Pia Christ1
Axel Lorentz- 1Institute for Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
- 2Food Science and Nutrition, the Robert H. Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, The Hebrew University, Rehovot, Israel
Allergic diseases are known to vary in the severity of their symptoms throughout the day/night cycle. This rhythmicity is also observed in mast cell function and responsiveness. Mast cells are key effector cells of allergic reactions and release cytokines, chemokines, and important inflammatory mediators such as histamine, which have been shown to display diurnal variation. Recent research clarified that mast cells are controlled by their internal clock—which is regulated by a specific set of clock genes—as well as external factors such as light sensed by the suprachiasmatic nuclei, hormonal status, or diet. Here, we give an overview of the connections between circadian clock, mast cells, and allergic disease. Further work aimed at studying the role of chronotherapy/chronomedicine should take into account this rhythmic nature of not only mast cells but also the immune responses generated by mast cell signaling.
Introduction
The human biological clock is a remarkable built-in mechanism, which works according to the Earth’s rotation and to changes in light, temperature, and environment, to create a 24-h rhythm. This rhythm is orchestrated by a central pacemaker in the brain that resets the clocks in peripheral organs and tissues to control the expression of key genes throughout the day. The circadian clock, driven by cell-autonomous biological clocks (1, 2), takes its cues from cycles of light and dark but also from levels of hormones or metabolic status such as feeding to directly modulate peripheral clocks, thereby affecting many physiological processes, which include response to medications or immunity (3–6). A multitude of immunological processes have been shown to be linked to the biological clock or to function under the control of circadian rhythms. Steroid levels, for example, are known to naturally cycle with the circadian clock whereby the feedback loop, which controls the release of cortisol is most apt to respond to synthetic corticosteroid treatment in the morning rather than at other times of day giving way to the inclusion of timing in the treatment of various conditions, a term known as chronotherapy or chronomedicine (7). Chronomedicine has taken a boost in interest as the Nobel Prize for Physiology or Medicine was recently awarded to Jeffrey Hall, Michael Rosbash, and Michael Young who elucidated the cellular mechanism behind circadian rhythms (8). Now it is known that many immunological processes including the number of immune cells, cytokines, and chemokines differ throughout the day with peak times dependent on tissue and circadian gene expression (9) leading to a connection between the biological clock and levels of inflammation, development of disease, and response to treatment (10, 11).
Allergic conditions such as asthma or allergic rhinitis have historically shown circadian bias as the severity of symptoms is exacerbated between midnight and morning time and exhibits prominent 24-h variation (12, 13). Mast cells are known to have multiple immunoregulatory functions through the release of their mediators, such as histamine, leukotrienes, cytokines, chemokines and proteases and also serve as the key drivers of long-term pathophysiological changes associated with chronic allergic responses (14, 15). Mast cell activation occurs during type I allergic reactions via antigen-mediated aggregation of immunoglobulin E-bound FcεRIs (Figure 1) (16, 17). As they are the main effector cells in allergy, the rhythmicity of mast cells has also come under investigation. For example, in some of the earlier findings, serum mast cell tryptase and plasma histamine levels were shown to be lower in the afternoon but peaked during night (18, 19). In the following review, we give a brief overview of the role of the circadian clock in regulating mast cells and allergic reactions. As there are various types of mast cells (20), it is conceivable to think that the circadian clock regulates the expression of type-specific genes leading to different functions.
Figure 1. The mast cell clock in type I allergic reaction. Allergens are taken up by antigen-presenting cells such as dendritic cells (DC), which present them to naïve CD4+ T cells via major histocompatibility complex class II. In the presence of IL-4, naïve CD4+ T cells differentiate into Th2 cells. Secretion of IL-4 or IL-13 by Th2 cells causes an isotype switch to IgE in B cells. Allergen-specific IgE engages to FcεRI on mast cells. If allergens bind to specific IgE, FcεRI is cross-linked, followed by the release of mast cell mediators such as histamine and tryptase and induction of allergic symptoms. The circadian clock consists of the central oscillator, located in the suprachiasmatic nucleus (SCN) of the hypothalamus, and peripheral oscillators present in virtually all cell types. Light activates photoreceptors and via retinohypothalamic tract (RHT) the central SCN clock. Peripheral circadian clocks are synchronized and entrained by autonomic innervation and humoral factors. Clocks in peripheral tissues use the same molecular components like present in SCN, as the core molecular clock consists of interlocked transcriptional and translational feedback loops. Core clock proteins BMAL1 and CLOCK form a heterodimer and, by binding to E-box-motifs, induce the expression of other clock components. Among them are BMAL1 positively regulatory proteins like RORα as well as negatively regulatory proteins like REV-ERBs, PERs, and CRYs, thus concurrently attenuate their own transcription and initiate a new transcription cycle. DBP and NFIL3 form another loop that regulates transcription of genes containing D-box sequences, including those for PERs, and thus cooperate with the core clock to establish robust 24-h rhythms. The mast cell clock may temporally gate expression of FcεRI, ST2, OCT3, etc., via CLOCK and E-box elements, thereby generating a marked circadian variation in IgE/mast cell-mediated allergic reactions.
The Molecular Mechanism of the Circadian Clock
In mammals, the core molecular clock consists of interlocked transcriptional and translational feedback loops that regulate the expression of clock genes (Figure 1). The transcription factors brain and muscle ARNT-like protein 1 (BMAL1) and circadian locomotor output cycles Kaput (CLOCK) form a heterodimer and induce the transcription of other clock genes via binding to E-box-motifs (5′-CANNTG-3′). Among the transcriptional output are BMAL1 positively regulatory proteins like RAR-related orphan receptor alpha (RORα), as well as negatively regulatory proteins like REV-ERBs (REV-ERBα, REV-ERBβ), Periods 1-3 (PER1, PER2, PER3), and Cryptochromes (CRY1, CRY2). RORα and REV-ERBα/β act by binding to the ROR response element (RORE) of target genes. Upon oligomerization, PER and CRY inhibit BMAL1/CLOCK dimers and concurrently attenuate their own transcription, thus initiating a new transcription cycle. Albumin D-box binding protein (DBP) and the repressor nuclear factor interleukin 3 establish another loop that regulates transcription of genes containing D-box sequences, including those for PERs, and thus contribute to set robust 24-h rhythms. Furthermore, posttranslational modifications as well as other secondary clock proteins that feedback to the core clock mechanism add to the complexity of this molecular network (2, 21–24).
The Circadian Clock in Mast Cells
It has previously been demonstrated that mast cells have a functional molecular clock and that the core clock genes show rhythmic circadian expression patterns (25, 26). Murine clock genes mClock, mBmal1, mPer1, and mPer2, as well as mast cell-specific genes mMcpt-5, mMcpt-7, mc-kit, and mFcεRI αchain (and the proteins mMCPT5 and mc-Kit) showed circadian mRNA expression in mast cells isolated from mouse jejunum (25). Murine bone marrow-derived mast cells (BMMCs) demonstrated circadian expression of mPer1, mPer2, mBmal1, mRev-erbα, and mDbp (26) and human intestinal mast cells also exhibited circadian regulation of the expression of hPer1, hPer2, and hBmal1 as well as hTryptase and hFcεRI (25).
As the IgE/mast cell axis plays a central role in allergic diseases, including allergic rhinitis, asthma, urticaria, and food allergy, further work on the role of IgE stimulation is important to understand the cellular underpinnings of these events (15, 27). Experiments of our group showed that human intestinal mast cells produce a circadian release of de novo synthesized cysteinyl leukotrienes and pre-stored histamine upon IgE-mediated activation (25, 26). Moreover, stimulation at different time points via FcεRI resulted in rhythmic interleukin (IL)-13 and IL-6 cytokine mRNA expression in BMMCs. FcεRI α chain mRNA and protein levels displayed a circadian pattern, which could explain the circadian oscillation of cytokine production in response to activation via FcεRI (26). We subsequently found that the phosphorylation of the signaling molecule extracellular-signal regulated kinase 1/2 (ERK1/2) in response to FcεRI crosslinking showed circadian rhythms (28). ERK1/2 plays a major role in cytokine expression, degranulation, and arachidonic acid metabolism in mast cells (29). Thus, the clock affects activation of signaling molecules, such as ERK1/2, and thereby the functionality of mast cells resulting in circadian production and release of mediators. The impact of the clock on the reactivity of mast cells may explain how mast cells can contribute to the circadian variation of allergic symptoms. Noteworthy, cells in culture are reset by dexamethasone treatment, medium change, or serum shock. These treatments could affect several signaling as well as metabolic pathways, which might also interfere with the analyses (30, 31).
Different mouse models can further elucidate these roles. Wild-type mice displayed variations in allergic reactions depending on time of day while this variation was lacking in Per2- and Clock-mutated mice (32). Using mice with a loss-of-function mutation of Per2 (mPer2m/m mice), Nakamura et al. identified PER2 as a regulator of time of day-dependent variation in passive cutaneous anaphylactic reaction. The time-of-day-dependent variation observed in wild-type mice was absent in mPer2m/m mice. Moreover, loss of rhythmic secretion of corticosterone was obtained in mPer2m/m mice, accompanied by a decreased sensitivity to dexamethasone. Interestingly, there was no difference in IgE-mediated degranulation between BMMCs of wild-type and mPer2m/m mice, as PER2 possibly regulates the response to glucocorticoids in mast cells. However, Per2 mutations affect all cells and, therefore, it could not be identified, whether it is PER2s’ control of adrenal glands and glucocorticoid secretion and/or its impact on mast cell clock that is causative for time-of-day-dependent variations in passive cutaneous anaphylactic reaction (33).
The important role of the mast cell-intrinsic clockwork in IgE/mast cell-mediated allergic reactions is supported by the finding that the time-of-day-dependent variation of cutaneous anaphylactic reaction was also absent in mice with a Clock mutation in mast cells. Using mast cell-deficient W/Wv mice subcutaneously reconstituted with BMMCs generated from wild-type mice and mice with a dominant negative-type mutation of Clock (ClockD19/D19 mice), Nakamura et al. reported that this Clock mutation was accompanied by the loss of temporal regulation of FcεRI expression, signaling, and the absence of variations in IgE-mediated degranulation in vivo and vitro (34). They observed circadian mRNA expression of FcεRI β, the β subunit of FcεRI, which has been shown to function as an amplifier of the high-affinity IgE receptor (35). However, they did not detect circadian expression of other FcεRI signaling–associated molecules upstream of Ca2+ signaling, such as FcεRI α and FcεRI γ, Syk, and STIM1 whereas Wang et al. and we found circadian expression of FcεRI α (25, 26). Several E-box–like elements to which the CLOCK/BMAL1 complex can theoretically bind are present in the promoter region of the mouse FcεRI β chain; therefore, the authors further tested whether CLOCK binds to the promoter region of FcεRI β. They observed that the transcription of FcεRI is under control of the mast cell clock as CLOCK could be shown to bind to the promoter of FcεRI β chain (34). Table 1 summarizes clock genes analyzed in mast cells and depicts there circadian impact on mast cells.
Table 1. Clock genes analyzed in mast cells.
Mechanisms Underlying the Circadian Function of Mast Cells
The molecular mechanisms underlying the circadian function of mast cells are still under investigation but core transcription factors of the molecular clock (i.e., CLOCK) together with common regulator sequences such as the E-box elements seem to be critical for this mechanisms (Figure 1). Downstream targets include mast cell mediators such as cytokines and histamine release, both of which in turn can serve as modulators of the circadian clock. For example, pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α or IL-1β, known to be expressed by mast cells (46), have been shown to be involved in altered expression of clock genes in cultured fibroblasts (30). TNF-α has also been found to have an impact on the expression of core clock genes in mice (47). IL-33 is a cytokine that executes diverse functions in innate and acquired immune responses, including allergic reactions (48). It strongly stimulates innate immune cells such as mast cells, basophils, and group-2 innate lymphoid cells to produce various cytokines/chemokines, including IL-6, IL-13, and TNF-α via the IL-1 receptor-like 1 protein ST2 (49). Kawauchi et al. observed that, similar to IgE/mast cell-mediated allergic reactions and expression of FcεRI β, CLOCK also temporally regulates mast cell response to IL-33 that was absent in Clock-mutated mice by directly binding to the promotor region of ST2 and thus inducing ST2 expression. Thereby, CLOCK affects time-of-day-dependent cytokine release of IL-6, IL-13, and TNF-α in wild-type BMMCs, as well as IL-13 and Gob-5 mRNA expression, and neutrophil infiltration (38).
Histamine levels are another potent downstream target. Allergic symptoms exacerbate during nighttime and plasma histamine levels exhibit nocturnal peaks. In mastocytosis patients, peak levels of plasma histamine were observed in the early morning with the lowest in the afternoon (19). Interestingly, circadian variations of plasma histamine levels were diminished in mast cell-deficient mice reconstituted with Clock-mutated BMMCs demonstrating the influence of the mast cell clock (37). Organic cation transporter 3 (OCT3), which is involved in histamine transport, is temporally controlled by Clock in mast cells by binding to the promoter of mouse OCT3. Circadian variations in plasma histamine levels were lost upon inhibition of OCT3. Stress caused desynchronization of the mast cell clock, which was associated with the loss of circadian variations in OCT3 expression and thereby plasma histamine levels (37). Thus, stress can disrupt the proper role of mast cells in regulating histamine levels, which in turn serve as modulators of circadian rhythm.
Histamine release also connects mast cells, the biological clock, and the hypothalamus. Intracranial mast cells of dogs passively sensitized with IgE and subsequently antigen-treated caused a marked increase in cortisol secretion of the adrenal gland, whereas pretreatment with histamine H1 blocker or anti-corticotropin-releasing factor antibodies, attenuated the increasing cortisol level. This demonstrates the influence of brain mast cells on hypothalamic–pituitary–adrenal axis (50), which can be activated by anaphylactic shock or administration of histamine (51, 52). Additionally, histamine was shown to inhibit dopamine release in the mouse striatum by modulating presynaptic H3 receptors (53). These studies implicate a possible contribution of mast cells to the regulation of the systemic clock by histamine release.
Chronoregulation of Mast Cells
While mast cells have downstream mediators, which can account for the rhythmicity of certain conditions, they are themselves under the control of various biological functions. One of these functions is nutritional status. Restricted food intake and base energy consumption of an organism can reset the circadian clock, alleviate inflammation, and have been suggested to be beneficial for health (54, 55). We thus analyzed relative mRNA of mast cell-specific markers, including mast cell protease 4 (MCPT-4), mast cell chymase1 (MCPT-5/CMA1), and c-Kit receptor (C-KIT/CD117) for circadian expression in mice jejunum under various feeding conditions. Under conditions of ad libitum food intake, mMcpt-4 and mMcpt-5 displayed an oscillatory pattern while during time-restricted feeding, they expressed a higher amplitude, showed a phase advance, and became more robust although the daily average level wasn’t increased significantly. Interestingly, an adaptation to food intake time could be detected, as mMcpt-4 peaked just before food was given under restricted feeding conditions (55). These findings highlight a role of nutrition in regulating peripheral clocks in tissues and cells.
Indirectly responsible for the timing of food intake is the principal environmental stimulus for circadian rhythms in mammals, the light pattern based on 24 h light–dark cycles (5). Initiated by light activating intrinsically photosensitive ganglion cells in the retina, the suprachiasmatic nucleus (SCN) of the anterior hypothalamus is entrained via the retinohypothalamic tract (RHT). The SCN, region of the circadian pacemaker, in turn synchronizes peripheral clocks by using mediators such as neuronal signals and hormones (56). Hormones and neurotransmitters released by autonomic nervous system and the hypothalamus–pituitary–adrenal gland axis control and modulate clocks and functions of various cell types, including mast cells.
Mechanical disruption of the SCN resulted in the absence of a time of day-dependent variation in passive systemic anaphylactic reaction in mice, accompanied by the loss of circadian variations in serum histamine, MCP-1 (CCL2), and IL-6 levels (57). Mast cell clocks may also be controlled by rhythmic secretion of glucocorticoids of the adrenal glands as the rhythmic response to IgE-dependent activation in a mouse model of passive cutaneous anaphylaxis was lost not only in Per2-mutant mice but also in adrenalectomized mice, associated with an aberrant daily level of serum corticosterone. If serum corticosterone level was high during day-time, Per2 expression in mast cells was high as well, indicating the influence of the systemic clock on mast cells (33). It is well known that plasma concentrations of adrenocorticotrophic hormone and cortisol show circadian variations in humans (58), controlled by SCN and adrenal glands (59), and that glucocorticoids are potent in resetting circadian clocks. Inhalation of dexamethasone—a glucocorticoid receptor agonist—caused a 6-h phase advance in gene expression of mPer1, mPer2, and mClca3 in lungs of ovalbumin-treated and control mice (60). Stability of core clock proteins is determined by posttranslational modifications. Casein kinases CK1δ and CK1ε play a pivotal role as they phosphorylate PER proteins, leading to their degradation (61). Corticosterone or treatment with PF670462, a selective inhibitor of casein kinase 1d/ε, averted IgE-mediated allergic reactions in vitro and vivo. Passive cutaneous anaphylactic reactions exhibited increased levels of PER2 in mast cells that were ameliorated by PF670462 or corticosterone treatment of mice (39).
Concluding Remarks
The circadian clock modulates a multitude of human conditions including asthma and allergy although the cellular mechanisms regulating the clock are still under investigation. Mast cells, which serve as key effector cells in allergic disease were shown to be under control of the SCN and to have a circadian expression and release of their mediators in response to activation. Being ubiquitously distributed throughout connective and mucosal tissues and near blood vessels, mast cells are uniquely able to affect other immune cells and serve as a transition point from innate to adaptive immune response (46, 62). Hence, disrupted mast cell clocks could impair the subsequent adaptive immune responses and trigger or fortify allergic symptoms.
As there is growing evidence on the importance of the biological clock in allergic syndromes, targeting mast cell clock can be considered a valuable target of chronotherapy. Resetting the mast cell clock has shown promise in patients responding to subcutaneous allergen immunotherapy as well as to artificial glucocorticoids for asthma treatment (11, 63, 64). The biological clock is quickly becoming another lever in the field of personalized medicine, which aims to add the time factor as another dimension of therapy. Getting a better understanding of the role of mast cells, and other effector cells, in their circadian responses can help people live better lives just by changing the timing or scheduling of medications. Although practical challenges remain, the goal of uncovering the timing of mast cell signaling holds great promise for future medical applications and the understanding of human health and disease.
Author Contributions
AL, PC, and AS designed the manuscript and were involved in drafting. OF revised the manuscript. All authors read, corrected, and approved the final manuscript. Figure was made by AL.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Funding
This work was supported by the German Research Foundation (DFG, LO 581/7-1) to AL and OF.
References
1. Dibner C, Schibler U. Circadian timing of metabolism in animal models and humans. J Intern Med (2015) 277:513–27. doi:10.1111/joim.12347
2. Man K, Loudon A, Chawla A. Immunity around the clock. Science (2016) 354:999–1003. doi:10.1126/science.aah4966
3. Dickmeis T, Weger BD, Weger M. The circadian clock and glucocorticoids – interactions across many time scales. Mol Cell Endocrinol (2013) 380:2–15. doi:10.1016/j.mce.2013.05.012
4. Oster H, Challet E, Ott V, Arvat E, de Kloet ER, Dijk DJ, et al. The functional and clinical significance of the 24-hour rhythm of circulating glucocorticoids. Endocr Rev (2017) 38:3–45. doi:10.1210/er.2015-1080
5. Scheiermann C, Kunisaki Y, Frenette PS. Circadian control of the immune system. Nat Rev Immunol (2013) 13:190–8. doi:10.1038/nri3386
6. Theoharides TC. Neuroendocrinology of mast cells: challenges and controversies. Exp Dermatol (2017) 26:751–9. doi:10.1111/exd.13288
7. Peeples L. Medicine’s secret ingredient – it’s in the timing. Nature (2018) 556:290–2. doi:10.1038/d41586-018-04600-8
8. Callaway E, Ledford H. Medicine Nobel awarded for work on circadian clocks. Nature (2017) 550:18–18. doi:10.1038/nature.2017.22736
9. Cermakian N, Lange T, Golombek D, Sarkar D, Nakao A, Shibata S, et al. Crosstalk between the circadian clock circuitry and the immune system. Chronobiol Int (2013) 30:870–88. doi:10.3109/07420528.2013.782315
10. Wendeu-Foyet MG, Menegaux F. Circadian disruption and prostate cancer risk: an updated review of epidemiological evidences. Cancer Epidemiol Biomarkers Prev (2017) 26:985–91. doi:10.1158/1055-9965.EPI-16-1030
11. Bavishi AA, Grammer LC, Pongracic J, Rychlik K, Kumar R, Zee P, et al. Diurnal variations in subcutaneous allergen immunotherapy reactions. Ann Allergy Asthma Immunol (2017) 118:103–7. doi:10.1016/j.anai.2016.10.007
12. Durrington HJ, Farrow SN, Loudon AS, Ray DW. The circadian clock and asthma. Thorax (2014) 69:90–2. doi:10.1136/thoraxjnl-2013-203482
13. Smolensky MH, Lemmer B, Reinberg AE. Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma. Adv Drug Deliv Rev (2007) 59:852–82. doi:10.1016/j.addr.2007.08.016
14. Amin K. The role of mast cells in allergic inflammation. Respir Med (2012) 106:9–14. doi:10.1016/j.rmed.2011.09.007
15. Galli SJ, Tsai M. IgE and mast cells in allergic disease. Nat Med (2012) 18:693–704. doi:10.1038/nm.2755
16. Cildir G, Pant H, Lopez AF, Tergaonkar V. The transcriptional program, functional heterogeneity, and clinical targeting of mast cells. J Exp Med (2017) 214:2491–506. doi:10.1084/jem.20170910
17. Lorentz A, Baumann A, Vitte J, Blank U. The SNARE machinery in mast cell secretion. Front Immunol (2012) 3:143. doi:10.3389/fimmu.2012.00143
18. Dugas-Breit S, Przybilla B, Schopf P, Rueff F. Possible circadian variation of serum mast cell tryptase concentration. Allergy (2005) 60:689–92. doi:10.1111/j.1398-9995.2005.00771.x
19. Friedman BS, Steinberg SC, Meggs WJ, Kaliner MA, Frieri M, Metcalfe DD. Analysis of plasma histamine levels in patients with mast cell disorders. Am J Med (1989) 87:649–54. doi:10.1016/S0002-9343(89)80398-5
20. Gurish MF, Austen KF. Developmental origin and functional specialization of mast cell subsets. Immunity (2012) 37:25–33. doi:10.1016/j.immuni.2012.07.003
21. Buhr ED, Takahashi JS. Molecular components of the mammalian circadian clock. Handb Exp Pharmacol (2013) 217:3–27. doi:10.1007/978-3-642-25950-0_1
22. Geiger SS, Fagundes CT, Siegel RM. Chrono-immunology: progress and challenges in understanding links between the circadian and immune systems. Immunology (2015) 146:349–58. doi:10.1111/imm.12525
23. Koike N, Yoo SH, Huang HC, Kumar V, Lee C, Kim TK, et al. Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science (2012) 338:349–54. doi:10.1126/science.1226339
24. Pett JP, Korenčič A, Wesener F, Kramer A, Herzel H. Feedback loops of the mammalian circadian clock constitute repressilator. PLoS Comput Biol (2016) 12:e1005266. doi:10.1371/journal.pcbi.1005266
25. Baumann A, Gönnenwein S, Bischoff SC, Sherman H, Chapnik N, Froy O, et al. The circadian clock is functional in eosinophils and mast cells. Immunology (2013) 140:465–74. doi:10.1111/imm.12157
26. Wang X, Reece SP, Van Scott MR, Brown JM. A circadian clock in murine bone marrow-derived mast cells modulates IgE-dependent activation in vitro. Brain Behav Immun (2011) 25:127–34. doi:10.1016/j.bbi.2010.09.007
27. Siebenhaar F, Redegeld FA, Bischoff SC, Gibbs BF, Maurer M. Mast cells as drivers of disease and therapeutic targets. Trends Immunol (2018) 39:151–62. doi:10.1016/j.it.2017.10.005
28. Baumann A, Feilhauer K, Bischoff SC, Froy O, Lorentz A. IgE-dependent activation of human mast cells and fMLP-mediated activation of human eosinophils is controlled by the circadian clock. Mol Immunol (2015) 64:76–81. doi:10.1016/j.molimm.2014.10.026
29. Feuser K, Feilhauer K, Staib L, Bischoff SC, Lorentz A. Akt cross-links IL-4 priming, stem cell factor signaling, and IgE-dependent activation in mature human mast cells. Mol Immunol (2011) 48:546–52. doi:10.1016/j.molimm.2010.10.010
30. Tahara Y, Shibata S. Entrainment of the mouse circadian clock: effects of stress, exercise, and nutrition. Free Radic Biol Med (2018) 119:129–38. doi:10.1016/j.freeradbiomed.2017.12.026
31. Uchoa ET, Aguilera G, Herman JP, Fiedler JL, Deak T, de Sousa MBC. Novel aspects of glucocorticoid actions. J Neuroendocrinol (2014) 26:557–72. doi:10.1111/jne.12157
32. Nakao A, Nakamura Y, Shibata S. The circadian clock functions as a potent regulator of allergic reaction. Allergy (2015) 70:467–73. doi:10.1111/all.12596
33. Nakamura Y, Harama D, Shimokawa N, Hara M, Suzuki R, Tahara Y, et al. Circadian clock gene Period2 regulates a time-of-day-dependent variation in cutaneous anaphylactic reaction. J Allergy Clin Immunol (2011) 127:.e1–3. doi:10.1016/j.jaci.2011.02.006
34. Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, et al. Circadian regulation of allergic reactions by the mast cell clock in mice. J Allergy Clin Immunol (2014) 133:568–75. doi:10.1016/j.jaci.2013.07.040
35. Lin S, Cicala C, Scharenberg AM, Kinet JP. The FcεRIβ subunit functions as an amplifier of FcεRIγ-mediated cell activation signals. Cell (1996) 85:985–95. doi:10.1016/S0092-8674(00)81300-8
36. Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, et al. Biological clock dysfunction exacerbates contact hypersensitivity in mice. Br J Dermatol (2013) 168(1):39–46. doi:10.1111/j.1365-2133.2012.11176.x
37. Nakamura Y, Ishimaru K, Shibata S, Nakao A. Regulation of plasma histamine levels by the mast cell clock and its modulation by stress. Sci Rep (2017) 7:39934. doi:10.1038/srep39934
38. Kawauchi T, Ishimaru K, Nakamura Y, Nakano N, Hara M, Ogawa H, et al. Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response. Allergol Int (2017) 66:472–8. doi:10.1016/j.alit.2017.02.004
39. Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, et al. Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock. J Allergy Clin Immunol (2016) 137:1226–35. doi:10.1016/j.jaci.2015.08.052
40. Fu L, Lee CC. The circadian clock: pacemaker and tumour suppressor. Nat Rev Cancer (2003) 3:350–61. doi:10.1038/nrc1072
41. Ukai-Tadenuma M, Kasukawa T, Ueda HR. Proof-by-synthesis of the transcriptional logic of mammalian circadian clocks. Nat Cell Biol (2008) 10:1154–63. doi:10.1038/ncb1775
42. Korenčič A, Bordyugov G, Košir R, Rozman D, Goličnik M, Herzel H. The interplay of cis-regulatory elements rules circadian rhythms in mouse liver. PLoS One (2012) 7:e46835. doi:10.1371/journal.pone.0046835
43. Aguilar-Arnal L, Hakim O, Patel VR, Baldi P, Hager GL, Sassone-Corsi P. Cycles in spatial and temporal chromosomal organization driven by the circadian clock. Nat Struct Mol Biol (2013) 20:1206–13. doi:10.1038/nsmb.2667
44. Fontenot MR, Berto S, Liu Y, Werthmann G, Douglas C, Usui N, et al. Novel transcriptional networks regulated by CLOCK in human neurons. Genes Dev (2017) 31:2121–35. doi:10.1101/gad.305813.117
45. Mermet J, Yeung J, Hurni C, Mauvoisin D, Gustafson K, Jouffe C, et al. Clock-dependent chromatin topology modulates circadian transcription and behavior. Genes Dev (2018) 32:347–58. doi:10.1101/gad.312397.118
46. Mukai K, Tsai M, Saito H, Galli SJ. Mast cells as sources of cytokines, chemokines, and growth factors. Immunol Rev (2018) 282:121–50. doi:10.1111/imr.12634
47. Paladino N, Mul Fedele ML, Duhart JM, Marpegan L, Golombek DA. Modulation of mammalian circadian rhythms by tumor necrosis factor-α. Chronobiol Int (2014) 31:668–79. doi:10.3109/07420528.2014.886588
48. Cayrol C, Girard JP. IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy. Curr Opin Immunol (2014) 31:31–7. doi:10.1016/j.coi.2014.09.004
49. Oboki K, Ohno T, Kajiwara N, Saito H, Nakae S. IL-33 and IL-33 receptors in host defense and diseases. Allergol Int (2010) 59:143–60. doi:10.2332/allergolint.10-RAI-0186
50. Matsumoto I, Inoue Y, Shimada T, Aikawa T. Brain mast cells act as an immune gate to the hypothalamic-pituitary-adrenal axis in dogs. J Exp Med (2001) 194:71–8. doi:10.1084/jem.194.1.71
51. Hirose T, Matsumoto I, Suzuki T. Adrenal cortical secretory responses to histamine and cyanide in dogs with hypothalamic lesions. Neuroendocrinology (1976) 21:304–11. doi:10.1159/000122538
52. Suzuki T, Hirai K, Otsuka K, Matsui H, Ohukuzi S. Anaphylactic shock and the secretion of adrenal 17-hydroxycorticosteroid in the dog. Nature (1966) 21:1185–6. doi:10.1038/2111185a0
53. Schlicker E, Fink K, Detzner M, Göthert M. Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors. J Neural Transm (1993) 93:1–10. doi:10.1007/BF01244933
54. Froy O. Circadian rhythms, nutrition and implications for longevity in urban environments. Proc Nutr Soc (2017) 1–7. doi:10.1017/S0029665117003962
55. Sherman H, Frumin I, Gutman R, Chapnik N, Lorentz A, Meylan J, et al. Long-term restricted feeding alters circadian expression and reduces the level of inflammatory and disease markers. J Cell Mol Med (2011) 15:2745–59. doi:10.1111/j.1582-4934.2010.01160.x
56. Paganelli R, Petrarca C, Di Gioacchino M. Biological clocks: their relevance to immune-allergic diseases. Clin Mol Allergy (2018) 16:1–8. doi:10.1186/s12948-018-0080-0
57. Nakamura Y, Ishimaru K, Tahara Y, Shibata S, Nakao A. Disruption of the suprachiasmatic nucleus blunts a time of day-dependent variation in systemic anaphylactic reaction in mice. J Immunol Res (2014) 2014:474217. doi:10.1155/2014/474217
58. Krieger DT. Rhythms of acth and corticosteroid secretion in health and disease, and their experimental modification. J Steroid Biochem (1975) 6:785–91. doi:10.1016/0022-4731(75)90068-0
59. Oster H, Damerow S, Kiessling S, Jakubcakova V, Abraham D, Tian J, et al. The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock. Cell Metab (2006) 4:163–73. doi:10.1016/j.cmet.2006.07.002
60. Hayasaka N, Yaita T, Kuwaki T, Honma S, Honma K, Kudo T, et al. Optimization of dosing schedule of daily inhalant dexamethasone to minimize phase shifting of clock gene expression rhythm in the lungs of the asthma mouse model. Endocrinology (2007) 148(7):3316–26. doi:10.1210/en.2007-0010
61. Lee H, Chen R, Lee Y, Yoo S, Lee C. Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock. Proc Natl Acad Sci U S A (2009) 106:21359–64. doi:10.1073/pnas.0906651106
62. Velez TE, Bryce PJ, Hulse KE. Mast cell interactions and crosstalk in regulating allergic inflammation. Curr Allergy Asthma Rep (2018) 18:30. doi:10.1007/s11882-018-0786-6
63. Beam WR, Weiner DE, Martin RJ. Timing of prednisone and alterations of airways inflammation in nocturnal asthma. Am Rev Respir Dis (1992) 146:1524–30. doi:10.1164/ajrccm/146.6.1524
Keywords: mast cells, biological clock, circadian rhythm, allergy, IgE
Citation: Christ P, Sowa AS, Froy O and Lorentz A (2018) The Circadian Clock Drives Mast Cell Functions in Allergic Reactions. Front. Immunol. 9:1526. doi: 10.3389/fimmu.2018.01526
Received: 23 April 2018; Accepted: 20 June 2018;
Published: 06 July 2018
Edited by:
Marcus Maurer, Charité Universitätsmedizin Berlin, GermanyReviewed by:
Ulrich Blank, Institut National de la Santé et de la Recherche Médicale (INSERM), FranceMichael Huber, RWTH Aachen Universität, Germany
Nicolas Charles, Institut National de la Santé et de la Recherche Médicale (INSERM), France
Frank A. Redegeld, Utrecht University, Netherlands
Copyright: © 2018 Christ, Sowa, Froy and Lorentz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Axel Lorentz, lorentz@uni-hohenheim.de