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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1485053
This article is part of the Research Topic Therapeutic Mechanism of Osteosarcoma View all 8 articles

Bibliometric Analysis of Targeted Immunotherapy for Osteosarcoma-Current Knowledge, Hotspots and Future Perspectives

Provisionally accepted
Yunxiang Hu Yunxiang Hu 1*Rui Yang Rui Yang 2† M D Shuai Ni † M D Shuai Ni 2Zefeng Song Zefeng Song 3
  • 1 Second Affiliated Hospital of Dalian Medical University, Dalian, China
  • 2 Dalian Medical University, Dalian, Liaoning, China
  • 3 Dalian University of Technology, Dalian, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Objective: The objective of this study is to conduct a bibliometric analysis on examining the current condition, areas of interest, and rising trends of immunotherapy for osteosarcoma (ITFOS), as well as its importance in associated research domains. Methods: An extensive collection of academic papers on the use of ITFOS was obtained from the Web of Science between January 1, 2000 and October 20, 2023. Then, using a variety of tools like HisCite, VOSviewer, CiteSpace, and the bibliometrix package, a bibliometric study was carried out. This study included the collection of information on country, institution, author, journal, and keywords. Results: A comprehensive analysis was undertaken on a total of 616 publications obtained from 247 journals, encompassing the contributions of 3725 authors affiliated with 831 institutes spanning across 43 countries/regions. Notably, China exhibited the highest quantity of published 277 (44.99%) articles on ITFOS. The most productive institution was Zhejiang University, with 26 (4.22%) publications. The author with the highest publication output was Tsukahara, Tomohide from Japan with 15 (2.44%) publications. The article with the most citation was “DOI: 10.1200/JCO.2014.58.0225". Frontiers in Immunology demonstrated the highest level of productivity, having published a total of 31 (5.03%) articles. The most frequently used were "osteosarcoma," "immunotherapy," and "cancer,". Meanwhile, "sequencing", "prognostic signature" and "immune microenvironment " have been identified as the research frontiers for the forthcoming years. Conclusion: This paper provides a thorough evaluation of current research trends and advancements in ITFOS. It includes relevant research findings and emphasizes collaborative efforts among authors, institutions, and countries.

    Keywords: Osteosarcoma, Immune function, Immunotherapy, Immune check point inhibitor, targeted therapy

    Received: 23 Aug 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Hu, Yang, Shuai Ni and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yunxiang Hu, Second Affiliated Hospital of Dalian Medical University, Dalian, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.