This article is a correction to:
Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein
Mark A. Kroenke1*
Marta Starcevic Manning2Christina L. Zuch de Zafra3†Xinwen Zhang4Kevin D. Cook5Michael Archer6†Martijn P. Lolkema7Jin Wang2Sarah Hoofring2Gurleen Saini2†Famke Aeffner3Elizabeth Ahern8Elena Garralda Cabanas9Ramaswamy Govindan10Mun Hui11Shalini Gupta2Daniel T. Mytych1- 1Clinical Immunology, Amgen, Thousand Oaks, CA, United States
- 2Translational Safety & Bioanalytical Sciences, Amgen, Thousand Oaks, CA, United States
- 3Translational Safety & Bioanalytical Sciences, Amgen, South San Francisco, CA, United States
- 4Clinical Pharmacology, Modeling, and Simulation, Amgen, South San Francisco, CA, United States
- 5Pharmacokinetics and Drug Metabolism, Amgen, South San Francisco, CA, United States
- 6Global Safety, Amgen, Thousand Oaks, CA, United States
- 7Early Development, Amgen, Thousand Oaks, CA, United States
- 8Medical Oncology, Monash Health, Clayton, VIC, Australia
- 9Research Unit, Hospital Universitario Vall d’Hebron, Barcelona, Spain
- 10Division of Hematology and Oncology, Washington University Medical School, St. Louis, MO, United States
- 11Chris O’Brien Lifehouse, Camperdown, NSW, Australia
By Kroenke MA, Starcevic Manning M, Zuch de Zafra CL, Zhang X, Cook KD, Archer M, Lolkema MP, Wang J, Hoofring S, Saini G, Aeffner F, Ahern E, Cabanas EG, Govindan R, Hui M, Gupta S and Mytych DT (2024). Front. Immunol. 15:1345473. doi: 10.3389/fimmu.2024.1345473
Error in Figure/Table
In the published article, there was an error in Figure 2A as published. The Figure 2A y-axis should read “Serum concentration (ng/mL)”. The corrected Figure 2 is attached.
Figure 2
Figure 2 IL-21 mutein domain enhanced the antibody response to 22D4 in cynomolgus monkeys. Cynomolgus monkeys were dosed with 5 mg/kg AMG 256, 5 mg/kg 22D4, or 5 mg/kg 22D4 plus 0.1 mg/kg recombinant human IL-21. (A) AMG 256 or 22D4 serum levels were measured over time in each of the 3 treatment groups. (B) The ADA response in each dosing group was assessed on day 15 and day 25 by UNISA. (C) Domain characterization was performed on AMG 256 dosed animals at the day 25 time point. Serum samples were pre-treated with either AMG 256 or 22D4 and re-tested in the antibody assay. Percent depletion indicates the signal change from the pre-treated sample relative to the untreated sample.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: PD-1, IL-21, immunogenicity, anti-drug antibodies, mutein, IgE
Citation: Kroenke MA, Manning MS, Zuch de Zafra CL, Zhang X, Cook KD, Archer M, Lolkema MP, Wang J, Hoofring S, Saini G, Aeffner F, Ahern E, Cabanas EG, Govindan R, Hui M, Gupta S and Mytych DT (2024) Corrigendum: Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein. Front. Immunol. 15:1441999. doi: 10.3389/fimmu.2024.1441999
Received: 01 June 2024; Accepted: 13 June 2024;
Published: 20 June 2024.
Edited and Reviewed by:
Michael Dougan, Massachusetts General Hospital and Harvard Medical School, United StatesCopyright © 2024 Kroenke, Manning, Zuch de Zafra, Zhang, Cook, Archer, Lolkema, Wang, Hoofring, Saini, Aeffner, Ahern, Cabanas, Govindan, Hui, Gupta and Mytych. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Mark A. Kroenke, bWtyb2Vua2VAYW1nZW4uY29t
†Present address: Christina L. Zuch de Zafra, Nonclinical Sciences, Seagen, South San Francisco, CA, United States Michael Archer, Drug Safety and Pharmacovigilance, Atara Biotherapeutics, Thousand Oaks, CA, United States Gurleen Saini, Immunogenicity Characterization, Boehringer Ingelheim, Ridgefield, CT, United States