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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1523990
This article is part of the Research Topic Risk and Protective Factors in the Natural History of Autoimmunity View all 5 articles

Maternal Seafood Intake, Dietary Contaminant Exposure, and Risk of Juvenile Idiopathic Arthritis: Exploring Gene-Environment Interactions

Provisionally accepted
Vilde Øverlien Dåstøl Vilde Øverlien Dåstøl 1,2*Kristine Løkås Haftorn Kristine Løkås Haftorn 1Hamid Khoshfekr Rudsari Hamid Khoshfekr Rudsari 1Piotr Pawel Jaholkowski Piotr Pawel Jaholkowski 3,4Ketil Størdal Ketil Størdal 2,5Siri Eldevik Håberg Siri Eldevik Håberg 6,7Clarice Weinberg Clarice Weinberg 8Lisa G. Rider Lisa G. Rider 9Ole A Andreassen Ole A Andreassen 3,4Anne Lise Brantsæter Anne Lise Brantsæter 10Ida Caspersen Ida Caspersen 1,6Helga Sanner Helga Sanner 1,11
  • 1 Department of Rheumatology, Oslo University Hospital, Oslo, Norway
  • 2 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
  • 3 Center for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
  • 4 KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Oslo, Norway
  • 5 Department of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway
  • 6 Centre for Fertility and Health, Norwegian Institute of Public Health (NIPH), Oslo, Oslo, Norway
  • 7 Department of Global Public Health and Primary Care, University of Bergen, Bergen, Hordaland, Norway
  • 8 Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences (NIH), Durham, North Carolina, United States
  • 9 Environmental Autoimmunity Group, Clinical Research Branch, National Institutes of Health (NIH), Bethesda, Maryland, United States
  • 10 Department of Food Safety and Centre for Sustainable Diets, Norwegian Institute of Public Health (NIPH), Oslo, Oslo, Norway
  • 11 Oslo New University College, Oslo, Oslo, Norway

The final, formatted version of the article will be published soon.

    Objectives: Juvenile idiopathic arthritis (JIA) originates from a complex interplay between genetic and environmental factors. We investigated the association between seafood intake and dietary contaminant exposure during pregnancy and JIA risk, to identify sex differences and geneenvironment interactions.Methods: We used the Norwegian Mother, Father, and Child Cohort Study (MoBa), a populationbased prospective pregnancy cohort (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008). JIA patients were identified through the Norwegian Patient Registry, with remaining mother-child pairs serving as controls. We assessed maternal seafood intake and dietary contaminants typically found in seafood using a food frequency questionnaire completed during pregnancy, mainly comparing high (≥90 th percentile, P90) vs low (

    Keywords: Juvenile idiopathic arthritis (JIA), MoBa, fish, contaminants, heavy metals, Polygenic risk score, gene-environment interaction, sex differences

    Received: 06 Nov 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Dåstøl, Haftorn, Rudsari, Jaholkowski, Størdal, Håberg, Weinberg, Rider, Andreassen, Brantsæter, Caspersen and Sanner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Vilde Øverlien Dåstøl, Department of Rheumatology, Oslo University Hospital, Oslo, Norway

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