This article is a commentary on:
Rheumatoid arthritis and the risk of end-stage renal disease: A nationwide, population-based study
Qingfeng Peng1
Gang Wang
Jie Li- 1Department of Nephrology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, Hunan, China
- 2Department of Rheumatology and Immunology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, Hunan, China
A Commentary on
Rheumatoid arthritis and the risk of end-stage renal disease: a nationwide, population-based study
by Suh, S. H., Jung, J. H., Oh, T. R., Yang, E. M., Choi, H. S., Kim, C. S., Bae, E. H., Ma, S. K., Han, K.-D., and Kim, S. W. (2023). Front. Med. 10:1116489. doi: 10.3389/fmed.2023.1116489
We read with interest the recent publication by Suh et al. on the rheumatoid arthritis (RA) and the risk of end-stage renal disease (ESRD): a nationwide, Population-based study (1). The authors conclude that RA increase the risk of ESRD. As the risk of ESRD imposed by RA is relatively higher in relatively young and healthy individuals, kidney-protective treatment, such as biologic agents, should be preferentially considered among these patients with RA (1). We support and appreciate the authors' work and agree with their conclusions, but have some concerns about some of the details in the article.
Firstly, in recent years, the pathogenic role of inflammation in RA-related kidney damage has been increasingly studied. Two prospective studies of patients with inflammatory arthritis have shown that the severity of arthritis and the duration of inflammation are important risk factors for chronic kidney disease (CKD) (2, 3). A 5-year follow-up study by Chiu et al. demonstrated that even after adjusting for traditional cardiovascular risk factors, RA patients still have a higher risk of developing CKD compared to those without RA, and chronic inflammation is considered one of the main factors contributing to the increased risk of CKD in RA patients (4). A retrospective study by Kochi et al. showed that persistently high levels of CRP, even after adjusting for classic CKD risk factors, remain an important risk factor for CKD in RA patients (5). A Japanese cohort study found a close association between elevated CRP levels and the incidence of CKD, with sustained elevation of CRP for at least 6 months being an important risk factor for CKD in RA patients (6). In summary, disease activity and related inflammatory status of RA are important confounding factors in this study, and we recommend that patients be evaluated for indicators of RA disease activity such as CRP, ESR, CDAI, SDAI, and DAS28-ESR.
Secondly, RA therapeutic drugs are generally believed to cause renal damage, including non-steroidal anti-inflammatory drugs (NSAIDs), nephrotoxic disease-modifying antirheumatic drugs (DMARDs), and corticosteroids. A cohort study by Chiu et al. including 12,579 RA patients from the Taiwan National Health Insurance database showed a close correlation between NSAID use and increased risk of CKD in RA patients (4). A retrospective cohort study by Tokoroyama showed that in 813 patients without prior CKD, the cumulative incidence of CKD increased to 59.5% over time, and in addition to well-known cardiovascular risk factors, the use of prednisolone and NSAIDs increased the risk of death (7). Among DMARDs, gold, penicillamine, or bucillamine may be associated with proteinuria formation (8, 9). Calcineurin inhibitors such as cyclosporine and tacrolimus can induce a decrease in glomerular filtration rate (GFR) (10). There are also reports describing TNF-α inhibitors not only effective in treating active RA but also stabilizing or improving kidney function by reducing secondary amyloidosis (11). Therefore, drugs are an important confounding factor in this study and should be further clarified.
Thirdly, research has shown that renal impairment in RA is associated with the presence of elevated serum uric acid levels and extra-articular diseases (12). The potential link between uric acid and renal impairment may be mediated by hyperuricemia-related cardiovascular diseases, hypertension, and insulin resistance (13). Similarly, the presence of extra-articular diseases in RA, such as interstitial pulmonary fibrosis and systemic vasculitis, has been found to be an independent predictor of renal impairment (12). This is explained by the fact that RA patients with extra-articular manifestations may have higher disease activity and are more likely to develop amyloidosis of the kidneys. Therefore, this study should clarify the impact of RA-related comorbidities such as interstitial pulmonary fibrosis and systemic vasculitis on the study.
Finally, GFR is the best indicator for assessing kidney function, and many equations have been used in recent decades to estimate GFR. In this study, the authors chose the MDRD (Modification of Diet in Renal Disease) equation instead of the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation. Compared to the CKD-EPI equation, the MDRD study equation may overestimate the incidence of CKD, while the CKD-EPI equation performs better in terms of bias, study performance, and accuracy (14). Meanwhile, muscle wasting is a common feature of RA patients, so serum creatinine levels will inevitably be influenced by the muscle mass of RA patients, and eGFR values calculated using serum creatinine levels may underestimate the actual kidney function of RA patients.
In conclusion, before these issues are clarified, this study's findings should be interpreted cautiously.
Author contributions
QP and GW wrote the paper. JL reviewed and edited the manuscript. All authors had access to the data. All authors contributed to the article and approved the submitted version.
Acknowledgments
We would like to thank the members and staff of the Department of Rheumatology and Immunology of the Zhuzhou Central Hospital who contributed to this manuscript.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1. Suh SH, Jung JH, Oh TR, Yang EM, Choi HS, Kim CS, et al. Rheumatoid arthritis and the risk of end-stage renal disease: a nationwide, population-based study. Front Med. (2023) 10:1116489. doi: 10.3389/fmed.2023.1116489
2. Chi C-C, Wang J, Chen Y-F, Wang S-H, Chen F-L, Tung T-H. Risk of incident chronic kidney disease and end-stage renal disease in patients with psoriasis: A nationwide population-based cohort study. J Dermatol Sci. (2015) 78:232–8. doi: 10.1016/j.jdermsci.2015.03.012
3. Chiu H-Y, Huang H-L, Li C-H, Yin Y-J, Chen H-A, Hsu S-T, et al. Increased risk of glomerulonephritis and chronic kidney disease in relation to the severity of psoriasis, concomitant medication, and comorbidity: a nationwide population-based cohort study. Br J Dermatol. (2015) 173:146–54. doi: 10.1111/bjd.13599
4. Chiu H-Y, Huang H-L, Li C-H, Chen H-A, Yeh C-L, Chiu S-H, et al. Increased risk of chronic kidney disease in rheumatoid arthritis associated with cardiovascular complications - a national population-based cohort study. PLoS ONE. (2015) 10:e0136508. doi: 10.1371/journal.pone.0136508
5. Kochi M, Kohagura K, Shiohira Y, Iseki K, Ohya Y. Inflammation as a risk of developing chronic kidney disease in rheumatoid arthritis. PLoS ONE. (2016) 11:e0160225. doi: 10.1371/journal.pone.0160225
6. Kochi M, Kohagura K, Shiohira Y, Iseki K, Ohya Y. Chronic kidney disease, inflammation, and cardiovascular disease risk in rheumatoid arthritis. J Cardiol. (2018) 71:277–83. doi: 10.1016/j.jjcc.2017.08.008
7. Tokoroyama T, Ando M, Setoguchi K, Tsuchiya K, Nitta K. Prevalence, incidence and prognosis of chronic kidney disease classified according to current guidelines: a large retrospective cohort study of rheumatoid arthritis patients. Nephrol Dial Transplant. (2017) 32:2035–42. doi: 10.1093/ndt/gfw315
8. Hall CL. The natural course of gold and penicillamine nephropathy: a longterm study of 54 patients. Adv Exp Med Biol. (1989) 252:247–56. doi: 10.1007/978-1-4684-8953-8_23
9. Yoshida A, Morozumi K, Takeda A, Koyama K, Oikawa T. Membranous glomerulonephritis in patients with rheumatoid arthritis. Clin Ther. (1994) 16:1000–6.
10. Azzi JR, Sayegh MH, Mallat SG. Calcineurin inhibitors: 40 years later, can't live without. J Immunol. (2013) 191:5785–91. doi: 10.4049/jimmunol.1390055
11. Fernández-Nebro A, Tomero E, Ortiz-Santamaría V, Castro MC, Olivé A, de Haro M, et al. Treatment of rheumatic inflammatory disease in 25 patients with secondary amyloidosis using tumor necrosis factor alpha antagonists. Am J Med. (2005) 118:552–6. doi: 10.1016/j.amjmed.2005.01.028
12. Daoussis D, Panoulas VF, Antonopoulos I, John H, Toms TE, Wong P, et al. Cardiovascular risk factors and not disease activity, severity or therapy associate with renal dysfunction in patients with rheumatoid arthritis. Ann Rheum Dis. (2010) 69:517–21. doi: 10.1136/ard.2008.105049
13. Panoulas VF, Milionis HJ, Douglas KMJ, Nightingale P, Kita MD, Klocke R, et al. Association of serum uric acid with cardiovascular disease in rheumatoid arthritis. Rheumatology. (2007) 46:1466–70. doi: 10.1093/rheumatology/kem159
Keywords: rheumatoid arthritis, end-stage renal disease, chronic kidney disease, nationwide population-based study, risk factor
Citation: Peng Q, Wang G and Li J (2023) Commentary: Rheumatoid arthritis and the risk of end-stage renal disease: a nationwide, population-based study. Front. Med. 10:1194649. doi: 10.3389/fmed.2023.1194649
Received: 27 March 2023; Accepted: 26 April 2023;
Published: 25 May 2023.
Edited by:
Piergiorgio Messa, University of Milan, ItalyReviewed by:
Jinwei Wang, First Hospital, Peking University, ChinaCopyright © 2023 Peng, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jie Li, lijiecsu2021@163.com
†ORCID: Gang Wang orcid.org/0000-0002-8836-1593
Jie Li orcid.org/0000-0003-4525-8913