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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1482308
This article is part of the Research Topic Molecular Mechanisms and Therapeutic Strategies in Inflammation View all 7 articles

Adropin: a key player in immune cell homeostasis and regulation of inflammation in several diseases

Provisionally accepted
Junmin Wang Junmin Wang *Ning Ding Ning Ding *Chong Chen Chong Chen *Simin Gu Simin Gu *Jing Liu Jing Liu *Yanping Wang Yanping Wang *Liubing Lin Liubing Lin *Yiyuan Zheng Yiyuan Zheng *YONG LI YONG LI *
  • Shanghai University of Traditional Chinese Medicine, Shanghai, China

The final, formatted version of the article will be published soon.

    Adropin is a secreted peptide encoded by the energy homeostasis-associated gene (ENHO), located chromosome 9p13.3, with a conserved amino acid sequence across humans and mice. Its expression is regulated by various factors, including fat, LXRα, ERα, ROR, and STAT3. Adropin plays a critical role in glucose and lipid metabolism, as well as insulin resistance, by modulating multiple signaling pathways that contribute to the reduction of obesity and the improvement of blood lipid and glucose homeostasis. Additionally, it influences immune cells and inflammation, exerting anti-inflammatory effects across various diseases. While extensive research has summarized the regulation of cellular energy metabolism by adropin, limited studies have explored its role in immune regulation and inflammation. To enhance the understanding of adropin's immune-modulating and anti-inflammatory mechanisms, this review synthesizes recent findings on its effects in conditions such as atherosclerosis, diabetes, fatty liver, non-alcoholic hepatitis, and inflammation. Furthermore, the review discusses the current research limitations and outlines potential future directions for adropin-related investigations. It is hoped that ongoing research into adropin will contribute significantly to the advancement of medical treatments for various diseases.

    Keywords: Adropin, Inflammation, Immunity, Disease, Pathway

    Received: 18 Aug 2024; Accepted: 02 Jan 2025.

    Copyright: © 2025 Wang, Ding, Chen, Gu, Liu, Wang, Lin, Zheng and LI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Junmin Wang, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Ning Ding, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Chong Chen, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Simin Gu, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Jing Liu, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Yanping Wang, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Liubing Lin, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Yiyuan Zheng, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    YONG LI, Shanghai University of Traditional Chinese Medicine, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.