- 1JSC Generium, Moscow, Russia
- 2Institute Jules Bordet, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium
Editorial on the Research Topic
Underlying molecular interconnections of the estrogen receptor alpha and associated factors involved in breast cancer development: the way to new therapeutic approaches, volume II
Estrogen Receptor alpha (ERα) belongs to a class of ligand- dependent nuclear receptors functioning as transcription factors that contribute to the development of the mammary gland and its unfortunate neoplastic transformation. This phenomenon is partly the result of a cooperation between estrogen production and a multitude of other extracellular signals (hormonal, immunological, calcium variation…) (1–3). Therefore, ERα can be viewed as a hub in which the incorrect processing of these signals contributes to tumorigenesis preceding its progressive evolution to resistance to antiestrogens (tamoxifen and related SERMs) in addition to inhibitors of estrogen biosynthesis (aromatase inhibitors). The administration of low doses of estrogens or receptor degraders (SERDs), which induce apoptosis in the tumor (4), represents an alternative approach that identifies ERα as a therapeutic target.
Our Research Topic is dedicated to the search for novel approaches to overcome this endocrine resistance. Its first volume describes some aspects that could be taken into account as therapeutic approaches; regulation of the expression of the receptor (turnover, successive transient conformational changes implicated in the transport to the nucleus, homo dimerization of the receptor required for its association with the palindromic sequence of nucleotides of the DNA localized in the promoters of the genes to be transcribed, as well as heterodimerization of the ERα with another transcription factor with which it associates as a co-regulator). This large number of potential therapeutic approaches suggests a myriad of underlying therapeutic possibilities. A view that is largely confirmed by the investigations collected in this second volume.
Kiliti et al. provides a detailed overview of the AIB1 co-activator as an example. AIB1 is overexpressed in a subset of breast cancers associated with a poor prognosis. The authors describe its hormone-independent mechanism of action, and its role as an oncogene interacting with other nuclear receptors, in particular AR (also a known factor in breast cancer development). This status would logically derive from the high plasticity of its ERα recruitment region where the anchorage LxxLL motif would not be stabilized in conformation to satisfy its transient function. A property that in fact concerns all coregulators. Seeking to stabilize the exposure of such a coregulator recruitment region in a drug design program represents obviously a time–consuming enterprise, a factor that may explain the relative lack of relevant publications on this subject.
This pessimistic view has led the scientific community to shift their focus to curative approaches without addressing direct/stable interactions between ERα and its coregulators. The knowledge that glucose starvation enhances the antiproliferative and antiestrogenic potency of hormone–dependent breast cancer cells provides hope in the blockade of metabolic energy (ATP) production for such a task (5) since the dynamic of coregulator exposure is highly energy-dependent (6, 7).
This approach, which is not restricted to glycolysis but also to a large panel of metabolic pathways regulating energy production (8, 9), led Cipolletti et al. to start an investigation on GART, an enzyme for the de novo purine metabolic pathway whose expression correlates with longer relapse-free survival in breast cancer patients. Using ERα-positive breast cancer cells, the authors identified lometrexol, a GART inhibitor, as an ER that exerts an antiproliferative effect, even in tamoxifen-resistant cells, similar to that of fulvestrant, a SERD; a synergistic effect with the CDK4/CDK6 inhibitors was also observed. Therefore, targeting GART for treatment at different stages of the disease may be plausible.
Complementary to these investigations, we received four clinical reports from Chinese Institutions revealing a local interest in our therapeutic approach. Two of them were accepted. Wang et al. delivered an exhaustive panoramic review of the worldwide literature on endocrine therapy including an evaluation of drug efficacy, molecular markers, and receptor interactions, providing guidelines for further investigations. Zhang et al. provided a case report of a neoadjuvant combination of concomitant endocrine therapy and chemotherapy in a patient with locally advanced breast cancer unresponsive to two prior chemotherapies. In this patient, the switch to combination therapy with fulvestrant and capecitabine resulted in tumor regression without adverse events, suggesting that this unexplored approach may be appropriate for ER-positive cancers in a locally advanced clinical setting. The information contained in these publications may also be of interest to breast medical oncologists.
Author‘s note
GL initiated this publication project in collaboration with Filippo Acconcia as co-Editor. Seven accepted contributions were reported in the first Volume in 2021. The follow-up to this project was conducted with PM who managed all received manuscripts except for the contribution by F. Acconcia, which justified its first authorship. GL was responsible for manuscript writing under a conceptual agreement.
Author contributions
PM: Writing – review & editing. LG: Writing – review & editing, Writing – original draft.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
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3. Leclercq G. Pathological maintenance and evolution of breast cancer: the convergence of irreversible biological actions of ER alpha. Endocrines. (2021) 2:1–14. doi: 10.3390/endocrines2010001
4. Maximov PY, Fan P, Abderahman B, Curpan R, Jordan VC. Estrogen receptor complex to trigger or delay estrogen-induced apoptosis in long-term estrogen deprived breast cancer. Font Endocrinol. (2022) 13. doi: 10.339/endo2O22869502
5. Scherbakov AM, Sorokin DV, Omelchuck OA, Schekotikhin AE, Krasil’nikov MA. Glucose starvation greatly enhance antiprolative and antiestrogenic potency of oligomycin A in MCF-7 breast cancer. Biochimie. (2021) 186:51–8. doi: 10.1016/j.biochi.2021.04.003
6. Katzenellenbogen JA. Stringing along the estrogen receptor to engage DNA. Proc Natl Acad Sci USA. (2023) 120:e230060812. doi: 10.1073/pnas.2300608120
7. Chen X, Jin S, Chen M, Bueno C, Wolynes PG. The marionette mechanism of domain-domain communication in the antagonist, agonist, and coactivator response of estrogen receptor. Proc AetlA cad Sci USA. 120(6):e2216906120. doi: 10.1073/pnas.2216906120
8. Hussein S, Khanna P, Yunus N, Gatza ML. Nuclerar receptor-mediated metabolic reprogramming and impact on HR+ Breast cancer. Cancers. (2021) 13:4808. doi: 10.3390/cancers13194808
Keywords: estrogen receptor alpha, transcription, coregulators, breast cancer, endocrine dependency, endocrine treatment resistance, therapeutic perspectives
Citation: Maximov PY and Leclercq G (2024) Editorial: Underlying molecular interconnections of the estrogen receptor alpha and associated factors involved in breast cancer development: the way to new therapeutic approaches, volume II. Front. Endocrinol. 15:1427468. doi: 10.3389/fendo.2024.1427468
Received: 03 May 2024; Accepted: 15 May 2024;
Published: 14 June 2024.
Edited and Reviewed by:
Antonino Belfiore, University of Catania, ItalyCopyright © 2024 Maximov and Leclercq. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Guy Leclercq, R3V5LmxlY2xlcmNxQHVsYi5iZQ==