Tobias Schmid1*
Bernhard Brüne1,2,3,4- 1Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany
- 2German Cancer Consortium (DKTK) Partner Site Frankfurt, Frankfurt, Germany
- 3Frankfurt Cancer Institute, Goethe-University Frankfurt, Frankfurt, Germany
- 4Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, Germany
Bioactive lipid mediators play a major role in regulating inflammatory processes. Herein, early pro-inflammatory phases are characterized and regulated by prostanoids and leukotrienes, whereas specialized pro-resolving mediators (SPM), including lipoxins, resolvins, protectins, and maresins, dominate during the resolution phase. While pro-inflammatory properties of prostanoids have been studied extensively, their impact on later phases of the inflammatory process has been attributed mainly to their ability to initiate the lipid-mediator class switch towards SPM. Yet, there is accumulating evidence that prostanoids directly contribute to the resolution of inflammation and return to homeostasis. In this mini review, we summarize the current knowledge of the resolution-regulatory properties of prostanoids and discuss potential implications for anti-inflammatory, prostanoid-targeted therapeutic interventions.
Introduction
Inflammation is an integral part of protective host responses against pathogens or injury (1). Herein, inflammatory processes usually follow a defined sequence of reactions characterized by the rapid induction of a pro-inflammatory response, which is closely followed by an anti-inflammatory response. To regain homeostasis resolution of inflammation represents an integral and crucial part of acute inflammation. In fact, failure to completely resolve inflammatory processes is associated with the emergence of chronic inflammatory conditions. While resolution was considered to merely represent the downregulation or inactivation of inflammatory mediators for a long time, it is now appreciated to be active and complex, involving the formation of pro-resolving mediators (2). Moreover, it is widely accepted that resolution processes are initiated early during inflammation, and classical pro-inflammatory mediators have been shown to directly impact on resolution as well (3). Therefore, pro-resolving therapeutic approaches are increasingly being considered rather than anti-inflammatory ones as the latter might diminish the host response against pathogenic challenges (4, 5). Since lipid mediators play a crucial, yet often ambivalent role during the inflammatory process, and prostanoid synthesis represents a major target for anti-inflammatory therapies, the present mini review aims to recapitulate the current understanding of the role of prostanoids in the context of resolution of inflammation.
The Course of Inflammation
Cellular Mediators
Upon an insult (e.g., pathogen contact, injury) local resident immune cells are the first responders. Among these, tissue resident macrophages (MΦ) represent not only an important first line of defense but even more importantly they establish an environment prone to recruit neutrophils and monocytes from the circulation. Neutrophils are main executers in the acute inflammatory environment, i.e. they produce high amounts of reactive oxygen and nitrogen species to eliminate pathogens, and secrete a plethora of inflammatory mediators (6). Within the inflammatory environment neutrophils rapidly die by apoptotic processes and are phagocytosed by MΦ in a process termed efferocytosis (7, 8). Importantly, uptake of apoptotic cells (AC) induces a shift in MΦ polarization from a pro-inflammatory to an anti-inflammatory and immunomodulatory phenotype (9–14). MΦ and other antigen-presenting cells such as dendritic cells (DC) eventually activate adaptive immune responses, which ensures complete removal of the invading pathogens and enables accelerated responses upon anew contact to the triggering stimulus (15). The return to cellular homeostasis further requires successful emigration of infiltrated immune cells from the cleared site of inflammation (16). In contrast to the concept of a rapid return to homeostasis, recent reports provided evidence that resolution is followed by a longer lasting, immune-suppressive post-resolution phase characterized by infiltrating regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC), but also MΦ, which might be decisive for a successful adaptation vs. chronic inflammation and/or autoimmunity (17–19).
Lipid Mediators
Regulation and execution of inflammatory reactions is mediated by soluble mediators, such as cytokines and chemokines. In addition, bioactive lipids emerged as crucial factors during all phases of the inflammatory process (20, 21). Specifically, while leukotrienes and prostaglandins appear early during the onset of inflammation, specialized pro-resolving mediators (SPM), such as lipoxins, resolvins, and maresins, are produced later on, facilitating the resolution of inflammation (22). Prostanoids, like leukotrienes, belong to the eicosanoid family of lipid mediators (23). Both classes are synthesized from arachidonic acid (AA) after the latter is released from membrane phospholipids by phospholipase A2 (24). While leukotrienes are synthesized by the lipoxygenases, prostanoid formation initially requires conversion of AA to the unstable prostaglandin H2 (PGH2) via the bifunctional cyclooxygenases 1 (Cox-1) and 2 (25, 26). In line with the established pro-inflammatory function of the prostanoids, the cyclooxgenases became an important target in the therapy of inflammatory diseases, and as of today, non-steroidal anti-inflammatory drugs (NSAIDs) rank amongst the most important anti-inflammatory drugs (27, 28). Of note, while Cox-1 is constitutively expressed in most cells, Cox-2 often is inducible and emerged as the more important cyclooxygenase in the context of inflammation. Consequently Cox inhibitors (Coxibs) selectively targeting Cox-2 emerged as promising novel anti-inflammatory therapeutics (29, 30). The short-lived Cox product PGH2 is then substrate to specific synthases, which produce potent prostanoids including PGD2, PGE2, PGF2α, and PGI2, as well as thromboxane A2 (TXA2) (Figure 1).
Figure 1 Prostanoid synthesis. Arachidonic acid, liberated from membrane phospholipids by phospholipase A2, is converted to prostaglandin H2 (PGH2) by the dual peroxidase/cyclooxygenase activity of the cyclooxygenases (Cox-1, Cox-2). PGH2 serves as the substrate for the terminal synthases to produce PGD2, PGE2, PGF2α, PGI2, and thromboxane A2 (TXA2). PGD2 is further dehydrated and isomerized spontaneously to 15-deoxy−Δ12,14-PGJ2 (15d-PGJ2). Alternatively, arachidonic acid can be converted to lipoxins, i.e. SPM, via the activity of the lipoxygenases (LO). L-PGDS, lipocalin-type PGD synthase; H-PGDS, hematopoietic-type PGDS; mPGES, microsomal PGES; cPGES, cytosolic PGES; TXAS, TXA synthase.
Interestingly, the production of the different lipid mediators appears to be tightly connected across the course of inflammation. For example, the presumably pro-inflammatory PGE2 was shown to attenuate the synthesis of leukotrienes and to induce the production of SPM, thus initiating the so-called lipid-mediator class switch (31). While the SPM-regulatory impact of prostanoids on the resolution of inflammation is rather well characterized, there is accumulating evidence that prostanoids also directly impinge on other aspects of the resolution process. In the following sections, we will therefore summarize the current understanding of the role of the most prominent prostanoids in resolution of inflammation, aside from the aforementioned lipid-mediator class switch, with a special focus on PGE2.
Prostanoids in the Resolution of Inflammation
Thromboxane A2
TXA2 is predominantly produced by platelets, but also at appreciable amounts by MΦ (32). Interestingly, while thromboxane A synthase (TXAS) appears to be coupled to the activity of Cox-1 and Cox-2 constitutes the dominant Cox in inflammatory conditions, the activity of TXA2 is largely pro-inflammatory (33, 34). In fact, there is little evidence that TXA2 might contribute to the resolution of inflammation. In line, Kupffer cell-derived TXA2 was shown to contribute to liver fibrosis, a common outcome of ineffective resolution (35). The observation that TXA2 synthesis is induced by pro-inflammatory stimuli, while it is suppressed upon inflammatory restimulation (36), further suggest that the prevention of TXA2, e.g. via redirection of Cox-1-provided PGH2 towards PGE2 synthesis, might be part of the immune-suppressive environment typical for the post-resolution phase (18).
Prostaglandin I2 (Prostacyclin)
PGI2 (prostacyclin) has been characterized as the counterpart of TXA2 as it inhibits platelet aggregation and acts as a potent vaso- and bronchodilator (37). It is produced primarily by vascular endothelial and smooth muscle cells, yet other cells such as fibroblasts and dendritic cells also synthesize PGI2 (38). In the context of inflammation, PGI2 was shown to inhibit LPS-induced expression of pro-inflammatory cytokines in MΦ, DC, CD4+ T cells, and endothelial cells (39–42). PGI2 further synergizes with anti-inflammatory cytokines interleukin-4 (IL-4) and IL-13 to suppress pro-inflammatory cytokines (43). Along the same lines, PGI2 receptor (IP) deficient mice displayed stronger allergic inflammation, which was attributable to enhanced Th2 cell function (44). Thus, PGI2 emerges as a predominant anti-inflammatory mediator, positioning it also as a counterpart of TXA2 in the context of inflammation.
Prostaglandin D2
PGD2 is produced by numerous immune cells including activated MΦ, DC, Th2 cells, eosinophils, platelets, but also endothelial cells (45). However, since its main source are mast cells (46, 47), PGD2 has been characterized extensively in the context of allergic reactions (48). PGD2 can further be metabolized to the cyclopentenone, PGJ2-type prostanoids, including PGJ2 and 15d-PGJ2, which also display biological activity in the context of resolution of inflammation (49). PGD2 binds to the PGD2 receptors 1 (DP1) and DP2 [also known as chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)] (50). Activation of DP2 is of specific importance in allergic inflammation, where mast cell-derived PGD2 stimulates the recruitment of innate lymphoid type 2 cells (51) and Th2 cells (52), and causes activation of these as well as of basophils and eosinophils (53). While PGD2 was shown to contribute to allergic inflammation, PGD2 synthase (PGDS) decreases during the acute inflammatory phase, while it rises again at later stages corresponding to the resolution phase in animal models (54). PGD2 and 15d-PGJ2 both exert pro-inflammatory functions via CRTH2 (55). In contrast, PGD2-dependent activation of DP1 as well as 15d-PGJ2-mediated activation of peroxisome proliferator-activated receptor γ (PPARγ) inhibit the production of inflammatory cytokines and chemokines by antigen-presenting cells including DC or MΦ by interfering with inflammatory transcription factors nuclear factor kappa B (NFκB), activator protein 1 (AP1), and signal transducer and activator of transcription 3 (STAT3) (56–58) and additionally by enhancing the activity of anti-inflammatory nuclear factor erythroid 2-like 2 (Nrf2) (59, 60). Consequently, PGD2 and 15d-PGJ2 support emigration of MΦ to the draining lymph nodes and attenuate the recruitment of leukocytes (54). They further inhibit effector functions of and induce apoptosis in T lymphocytes (57). Thus, PGD2 contributes to normalize the local environment, an important aspect of the resolution of inflammation (61).
Prostaglandin F2α
PGF2α is produced by the aldo-keto reductase (AKR) 1C3, also known as PGF2α synthase (PGFS) using PGH2 or PGD2 (62). Alternatively, PGE2 can be converted to PGF2α by AKR1C1 or AKR1C2 (63). While PGF2α is synthesized in most tissues (64), its prime site of production is the female reproductive system (65), where PGF2α has been shown to be of functional importance (66, 67). Nevertheless, PGF2α also appears to be involved in inflammatory processes (64, 68). PGF2α is elevated in rheumatoid arthritis (69) and was shown to contribute to and correlate with fibrosis (70, 71), which is characteristic for insufficient resolution. Interestingly though, PGFS expression and concomitantly PGF2α levels decrease similar to PGD2 during acute inflammation, only to increase again in the resolution phase (72), which might be indicative for an active role of PGF2α in the resolution of inflammation. Yet, the exact role of PGF2α in inflammation-resolving processes remains to be determined.
Prostaglandin E2
The best characterized and presumably most important prostanoid in the context of inflammation is PGE2. It can be synthesized by all cell types. In the context of inflammation the prime producers are fibroblasts, epithelial cells, and immune cells (73). PGE2 exerts its functions via four G-protein-coupled PGE2 receptors (EP1-4) (74). While EP2 and 4 represent Gαs-coupled receptors increasing cAMP levels upon activation (75), the Gαi-coupled EP3 variants inhibit adenylate cyclase, thus reducing cAMP (76), and Gαq EP1 enhances intracellular Ca2+ levels (74). The distinct downstream signals as well as the cell type-specific distribution of the receptors, and their differential sensitivity for PGE2 account for the diverse functions of PGE2 also in inflammation (77).
Upon inflammatory stimulation, both the expression of Cox-2 and microsomal PGE2 synthase 1 (mPGES-1) are induced in MΦ (78), skewing the prostanoid spectrum towards PGE2 production in the acute inflammatory phase (73). PGE2 signals towards enhanced recruitment of neutrophils, MΦ, and mast cells (79–81) and enhances the expression and secretion of pro-inflammatory cytokines in DC, MΦ, and T cells (82–84). Its NFκB-activating properties further support neutrophil survival, thereby extending the pro-inflammatory impact of neutrophils in the inflammatory niche (85, 86). Yet, this initial increase in PGE2 is only moderate and transient in character, and PGE2 levels rise again during the resolution phase, eventually increasing to much higher levels in the post-resolution phase (18, 87, 88). This seemingly biphasic regulation of PGE2 might at least in part be due to a shift from transcriptional to post-transcriptional programs governing not only PGE2 production, but more generally the course of inflammation (89). With respect to the regulation of PGE2 synthesis, Cox-2 rapidly accumulates during early inflammation. In a negative feedback loop, elevated PGE2 induces the expression of dual specificity phosphatase 1 (DUSP1), thereby enhancing the activity of the RNA-binding protein tristetraprolin (TTP), which destabilizes the mRNA of Cox-2, but also of pro-inflammatory tumor necrosis factor (TNF) (90). The second wave of PGE2 production by MΦ appears to be facilitated by another increase of Cox-2 expression induced by sphingosine-1-phosphate released from apoptotic cells, which activates the RNA-stabilizing protein human antigen R (HuR) in MΦ to increase Cox-2 expression (91). As a side note, while PGE2 is predominantly produced in a Cox-2/mPGES-1 dependent manner during the inflammatory and early resolution phase, PGE2 levels during the post-resolution phase are approx. 3-fold higher, which is due to enhanced Cox-1/mPGES-1 expression in MΦ (18). While these findings might explain the kinetics of PGE2 production and even some of the inhibitory effects of PGE2 on pro-inflammatory mediators, further evidence for an immunosuppressive function of MΦ-derived PGE2 emerged in the tumor context, where PGE2 inhibits CD80 expression via EP2, thereby attenuating activation of cytotoxic T cells (92, 93). Similarly, PGE2 suppresses cytolytic functions of NK cells (94, 95) and inhibits phagocytic and bacteria killing activities of MΦ, thus preventing the establishment of appropriate inflammatory, anti-microbial responses largely via EP2-dependent cAMP induction (96–98). In line, EP2- and EP4-signaling limits secretion of TNF and IL-1β, and enhances expression of anti-inflammatory IL-10 in response to LPS by microglia (99), i.e. resident MΦ of the central nervous system (100). In general, EP2- and EP4-activation by PGE2 appears to be crucial to establish an anti-inflammatory and resolving MΦ phenotype (101, 102), which is characterized by further immune-modulatory factors such as transforming growth factor β (TGFβ) (103). Nevertheless, there are contradictory reports regarding the exact impact of PGE2 on T cell functions. On the one hand, PGE2 appears to inhibit IL-2 production by T cells, thereby attenuating both T cell activation and activation-dependent apoptosis (104–106). On the other hand, while PGE2 appears to contribute to sustained inflammation by differentiation and activation of Th1 and γδ T cells, considered to support inflammation (107–109), other findings indicate that PGE2 selectively inhibits Th1 cytokine production leaving Th2 cytokines, such as IL-4 and IL-5, unaffected (110, 111), thus provoking a PGE2-dependent shift towards Th2 responses, which are associated with repair mechanisms instead (112–114). This notion is substantiated by the high levels of PGE2 observed in Th2-driven diseases such as atopic allergy (115). Indeed, the intricate impact of PGE2 on the balance between different T cell subtypes might be one of the key mechanisms how PGE2 affects a self-limiting inflammation throughout resolution and post-resolution phases. Elevated PGE2 impairs interferon γ (IFN γ) synthesis, thereby directly attenuating Th1 responses, while leaving Th2 responses unaltered (110, 111). PGE2 further favors Th17 responses via EP2 and EP4 by shifting the IL-12/IL-23 balance towards Th17-supportive IL-23 (116–118). While Th17 cells are largely inflammatory in nature contributing to severe inflammatory diseases (107, 119), they have been shown to be highly plastic, being able to trans-differentiate into Treg thereby contributing to resolution of inflammation (120). Yet, PGE2 not only promotes differentiation of naïve T cells or Th17 cells towards Tregs (121, 122), it also supports further expansion of differentiated Tregs (123). Conclusively, the concentration, source, and timing of PGE2 appear critical to determine the exact T cell response in the context of inflammatory responses. Moreover, while the pro-resolving activity of cyclooxygenase metabolites has long been attributed predominantly to PGD2 and 15d-PGJ2 (124), PGE2 emerged as an important facilitator of the lipid-mediator class switch inducing not only the production of PGD2 and its derivatives, but also of the so-called specialized pro-resolving mediators (SPM) (20). SPM, synthesized by 15-lipoxygenase (ALOX15) (31, 125–127), are key players in the resolution of inflammation (114, 128). PGE2 induces the expression of the relevant lipoxygenases, thereby skewing the balance towards a pro-resolving lipid mediator profile (129, 130). While SPM levels are mostly considered to reciprocally reflect PGE2 levels during the course of inflammation, they in fact coexist (131). The exact temporal and spatial distribution of both PGE2 and SPM might eventually determine the course of the resolution of inflammation. Of note, SPM also have been shown to affect the T cell balance (132–134). Yet, there is mounting evidence that PGE2 also directly supports further resolution-associated functions. Along these lines, PGE2 has been shown to inhibit pro-inflammatory cytokine production (99, 135) and to stimulate the expression of anti-inflammatory cytokines (136, 137), thereby contributing to the early steps of the resolution process (138). Furthermore, blocking PGE2 synthesis attenuated efficient resolution in a peritonitis model by preventing the emigration of MΦ from the site of inflammation in a CX3CL1-dependent manner (87). Extending beyond its impact on the resolution phase, PGE2 contributes to the immune suppressive post-resolution phase, where PGE2 suppresses innate immune responses, inhibits lymphocyte functions, and contributes to the generation and activity of Treg (121, 139) and MDSC (140). While these immune suppressive effects appear negative in the context of novel infections, they lower the risk of autoimmune responses (18, 19) (Figure 2). The complexity of the resolution of inflammation both at cellular as well as (lipid) mediator level, highlights the need for further studies unraveling details of the resolution phase to allow for the development of refined therapeutic intervention strategies, especially for chronic inflammatory diseases lacking proper resolution mechanisms.
Figure 2 PGE2 in the context of inflammation. An inflammatory insult is recognized by resident immune cells such as resident MΦ. Upon inflammatory stimulation Cox-2 and mPGES-1 are induced in MΦ resulting in increased PGE2 synthesis. PGE2 then contributes to the MΦ-mediated recruitment of neutrophils, which act as a first line of defense to eliminate the pathogenic stimulus and incite further inflammatory responses. Already at this early stage of the inflammatory process PGE2 initiates the lipid mediator class switch towards the production of specialized pro-resolving mediators (SPM) including lipoxins, resolvins, maresins, and protectins e.g. in neutrophils. Neutrophils are rapidly followed by monocytes again facilitated by PGE2, which upon infiltration into the affected tissue differentiate into pro-inflammatorily activated MΦ and release soluble mediators including cytokines and chemokines, as well as further PGE2. PGE2-triggered transcriptional programs eventually induce post-transcriptional feedback circuits, which reduce Cox-2 mRNA stability and thus protein expression to eventually inhibit PGE2 production, and also attenuate the expression of pro-inflammatory cytokines such as TNF. In addition, anti-inflammatory mediators (including IL-10) are induced restricting the intensity of the inflammatory reactions. Within the inflammatory niche, activated neutrophils rapidly undergo apoptotic cell death and are phagocytosed by MΦ, which causes a shift in MΦ polarization towards an alternatively activated, immune-modulatory, resolution phenotype characterized by the secretion of e.g. TGFβ. Apoptotic cells further release sphingosine-1-phosphate (S1P), which enhances the mRNA stability of Cox-2 again, resulting in increasing PGE2 production. Within the resolving environment PGE2 supports a shift from Th1 T cells to the repair-associated Th2-type further supporting tissue normalization. In addition, PGE2 attenuates expression of CX3CL1 in MΦ, thereby eventually allowing their emigration from the resolving tissue. PGE2 further supports the recruitment of T cells and myeloid cells, which differentiate into regulatory T cells and myeloid-derived suppressor cells, respectively, thereby establishing an immune-suppressive post-resolution environment. Lower part: During inflammation, PGE2 levels transiently increase in the acute inflammatory phase. After a decrease during the anti-inflammatory and the early resolution phase, PGE2 tends to increase again during the progress of resolution, reaching highest levels in the post-resolution phase. AC, apoptotic cells; MΦ, macrophages (gray – naïve, resident; red – pro-inflammatory; blue – anti-inflammatory; green – resolution phase); MDSC, myeloid-derived suppressor cells; MO, monocytes; PMN, neutrophils (gray – naïve, red – inflammatory); T cells (red – Th1; blue – Th2; green – Treg); ⇨, infiltration/emigration; →, development within the inflammatory niche.
Therapeutic Considerations
Cox inhibitors are amongst the most widely used over the counter anti-inflammatory drugs worldwide (141). Despite the undisputed beneficial effects of the broad spectrum Cox inhibitors, specific Cox-2 inhibitors (Coxibs) were developed to more selectively interfere with the production of inflammation-associated prostanoids (142). Due to the prominent role of PGE2 in the establishment of inflammatory processes, recent therapeutic approaches aimed at inhibiting the inflammation-associated terminal PGE2 synthase mPGES-1 to selectively block the production of PGE2 only (73, 143, 144). Yet, considering the major impact of PGE2 on successful resolution of inflammation, therapeutic approaches targeting PGE2 synthesis should be critically revisited as continued PGE2 inhibition in inflammatory diseases might be expected to lead to chronic diseases due to insufficient resolution. In fact, even attenuating inflammation itself might interfere with successful resolution, since the process of resolution is initiated already very early during the inflammatory process (3). Thus, it might be warranted to focus on therapeutic approaches promoting resolution rather than on anti-inflammatory ones in the future (4, 145). Indeed, there are numerous efforts to target SPM production or receptors (146). Considering promising effects of PGE2 receptor antagonists (e.g. EP4) in the context of chronic inflammatory diseases (147), it will be interesting to see combinatorial approaches in the future.
Author Contributions
TS and BB wrote and edited the manuscript. All authors contributed to the article and approved the submitted version.
Funding
This work was supported by grants of the DFG (GRK 2336 TP6, SCHM2663/7, SFB1039 B04).
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Keywords: prostaglandin, prostacyclin, thromboxane, specialized pro-resolving mediator, inflammation, resolution, macrophage
Citation: Schmid T and Brüne B (2021) Prostanoids and Resolution of Inflammation – Beyond the Lipid-Mediator Class Switch. Front. Immunol. 12:714042. doi: 10.3389/fimmu.2021.714042
Received: 24 May 2021; Accepted: 30 June 2021;
Published: 12 July 2021.
Edited by:
Amiram Ariel, University of Haifa, IsraelReviewed by:
Eoin Brennan, University College Dublin, IrelandValerio Chiurchiù, Italian National Research Council, Italy
Copyright © 2021 Schmid and Brüne. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Tobias Schmid, t.schmid@biochem.uni-frankfurt.de