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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1499735
This article is part of the Research Topic Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) - Pathogenesis, Prevention and Treatment View all 9 articles

The association between working hours and working type with Nonalcoholic fatty liver disease (NAFLD): Results from the NHANES 1999-2014

Provisionally accepted
Ruli Wang Ruli Wang 1Ningxi Wu Ningxi Wu 1Qu Huan Qu Huan 2Xiaowei Zheng Xiaowei Zheng 3Haoyang Zhang Haoyang Zhang 1Lihong Zhu Lihong Zhu 1Xiaolei Wang Xiaolei Wang 1Xiaodie Yao Xiaodie Yao 1Le Zhang Le Zhang 1*
  • 1 Wuxi Children’s Hospital, Wuxi, China
  • 2 Zhongda Hospital, Southeast University, Nanjing, Jiangsu Province, China
  • 3 Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Background: Previous research has indicated that long working hours are connected to a variety of health conditions, including nonalcoholic fatty liver disease (NAFLD).However, this association which has been observed in more population is limited. Our research is designed to evaluate the association between working hours, working type, and NAFLD.The study comprised adults with complete details on working hours, working type, and NAFLD from the NHANES 1999-2014. We employed the hepatic steatosis index (HSI) to evaluate NAFLD and examined the relationship between working hours or working type and hepatic steatosis using weighted multiple-variable regression models and restricted cubic spline (RCS) analysis. In addition, further subgroup analysis was performed based on sex, age, ratio of family income to poverty (PIR), education, and diabetes.Results: Long working hours were significantly linked to an elevated risk of NAFLD (OR: 1.57, 95%CI: 1.21-2.05), even after controlling for confounding factors. RCS analysis suggested that there was no nonlinear relationship between them. When weekly working hours > 50, the likelihood of NAFLD among the population heightened to 57% and this risk increased to 99% in the female population. As for working type, increasing physical intensity of work was associated with higher NAFLD risk, but only heavy manual labor continued to show significance after adjustment (OR:1.39, 95%CI:1.06-1.81). We observed that the relationship between heavy manual labor and NAFLD was more significant in the older and male populations.Conclusion：Our results indicate that long working hours and engaging in heavy physical labor are independent risk factors for NAFLD. As working hours increase and 3 individuals engage in heavy physical labor for extended periods, the risk of developing NAFLD significantly rises.

    Keywords: working hours, working type, Hepatic Steatosis Index, NAFLD, NHANES

    Received: 21 Sep 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 Wang, Wu, Huan, Zheng, Zhang, Zhu, Wang, Yao and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Le Zhang, Wuxi Children’s Hospital, Wuxi, China

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