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REVIEW article

Front. Gastroenterol.
Sec. Gastroenterology and Cancer
Volume 3 - 2024 | doi: 10.3389/fgstr.2024.1386069

The Reg protein family: potential new targets for the treatment of inflammatory bowel disease and colorectal cancer

Provisionally accepted
Anqi Yao Anqi Yao 1,2Cuilan Huang Cuilan Huang 1,2Xuyang Wang Xuyang Wang 1,2Renmin Zhou Renmin Zhou 3Wujuan Hao Wujuan Hao 3Qiong Lin Qiong Lin 1,2*
  • 1 Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, China
  • 2 Wuxi Children’s Hospital, Wuxi, Jiangsu Province, China
  • 3 Digestive Department, Affiliated Children's Hospital of Jiangnan University, Wuxi, China, wu xi, China

The final, formatted version of the article will be published soon.

    Inflammatory bowel disease (IBD) comprises Crohn's Disease (CD) and Ulcerative Colitis (UC), both characterized by chronic intestinal inflammation and an elevated risk of colorectal cancer due to persistent inflammation. The Regenerating gene (Reg) family proteins exhibit properties that promote cell proliferation, inhibit apoptosis, reduce inflammation, combat microbial infections, and potentially modulate the immune system. There is increasing evidence of the potential function of the Reg family of proteins in the development of IBD and colorectal cancer, but the exact mechanism of action of the Reg family of proteins has not yet been fully clarified. In this paper, we reviewed the Reg protein family's involvement in the development of IBD by regulating intestinal microbes and immunity to maintain intestinal homeostasis, also, explored its possible regulatory mechanisms and signaling pathways in the progression and treatment of colorectal cancer, which is expected to serve as a target and a new biomarker for the treatment of IBD and colorectal cancer in the future.

    Keywords: Reg protein family, inflammatory bowel disease, colorectal cancer, Crohn Disease, ulcerative colitis, Gastrointestinal microbiome

    Received: 20 Feb 2024; Accepted: 21 Aug 2024.

    Copyright: © 2024 Yao, Huang, Wang, Zhou, Hao and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qiong Lin, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, 211166, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.