This article is a correction to:
LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells
Huihui Liu†
Zhengyu Yu†
Bo TangShengchao MiaoChenchen QinYuan LiZeyin LiangYongjin ShiYang ZhangQingya WangMiao Yan
Zhengyang SongHanyun Ren*
Yujun Dong*- Department of Hematology, Peking University First Hospital, Beijing, China
A Corrigendum on
LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells
By Liu H, Yu Z, Tang B, Miao S, Qin C, Li Y, Liang Z, Shi Y, Zhang Y, Wang Q, Yan M, Song Z, Ren H and Dong Y (2021). Front. Immunol. 12:647894. doi: 10.3389/fimmu.2021.647894
In the original article, there was a mistake in Figure 3F as published. Figure 3F contains a duplicated FACS plot in Lyg1-/- group. We used the graph of Lyg1-/- group as that of Lyg1+/+ group by mistake. The corrected Figure 3 appears below.
FIGURE 3
Figure 3 LYG1 deficiency reduced allogeneic T cells function in spleens. Splenocytes of recipient mice were isolated on day 7 after transplantation and analyzed by flow cytometry and qPCR. (A) The percentages of H2Kb+ cells in living splenocytes. (B) The percentages of CD4+ T and CD8+ T cells in H2Kb+ splenocytes. (C, D) The percentages of CD69 expression in CD4+ T cells and CD8+ T cells. (E, F) The expression of effector (CD44hiCD62Llo) phenotype gated on CD4+ T and CD8+ T cells. (G, H) The percentages of IFN-g expression in CD4+ T cells and CD8+ T cells. (I) The percentages of T-bet expression in CD4+ T cells. (J, K) The percentages of Treg in CD4+ T cells and CD8+ T cells. The percentages of Figure 3 (C–K) were all gated on H2Kb+CD4+ cells or H2Kb+CD8+ cells. (L) Foxp3 expression of splenocytes were examined by qPCR. Independent experiment was performed 3 times. The results in the repeats were similar. n = 5 per group. Representative plots are shown and statistical results are expressed as the mean ± SD, *p < 0.05 compared with Lyg1+/+ group. ns, no significance.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: LYG1, aGVHD, allogeneic CD4+ T cells, alloreactivity, Th1 cells, Treg cells
Citation: Liu H, Yu Z, Tang B, Miao S, Qin C, Li Y, Liang Z, Shi Y, Zhang Y, Wang Q, Yan M, Song Z, Ren H and Dong Y (2021) Corrigendum: LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells. Front. Immunol. 12:762728. doi: 10.3389/fimmu.2021.762728
Received: 22 August 2021; Accepted: 02 September 2021;
Published: 16 September 2021.
Edited and reviewed by:
Antoine Toubert, Université Paris Diderot, FranceCopyright © 2021 Liu, Yu, Tang, Miao, Qin, Li, Liang, Shi, Zhang, Wang, Yan, Song, Ren and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Hanyun Ren, renhy0813@163.com; Yujun Dong, dongy@hsc.pku.edu.cn
†These authors have contributed equally to this work