Wenqian Shen1,2,3,4
Jiying Shen
Jin Yang- 1Department of Ophthalmology and the Eye Institute, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China
- 2Key National Health Committee Laboratory of Myopia, Fudan University, Shanghai, China
- 3Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China
- 4Key Laboratory of Visual Impairment and Restoration, Eye & ENT Hospital, Fudan University, Shanghai, China
- 5Department of Ophthalmology, Shanghai Heping Eye Hospital, Shanghai, China
Purpose: To investigate the effects of postoperative astigmatism on the visual outcomes following presbyopia-correcting surgery with multifocal intraocular lens implantation.
Methods: A comprehensive literature search was conducted using PubMed, Embase, and Web of Science for articles published until January 2023. Additionally, we included retrospective case series and prospective comparative studies. The combined mean difference (MD) with 95% confidence intervals (CI) and odds ratio (OR) with 95% CI were used to express continuous and categorical outcomes, respectively. All statistical analyses were performed using Review Manager (version 5.4.1).
Results: We included nine eligible studies that analyzed 3,088 eyes. The proportion of eyes with useful postoperative visual acuity (logMAR ≤ 0.20) and residual astigmatism significantly differed with respect to the magnitude of astigmatism and presence/absence of blurred vision (p < 0.001 for both). Additionally, the mean uncorrected distance visual acuity (MD, 0.14; 95% CI, 0.06 to 0.21; p = 0.0003) and uncorrected intermediate visual acuity (MD, 0.07; 95% CI, 0.00 to 0.13; p = 0.04), but not the uncorrected near visual acuity (MD, 0.02; 95%CI-0.01 to 0.05; p = 0.17), significantly differed according to the magnitude of astigmatism.
Conclusion: Astigmatism, even at low levels (≥ 0.5D), has a significant effect on visual outcomes, especially on UDVA and UIVA, following multifocal intraocular lens implantation. Accurate preoperative and postoperative evaluation of astigmatism is important.
1 Introduction
Astigmatism is a refractive condition in which parallel rays of light entering the eye do not converge to a single focal point; further, it can be categorized as corneal, lenticular, and retinal astigmatism (1). In China, >47% of patients with cataract have preexisting astigmatism of >1.0 diopters (D) (2, 3); moreover, ≈90% of these patients exhibit astigmatism of ≥0.5 D (4). Therefore, it is important to minimize postoperative residual astigmatism (RA) in these patients to allow excellent visual acuity (VA) and satisfactory vision quality.
Multifocal intraocular lenses (MIOLs) are widely used to treat patients with cataracts and presbyopia. MIOLs can be refractive, diffractive, or a combination of both (5). MIOL implantation is widely considered as among the most effective methods for allowing favorable postoperative vision at all distances; further, it allows generally good satisfaction and spectacle independence. However, neuroadaption, lens dislocation, residual refractive error, and lens opacification may limit the visual performance of MIOL, leading to blurred vision and photic phenomena (6). Specifically, astigmatism is a crucial limiting factor that significantly influences the performance of MIOLs (7–9), while individuals with uncorrected astigmatism or astigmatism with coma appear to be more perceptually adapted to their astigmatism (10–13). However, the mechanisms underlying the vulnerability of eyes with MIOLs to astigmatism remains unclear, with some studies attributing this phenomenon to the intricate light diffraction with MIOLs and eyes (14). Moreover, a previous study using an experimental optical system reported that MIOLs led to interference of the posterior and anterior lines of the nearest and next focuses, respectively, when astigmatism created focal lines for each focal spot in the IOL; furthermore, light energy passed through the expanded conoid of Sturm, which could be attributed to the multiple foci of the MIOLs (15).
The visual outcomes of patients with astigmatism following MIOL implantation and the effect of astigmatism on MIOL performance remain inconclusive. Therefore, this systematic review and meta-analysis aimed to determine the effect of astigmatism on MIOL, which could inform the clinical treatment of patients with presbyopia and cataracts.
2 Methods
2.1 Study selection
Full texts or abstracts for studies that evaluated the clinical outcomes of MIOL implantation after cataract surgery were eligible for inclusion. The inclusion criteria for studies were as follows (1): population and intervention: patients who underwent cataract surgery followed by MIOL implantation (2); study design: observational studies, prospective or retrospective studies, randomized controlled trials (RCT), controlled studies, or case series; and (3) outcome measurement: visual acuity (logarithm of the minimum angle of resolution [logMAR]) and astigmatism (in diopters).
2.2 Method of literature search
A literature search was performed using PubMed, Embase, and Web of Science databases. The search terms were as follows: (“astigmatism”) and (“multifocal intraocular lens” or “multifocal IOL” or “MIOL”). Additionally, we performed a manual search of the reference lists of the included articles and relevant systematic reviews to identify additional studies. The searches were not limited by publication year, study design, or language. The first author independently performed the selection of studies, including searching, duplicate checking, title and abstract screening, and full-text article screening based on the eligibility criteria.
2.3 Measurement outcomes
The magnitude of astigmatism and the following visual outcomes were documented: uncorrected distance visual acuity (UDVA), uncorrected intermediate visual acuity (UIVA), uncorrected near visual acuity (UNVA), and RA. We only extracted logMAR visual acuity scores for the meta-analysis. In case the study did not report the mean VA, we used the proportion of eyes with useful VA (logMAR ≤ 0.20, according to the necessary distance VA to drive a car and the necessary near VA to read a newspaper). A low proportion of eyes with useful VA indicates that astigmatism has a significant effect on MIOL performance.
2.4 Data extraction
We extracted the following basic information regarding the included studies: first author, publication year, region, study design, number of eyes in different groups, follow-up period, and outcome indicators. If the study reported the outcome indicators at several time points, this study included the data collected at 3 postoperative months or close to each other.
2.5 Quality evaluation
The Newcastle–Ottawa scale (NOS) was used to assess the quality of the methodology in six cohort studies. The NOS comprised the following three broad domains: selection, comparability, and outcome. The highest possible total NOS score was 9, with a score of >7 indicating high quality. In addition, the Methodological Index for Non-Randomized Studies was used to assess the methodological quality of the selected non-randomized studies. The Agency for Healthcare Research and Quality (AHRQ) methodology checklist was used for the cross-sectional study, which included 11 items with a summary judgment.
2.6 Statistical analysis
Statistical analyses were performed using Review Manager software (RevMan, version 5). Between-study heterogeneity was tested using chi-square statistics, with I2 > 50% and p < 0.05 indicating statistical significance. Fixed-and random-effects models were used in the absence and presence of heterogeneity, respectively. The odds ratios (ORs) were calculated for the proportion of prediction errors for each method. OR < 1 indicates a lower rate of the method’s outcome. Statistical significance was set at p < 0.05.
3 Results
3.1 Systematic review
The initial search yielded 1,486 articles. After removing duplicate studies, 967 articles remained; among them, 748 articles were excluded after title and abstract screening. There were no relevant meta-analyses. After full-text screening based on the eligibility criteria, we included nine studies that assessed the effects of astigmatism on MIOLs. Figure 1 shows a flow diagram of the selection process.
Figure 1. Flow chart depicting the selection of included studies.
3.2 Study characteristics
Table 1 presents the main characteristics of the nine studies; among them, there were six retrospective case series and three prospective comparative studies. These studies included a total of 3,088 eyes. Three, one, and four studies were conducted in Europe, the United States, and Asia, respectively.
Table 1. Characteristics of the included studies.
3.3 Quality assessment
The methodology quality of the six included cohort studies was assessed using the NOS (Table 1). Among the six retrospective studies, one and five studies had an NOS score of 8 and 7, respectively. The MINORS of the included non-randomized studies and the AHRQ methodology checklist of quality assessment of the included cross-sectional study are displayed in Tables 2, 3, respectively.
Table 2. Methodological index for non-randomized studies (MINORS).
Table 3. Quality assessment of the cross-sectional study with AHRQ methodology checklist.
3.4 Clinical outcomes
3.4.1 Useful postoperative visual acuity
Four studies reported the proportion of eyes with a useful postoperative VA (logMAR ≤ 0.20); among them, two studies reported the outcomes of two different types of MIOLs. We performed an analysis of different magnitudes of astigmatism (1.5D, 1.0D, and 0.5D) to explore the tolerance of eyes with MIOL to astigmatism. The proportion of eyes with a useful VA was significantly different between eyes with astigmatism of 1.5D and eyes with no astigmatism (OR, 0.01; 95% confidence interval [CI], 0.00–0.04; p < 0.001; I2 = 64%; Figure 2). We further performed sensitivity analysis and observed slight changes in the significance of the difference when we deselected any included studies; this indicated good stability. Moreover, there was a considerable decrease in heterogeneity (OR, 0.01; 95% confidence interval [CI], 0.00–0.02; p < 0.001; I2 = 0%; Figure 3) when we excluded the study by Hayashi et al. performed in 2000 (16), which may have been the source of the heterogeneity. Significant differences were also found in the proportion of eyes with a useful VA between eyes with astigmatism of 1.0D (OR, 0.04; 95% CI, 0.03–0.06; p < 0.001; I2 = 43%; Figure 4), and 0.5D (OR, 0.04; 95% CI, 0.03–0.06; p < 0.001; Figure 5) and eyes without astigmatism. The I2 value was relatively low, which indicated a quantitatively small heterogeneity.
Figure 2. Forest plot of the proportion of eyes with a useful postoperative visual acuity (logMAR ≤0.20) when astigmatism was 1.5D.
Figure 3. Forest plot of the proportion of eyes with a useful postoperative visual acuity (logMAR ≤0.20) when astigmatism was 1.5D, following removal of the study conducted in 2000 by Hayashi et al.
Figure 4. Forest plot of the proportion of the eyes with a useful postoperative visual acuity (logMAR ≤0.20) when astigmatism was 1.0D.
Figure 5. Forest plot of the proportion of the eyes with a useful postoperative visual acuity (logMAR ≤0.20) when astigmatism was 0.5D.
3.4.2 Residual astigmatism
Three studies reported the proportion of residual astigmatism >0.75D in eyes with blurred vision after MIOL implantation (Figure 6). The proportion of residual astigmatism significantly differed according to the presence or absence of blurred vision (OR, 13.14; 95% CI 6.43–26.86; p < 0.0001).
Figure 6. Forest plot of the proportion of residual astigmatism >1.0D.
3.4.3 Mean postoperative visual acuity
Three studies reported the mean postoperative UDVA, UIVA, and UNVA. Hayashi et al. reported the outcomes of two different types of multifocal IOLs, while Richard et al. explored the effects using two different classification methods of astigmatism (refractive and corneal astigmatism). Figure 7 shows the mean postoperative UDVA at selected time points. UDVA significantly differed according to the magnitude of astigmatism (mean difference [MD], 0.14; 95% CI, 0.06 to 0.21; p = 0.0003). I2 was 93%, which indicated a large heterogeneity. Subsequently, we performed a subgroup analysis according to the type of implanted IOL (trifocal IOL and bifocal IOL). However, the source of heterogeneity could not be identified. We also performed sensitivity analysis and observed good stability.
Figure 7. Forest plot of uncorrected distance visual acuity (UDVA).
The mean UIVA significantly differed according to the magnitude of astigmatism (MD 0.07; 95% CI, 0.00 to 0.13; p = 0.04; Figure 8). The I2 value was 73%; moreover, subgroup analysis was performed but did not eliminate the significant heterogeneity. In this case, our sensitivity analysis still showed good stability. Finally, the mean UNVA did not significantly differ according to the astigmatism magnitude (MD: 0.02; 95%CI −0.01, 0.05; p = 0.17; Figure 9) and the I2 was very low.
Figure 8. Forest plot of uncorrected intermediate visual acuity (UIVA).
Figure 9. Forest plot of uncorrected near visual acuity (UNVA).
4 Discussion
Modern cataract surgery with MIOL implantation can allow good spectacle independence and stable vision (17). However, astigmatism, which is among the most common refractive errors in adults worldwide (18), is among the major causes of dissatisfaction following MIOL implantation (19–21). The high prevalence of astigmatism among patients undergoing cataract surgery presents a significant public health challenge (4). Therefore, it is important to elucidate the independent role of astigmatism in the outcomes of MIOL implantation.
Residual astigmatism has been shown to affect VA following MIOL implantation unlike monofocal IOL (22, 23). Additionally, VA has been shown to be negatively correlated with the magnitude of astigmatism, with the decline being more evident in distance VA (14, 16, 24–28). Moreover, a high incidence of astigmatism has been reported in patients with blurred vision following MIOL implantation (19–21). Recent studies have shown that vision is greatly influenced when the magnitude of astigmatism is ≥1.0D and ≥0.75D in eyes with bifocal and trifocal IOLs, respectively (14, 16, 24, 25); however, there remains controversy (27–30).
In our study, most of the included studies did not report the mean VA; therefore, we analyzed the proportion of eyes with a useful postoperative VA according to the magnitude of astigmatism (1.5D, 1.0D, and 0.5D), which revealed significant differences. Previous studies (29) have reported impaired visual quality (optical parameters, patient satisfaction, etc.) even with relatively low astigmatism (<1.0D). Lee et al. (31) found no significant correlation between the aforementioned parameters and VA, which indicates a discrepancy between optical quality and VA in eyes implanted with MIOL. However, we observed a significant difference in VA when astigmatism was 0.5D, indicating a postoperative effect of astigmatism on VA even at low astigmatism levels. Compared with astigmatism with a magnitude of 1.0D and 0.5D, a much more significant difference was observed at a magnitude of 1.5D. Similar results was observed in the analysis of astigmatism with a magnitude of 1.0D and 0.5D, which is consistent with the aforementioned previous reports.
To further confirm this effect, we analyzed residual astigmatism in patients with blurred vision following MIOL implantation. Our findings indicated a correlation between astigmatism and blurred vision in MIOL-implanted eyes, which may contribute towards dissatisfaction following MIOL implantation (19–21). Given the small number of included studies, our analysis was based on astigmatism with a magnitude of >0.75D; however, a significant difference was observed even at a magnitude of <1.0D.
Moreover, we sought to identify the effects of postoperative astigmatism on VA at all distances. Only few studies reported the mean postoperative VA; moreover, most of the studies reported that the MIOL was significantly affected when the magnitude of astigmatism was ≥1.0D. For consistency purposes, we selected studies that considered an astigmatism magnitude of ≈1.0D for comparison with no or relatively low astigmatism. We found that the UDVA and UIVA, but not UNVA, significantly differed according to the astigmatism magnitude (14, 16, 24–28). Although the significant difference was less evident in UIVA than in UDVA, most studies only reported the effect of postoperative astigmatism on UDVA; nonetheless, UIVA is as important in our daily lives as other VAs. The observed discrepancies in VA at different distances could be attributed to the complex multifocal structure and narrow VA peak curve at a long distance (32, 33). This phenomenon is more significant with implantation of trifocal IOLs given the more complex light diffraction in the eyes (14).
This study has several strengths. First, we performed a systematic and comprehensive database search without time restrictions to improve statistical power and reduce publication bias. Further, this study demonstrates the scarcity of relevant research given the publication years and small number of the included. Nonetheless, to our knowledge, this is the first meta-analysis to assess the effects of corneal astigmatism, particularly low-level postoperative astigmatism, on MIOLs.
However, this study has several limitations. First, this is a new and developing research topic; accordingly, there were few relevant studies. Moreover, several related studies were excluded since they only reported the correlation results without providing raw data. Second, there was significant heterogeneity among the included studies, which may be partly attributed to differences in other factors that influence the visual outcomes following MIOL implantation, such as study design, population characteristics, follow-up time, models of MIOL, and outcome measurement. For these multiple factors, it is difficult to detect the source of heterogeneity. However, Figure 3 shows the heterogeneity caused by a study performed in 2000 (16), which is justified because the refractive model of MIOL used in 2000 is not commonly used nowadays.
5 Conclusion
Astigmatism is prevalent among patients with cataract and significantly influences UDVA and UIVA following MIOL implantation. Additionally, visual outcomes appeared to be affected when the postoperative astigmatism was ≥0.5D. Therefore, Accurate preoperative and postoperative evaluation of astigmatism is important. Moreover, it should be treated tactfully, including through a corneal relaxing incision or toric, rather than non-toric, IOL implantation to control postoperative astigmatism of ≤0.5D. Further research is warranted to inform guidelines for astigmatism correction in patients undergoing MIOL implantation.
Data availability statement
The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.
Author contributions
WS was responsible for conception and design, extracted the data, and wrote the manuscript. WS, BZ, LZ, JS, and DM collected the literature. WS and BZ analyzed the data. JY critically revised the manuscript. All authors contributed to the article and approved the submitted version.
Funding
This study was supported by the National Natural Science Foundation of China (Grant No. 82171039).
Acknowledgments
We would like to thank the colleagues from our research group for their assistance.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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Keywords: astigmatism, multifocal intraocular lens, cataract surgery, meta-analysis, systematic review
Citation: Shen W, Zhuo B, Zhang L, Shen J, Ma D and Yang J (2023) Effect of astigmatism on visual outcomes after multifocal intraocular lens implantation: a systematic review and meta-analysis. Front. Med. 10:1214714. doi: 10.3389/fmed.2023.1214714
Edited by:
Hun Lee, University of Ulsan, Republic of KoreaReviewed by:
Pablo De Gracia, University of Detroit Mercy, United StatesXuhua Tan, Sun Yat-sen University, China
Copyright © 2023 Shen, Zhuo, Zhang, Shen, Ma and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jin Yang, amluX2VyNzZAaG90bWFpbC5jb20=