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CORRECTION article

Front. Immunol., 15 August 2023
Sec. T Cell Biology
Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1273921
This article is part of the Research Topic Women in T Cell Biology View all 16 articles

Corrigendum: Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells

This article is a correction to:

  1. Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells

    1. Read original article
Martina KunklMartina Kunkl1Carola AmorminoCarola Amormino1Francesco Spallotta,Francesco Spallotta1,2Silvana Caristi&#x;Silvana Caristi1†Maria Teresa FiorilloMaria Teresa Fiorillo1Alessandro Paiardini*Alessandro Paiardini3*Raymond KaempferRaymond Kaempfer4Loretta Tuosto,*Loretta Tuosto1,2*
  • 1Department of Biology and Biotechnology “Charles Darwin”, Sapienza University, Rome, Italy
  • 2Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy
  • 3Department of Biochemical Sciences “A. Rossi Fanelli”, Sapienza University of Rome, Rome, Italy
  • 4Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel

A corrigendum on
Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells

by Kunkl M, Amormino C, Spallotta F, Caristi S, Fiorillo MT, Paiardini A, Kaempfer R and Tuosto L (2023) Front. Immunol. 14:1170821. doi: 10.3389/fimmu.2023.1170821

In the published article, there was an error in Figure 3 as published. Figure 3 was substituted with Figure 4, which was duplicated. The corrected Figure 3 and its caption appear below.

FIGURE 3
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Figure 3 Stimulation of CD4+ T cells by SEB induces the secretion of inflammatory cytokines in the absence of MHC class II- and B7-expressing APCs. (A–G) Human CD4+ T cells isolated by the peripheral blood of healthy donors (HD) were unstimulated (Med) or stimulated for different times with 1 μg ml-1 SEB. IFN-γ (A), IL-2 (B), IL-6 (C), TNF-α (D), IL-17A (E), IL-22 (F) and GM-CSF (G) levels in culture supernatant were measured by ELISA. Data show the mean ± SEM of different HD (n = 4). Statistical significance was calculated by One-way ANOVA. Means values (pg ml-1): 24 hours; IFN-γ, Med = 0, SEB = 328.7; IL-2, Med = 0, SEB = 1966; IL-6, Med = 92.2; SEB = 249; TNF-α, Med = 0, SEB = 1959; IL-17A, Med = 0, SEB = 251.7; IL-22, Med = 37.4, SEB = 1197; GM-CSF, Med = 19.1, SEB = 916.5. 48 hours; IFN-γ, Med = 0, SEB = 1738; IL-2, Med = 0, SEB = 2600; IL-6, Med = 96.7, SEB = 498.8; TNF-α, Med = 0, SEB = 3361; IL-17A, Med = 0, SEB = 1884; IL-22, Med = 178.6, SEB = 5726; GM-CSF, Med = 22,3, SEB = 3426. 72 hours; IFN-γ, Med = 0, SEB = 3099; IL-2, Med = 0.9, SEB = 2303; IL-6, Med = 95, SEB = 851.5; TNF-α, Med = 2.6, SEB = 3591; IL-17A, Med = 0, SEB = 4211; IL-22, Med = 140.9, SEB = 10737; GM-CSF, Med = 42.3, SEB = 7633. (*) p < 0.05, (**) p < 0.01, (***) p < 0.001, (****) p < 0.0001. NS, not significant.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: staphylococcal superantigens, T cells, TCR (T cell receptor), CD28, inflammation

Citation: Kunkl M, Amormino C, Spallotta F, Caristi S, Fiorillo MT, Paiardini A, Kaempfer R and Tuosto L (2023) Corrigendum: Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells. Front. Immunol. 14:1273921. doi: 10.3389/fimmu.2023.1273921

Received: 07 August 2023; Accepted: 08 August 2023;
Published: 15 August 2023.

Approved by:

Frontiers Editorial Office, Frontiers Media SA, Switzerland

Copyright © 2023 Kunkl, Amormino, Spallotta, Caristi, Fiorillo, Paiardini, Kaempfer and Tuosto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Loretta Tuosto, loretta.tuosto@uniroma1.it; Alessandro Paiardini, alessandro.paiardini@uniroma1.it

†Deceased

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.