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CASE REPORT article

Front. Endocrinol.
Sec. Pediatric Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1466411
This article is part of the Research Topic Puberty: Neurologic and Physiologic Development - Volume II View all 6 articles

Central precocious puberty associated with duplicated pituitary: a case report and literature review

Provisionally accepted
Kun Yang Kun Yang 1*Yanmei Sang Yanmei Sang 2Li Dai Li Dai 1Weizhong Wang Weizhong Wang 1
  • 1 Baoding Hospital, Beijing Children’s Hospital, Capital Medical University, Baoding, Hebei Province, China
  • 2 Beijing Children’s Hospital, Capital Medical University, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Patients with duplicated pituitary often have severe neurodevelopmental abnormalities and craniofacial deformities. Till now, only 8 patients diagnosed with duplicated pituitary show barely central precocious puberty (CPP) are reported in the published literature. Herein, we report a 6-year-old and 3-month-old girl diagnosed with pituitary duplication presented with CPP. She has enlarged breasts for more than one year, accelerated height of linear growth, advanced bone age, increased hormone level, and the increased volume of uterus and ovary. A duplicated pituitary gland was shown in the MRI. As the gonadotropin-releasing hormone analogue (GnRHa) stimulation test was positive, the child was treated with GnRHa. After two years of follow-up, there was a delay in the progression of sexual development, a reduction in symptoms of precocious puberty, and an increase in predicted adult height.

    Keywords: GnRHa, central precocious puberty (CPP), duplicated pituitary, female, HIGHT

    Received: 17 Jul 2024; Accepted: 02 Jan 2025.

    Copyright: © 2025 Yang, Sang, Dai and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kun Yang, Baoding Hospital, Beijing Children’s Hospital, Capital Medical University, Baoding, Hebei Province, China

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