Proactive approaches to preventing postpartum depression in non-depressive pregnant women: a comprehensive scoping review

Introduction: Postpartum depression is a significant global health challenge that affects mothers, infants, and families. Although various preventive strategies show promise, comprehensive reviews evaluating interventions among pregnant women without a clinical diagnosis of depression remain limited. This scoping review aims to identify and synthesize the existing evidence on proactive postpartum depression prevention programs initiated during pregnancy.

Methods: Following PRISMA guidelines for scoping reviews, we systematically searched PubMed and Scopus, supplemented by manual reference reviews. Our search strategy combined terms related to postpartum depression, pregnancy, and preventive interventions. Studies were included if they evaluated interventions conducted during pregnancy, targeting women without a clinical diagnosis of depression, and assessed PPD outcomes using established diagnostic criteria or validated screening tools. Only English-language articles published between 2013 and 2023 were considered.

Results: A total of 49 studies met the inclusion criteria. Interventions were categorized into nine themes: psychoeducation (n = 18), home visits (n = 6), cognitive behavioral therapy (CBT) (n = 6), mindfulness (n = 6), exercise (n = 4), dietary supplements (n = 3), interpersonal therapy (IPT) (n = 4), consultation (n = 1), and inhalation aromatherapy (n = 1). Psychoeducational and mindfulness-based interventions consistently reduce PPD risk, particularly when delivered in structured, theory-driven formats and incorporating family support. Digital CBT interventions demonstrated limited effectiveness due to lower engagement, while home-visit and consultation-based interventions were effective when integrated into existing maternal healthcare despite scalability challenges. Exercise and dietary supplement interventions yielded inconsistent outcomes, indicating that factors such as adherence, duration, and intensity are crucial determinants of effectiveness.

Conclusion: Various proactive interventions are available to prevent PPD, and this scoping review systematically maps the different strategies used and their outcomes. Proactive, theory-based, and multi-component interventions, particularly psychoeducational and mindfulness programs, demonstrate promising potential. Future research should emphasize evaluating long-term outcomes, optimizing digital engagement strategies, and developing culturally tailored models to enhance scalability and accessibility across diverse populations, including low-resource settings.

1 Introduction

Mental health is a critical public health issue, with the World Health Organization (WHO) reporting that one in eight people worldwide experience mental health disorders (1). Notably, 71% of individuals with psychosis do not receive treatment, and depression accounts for 28.9% of mental disorders, making it the second leading cause of Global Years of Healthy Life Lost due to disability (2). Postpartum depression (PPD) is a major maternal and child health concern, characterized by symptoms such as sadness, hopelessness, loss of interest, sleep disturbances, fatigue, and poor concentration (3, 4). A systematic review found that approximately 17.22% of women experience PPD, which can significantly affect their quality of life, disrupt family dynamics, and impair child development if left untreated (5). PPD can also interfere with maternal-infant bonding and the mother's ability to care for her baby, leading to breastfeeding difficulties and developmental challenges (6–8). Despite the prevalence of PPD, over 75% of affected women, particularly in low- and middle-income countries, do not receive treatment, with only 13.6% actively seeking help (9). Barriers to care include financial constraints, lack of awareness about perinatal depression, a shortage of trained healthcare professionals, and the social stigma associated with mental health disorders (10, 11). Access to psychiatric care remains limited, especially in developing countries. Given these challenges, PPD prevention is a critical priority to improve maternal and infant well-being.

Although the exact causes of PPD remain unclear, multiple risk factors contribute to its onset, including hormonal changes, psychosocial and social stressors (6). Specific risk factors include a history of depression, prenatal depression, intimate partner violence, concerns about the child's health, breastfeeding difficulties, low family and spousal support, lack of awareness, and cultural confinement practices (12–15). Conversely, self-efficacy and social support have been identified as protective factors against PPD (16, 17). Bandura's Self-Efficacy Theory suggests that individuals with strong self-efficacy are better equipped to manage stress and depressive symptoms (18). Additionally, James S. House identified four types of functional support—emotional, instrumental, informational, and appraisal—that can help mitigate PPD risk. Addressing these risk and protective factors during pregnancy through targeted interventions may be key to PPD prevention (19, 20). Previous reviews have explored various preventive measures, including nutrition, physical activity, mindfulness, and psychological and psychosocial interventions. While some studies have compared these approaches, they often included both pregnant and postpartum women, some of whom were already experiencing depression (21–26). A review of psychosocial and psychological interventions suggested that early pregnancy interventions can effectively reduce PPD risk in at-risk women (21). More recently, an umbrella review by Motrico et al. examined multiple PPD prevention strategies (27). However, there remains a lack of research focusing exclusively on pregnant women without clinical depression, making it difficult to assess the true effectiveness of preventive interventions in this population. Including depressive participants in such studies may confound results, as their use of medications or psychological therapy could either overestimate or underestimate intervention effects.

Despite these research efforts, a comprehensive mapping of PPD prevention programs exclusively targeting non-depressive pregnant women is still lacking. To address this gap, we conducted a scoping review to identify and synthesize available evidence on intervention programs aimed at preventing PPD in non-depressive pregnant women. This review examines the scope and characteristics of these interventions, highlights key initiatives, and explores their implications for clinical practice and policy development to enhance maternal mental health care.

2 Methods

This scoping review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for scoping reviews to systematically map interventions aimed at preventing PPD during pregnancy.

2.1 Study selection

Studies were selected via electronic databases, including Pubmed and Scopus, which included multiple additional databases (e.g., Embase, PsycINFO, Cochrane) that would increase redundancy due to significant overlap in indexed journals. The combined use of PubMed and Scopus facilitated an efficient and systematic literature search, reducing duplication while ensuring the inclusion of diverse intervention studies.

The search strategy included the following terms: The search strategy included the following terms: (“postpartum period”[MeSH Terms] OR “postpartum” OR “postnatal” OR “puerperal” OR “peripartum period”[MeSH Terms] OR “peripartum” OR “prenatal” OR “antenatal” OR “pregnancy”[MeSH Terms] OR “intrapartum” OR “pregnant women”[MeSH Terms]) AND (“depression, postpartum”[MeSH Terms] OR “depression postpartum” OR “depressive disorder”[MeSH Terms] OR “depression”[MeSH Terms] OR “depress*”) AND ((prevent* OR “intervention*”)).

Additionally, systematic reviews and meta-analyses on PPD prevention were manually searched, and reference lists from relevant randomized controlled trials (RCTs) were reviewed. Supplementary Table 1 provides search strings and detailed results from each database. Given the increasing role of digital health in prevention, we focused on studies published between 2013 and 2023. Only English-language articles were included.

2.2 Eligibility criteria

This scoping review included original studies evaluating interventions for preventing PPD in pregnant women without a clinical diagnosis of depression or severe depressive symptoms. To ensure a comprehensive assessment, both pharmacological and non-pharmacological interventions were considered without restrictions on intervention type. Studies were eligible if PPD was assessed at least once postpartum using established diagnostic criteria, including the International Classification of Diseases, 11th Revision (ICD-11), the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), or validated screening tools such as the Edinburgh Postnatal Depression Scale (EPDS), Beck Depression Inventory (BDI) (3, 4, 28, 29). EPDS is widely used to screen for depressive and anxiety symptoms during or after pregnancy, while BDI measures depression severity, aiding healthcare providers in screening and monitoring treatment progress (28, 29). Studies that included both depressed and non-depressed perinatal women at baseline were considered only if separate results were reported for non-depressed participants. The selection process adhered to the PICO framework: P: Pregnant women without a clinical diagnosis of depression or severe depressive symptoms; I: Preventive intervention programs; C: Care as usual or other comparison conditions (including active controls, enhanced usual care, or no comparison group; O: Postpartum depression as the primary outcome. Studies were included if they met the following criteria: (1) the intervention was conducted during pregnancy, (2) participants were pregnant women without depression at baseline, (3) the study was published in English, and (4) the publication period was between 2013 and 2023. Exclusion criteria included cohort, case-control, and cross-sectional studies, case reports, case series, reviews, letters, protocols, book chapters, and opinion papers.

2.3 Data charting process

After retrieving studies from PubMed and Scopus, records were imported into EndNote 20, where duplicates were automatically and manually removed. The EndNote library was shared with the research team for independent screening of titles, abstracts, and full texts. Two researchers extracted data independently using a shared Excel spreadsheet, categorizing articles by intervention type through discussion and consensus.

Figure 1 presents the PRISMA flow diagram detailing our study selection process. We identified a total of 2,914 records from PubMed (1,239 articles) and Scopus (1,675 articles), along with 81 additional records from reference reviews. After removing 847 duplicate records, 2,148 records were screened by title and abstract. Of these, 2,017 records were excluded as irrelevant, leaving 131 full-text articles to be retrieved. Two full-text articles were not obtained due to the unavailability of an English version, resulting in 129 full-text articles assessed for eligibility. Among these, 80 articles were excluded for the following reasons: nine articles focused solely on prenatal depression; 24 involved populations other than pregnant women; 46 included participants with depression at baseline; and one lacked data specific to pregnant women. Ultimately, 49 studies met our inclusion criteria and were included in this review.

Figure 1

Figure 1. PRISMA flow diagram of the selection process of studies on preventing postpartum depression from pregnancy.

2.4 Collating, summarising, and reporting results

The papers were organized by theme and summarised without considering the evidence's strength. This study gives insights into global early prevention programs for PPD. This review maps global PPD prevention programs, identifying intervention categories without assessing study quality. The aim is to explore intervention approaches, target populations, and contextual variations to assess their potential effectiveness across different settings.

3 Results

3.1 Characteristics of the included study

This scoping review included 49 studies (see Table 1) evaluating interventions to prevent PPD in pregnant women without a clinical diagnosis of depression. These studies were conducted in high-income (n = 26) (31, 32, 34, 36–40, 45, 46, 48, 50, 53, 57, 60, 63–65, 68–70, 75–77, 79) and upper-middle-income (n = 22) (30, 35, 41–44, 47, 51, 54–56, 58, 59, 61, 62, 66, 67, 71–74, 78) countries, with one study spanning 23 countries (33). Most studies employed RCT design, while others used quasi-experimental and pre-post-experimental approaches. Sample sizes ranged from 30 to 5,017 participants (31).

Table 1

Table 1. Summary of prevention programs on postpartum depression from pregnancy.

Interventions were categorized into nine themes: psychoeducation (n = 18), home visits (n = 6), cognitive behavioral therapy (CBT) (n = 6), mindfulness (n = 6), exercise (n = 4), dietary supplements (n = 3), interpersonal therapy (IPT) (n = 4), consultation (n = 1), and inhalation aromatherapy (n = 1) (see Table 2). Most studies targeted healthy pregnant women, while others focused on high-risk groups, such as those with social risk factors, adolescent pregnancyor pregnancy complications. Eight studies included both pregnant women and their partners, emphasizing family involvement in PPD prevention. The EPDS was the most commonly used outcome measure, alongside the Beck Depression Inventory and the Patient Health Questionnaire. The contents of each intervention are presented in Supplementary Table 2.

Table 2

Table 2. Summary of intervention types, modes of delivery, and reported outcomes in preventing postpartum depression.

3.2 Characteristics of the intervention prevention

3.2.1 Cognitive behavioral therapy intervention

Six studies integrated CBT interventions into prenatal care to help pregnant women manage anxiety, depression, and stress through psychoeducation, behavioral activation, and problem-solving. These interventions targeted both healthy pregnant women and those at high risk of PPD, delivered via in-person group sessions or digital platforms (Zoom, apps, and websites). Digital programs included a five-session Zoom-based CBT intervention (30), self-paced CBT modules via the Luna Baby App (31) and an interactive CBT-based website for mood regulation (33). In-person approaches for high-risk women included a three-session CBT program focusing on thought restructuring, an eight-session group-based CBT intervention addressing anxiety and postpartum adjustment (34) and seven cognitive-behavioral counseling sessions incorporating solution-focused techniques (35).

The effectiveness of CBT-based interventions in preventing PPD varies based on the delivery mode. Online CBT interventions targeting healthy pregnant women demonstrated limited effectiveness, with RCTs assessing digital CBT adaptations, including the Thinking Healthy Program (30) and a smartphone-based CBT program (31) showing no significant reductions in depressive symptoms compared to control groups. Similarly, an eight-session internet-based CBT intervention by Barrera et al. failed to show superiority over standard informational materials at 3 and 6 months postpartum (33).

Conversely, in-person CBT interventions were more effective, particularly in high-risk populations. The Mothers and Babies Program (32) and other structured onsite CBT interventions demonstrated significant reductions in depressive symptoms, especially among participants with elevated baseline EPDS scores (34). A study comparing CBT and solution-focused counseling reported significantly lower EPDS scores in both intervention groups at 15 days postpartum, with no significant difference between therapeutic approaches (35).

Overall, in-person CBT interventions were effective, particularly among high-risk pregnant women, whereas digital CBT programs had limited impact on healthy pregnant women. The lack of direct engagement in digital CBT may contribute to lower adherence and reduced effectiveness. These findings highlight the need for hybrid models that integrate interactive features, real-time therapist support, and personalized guidance to improve digital CBT engagement and efficacy in PPD prevention.

3.2.2 Mindfulness-based interventions

Mindfulness interventions aimed to enhance self-awareness, emotional regulation, and stress management in pregnant women through meditation, breathing exercises, and mindful movement. These interventions were delivered via mobile apps, online platforms, and in-person hospital training, increasing accessibility and adaptability for diverse populations. Digital approaches included mobile app-based mindfulness programs with guided exercises (42, 44, 45) and WeChat-supported training with childbirth education (43). In-person formats featured mindful self-compassion training (47) and group-based mindfulness sessions involving both pregnant women and their husbands (46), reinforcing social and emotional support during pregnancy.

Effectiveness varied based on delivery method and target population. Among six studies evaluating mindfulness interventions, five reported significant reductions in depressive symptoms, particularly in high-risk pregnant women. Mobile-delivered mindfulness interventions with psychotherapist support (54) and smartphone-based mindfulness programs (78) effectively reduced depressive symptoms, demonstrating the importance of guided facilitation in digital approaches. Similarly, an RCT with healthy pregnant women demonstrated significant improvements compared to usual care, suggesting that mindfulness can be beneficial even for low-risk populations (46). Interventions combining mindfulness with self-compassion techniques showed sustained benefits up to one year postpartum, while a four-week mindfulness-based childbirth and parenting program significantly reduced depression, anxiety, and fear of childbirth (43). However, one study found no significant differences in depressive symptoms with an app-based mindfulness program compared to usual care, highlighting the need for structured engagement strategies in digital mindfulness interventions (63).

Mindfulness interventions were largely effective in preventing PPD, with in-person and therapist-supported digital formats yielding the most significant benefits. Interventions that combined self-compassion techniques or social support showed greater long-term effectiveness. However, standalone app-based mindfulness programs without therapist interaction had limited impact, suggesting that active engagement and guided facilitation may be crucial for optimizing digital mindfulness interventions. These findings emphasize the need for hybrid models integrating digital and in-person mindfulness approaches, ensuring accessibility and sustained maternal mental health benefits.

3.2.3 Interpersonal therapy (IPT)

IPT interventions aimed to support pregnant women at risk of PPD by strengthening social support, communication skills, and relationship management. These programs utilized group discussions and individual therapy to provide tailored support, addressing emotional and interpersonal challenges. Delivery formats varied, including small-group IPT sessions (75), couple-based IPT programs (78) and adolescent-focused IPT interventions (76, 77) ensuring accessibility across different populations

Four studies evaluated the impact of IPT on PPD prevention, with two focusing on adult pregnancy and two targeting pregnant adolescents. IPT intervention for adult pregnant women with postnatal booster sessions effectively reduced PPD incidence in the US and China at six months postpartum (75, 78). Zlotnick et al. (75) examined IPT's impact on high-risk pregnant women, engaging 205 women, while Ngai et al. (78) studied 455 healthy first-time parents, both demonstrating significant reductions in postpartum depressive symptoms. Conversely, IPT interventions for adolescent pregnancies showed no significant preventive effect. Phipps et al. (76, 77) assessed the same IPT program across two studies (2013, 2020), with the first including 106 primiparous adolescents and the second 250 general pregnant adolescents. Neither study demonstrated IPT's effectiveness in preventing PPD among adolescent populations, suggesting that traditional IPT models may not fully address the unique psychosocial stressors of teenage pregnancies.

IPT demonstrated effectiveness in reducing PPD risk when applied to adult populations, particularly high-risk women and first-time parents. Couple-based IPT interventions were particularly beneficial, reinforcing partner support and emotional resilience during pregnancy. However, IPT programs for adolescent pregnancies failed to prevent PPD, highlighting the need for age-specific adaptations that account for developmental, social, and structural challenges unique to adolescent mothers. These findings suggest that tailored intervention strategies—incorporating peer support, parental involvement, and adolescent-focused mental health frameworks—may enhance the efficacy of IPT in younger populations.

3.2.4 Home visit programs

Home-visit interventions provided personalized psychoeducation, emotional support, and lifestyle guidance to pregnant women, with variations in structure, duration, and professional involvement. These programs were integrated into maternity care systems in the UK (38, 39), the US (36, 37, 40), and Turkey (72), demonstrating different approaches to maternal mental health support. In the UK, home visits were embedded into routine maternity care. Pregnancy Outreach Workers offered flexible support (39) and NHS health visitors conducted structured sessions focusing on maternal mental health and bonding (39). In the US, home-visit interventions had a stronger emphasis on therapy-based support, incorporating individualized cognitive-behavioral therapy (CBT) sessions (40), group-based emotional regulation programs (36) and frequent stress-management visits (37)In Turkey, home visits were supplemented with digital check-ins and postpartum follow-up calls to enhance accessibility (72).

Three studies by Tandon et al. in the US evaluated the Mothers and Babies 1-1 (MB) program, which integrates cognitive-behavioral intervention into home visits. The first RCT demonstrated that women receiving MB-based home visits had significant reductions in depressive symptoms at three and six months postpartum compared to the control group (40). The second study compared the effectiveness of mental health professionals and paraprofessionals delivering the intervention. While there was no significant difference between intervention and usual care groups, paraprofessional-led visits were as effective as those led by mental health professionals, suggesting the feasibility of task-shifting in home-visit programs (36). The third quasi-experimental study found that the intervention, when delivered by lay-home workers, significantly reduced Beck Depression Inventory (BDI) scores, with higher attendance linked to greater reductions in depressive symptoms (37).

Additional home-visit interventions were evaluated in the UK and Turkey. In the UK, Cooper et al. (39) examined a program focused on enhancing mother-infant relationships but found no significant effect on PPD prevention. Another RCT by Kenyon et al. (38) assessed a home-visit intervention for nulliparous women under 28 weeks gestation with social risk factors; while the intervention group showed a reduction in mean EPDS scores, there was no statistically significant difference from the control group. In Turkey, Öztoprak et al. (72) evaluated a nurse-led home-visit counseling program, finding that three home visits significantly reduced PPD symptoms among participants.

Home-visit interventions demonstrated mixed effectiveness, with structured CBT-based programs yielding the most promising results. The US-based MB program showed significant reductions in depressive symptoms, particularly when delivered by paraprofessionals or lay-home workers, supporting task-shifting as a viable strategy. In contrast, UK-based home visits without integrated mental health components showed limited impact on PPD prevention. The nurse-led program in Turkey successfully reduced PPD symptoms, indicating that trained healthcare professionals providing home-based psychological support may enhance intervention efficacy. These findings suggest that home-visit programs are most effective when they incorporate structured psychological interventions, particularly CBT-based approaches or counseling by trained professionals. The scalability of these programs, especially in low-resource settings, may benefit from task-sharing models and digital follow-ups to increase accessibility and sustainability.

3.2.5 Psychoeducation/education interventions

Psychoeducational interventions aim to enhance maternal knowledge, self-efficacy, emotional well-being, and resilience by incorporating theoretical frameworks such as Bandura's Social Cognitive Theory, Self-Efficacy Theory, Health Locus of Control Theory, Social Support Theory, Bowlby's Attachment Theory, and the PRECEDE-PROCEED Model (55, 56, 58, 65, 68). These interventions are delivered through in-person classes, digital platforms, mobile health (mHealth) apps, and hybrid models, often involving partners to enhance social support.

Among the 18 studies assessing psychoeducational interventions for PPD prevention, 12 targeted pregnant women only, while six included both pregnant women and their husbands. Effectiveness varied across different intervention designs. Programs focusing on healthy pregnant women primarily emphasized childbirth preparation, stress management, and postpartum adaptation. Notable programs, including the Self-Efficacy-Based Psychoeducation Program (55) and the Health Locus of Control Psychoeducation Program (61), demonstrated significant reductions in depressive symptoms when compared to control groups. Similarly, individualized prenatal education focused on breastfeeding, birth planning, and psychological preparation (67) resulted in improved maternal confidence and lower EPDS scores postpartum. Digital education interventions, such as the Mamma Mia Web-Based Program (60) and the Online Maternal Mental Health Consultation Program (48), allowed for self-paced learning and interactive engagement, though some digital-only interventions without interactive support showed inconsistent results (65).

For pregnant women at higher risk of PPD, interventions were designed to build emotional resilience, improve coping mechanisms, and facilitate early detection of mood disturbances. The CBT Psychoeducation Program (54) the PRECEDE-PROCEED Psychoeducation Model (56) and the Lifestyle-Based Psychoeducation Program (61) integrated structured cognitive-behavioral and psychoeducational techniques, resulting in greater self-regulation and lower postpartum depressive symptoms. Similarly, psychoeducation programs tailored for pregnant women with medical complications- such as the High-Risk Pregnancy Mental Health Program (59, 62) and the Psychosomatic Antenatal Education Program (63) effectively reduced anxiety and improved birth preparedness.

Partner-inclusive interventions demonstrated higher effectiveness in reducing PPD rates, emphasizing the role of family support in maternal mental health. Programs such as the Postpartum Support Program (65) and the Couple-Based Pregnancy Program (69) reinforced partner involvement, resulting in lower EPDS scores and improved postpartum adaptation. Studies found that when partners actively participated, maternal depressive symptoms significantly decreased compared to interventions targeting only pregnant women (42, 59). Additionally, lifestyle-based psychoeducation (67) showed that couple-focused education had a greater impact than individual-based programs. However, digital partner-based interventions, such as the Supportive Parenting App (65) had mixed results, likely due to limited engagement or inadequate personalization.

Hybrid models integrating in-person sessions with digital follow-ups demonstrated high effectiveness in sustaining maternal engagement and knowledge retention. Programs such as the Home Visit with Digital Follow-Up Program (41) and the Three-Step Perinatal Psychoeducation Model (68) provided continuous maternal support beyond traditional clinical settings, reinforcing educational retention and adherence. The Multidisciplinary Psychosocial Intervention (64) introduced a stratified approach, offering psychotherapy, counseling, or general psychoeducation based on PPD risk levels, showing positive results in reducing depressive symptoms in high-risk women.

Psychoeducational interventions demonstrated strong effectiveness in reducing postpartum depressive symptoms, particularly when grounded in self-efficacy, social support, and emotional regulation theories. Programs that incorporated partners or family members had greater long-term benefits, highlighting the importance of shared postpartum adaptation. Digital interventions increased accessibility and flexibility, but engagement and interaction levels influenced their effectiveness. Hybrid models combining face-to-face education with digital reinforcement were among the most effective strategies, ensuring long-term maternal support and continuous learning. These findings suggest that structured, theory-based psychoeducational interventions, especially those incorporating family support, interactive digital tools, and long-term engagement strategies, are essential for effective PPD prevention. Future research should focus on optimizing digital components, ensuring accessibility in diverse populations, and evaluating long-term mental health outcomes to strengthen the sustainability of these interventions.

3.2.6 Exercise-based interventions

Exercise-based interventions have been implemented to promote moderate physical activity during pregnancy, aiming to improve physical and mental well-being. These interventions commonly incorporate aerobic activities, strength training, and flexibility exercises, delivered either in structured group settings or as guided home-based programs. Aquatic-based interventions, such as a 17-week aerobic and strength-training program (49) and a five-month structured aquatic aerobic exercise program with controlled heart rate monitoring (50), improved cardiovascular fitness, and significantly reduced depressive symptoms compared to controls. However, not all interventions were effective. A 16-week moderate-intensity exercise program by Coll et al. showed no significant reduction in PPD incidence. At the same time, home-based stretching and breathing intervention by Mohammadi et al. was ineffective, likely due to poor adherence (51, 52).

Exercise-based interventions offer a promising, non-pharmacological approach to PPD prevention, but effectiveness is highly dependent on supervision and adherence. Structured, supervised programs, mainly aquatic and group-based land interventions, demonstrated the most consistent benefits, emphasizing the role of social engagement and guided facilitation in the success of the intervention. In contrast, home-based and self-guided exercise programs had lower effectiveness, highlighting the need for strategies to improve adherence, such as digital tracking tools or personalized coaching.

3.2.7 Dietary supplements

Three studies examined the role of nutritional supplementation in preventing PPD, focusing on vitamin B6 and omega-3 fatty acids. Vitamin B6 supplementation (40 mg twice daily from the 28th week of pregnancy until one month postpartum) significantly reduced depressive symptoms at 1.5 months postpartum compared to controls, suggesting a potential role in maternal mood regulation (71). In contrast, omega-3 supplementation (16 weeks of fish oil capsules during the third trimester) showed no significant effect on depressive symptoms in healthy pregnant women, indicating limited impact on PPD prevention (72, 73).

These findings suggest that vitamin B6 may help reduce postpartum depressive symptoms, while omega-3 supplementation appears ineffective. Further research is needed to determine the optimal dosage, timing, and target populations for supplementation.

3.2.8 Inhalation aromatherapy and consultation

Aromatherapy interventions utilize natural relaxation techniques to reduce stress and anxiety. Kianpour et al. (44) provided lavender and rose water essential oils for pregnant women to inhale before sleep from 38 weeks of gestation to 6 weeks postpartum, with phone call follow-ups ensuring adherence. Compared to an odorless placebo, aromatherapy significantly reduced EPDS scores, suggesting its potential role in lowering PPD risk.

mHealth consultation interventions provide on-demand medical support to address health concerns and promote maternal well-being. Arakawa et al. evaluated a healthcare service via the LINE messaging app, offering 10-minute consultations through voice calls, text, or video, with unlimited access from pregnancy to postpartum. The intervention significantly reduced the risk of elevated postpartum depressive symptoms, highlighting mHealth's potential in PPD prevention (48).

Across interventions, psychoeducational and mindfulness-based programs consistently reduced PPD risk, especially when delivered in structured, theory-driven formats and incorporating family support. In contrast, digital CBT interventions for healthy pregnant women exhibited limited effectiveness, likely due to reduced engagement, while in-person CBT interventions showed significant benefits among high-risk groups. Home-visit programs yielded mixed results: those integrating psychological components (e.g., the Mothers and Babies program) were effective, whereas programs lacking such components showed limited impact. Exercise-based interventions and dietary supplements produced inconsistent outcomes, underscoring that factors such as adherence, intervention intensity, and duration are critical. Additional modalities—such as inhalation aromatherapy and mHealth consultations—demonstrated promising results in reducing depressive symptoms (see Table 2).

4 Discussion

This scoping review identified and synthesized available evidence on intervention programs aimed at preventing postpartum depression (PPD) among pregnant women without a clinical diagnosis of PPD. A total of 49 studies were included, representing diverse geographic, methodological, and thematic variations in interventions. The interventions fell into nine key categories: educational/psychoeducational interventions, CBT, mindfulness, exercise, home-visit programs, dietary supplements, IPT, inhalation aromatherapy, and consultation-based approaches. The findings demonstrate that while several interventions show promise in reducing PPD risk, variations in delivery formats, target populations, and methodological rigor contribute to mixed evidence regarding their overall effectiveness.

Educational and psychoeducational interventions were the most commonly studied preventive approaches, with 18 studies examining their efficacy. These interventions typically focused on improving maternal knowledge, self-efficacy, and emotional preparedness for childbirth and postpartum. They also trained pregnant women on how to cope with the difficulties in childcare or to seek support from their family members. 16/18 interventions demonstrated significant reductions in depressive symptoms, particularly when interventions were tailored to high-risk populations or involved partners (54–56, 58). A systematic review by Dennis et al. (21) concluded from four trials that education programs had no preventive effect on PPD, which is not in line with our review. Differences in the content and duration of programs between reviews can explain this inconsistency. Moreover, with four trials included in the review of Dennis, there may not be enough evidence to conclude the effectiveness of education and psychoeducation intervention among pregnant women. Therefore, it is crucial to conduct a detailed and up-to-date review of educational programs to determine the overall impact.

WHO recommends CBT as an evidence-based psychosocial intervention to support perinatal women with depressive symptoms at the community level (80). Six studies assessed the efficacy of CBT in preventing postpartum depression (PPD). The findings indicate that none of the three digital CBT interventions demonstrated significant efficacy, whereas two of the three face-to-face interventions significantly reduced the incidence of PPD in pregnant individuals identified as being at high risk, despite the absence of a clinical diagnosis of major depressive disorder at baseline. These results align with a meta-analysis by Muira et al. (20), which found no significant difference in PPD incidence between application-based CBT and control groups, with substantial heterogeneity in the reduction of Edinburgh Postnatal Depression Scale (EPDS) scores. Moreover, a comprehensive review of seven systematic reviews on CBT interventions concluded that initiating CBT during pregnancy may reduce the risk of developing PPD, although effect sizes varied (81). These findings highlight the clinical relevance of early screening for perinatal individuals at high risk of PPD as a preventive strategy. While internet-based interventions offer a scalable and cost-effective approach, modifications may be necessary to optimize patient engagement, adherence, and therapeutic efficacy.

Mindfulness-based interventions are cognitive-behavioral therapeutic approaches that cultivate present-moment awareness through structured meditation practices, including breathwork, body scanning, auditory perception, and cognitive diffusion techniques. These interventions facilitate emotional regulation and enhance self-compassion, enabling pregnant individuals to develop adaptive coping mechanisms for stressors associated with pregnancy, labor, and the postpartum period (44–47). Among six studies evaluating the efficacy of mindfulness interventions, five reported a significant reduction in depressive symptoms. Furthermore, a systematic review by. Trapani et al. (22) demonstrated that mindfulness-based programs may effectively prevent PPD within the first three months postpartum.

The impact of home-visit programs on PPD prevention remains variable. Of the six studies included, two reported a statistically significant reduction in depressive symptoms. The Mothers and Babies 1-on-1 program in the United States demonstrated effectiveness when administered by trained home visitors or lay health workers to pregnant individuals identified as being at high risk for PPD (37, 40). However, small-group interventions targeting the general obstetric population did not yield comparable results (36). In contrast, a home-visit program implemented in the United Kingdom failed to produce significant reductions in perinatal depressive symptoms. Notably, baseline EPDS scores were unavailable in both UK-based studies, limiting the ability to quantify intervention efficacy (38, 39). Given the heterogeneity in study design, participant characteristics, and intervention modalities, the overall effectiveness of home-visit programs remains inconclusive. Moreover, home-visit interventions were implemented in the countries with home-visit programs available that support perinatal women. Therefore, it is challenging for countries without this program.

Interpersonal therapy (IPT) is an evidence-based psychosocial intervention that has demonstrated efficacy in the prevention of postpartum depression (PPD), particularly among individuals with identifiable risk factors. IPT aims to enhance interpersonal functioning and strengthen social support networks by addressing role transitions, resolving interpersonal conflicts, and processing grief—factors that are particularly salient during the perinatal period. Consistent with the therapeutic principles of IPT, a study conducted in China that incorporated spousal involvement, as well as another study targeting high-risk pregnant individuals, reported significant effectiveness (75, 78). However, our review found that IPT-based interventions were ineffective among healthy adolescent pregnant individuals in two studies conducted in the United States. Unlike older pregnant individuals, adolescents often experience reduced autonomy in their interpersonal relationships and social environments. Many remain financially and emotionally dependent on their families, which may limit the effectiveness of interventions centered on interpersonal role transitions (82). Moreover, adolescent pregnancies are frequently unintended, and young mothers may encounter heightened levels of social stigma, isolation, and parental oversight, further influencing the impact of their social support systems (83). These unique psychosocial challenges may attenuate the effectiveness of IPT-based interventions in this population, necessitating the development of tailored approaches that address the distinct needs of adolescent mothers.

The role of physical activity in PPD prevention remains controversial. Of four studies evaluating exercise interventions, two reported a significant reduction in EPDS scores between intervention and control groups. These findings align with a meta-analysis indicating that aerobic exercise is beneficial for both the prevention and treatment of PPD, despite considerable heterogeneity in outcomes (84). Physiologically, moderate-intensity aerobic exercise stimulates endorphin release and regulates neuroendocrine pathways, contributing to improved mood, sleep quality, self-awareness, and self-esteem while alleviating symptoms of anxiety and depression (85, 86). Consequently, individualized exercise regimens, including frequency, intensity, and duration, should be considered when designing PPD prevention and management strategies.

Additional prevention modalities reviewed in this study include dietary supplementation, inhalation aromatherapy, and psychological counseling. Evidence suggests that vitamin B6 supplementation may confer a protective effect against PPD, aligning with findings from previous reviews (24, 87). However, the assessment of adherence through plasma biomarker analysis rather than self-reported intake should be considered to improve methodological rigor. Moreover, a digital perinatal consultation program in Japan demonstrated effectiveness in reducing perinatal depressive symptoms; however, its implementation required substantial involvement from healthcare providers, including physicians and nurses, for continuous monitoring and follow-up (48). While such a model may be viable in high-resource settings, its feasibility in low- and middle-income contexts warrants further investigation.

5 Implications of the review

Our review highlights several implications for both clinical practice and future research in preventing PPD among pregnant women without a clinical diagnosis of depression. We identified nine key intervention programs with varying impacts, with education and psychoeducation interventions emerging as the most common and consistently effective strategies. Integrating structured, theory-based psychoeducation into routine prenatal care, particularly through targeted depression screenings, could enhance accessibility and cost-effectiveness (88). Programs based on Bandura's Self-Efficacy Theory, Health Locus of Control Theory, and Social Support Theory effectively improve maternal confidence, coping skills, and social support networks (55, 65). Additionally, family involvement, especially partner participation, enhances maternal mental health outcomes, yet remains underutilized, warranting further research into optimizing family-centered approaches (89). Similarly, mindfulness-based interventions, delivered both in-person and online, have demonstrated strong effectiveness in settings such as China and Taiwan, where cultural practices like “doing the month” support postpartum recovery (44, 46, 47). These findings suggest that mindfulness-based programs may be particularly beneficial in cultures that emphasize postpartum confinement and structured rest periods. However, our review also identifies a gap in the effective integration of technology in delivering CBT and mindfulness interventions. While digital health tools offer scalable and cost-effective solutions, existing technology-driven programs, such as app-based CBT, have shown limited effectiveness compared to in-person modalities (30, 31, 35). Integrating interactive features, real-time therapist support, and hybrid in-person and digital models could enhance effectiveness.

Moreover, the predominance of short-term outcome assessments, methodological heterogeneity, and the underrepresentation of low-resource settings limit the generalizability of current findings. Future research should prioritize long-term evaluations, standardize intervention protocols, and explore innovative digital solutions to enhance the accessibility, sustainability, and effectiveness of PPD prevention strategies across diverse populations. Expanding research to include culturally and contextually relevant interventions in low-resource settings is particularly important, given the existing disparities in maternal mental health care access (90).

6 Limitations

Our study is not without limitations. As a scoping review, it prioritizes breadth over depth, providing a qualitative overview rather than an in-depth analysis. Nevertheless, it successfully fulfills our objective of offering a comprehensive snapshot of intervention programs aimed at preventing PPD in women. Additionally, our inclusion criteria were limited to English-language papers, which may have led to the exclusion of culturally specific interventions published in other languages. Lastly, the broad scope of our research, encompassing a wide array of interventions, resulted in considerable data heterogeneity, rendering meta-analysis impractical. Consequently, a scoping review was the most appropriate approach for this study.

7 Conclusion

There are several proactive interventions that can be implemented to prevent PPD, and this scoping review systematically outlines the various strategies employed and their outcomes. This comprehensive scoping review demonstrates that proactive, multi-component interventions, particularly psychoeducational and mindfulness-based programs, offer significant promise for preventing postpartum depression among non-depressive pregnant women. However, variations in delivery mode, participant adherence, and contextual factors contribute to mixed effectiveness across intervention types. Future research should focus on long-term outcomes, optimize digital engagement strategies, and develop culturally tailored, scalable models that integrate family support into routine maternal healthcare. Such efforts will be critical for advancing global maternal mental health and reducing the burden of postpartum depression.

Data availability statement

The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.

Author contributions

NN: Writing – original draft, Writing – review & editing, Conceptualization. SP: Writing – original draft, Writing – review & editing, Conceptualization, Supervision.

Funding

The author(s) declare that no financial support was received for the research and/or publication of this article.

Acknowledgments

The authors gratefully acknowledge all the researchers who provided studies for the current review. The Faculty of Graduate Studies, Mahidol University, supports systematic review and meta-analysis training courses for the authors.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Supplementary material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fgwh.2025.1497740/full#supplementary-material

Supplementary Table 1 | Search terms in PubMed and Scopus.

Supplementary Table 2 | Contents of prevention programs on postpartum depression from pregnancy.

Abbreviations

CBT, cognitive behavioral therapy; EPDS, Edinburgh postnatal depression scale; MB, mothers and babies 1-1; MHP, mental health professionals; PPD, postpartum depression; PRISMA, preferred reporting items for systematic reviews and meta-analysis; RCT, randomized controlled trial; WHO, World Health Organization.

References

1. World Health Organization. World Mental Health Report: Transforming Mental Health for All. Geneva: World Health Organization (2022).

Google Scholar

2. World Health Organization. Global Health Estimates 2019: Disease Burden by Cause, Age, Sex, by Country and by Region, 2000–2019. Geneva: World Health Organization (2020).

Google Scholar

3. World Health Organization. International statistical classification of diseases and related health problems 11th revision (ICD-11). World Health Organization (2023). Available at: https://icd.who.int/browse/2024-01/mms/en#882114523 (Accessed August 09, 2024).

Google Scholar

4. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association (2013).

Google Scholar

5. Wang Z, Liu J, Shuai H, Cai Z, Fu X, Liu Y, et al. Mapping global prevalence of depression among postpartum women. Transl Psychiatry. (2021) 11(1):543. doi: 10.1038/s41398-021-01663-6

PubMed Abstract | Crossref Full Text | Google Scholar

6. Saharoy R, Potdukhe A, Wanjari M, Taksande AB. Postpartum depression and maternal care: exploring the Complex effects on mothers and infants. Cureus. (2023) 15(7):e41381. doi: 10.7759/cureus.41381

PubMed Abstract | Crossref Full Text | Google Scholar

7. Slomian J, Honvo G, Emonts P, Reginster JY, Bruyere O. Consequences of maternal postpartum depression: a systematic review of maternal and infant outcomes. Womens Health (Lond). (2019) 15:1745506519844044. doi: 10.1177/1745506519844044

PubMed Abstract | Crossref Full Text | Google Scholar

8. Bernard-Bonnin A-C, Canadian Paediatric Society, Disabilities MHaD, Committee. Maternal depression and child development. Paediatr Child Health (2004) 9(8):575–98. doi: 10.1093/pch/9.8.575

PubMed Abstract | Crossref Full Text | Google Scholar

9. Evans-Lacko S, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Benjet C, Bruffaerts R, et al. Socio-economic variations in the mental health treatment gap for people with anxiety, mood, and substance use disorders: results from the who world mental health (WMH) surveys. Psychol Med. (2018) 48(9):1560–71. doi: 10.1017/S0033291717003336

PubMed Abstract | Crossref Full Text | Google Scholar

10. Jones A. Help seeking in the perinatal period: a review of barriers and facilitators. Soc Work Public Health. (2019) 34(7):596–605. doi: 10.1080/19371918.2019.1635947

PubMed Abstract | Crossref Full Text | Google Scholar

11. Hadfield H, Wittkowski A. Women’s experiences of seeking and receiving psychological and psychosocial interventions for postpartum depression: a systematic review and thematic synthesis of the qualitative literature. J Midwifery Womens Health. (2017) 62(6):723–36. doi: 10.1111/jmwh.12669

PubMed Abstract | Crossref Full Text | Google Scholar

12. Zhao XH, Zhang ZH. Risk factors for postpartum depression: an evidence-based systematic review of systematic reviews and meta-analyses. Asian J Psychiatr. (2020) 53:102353. doi: 10.1016/j.ajp.2020.102353

PubMed Abstract | Crossref Full Text | Google Scholar

13. Liu X, Wang S, Wang G. Prevalence and risk factors of postpartum depression in women: a systematic review and meta-analysis. J Clin Nurs. (2022) 31(19–20):2665–77. doi: 10.1111/jocn.16121

PubMed Abstract | Crossref Full Text | Google Scholar

14. Taylor BL, Nath S, Sokolova AY, Lewis G, Howard LM, Johnson S, et al. The relationship between social support in pregnancy and postnatal depression. Soc Psychiatry Psychiatr Epidemiol. (2022) 57(7):1435–44. doi: 10.1007/s00127-022-02269-z

PubMed Abstract | Crossref Full Text | Google Scholar

15. Wang K, Li R, Li Q, Li Z, Li N, Yang Y, et al. Knowledge, attitude, and practice toward postpartum depression among the pregnant and lying-in women. BMC Pregnancy Childbirth. (2023) 23(1):762. doi: 10.1186/s12884-023-06081-8

PubMed Abstract | Crossref Full Text | Google Scholar

16. Han L, Zhang J, Yang J, Yang X, Bai H. Between personality traits and postpartum depression: the mediated role of maternal self-efficacy. Neuropsychiatr Dis Treat. (2022) 18:597–609. doi: 10.2147/NDT.S346327

PubMed Abstract | Crossref Full Text | Google Scholar

17. Zheng X, Morrell J, Watts K. Changes in maternal self-efficacy, postnatal depression symptoms and social support among Chinese primiparous women during the initial postpartum period: a longitudinal study. Midwifery. (2018) 62:151–60. doi: 10.1016/j.midw.2018.04.005

PubMed Abstract | Crossref Full Text | Google Scholar

18. Glanz K, Rimer BK, Viswanath K. Health Behaviour and Health Education: Theory, Research, and Practice. America: Jossey-Bass (2008).

Google Scholar

19. O’Hara MW. Psychosocial and psychological interventions reduce the risk of postnatal depression compared with standard care. Evid Based Nurs. (2014) 17(2):38–9. doi: 10.1136/eb-2013-101374

Crossref Full Text | Google Scholar

20. Miura Y, Ogawa Y, Shibata A, Kamijo K, Joko K, Aoki T. App-based interventions for the prevention of postpartum depression: a systematic review and meta-analysis. BMC Pregnancy Childbirth. (2023) 23(1):441. doi: 10.1186/s12884-023-05749-5

PubMed Abstract | Crossref Full Text | Google Scholar

21. Dennis CL, Dowswell T. Psychosocial and psychological interventions for preventing postpartum depression. Cochrane Database Syst Rev. (2013) 2:CD001134. doi: 10.1002/14651858.CD001134.pub3

Crossref Full Text | Google Scholar

22. Trapani S, Caglioni M, Villa G, Manara DF, Caruso R. Mindfulness-Based interventions during pregnancy and long-term effects on postpartum depression and maternal mental health: a systematic review and meta-analysis of randomized controlled trials. J Integr Complement Med. (2024) 30(2):107–20. doi: 10.1089/jicm.2023.0114

PubMed Abstract | Crossref Full Text | Google Scholar

23. He L, Soh KL, Huang F, Khaza'ai H, Geok SK, Vorasiha P, et al. The impact of physical activity intervention on perinatal depression: a systematic review and meta-analysis. J Affect Disord. (2023) 321:304–19. doi: 10.1016/j.jad.2022.10.026

PubMed Abstract | Crossref Full Text | Google Scholar

24. Miller BJ, Murray L, Beckmann MM, Kent T, Macfarlane B. Dietary supplements for preventing postnatal depression. Cochrane Database Syst Rev. (2013) 2013(10):CD009104. doi: 10.1002/14651858.CD009104.pub2

PubMed Abstract | Crossref Full Text | Google Scholar

25. Chen C, Wang X, Xu H, Li Y. Effectiveness of digital psychological interventions in reducing perinatal depression: a systematic review of meta-analyses. Arch Womens Ment Health. (2023) 26(4):423–39. doi: 10.1007/s00737-023-01327-y

PubMed Abstract | Crossref Full Text | Google Scholar

26. Lewkowitz AK, Whelan AR, Ayala NK, Hardi A, Stoll C, Battle CL, et al. The effect of digital health interventions on postpartum depression or anxiety: a systematic review and meta-analysis of randomized controlled trials. Am J Obstet Gynecol. (2024) 230(1):12–43. doi: 10.1016/j.ajog.2023.06.028

PubMed Abstract | Crossref Full Text | Google Scholar

27. Motrico E, Bina R, Kassianos AP, Le HN, Mateus V, Oztekin D, et al. Effectiveness of interventions to prevent perinatal depression: an Umbrella review of systematic reviews and meta-analysis. Gen Hosp Psychiatry. (2023) 82:47–61. doi: 10.1016/j.genhosppsych.2023.03.007

PubMed Abstract | Crossref Full Text | Google Scholar

28. Levis B, Negeri Z, Sun Y, Benedetti A, Thombs BD, Group DESDE. Accuracy of the Edinburgh postnatal depression scale (EPDS) for screening to detect major depression among pregnant and postpartum women: systematic review and meta-analysis of individual participant data. Br Med J (2020) 371:m4022. doi: 10.1136/bmj.m4022

PubMed Abstract | Crossref Full Text | Google Scholar

29. Cox JL, Holden JM, Sagovsky R. Detection of postnatal depression. Development of the 10-item Edinburgh postnatal depression scale. Br J Psychiatry. (1987) 150:782–6. doi: 10.1192/bjp.150.6.782

PubMed Abstract | Crossref Full Text | Google Scholar

30. Boran P, Donmez M, Baris E, Us MC, Altas ZM, Nisar A, et al. Delivering the thinking healthy programme as a universal group intervention integrated into routine antenatal care: a randomized-controlled pilot study. BMC Psychiatry. (2023) 23(1):14. doi: 10.1186/s12888-022-04499-6

PubMed Abstract | Crossref Full Text | Google Scholar

31. Nishi D, Imamura K, Watanabe K, Obikane E, Sasaki N, Yasuma N, et al. The preventive effect of internet-based cognitive behavioral therapy for prevention of depression during pregnancy and in the postpartum period (IPDP): a large scale randomized controlled trial. Psychiatry Clin Neurosci. (2022) 76(11):570–8. doi: 10.1111/pcn.13458

PubMed Abstract | Crossref Full Text | Google Scholar

32. Le HN, Rodriguez-Munoz MF, Soto-Balbuena C, Olivares Crespo ME, Izquierdo Mendez N, Marcos-Najera R. Preventing perinatal depression in Spain: a pilot evaluation of Mamas Y bebes. J Reprod Infant Psychol. (2020) 38(5):546–59. doi: 10.1080/02646838.2019.1687859

PubMed Abstract | Crossref Full Text | Google Scholar

33. Barrera AZ, Wickham RE, Munoz RF. Online prevention of postpartum depression for Spanish- and English-speaking pregnant women: a pilot randomized controlled trial. Internet Interv. (2015) 2(3):257–65. doi: 10.1016/j.invent.2015.06.002

PubMed Abstract | Crossref Full Text | Google Scholar

34. Bittner A, Peukert J, Zimmermann C, Junge-Hoffmeister J, Parker LS, Stobel-Richter Y, et al. Early intervention in pregnant women with elevated anxiety and depressive symptoms: efficacy of a cognitive-behavioral group program. J Perinat Neonatal Nurs. (2014) 28(3):185–95. doi: 10.1097/JPN.0000000000000027

PubMed Abstract | Crossref Full Text | Google Scholar

35. Ramezani S, Khosravi A, Motaghi Z, Hamidzadeh A, Mousavi SA. The effect of cognitive-behavioural and solution-focused counselling on prevention of postpartum depression in nulliparous pregnant women. J Reprod Infant Psychol. (2017) 35(2):172–82. doi: 10.1080/02646838.2016.1266470

PubMed Abstract | Crossref Full Text | Google Scholar

36. Tandon SD, Johnson JK, Diebold A, Segovia M, Gollan JK, Degillio A, et al. Comparing the effectiveness of home visiting paraprofessionals and mental health professionals delivering a postpartum depression preventive intervention: a cluster-randomized non-inferiority clinical trial. Arch Womens Ment Health. (2021) 24(4):629–40. doi: 10.1007/s00737-021-01112-9

PubMed Abstract | Crossref Full Text | Google Scholar

37. Tandon SD, McGown M, Campbell L, Smith JD, Yeh C, Brady C. Results from an effectiveness-implementation evaluation of a postpartum depression prevention intervention delivered in home visiting programs. J Affect Disord. (2022) 315:113–20. doi: 10.1016/j.jad.2022.07.033

PubMed Abstract | Crossref Full Text | Google Scholar

38. Kenyon S, Jolly K, Hemming K, Hope L, Blissett J, Dann SA, et al. Lay support for pregnant women with social risk: a randomised controlled trial. BMJ Open. (2016) 6(3):e009203. doi: 10.1136/bmjopen-2015-009203

PubMed Abstract | Crossref Full Text | Google Scholar

39. Cooper PJ, De Pascalis L, Woolgar M, Romaniuk H, Murray L. Attempting to prevent postnatal depression by targeting the mother-infant relationship: a randomised controlled trial. Prim Health Care Res Dev. (2015) 16(4):383–97. doi: 10.1017/S1463423614000401

PubMed Abstract | Crossref Full Text | Google Scholar

40. Tandon SD, Ward EA, Hamil JL, Jimenez C, Carter M. Perinatal depression prevention through home visitation: a cluster randomized trial of mothers and babies 1-on-1. J Behav Med. (2018) 41(5):641–52. doi: 10.1007/s10865-018-9934-7

PubMed Abstract | Crossref Full Text | Google Scholar

41. Oztoprak PU, Koc G, Erkaya S. Evaluation of the effect of a nurse navigation program developed for postpartum mothers on maternal health: a randomized controlled study. Public Health Nurs. (2023) 40(5):672–84. doi: 10.1111/phn.13226

PubMed Abstract | Crossref Full Text | Google Scholar

42. Sun Y, Li Y, Wang J, Chen Q, Bazzano AN, Cao F. Effectiveness of smartphone-based mindfulness training on maternal perinatal depression: randomized controlled trial. J Med Internet Res. (2021) 23(1):e23410. doi: 10.2196/23410

PubMed Abstract | Crossref Full Text | Google Scholar

43. Wang SL, Sun MY, Huang X, Zhang DM, Yang L, Xu T, et al. Benefits of mindfulness training on the mental health of women during pregnancy and early motherhood: a randomized controlled trial. Biomed Environ Sci. (2023) 36(4):353–66. doi: 10.3967/bes2023.041

PubMed Abstract | Crossref Full Text | Google Scholar

44. Leng LL, Yin XC, Chan CLW, Ng SM. Antenatal mobile-delivered mindfulness-based intervention to reduce perinatal depression risk and improve obstetric and neonatal outcomes: a randomized controlled trial. J Affect Disord. (2023) 335:216–27. doi: 10.1016/j.jad.2023.04.133

PubMed Abstract | Crossref Full Text | Google Scholar

45. Hassdenteufel K, Muller M, Abele H, Brucker SY, Graf J, Zipfel S, et al. Using an electronic mindfulness-based intervention (eMBI) to improve maternal mental health during pregnancy: results from a randomized controlled trial. Psychiatry Res. (2023) 330:115599. doi: 10.1016/j.psychres.2023.115599

PubMed Abstract | Crossref Full Text | Google Scholar

46. Pan WL, Chang CW, Chen SM, Gau ML. Assessing the effectiveness of mindfulness-based programs on mental health during pregnancy and early motherhood—a randomized control trial. BMC Pregnancy Childbirth. (2019) 19(1):346. doi: 10.1186/s12884-019-2503-4

PubMed Abstract | Crossref Full Text | Google Scholar

47. Guo L, Zhang J, Mu L, Ye Z. Preventing postpartum depression with mindful self-compassion intervention: a randomized control study. J Nerv Ment Dis. (2020) 208(2):101–7. doi: 10.1097/NMD.0000000000001096

PubMed Abstract | Crossref Full Text | Google Scholar

48. Arakawa Y, Haseda M, Inoue K, Nishioka D, Kino S, Nishi D, et al. Effectiveness of mhealth consultation services for preventing postpartum depressive symptoms: a randomized clinical trial. BMC Med. (2023) 21(1):221. doi: 10.1186/s12916-023-02918-3

PubMed Abstract | Crossref Full Text | Google Scholar

49. Aguilar-Cordero MJ, Sanchez-Garcia JC, Rodriguez-Blanque R, Sanchez-Lopez AM, Mur-Villar N. Moderate physical activity in an aquatic environment during pregnancy (SWEP study) and its influence in preventing postpartum depression. J Am Psychiatr Nurses Assoc. (2019) 25(2):112–21. doi: 10.1177/1078390317753675

PubMed Abstract | Crossref Full Text | Google Scholar

50. Navas A, Carrascosa MDC, Artigues C, Ortas S, Portells E, Soler A, et al. Effectiveness of moderate-intensity aerobic water exercise during pregnancy on quality of life and postpartum depression: a multi-center, randomized controlled trial. J Clin Med. (2021) 10(11):2432. doi: 10.3390/jcm10112432

PubMed Abstract | Crossref Full Text | Google Scholar

51. Coll CVN, Domingues MR, Stein A, da Silva BGC, Bassani DG, Hartwig FP, et al. Efficacy of regular exercise during pregnancy on the prevention of postpartum depression: the PAMELA randomized clinical trial. JAMA Netw Open. (2019) 2(1):e186861. doi: 10.1001/jamanetworkopen.2018.6861

PubMed Abstract | Crossref Full Text | Google Scholar

52. Mohammadi F, Malakooti J, Babapoor J, Mohammad-Alizadeh-Charandabi S. The effect of a home-based exercise intervention on postnatal depression and fatigue: a randomized controlled trial. Int J Nurs Pract. (2015) 21(5):478–85. doi: 10.1111/ijn.12259

PubMed Abstract | Crossref Full Text | Google Scholar

53. Shimpuku Y, Iida M, Hirose N, Tada K, Tsuji T, Kubota A, et al. Prenatal education program decreases postpartum depression and increases maternal confidence: a longitudinal quasi-experimental study in urban Japan. Women Birth. (2022) 35(5):e456–63. doi: 10.1016/j.wombi.2021.11.004

PubMed Abstract | Crossref Full Text | Google Scholar

54. Zhao Y, Lin Q, Wang J. An evaluation of a prenatal individualised mixed management intervention addressing breastfeeding outcomes and postpartum depression: a ramdomised controlled trial. J Clin Nurs. (2021) 30(9–10):1347–59. doi: 10.1111/jocn.15684

PubMed Abstract | Crossref Full Text | Google Scholar

55. Mohammadi F, Kohan S, Farzi S, Khosravi M, Heidari Z. The effect of pregnancy training classes based on bandura self-efficacy theory on postpartum depression and anxiety and type of delivery. J Educ Health Promot. (2021) 10:273. doi: 10.4103/jehp.jehp_105_21

PubMed Abstract | Crossref Full Text | Google Scholar

56. Beydokhti TB, Dehnoalian A, Moshki M, Akbary A. Effect of educational- counseling program based on precede-proceed model during pregnancy on postpartum depression. Nurs Open. (2021) 8(4):1578–86. doi: 10.1002/nop2.770

PubMed Abstract | Crossref Full Text | Google Scholar

57. Scorza P, Monk C, Lee S, Feng T, Berry OO, Werner E. Preventing maternal mental health disorders in the context of poverty: pilot efficacy of a dyadic intervention. Am J Obstet Gynecol MFM. (2020) 2(4):100230. doi: 10.1016/j.ajogmf.2020.100230

PubMed Abstract | Crossref Full Text | Google Scholar

58. Moshki M, Baloochi Beydokhti T, Cheravi K. The effect of educational intervention on prevention of postpartum depression: an application of health locus of control. J Clin Nurs. (2014) 23(15–16):2256–63. doi: 10.1111/jocn.12505

PubMed Abstract | Crossref Full Text | Google Scholar

59. Zhao Y, Munro-Kramer ML, Shi S, Wang J, Zhao Q. Effects of antenatal depression screening and intervention among Chinese high-risk pregnant women with medically defined complications: a randomized controlled trial. Early Interv Psychiatry. (2019) 13(5):1090–8. doi: 10.1111/eip.12731

PubMed Abstract | Crossref Full Text | Google Scholar

60. Haga SM, Drozd F, Lisoy C, Wentzel-Larsen T, Slinning K. Mamma Mia—a randomized controlled trial of an internet-based intervention for perinatal depression. Psychol Med. (2019) 49(11):1850–8. doi: 10.1017/S0033291718002544

PubMed Abstract | Crossref Full Text | Google Scholar

61. Sanaati F, Charandabi SM, Eslamlo HF, Mirghafourvand M. A randomized controlled trial on the effect of lifestyle education for Iranian women and their husbands on post-partum anxiety and depression. Health Educ Res. (2018) 33(5):416–28. doi: 10.1093/her/cyy026

PubMed Abstract | Crossref Full Text | Google Scholar

62. Zhao Y, Munro-Kramer ML, Shi S, Wang J, Luo J. A randomized controlled trial: effects of a prenatal depression intervention on perinatal outcomes among Chinese high-risk pregnant women with medically defined complications. Arch Womens Ment Health. (2017) 20(2):333–44. doi: 10.1007/s00737-016-0712-7

PubMed Abstract | Crossref Full Text | Google Scholar

63. Ortiz Collado MA, Saez M, Favrod J, Hatem M. Antenatal psychosomatic programming to reduce postpartum depression risk and improve childbirth outcomes: a randomized controlled trial in Spain and France. BMC Pregnancy Childbirth. (2014) 14:22. doi: 10.1186/1471-2393-14-22

PubMed Abstract | Crossref Full Text | Google Scholar

64. Cauli G, Iapichino E, Rucci P, Quartieri Bollani M, Marconi AM, Bassi M, et al. Promoting the well-being of mothers with multidisciplinary psychosocial interventions in the perinatal period. J Affect Disord. (2019) 246:148–56. doi: 10.1016/j.jad.2018.12.028

PubMed Abstract | Crossref Full Text | Google Scholar

65. Shorey S, Ng YPM, Ng ED, Siew AL, Mörelius E, Yoong J, et al. Effectiveness of a technology-based supportive educational parenting program on parental outcomes (part 1): randomized controlled trial. J Med Internet Res. (2019) 21(2):e10816. doi: 10.2196/10816

PubMed Abstract | Crossref Full Text | Google Scholar

66. Çankaya S, Şimşek B. Effects of antenatal education on fear of birth, depression, anxiety, childbirth self-efficacy, and mode of delivery in primiparous pregnant women: a prospective randomized controlled study. Clin Nurs Res. (2021) 30(6):818–29. doi: 10.1177/1054773820916984

PubMed Abstract | Crossref Full Text | Google Scholar

67. Ahmadpour P, Moosavi S, Mohammad-Alizadeh-Charandabi S, Jahanfar S, Mirghafourvand M. Effect of implementing a birth plan on maternal and neonatal outcomes: a randomized controlled trial. BMC Pregnancy Childbirth. (2022) 22(1):862. doi: 10.1186/s12884-022-05199-5

PubMed Abstract | Crossref Full Text | Google Scholar

68. Shorey S, Law E, Mathews J, Lim SH, Shi L, Chua JS, et al. Evaluating the effectiveness of the supportive parenting app on parental outcomes: randomized controlled trial. J Med Internet Res. (2023) 25:e41859. doi: 10.2196/41859

PubMed Abstract | Crossref Full Text | Google Scholar

69. Nakajima K, Hirose A, Nameda T. Evaluation of a pregnancy programme to enhance older Primiparas’ physical and mental health and marital relationships after childbirth: a non-randomized clinical trial. Nurs Open. (2023) 10(8):5108–16. doi: 10.1002/nop2.1746

PubMed Abstract | Crossref Full Text | Google Scholar

70. Ahrne M, Byrskog U, Essén B, Andersson E, Small R, Schytt E. Group antenatal care compared with standard antenatal care for Somali-Swedish women: a historically controlled evaluation of the Hooyo project. BMJ Open. (2023) 13(1):e066000. doi: 10.1136/bmjopen-2022-066000

PubMed Abstract | Crossref Full Text | Google Scholar

71. Khodadad M, Bahadoran P, Kheirabadi GR, Sabzghabaee AM. Can vitamin B6 help to prevent postpartum depression? A randomized controlled trial. Int J Prev Med. (2021) 12:136. doi: 10.4103/ijpvm.IJPVM_240_19

PubMed Abstract | Crossref Full Text | Google Scholar

72. Vaz JDS, Farias DR, Adegboye ARA, Nardi AE, Kac G. Omega-3 supplementation from pregnancy to postpartum to prevent depressive symptoms: a randomized placebo-controlled trial. BMC Pregnancy Childbirth. (2017) 17(1):180. doi: 10.1186/s12884-017-1365-x

PubMed Abstract | Crossref Full Text | Google Scholar

73. Sousa TM, Santos LCD. Effect of antenatal omega-3 supplementation on maternal depressive symptoms from pregnancy to 6 months postpartum: a randomized double-blind placebo-controlled trial. Nutr Neurosci. (2023) 26(6):551–9. doi: 10.1080/1028415x.2022.2068877

PubMed Abstract | Crossref Full Text | Google Scholar

74. Kianpour M, Moshirenia F, Kheirabadi G, Asghari G, Dehghani A, Dehghani-Tafti A. The effects of inhalation aromatherapy with rose and lavender at week 38 and postpartum period on postpartum depression in high-risk women referred to selected health centers of Yazd, Iran in 2015. Iran J Nurs Midwifery Res. (2018) 23(5):395–401. doi: 10.4103/ijnmr.IJNMR_116_16

PubMed Abstract | Crossref Full Text | Google Scholar

75. Zlotnick C, Tzilos G, Miller I, Seifer R, Stout R. Randomized controlled trial to prevent postpartum depression in mothers on public assistance. J Affect Disord. (2016) 189:263–8. doi: 10.1016/j.jad.2015.09.059

PubMed Abstract | Crossref Full Text | Google Scholar

76. Phipps MG, Raker CA, Ware CF, Zlotnick C. Randomized controlled trial to prevent postpartum depression in adolescent mothers. Am J Obstet Gynecol. (2013) 208(3):192.e1–6. doi: 10.1016/j.ajog.2012.12.036

PubMed Abstract | Crossref Full Text | Google Scholar

77. Phipps MG, Ware CF, Stout RL, Raker CA, Zlotnick C. Reducing the risk for postpartum depression in adolescent mothers: a randomized controlled trial. Obstet Gynecol. (2020) 136(3):613–21. doi: 10.1097/AOG.0000000000004003

PubMed Abstract | Crossref Full Text | Google Scholar

78. Ngai FW, Gao LL. Effect of couple-based interpersonal psychotherapy on postpartum depressive symptoms: a randomised controlled trial. Asian J Psychiatr. (2022) 78:103274. doi: 10.1016/j.ajp.2022.103274

PubMed Abstract | Crossref Full Text | Google Scholar

79. Claesson IM, Klein S, Sydsjo G, Josefsson A. Physical activity and psychological well-being in obese pregnant and postpartum women attending a weight-gain restriction programme. Midwifery. (2014) 30(1):11–6. doi: 10.1016/j.midw.2012.11.006

PubMed Abstract | Crossref Full Text | Google Scholar

80. World Health Organization. Thinking Healthy Psychosocial Management of Perinatal Depression Community Health Workers Version. Geneva: WHO (2015).

Google Scholar

81. Okatsau A, Aoyama S, Yamaji N, Kataoka Y. Cognitive behavioral therapy in perinatal mental health: an overview of systematic reviews. Jpn J Nurs Sci. (2022) 19(4):e12501. doi: 10.1111/jjns.12501

PubMed Abstract | Crossref Full Text | Google Scholar

82. Pine AE, Baumann MG, Modugno G, Compas BE. Parental involvement in adolescent psychological interventions: a meta-analysis. Clin Child Fam Psychol Rev. (2024) 27(3):1–20. doi: 10.1007/s10567-024-00481-8

PubMed Abstract | Crossref Full Text | Google Scholar

83. Smith W, Turan JM, White K, Stringer KL, Helova A, Simpson T, et al. Social norms and stigma regarding unintended pregnancy and pregnancy decisions: a qualitative study of young women in Alabama. Perspect Sex Reprod Health. (2016) 48(2):73–81. doi: 10.1363/48e9016

PubMed Abstract | Crossref Full Text | Google Scholar

84. Xu H, Liu R, Wang X, Yang J. Effectiveness of aerobic exercise in the prevention and treatment of postpartum depression: meta-analysis and network meta-analysis. PLoS One. (2023) 18(11):e0287650. doi: 10.1371/journal.pone.0287650

PubMed Abstract | Crossref Full Text | Google Scholar

85. Vega SR, Kleinert J, Sulprizio M, Hollmann W, Bloch W, Struder HK. Responses of serum neurotrophic factors to exercise in pregnant and postpartum women. Psychoneuroendocrinology. (2011) 36(2):220–7. doi: 10.1016/j.psyneuen.2010.07.012

PubMed Abstract | Crossref Full Text | Google Scholar

86. Ashrafinia F, Mirmohammadali M, Rajabi H, Kazemnejad A, Sadeghniiathaghighi K, Amelvalizadeh M, et al. The effects of pilates exercise on sleep quality in postpartum women. J Bodyw Mov Ther. (2014) 18(2):190–9. doi: 10.1016/j.jbmt.2013.09.007

PubMed Abstract | Crossref Full Text | Google Scholar

87. Sparling TM, Henschke N, Nesbitt RC, Gabrysch S. The role of diet and nutritional supplementation in perinatal depression: a systematic review. Matern Child Nutr. (2017) 13(1):e12235. doi: 10.1111/mcn.12235

PubMed Abstract | Crossref Full Text | Google Scholar

88. Organization WH. Who Recommendations on Maternal and Newborn Care for a Positive Postnatal Experience. Geneva: World Health Organization (2022).

Google Scholar

89. Noonan M, Jomeen J, Doody O. A review of the involvement of partners and family members in psychosocial interventions for supporting women at risk of or experiencing perinatal depression and anxiety. Int J Environ Res Public Health. (2021) 18(10):5396–416. doi: 10.3390/ijerph18105396

PubMed Abstract | Crossref Full Text | Google Scholar

90. Rahman A, Surkan PJ, Cayetano CE, Rwagatare P, Dickson KE. Grand challenges: integrating maternal mental health into maternal and child health programmes. PLoS Med. (2013) 10(5):e1001442. doi: 10.1371/journal.pmed.1001442

PubMed Abstract | Crossref Full Text | Google Scholar