This article is a correction to:
A Novel SNP-STR System Based on a Capillary Electrophoresis Platform
Hui Jian1†Li Wang2,3†Meili Lv4Yu Tan2,3Ranran Zhang1
Shengqiu Qu1Jijun Wang5
Lagabaiyila Zha6Lin Zhang1*
Weibo Liang1*- 1Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, China
- 2Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China
- 3Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China
- 4Department of Immunology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, China
- 5HI-TECH Industrial Sub-Branch of Chengdu Municipal Public Security Bureau, Chengdu, China
- 6Department of Forensic Medicine, School of Basic Medical Sciences, Central South University, Changsha, China
A Corrigendum on
A Novel SNP-STR system based on a capillary electrophoresis platform
by Jian H, Wang L, Lv M, Tan Y, Zhang R, Qu S, Wang J, Zha L, Zhang L and Liang W (2021). Front. Genet. 12:636821. doi: 10.3389/fgene.2021.636821
In the original article, there was an error. Individual STR data are identifiable and cannot be published, and as such, the following material containing STR profiling results has been removed: Table 6, Table 7, Supplementary Figures S5, S6 and Supplementary Table S3 as a result, the numbering of the figures and tables have been adjusted accordingly.
A correction has been made to SNP-STR Performance Assessment, paragraph 1. The corrected paragraph appears as follows:
“Haplotype frequencies are listed in Supplementary Table S3. The locus with the minimum number of haplotypes was rs13413321-TPOX and that with the maximum was rs9362476-SE33. The SNP minor allele frequencies in the SNP-STRs ranged from 0.487 (rs13413321-TPOX) to 0.022 (rs7786079-D7S820) (Table 3). Observed heterozygosity, expected heterozygosity, and the probability values (p) of the HWE test are listed in Supplementary Table S4. The p-values for rs17651965-CSF1PO, rs6736691-D2S1338, and rs9362476-SE33 were all less than 0.05. There was no significant linkage disequilibrium among the SNP-STR combinations located on the same chromosome after Bonferroni correction (p < 0.0003).”
A correction has been made to Profiling Results of the Casework, Traditional STR Profiling Results of the Casework, paragraph 1. The corrected paragraph appears as follows:
“According to SWGDAM guidelines, if one or more loci have three or more alleles present, excluding tri-allelic loci, then the sample is assumed to be a mixture (SWGDAM, Accessed 6 November 2017). The autosomal STR profile of the trace sample had a maximum of four alleles at only one locus (vWA). Three loci (D3S1358, D2S1338, and D12S391) were shown to have three alleles, respectively. It can be inferred as a two-person mixture based on the maximum allele count (Dembinski et al., 2018). The STR profile of the trace sample showed that most alleles, even most of the alleles with a higher peak, correspond to the victim, indicating that the victim acts as the major component of this mixture. The combined LR of autosomal STR profiling results for the trace sample was approximately 2.86 × 103.”
A correction has been made to Profiling Results of the Casework, SNP-STR Profiling Results of the Casework, paragraphs 1–3. The corrected paragraph appears as follows:
“In this case study, the SNP genotypes of the victim and suspect constituted one locus of informative genotype 1, eight loci of informative genotype 2, six loci of informative genotype 3, and three loci of the uninformative genotype. For the trace sample, all informative alleles were successfully detected by using allele-specific primers targeting minor contributor’s alleles. The loci that belonged to informative genotype 3 showed no peaks, as expected. The SNP-STR alleles of the trace sample and suspect corresponded to all of these markers. The average and combined LR values of SNP-STR informative alleles for this casework were calculated using the Bayesian model mentioned previously, and the results are shown in Table 6. The combined LR was obtained by multiplication because the SNP-STR markers are assumed to be independent. The combined LR reached 7.14 × 107.”
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: SNP-STR, microhaplotype, capillary electrophoresis, forensic genetics, unbalanced DNA mixtures, likelihood ratio (LR)
Citation: Jian H, Wang L, Lv M, Tan Y, Zhang R, Qu S, Wang J, Zha L, Zhang L and Liang W (2022) Corrigendum: A novel SNP-STR system based on a capillary electrophoresis platform. Front. Genet. 13:1036011. doi: 10.3389/fgene.2022.1036011
Received: 03 September 2022; Accepted: 05 October 2022;
Published: 27 October 2022.
Edited and reviewed by:
Enrico Domenici, University of Trento, ItalyCopyright © 2022 Jian, Wang, Lv, Tan, Zhang, Qu, Wang, Zha, Zhang and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Lin Zhang, zhanglin@scu.edu.cn; Weibo Liang, liangweibo@scu.edu.cn, liangweibo@gmail.com
†These authors have contributed equally to this work