Albert Giralt
Lluis FajasEditorial on the Research Topic
Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions
Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer (1). However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor’s origin, the specific genetic alterations and the surrounding microenvironment (2). In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer.
One of the most common and well-described metabolic adaptations occurring in cancer cells is the so-called Warburg effect, which consists on high rates of glycolysis and lactate export, even in the presence of oxygen (3). Abdel-Haleem et al. show that this metabolic phenotype, far from being an exclusive feature of tumors, is a common characteristic of the proliferative state and also a usual metabolic adaptation when robust transient responses are required. Interestingly, when Otto Warburg described this phenomenon almost a century ago, he proposed that the exacerbated aerobic glycolysis observed in cancer cells was due to defective mitochondria. However, as Herst and collaborators highlight in an extensive review about the role of mitochondria in health and disease, these organelles are not only usually functional in cancer cells but also all the more essential to generate metabolic intermediates for biosynthesis, to maintain redox balance and to trigger signaling pathways that promote cell growth and proliferation.
Cell cycle progression, cellular division, and metabolism are intricate processes that regulate each other. One of the mechanisms by which proliferating cells orchestrate these phenomena in a timely manner is by the use of the cell cycle machinery to control metabolism (4). On this subject, Denechaud et al. describe how the transcription factor E2F1 couples the progression of cell cycle with the expression of genes involved in several metabolic pathways and show that dysregulation of E2F1 activity contributes to the pathophysiology of metabolic disorders such as obesity and type 2 diabetes. Another emerging link between metabolism and proliferation is the epigenetic regulation of gene expression, which is treated here in two articles. On the one hand, Rabhi and collaborators and collaborators discuss how, in response to the nutritional status, variations in the intracellular levels of certain metabolites are sensed by epigenetic cofactors that in turn promote changes in gene expression. On the other hand, Bogner-Strauss comments on the very recent literature about the novel roles of the metabolite N-acetylaspartate in lipogenesis and cancer progression, which include, but are not limited to, epigenetic modulation.
In the recent years, the importance of the interactions between tumor cells and their surrounding microenvironment has become clear (5). Two reviews describe different strategies developed by tumors to acquire external nutrients to sustain biomass production. Recounvreux et al. highlight the relevance of macropinocytosis as a protein source for cancer cells under nutrient-deprived conditions, whereas Blücher et al. show how lipids and other molecules delivered by adipocytes fuel tumor growth in breast cancer, unveiling a possible link with obesity.
One of the most important aspects about the study of the metabolic adaptations occurring during proliferation is the possibility of developing novel therapies to treat cancer. Fendt discusses in an opinion article the opportunities, but also the challenges, for metabolism-based anticancer strategies.
Overall, in the present Research Topic, we cover some of the different metabolic adaptations that take place during proliferation and show that they ultimately depend on both internal and external cues (cell type, history, metabolic context, etc.). Importantly, understanding the specific metabolic profile of proliferating cells may contribute to the identification of metabolic vulnerabilities in the tumors that could be exploited to increase the efficacy of the current treatments.
Author Contributions
AG wrote the Editorial and LF edited it.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Funding
This work was supported by grants from the Swiss Ligue Contre le Cancer, the Swiss National Science Foundation, and the Fondation de France.
References
1. Pavlova NN, Thompson CB. The emerging hallmarks of cancer metabolism. Cell Metab (2016) 23:27–47. doi:10.1016/j.cmet.2015.12.006
2. Vander Heiden MG, DeBerardinis RJ. Understanding the intersections between metabolism and cancer biology. Cell (2017) 168:657–69. doi:10.1016/j.cell.2016.12.039
3. Liberti MV, Locasale JW. The Warburg effect: how does it benefit cancer cells? Trends Biochem Sci (2016) 41:211–8. doi:10.1016/j.tibs.2015.12.001
4. Fajas L. Re-thinking cell cycle regulators: the cross-talk with metabolism. Front Oncol (2013) 3:4. doi:10.3389/fonc.2013.00004
Keywords: Warburg effect, cancer metabolism, macropinocytosis, cell cycle proteins, epigenetic modifications, mitochondrial diseases, N-acetylaspartate, tumor microenvironment
Citation: Giralt A and Fajas L (2017) Editorial: Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions. Front. Endocrinol. 8:362. doi: 10.3389/fendo.2017.00362
Received: 07 November 2017; Accepted: 11 December 2017;
Published: 21 December 2017
Edited and Reviewed by: Ralf Jockers, Paris-Sorbonne University, France
Copyright: © 2017 Giralt and Fajas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Lluis Fajas, bGx1aXMuZmFqYXMmI3gwMDA0MDt1bmlsLmNo