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CORRECTION article

Front. Immunol., 20 December 2022
Sec. Alloimmunity and Transplantation
Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.1112027

Corrigendum: Mettl14-mediated m6A modification enhances the function of Foxp3+ regulatory T cells and promotes allograft acceptance

This article is a correction to:

  1. Mettl14-mediated m6A modification enhances the function of Foxp3+ regulatory T cells and promotes allograft acceptance

    1. Read original article
Yanzhuo Liu,Yanzhuo Liu1,2Yinglin Yuan,Yinglin Yuan1,2Zili Zhou,Zili Zhou1,2Yuanyuan Cui,Yuanyuan Cui1,2Yan TengYan Teng3Hao HuangHao Huang1Hao YuanHao Yuan1Yanling ZhangYanling Zhang1Lu Yang*Lu Yang3*Gaoping Zhao,*Gaoping Zhao1,2*
  • 1Department of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
  • 2Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
  • 3Institute of Neurology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China

A Corrigendum on
Mettl14-mediated m6A modification enhances the function of Foxp3+ regulatory T cells and promotes allograft acceptance

by Liu Y, Yuan Y, Zhou Z, Cui Y, Teng Y, Huang H, Yuan H, Zhang Y, Yang L and Zhao G (2022) Front. Immunol. 13:1022015. doi: 10.3389/fimmu.2022.1022015

In the published article, there was an error in Figure 4B as published. In the original publication of this article, the same GraphPad file was accidentally linked in Figures 4B, D, which is a mistake. The corrected Figure 4B and its caption appear below.

FIGURE 4
www.frontiersin.org

Figure 4 METTL14 deficiency Treg cells resulted in the loss of suppressive function after transplantation. (A–D) Serum was collected on day 7 after transplantation and cytokine levels were measured using ELISA assay. In the presence or absence of mAbs treatment, the scatter plots show the mean serum cytokine concentration in picograms per milliliter of IFN-γ (A), TGF-β (B), IL-10 (C) and IL-2 (D) from serum in Foxp3-Mettl14f/+ cKO mice and littermate controls (n=7). (E) The islets were isolated from BALB/c mice and transplanted them under the kidney capsule of littermate controls or Foxp3-Mettl14f/+ cKO mice with STZ-induced diabetes. These mice were treated with mAbs as described above. Treg cells were isolated on day 7 post-transplantation which were co-cultured with CFSE-labeled CD4+ naïve T cells from C57BL/6J mice, in round-bottom 96-well plates containing anti-CD3 (3 μg/ml) and anti-CD28 (5 μg/ml) monoclonal antibodies, at various ratios for 5 days. The suppressive effect on T cell expansion was detected using flow cytometry. (F) The suppressive function of Treg cells was quantified. The data are presented as the means ± SD. The data in (A-D) depict the mean values measured from seven separate experiments, while the data in (D) are representative of at least three independent experiments. The statistical analysis was performed with an unpaired Student’s t-test (two-tailed). ****P<0.0001 and ***P<0.001.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: N6-methyladenosine, Mettl14, Treg function, transplantation, allograft acceptance

Citation: Liu Y, Yuan Y, Zhou Z, Cui Y, Teng Y, Huang H, Yuan H, Zhang Y, Yang L and Zhao G (2022) Corrigendum: Mettl14-mediated m6A modification enhances the function of Foxp3+ regulatory T cells and promotes allograft acceptance. Front. Immunol. 13:1112027. doi: 10.3389/fimmu.2022.1112027

Received: 30 November 2022; Accepted: 06 December 2022;
Published: 20 December 2022.

Edited and Reviewed by:

Sina NASERIAN, Hôpital Paul Brousse, France

Copyright © 2022 Liu, Yuan, Zhou, Cui, Teng, Huang, Yuan, Zhang, Yang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Lu Yang, lyang@uestc.edu.cn; Gaoping Zhao, gzhao@uestc.edu.cn

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.