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ORIGINAL RESEARCH article

Front. Med.
Sec. Hepatobiliary Diseases
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1424667
This article is part of the Research Topic Hot Topics in Diabetes and Steatotic Liver Disease View all 6 articles

A Positive Relationship between Weight-Adjusted-Waist Index and Non-Alcoholic Fatty Liver Disease: A Study on US Adolescents

Provisionally accepted
Xiaoling Cui Xiaoling Cui 1Yufeng Gao Yufeng Gao 1*Yize Huang Yize Huang 2Luyang Kang Luyang Kang 1Han Lianxiu Han Lianxiu 1Weijie Sun Weijie Sun 1Kexing Han Kexing Han 1
  • 1 Department of Infectious Diseases, First Affiliated Hospital, Anhui Medical University, Hefei, China
  • 2 Tongling People's Hospital, Tongling, Anhui, China

The final, formatted version of the article will be published soon.

    Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition in children, underscoring the urgent need for noninvasive markers for early detection in this population. We utilized survey data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020 regarding liver ultrasound transient elastography (LUTE) for the diagnosis of NAFLD (dependent variable), and used multiple logistic regression models to explore the association between weight-adjusted waist circumference index (WWI) and the prevalence of NAFLD in US adolescents. Smoothing curves and threshold effect analyses were used to assess the nonlinear association between the independent variables and the dependent variable. Subgroup analysis was conducted to pinpoint particularly susceptible subgroups within our study cohort of 1,711 participants. Our findings indicated a positive correlation between WWI and NAFLD scores. Adjusting for all covariates revealed a significant association between increased WWI and the presence of NAFLD, with an odds ratio of 3.37 (95% CI: 2.74, 4.15). This association provedThis study explores the relationship between the weight-adjusted waist index (WWI) and NAFLD among adolescents in the US, employing data from the National Health and Nutrition Examination Survey (NHANES) for the years 2017-2020 and includes the LUTE method in its analysis.We utilized cross-sectional data from NHANES, analyzing the correlation between WWI (independent variable) and NAFLD (dependent variable) through multiple linear regression.

    Keywords: Non-alcoholic fatty liver disease, Liver steatosis, adolescents, Weight-adjusted waist index, BMI, Waist Circumference

    Received: 28 Apr 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Cui, Gao, Huang, Kang, Lianxiu, Sun and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yufeng Gao, Department of Infectious Diseases, First Affiliated Hospital, Anhui Medical University, Hefei, China

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