Administration of Multivalent Influenza Virus Recombinant Hemagglutinin Vaccine in Combination-Adjuvant Elicits Broad Reactivity Beyond the Vaccine Components
By Hernandez-Davies JE, Felgner J, Strohmeier S, Pone EJ, Jain A, Jan S, Nakajima R, Jasinskas A, Strahsburger E, Krammer F, Felgner PL and Davies DH (2021). Front. Immunol. 12:692151. doi: 10.3389/fimmu.2021.692151
Due to a production error, there was a mistake in Figure 6 as published. Part of the y axis title and scale in Figure 6B was obscured by a white area.
The corrected Figure 6 appears below. The publisher apologizes for this mistake.
Figure 6 Boosting is required to generate virus neutralization after receiving trivalent vaccine. (A) Means of signals at different time points for HA0 and HA1 variants of H1, H5 and H7 after administration of trivalent vaccine. (B) HI assay titers of individual sera used in panels (A, B) against PR8 reassortant influenza viruses expressing Cal09 H1, VN04 H5 and AH13 H7, respectively. Horizontal dotted line, 1/40 dilution cutoff (log-2 of 40 = 5.32) (C) serial dilutions of plasma from a representative mouse to determine titers at different time points using microarrays; shown are means of H1, H5 and H7 variants after serial dilutions. All data are representative of two separate experiments. PB1, post first boost; PB2, post second boost; red arrows, boosts. ****P < 0.0001; ***P ≤ 0.001; **P ≤ 0.01; *P < 0.05.
The original version of this article has been updated.
Keywords: vaccine, influenza, adjuvant, CpG, MPLA, ADDAVAX®, hemagglutinin
Citation: Frontiers Production Office (2021) Erratum: Administration of Multivalent Influenza Virus Recombinant Hemagglutinin Vaccine in Combination-Adjuvant Elicits Broad Reactivity Beyond the Vaccine Components. Front. Immunol. 12:754535. doi: 10.3389/fimmu.2021.754535
Received: 06 August 2021; Accepted: 06 August 2021;
Published: 20 August 2021.
Approved by:
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