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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1535776
This article is part of the Research Topic Ovarian Aging: Pathophysiology and Recent Development of Maintaining Ovarian Reserve, Volume IV View all articles

Diminished ovarian reserve is associated to euploidy rate: a single center study

Provisionally accepted
Edoardo Carnesi Edoardo Carnesi 1Stefano Castellano Stefano Castellano 1,2ELENA ALBANI ELENA ALBANI 1Andrea Busnelli Andrea Busnelli 1,3Antonella Smeraldi Antonella Smeraldi 1*Ozgur Bulbul Ozgur Bulbul 1Emanuela Morenghi Emanuela Morenghi 1,3Valentina Immediata Valentina Immediata 1Paolo Emanuele Levi-Setti Paolo Emanuele Levi-Setti 1,3*
  • 1 Division of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy
  • 2 Genomic Medicine Research Center, Department of Medicine and Surgery, University of Insubria, Via JH Dunant 5, 21100,, Varese, Italy
  • 3 Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy

The final, formatted version of the article will be published soon.

    Background: Reproductive success shows a well-documented decline with advancing maternal age, primarily due to chromosomal abnormalities (aneuploidies) in embryos. While ovarian reserve markers such as Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC) traditionally serve as quantitative predictors of fertility, emerging evidence suggests they may also reflect oocyte quality, particularly in patients with Diminished Ovarian Reserve (DOR). The relationship between these biomarkers and embryo chromosomal status remains complex and poorly understood.Methods: We conducted a retrospective analysis of in vitro fertilization (IVF) cycles performed between 2015 and 2022, involving 773 female patients who underwent IVF and pre-implantation genetic screening for aneuploidy (PGT-A). Our patient cohort was divided into two groups: Group 1, consisting of women who achieved at least one euploid embryo, and Group 2, comprising women who did not.The main outcome measures included the rate and number of euploid blastocysts and their correlation with ovarian reserve. Our results showed a statistically significant association between independent variables and embryo ploidy: AMH levels (OR 1.09; 95% CI 1.04-1.14, p<0.001), the age of the woman (OR 0.82; 95% CI 0.79-0.85, p<0.001), the number of oocytes retrieved (OR 1.050; 95% CI 1.01-1.08, p=0.05), and the fertilization rate (OR 6.69; p<0.001).Conclusion: Our findings suggest that AMH levels are associated with embryo ploidy rate. These insights could enhance counseling practices in assisted reproductive technology (ART), offering patients a more detailed understanding of their infertility prognosis and the factors influencing IVF outcomes.

    Keywords: AMH, Assisted reproduction (ART), PGT-A, Diminished Ovarian Reserve (DOR), Embryo ploidy rate

    Received: 27 Nov 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Carnesi, Castellano, ALBANI, Busnelli, Smeraldi, Bulbul, Morenghi, Immediata and Levi-Setti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Antonella Smeraldi, Division of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy
    Paolo Emanuele Levi-Setti, Division of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy

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