epidemiology of endometriosis remains underestimated. No data are available on prevalence of endometriosis in Kazakhstan. Therefore, the aim of this was to investigate the epidemiology, complications, surgical management approach, and outcomes of endometriosis in Kazakhstan by analyzing largescale Kazakhstani healthcare data from the Unified Nationwide Electronic Health System (UNEHS).A population-based study among women with endometriosis treated in any healthcare setting of the Republic of Kazakhstan during the period of 2014-2019 was performed. The International Classification of Diseases (ICD) 10 th edition was used to retrieve data on endometriosis ("N80" and "N97"). ICD 9 th edition's procedural codes were utilized to retrieve information on surgical procedures performed to manage patients with endometriosis.Results: In total, 7,682 records of women diagnosed with endometriosis were analyzed from all Kazakhstani regions. The overall prevalence of endometriosis among Kazakhstani female population was 0.12%, with 50.1% of them suffering from endometriosis of the uterus, 34.5% with ovarian endometriosis, and 9.5% with endometriosis of pelvic peritoneum. The most affected group was reproductive-age women (25-44 years old). Endometriosis rates were higher among women of 35-39, 40-44, and 45-49 years old age groups -0.4 per 1000 women of corresponding age. The most common procedures performed for surgical management were laparoscopic cystectomy and closed biopsy of the uterus, 16.4% and 13.5%, respectively.Conclusion: Among all registered cases of endometriosis, ovarian endometriosis is the most prevalent condition. However, the analysis of the UNEHS records on endometriosis reveals incomplete and inconsistent registration of the disease, which results in the underestimation of the disease's real burden. Clinical specialist and health authorities in Kazakhstan must work to ensure the endometriosis proper diagnosis end registration to improve the disease management and outcomes.

    Keywords: Endometriosis, Infertility, Epidemiology, Prevalence, Kazakhstan

    Received: 22 May 2024; Accepted: 17 Dec 2024.

    Copyright: © 2024 Aimagambetova, Sakko, Ukybassova, Terzic, Marat, Kamzayeva, Gusmanov, Zhakhina, Yerdessov, Mussina, Syssoyev and Gaipov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Gulzhanat Aimagambetova, Nazarbayev University, Nur-Sultan, Kazakhstan

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