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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1466839
This article is part of the Research Topic Beyond PD-1: novel checkpoint receptors and ligands as targets for immunotherapy View all 17 articles

VISTA in haematological malignancies: A review of the literature

Provisionally accepted

    The final, formatted version of the article will be published soon.

      In recent years, tumour immunotherapy has become an active research area, with the emergence of immune checkpoint inhibitors (ICIs) revolutionising immunotherapy.Clinical evidence indicates that programmed cell death protein 1 (PD-1) monoclonal antibodies and other drugs have remarkable therapeutic effects. V-domain Ig suppressor of T-cell activation (VISTA) is a new type of immune checkpoint receptor that is highly expressed in various tumours. It is co-expressed with PD-1, T-cell immunoglobulin domain, mucin domain-3 (Tim-3), T-cell immunoglobulin, and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) and is associated with prognosis, which suggests that it may be a target for immunotherapy. As an immune checkpoint receptor with no mature drugs, VISTA is highly expressed in acute myeloid leukaemia (AML), multiple myeloma (MM), and other haematological malignancies; however, its pathogenic mechanism should be defined to better guide treatment.

      Keywords: immune checkpoint receptors, Vista, haematological malignancies, tumour microenvironment, Immunotherapy

      Received: 18 Jul 2024; Accepted: 29 Nov 2024.

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