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REVIEW article

Front. Endocrinol.
Sec. Obesity
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1494560
This article is part of the Research Topic Multi-organ Linkage Pathophysiology and Therapy for MASLD and MASH Volume II View all articles

Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease

Provisionally accepted
YuHong Fan YuHong Fan Siyao Zhang Siyao Zhang Ye Wang Ye Wang Hongni Wang Hongni Wang Hongliang Li Hongliang Li *Bai Lan Bai Lan *
  • Gannan Medical University, Ganzhou, China

The final, formatted version of the article will be published soon.

    Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic metabolic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), nonalcoholic steatohepatitis (NASH), cirrhosis, and potentially liver cancer. This disease is closely associated with metabolic disorders driven by overnutrition, with key pathological processes including lipid dysregulation, impaired lipid autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and local inflammation. While hepatic lipid metabolism in NAFLD is welldocumented, further research into inter-organ communication mechanisms is crucial for a deeper understanding of NAFLD progression. This review delves into intrahepatic networks and tissuespecific signaling mediators involved in NAFLD pathogenesis, emphasizing their impact on distal organs.

    Keywords: Non-alcoholic fatty liver disease, inter-organ crosstalk, fatty acid synthesis, Mitochondrial homeostasis, Endoplasmic reticulum (ER) stress

    Received: 11 Sep 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Fan, Zhang, Wang, Wang, Li and Lan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hongliang Li, Gannan Medical University, Ganzhou, China
    Bai Lan, Gannan Medical University, Ganzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.