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REVIEW article

Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1531209
This article is part of the Research Topic Understanding and Managing Diabetic Neuropathy: Current Perspectives and Future Directions View all 8 articles

Immortalized Schwann Cell Lines as Useful Tools for Pathogenesisbased Therapeutic Approaches to Diabetic Peripheral Neuropathy

Provisionally accepted
Kazunori Sango Kazunori Sango 1*Hideji Yako Hideji Yako 2Naoko Niimi Naoko Niimi 1Shizuka Takaku Shizuka Takaku 1
  • 1 Diabetic Neuropathy Project, Department of Diseases and Infection, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
  • 2 Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

The final, formatted version of the article will be published soon.

    Growing evidence suggests that hyperglycemia-related abnormalities in Schwann cells play a pivotal role in the development and progression of diabetic peripheral neuropathy (DPN). Several immortalized Schwann cell lines have been established in our laboratory and utilized for the study of DPN; IMS32 from normal ICR mice, 1970C3 from normal C57BL/6 mice, IWARS1 and IKARS1 from wild-type and aldose reductase-deficient C57BL/6 mice, and IFRS1 from normal Fischer 344 rats. These cell lines retain biological features of Schwann cells and display high proliferative activities that enable us to perform molecular and biochemical analyses. In addition, these cells have exhibited metabolic alterations under exposure to diabetes-associated conditions, such as hyperglycemia, dyslipidemia, glycative and oxidative stress load. Herein, recent studies with these cell lines regarding the pathogenic factors of DPN (augmentation of the polyol and other collateral glycolysis pathways, glycative and oxidative stress-induced cell injury, autophagic and proteostatic disturbances, etc.) and therapeutic strategies targeting these factors are introduced.

    Keywords: Immortalized Schwann cells, Diabetic peripheral neuropathy, Polyol pathway, glycation, Oxidative Stress, autophagic and proteostatic disturbances

    Received: 22 Nov 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Sango, Yako, Niimi and Takaku. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kazunori Sango, Diabetic Neuropathy Project, Department of Diseases and Infection, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.