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Maria A. Chelombitko1*
Boris V. Chernyak1
Artem V. Fedorov2
Roman A. Zinovkin1,3
Ehud Razin4
Lakhsmi Bhargavi Paruchuru4*- 1Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
- 2Department of Cell Biology and Histology, Biology Faculty, Lomonosov Moscow State University, Moscow, Russia
- 3Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
- 4Department of Biochemistry and Molecular Biology, School of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
A Corrigendum on
The Role Played by Mitochondria in FcϵRI-Dependent Mast Cell Activation
By Chelombitko MA, Chernyak BV, Fedorov AV, Zinovkin RA, Razin E and Paruchuru LB (2020). Front. Immunol. 11:584210. doi: 10.3389/fimmu.2020.584210
In the original article, there was an error. The statement that mitochondrial ROS inhibit the activity of NEMO is wrong. Mitochondrial ROS are crucial for the activation of the IKK-NEMO complex.
A correction has been made to the section The Role Played by Mitochondria in the FcϵRI-Dependent Mast Cell Activation, subsection Mitochondrial ROS, paragraph 6. The correct paragraph appears below.
Mitochondrial ROS can stimulate NF-κB signaling by activating the kinase (IKK) of the inhibitor of NF-κB (IκB), which promotes its proteasome degradation and induces nuclear translocation of NF-κB (81, 84). Mitochondrial ROS-dependent activation of IKK can be mediated by several mechanisms, including the formation of intermolecular disulfide bonds in NF-κB essential modulator (NEMO), a component of the IKK complex (85).
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
References
81. Park J, Min J-S, Kim B, Chae U-B, Yun JW, Choi M-S, et al. Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways. Neurosci Lett. (2015) 584:191–196. doi: 10.1016/j.neulet.2014.10.016
84. Zinovkin RA, Romaschenko VP, Galkin II, Zakharova VV, Pletjushkina OY, Chernyak BV, et al. Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium. Aging. (2014) 6:661–74. doi: 10.18632/aging.100685
Keywords: mast cell, mitochondria, FcϵRI-dependent activation, IgE, allergy
Citation: Chelombitko MA, Chernyak BV, Fedorov AV, Zinovkin RA, Razin E and Paruchuru LB (2020) Corrigendum: The Role Played by Mitochondria in FcϵRI-Dependent Mast Cell Activation. Front. Immunol. 11:620293. doi: 10.3389/fimmu.2020.620293
Received: 22 October 2020; Accepted: 10 November 2020;
Published: 11 December 2020.
Edited and reviewed by: Pedro Manoel Mendes Moraes Vieira, Campinas State University, Brazil
Copyright © 2020 Chelombitko, Chernyak, Fedorov, Zinovkin, Razin and Paruchuru. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Maria A. Chelombitko, Y2hlbG9tYml0a29AbWFpbC5iaW8ubXN1LnJ1; Lakhsmi Bhargavi Paruchuru, YmhhcmdhdmkubGFrc2htaUBtYWlsLmh1amkuYWMuaWw=