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ORIGINAL RESEARCH article

Front. Earth Sci., 25 January 2023
Sec. Environmental Informatics and Remote Sensing
This article is part of the Research Topic Advances in Fluid-Solid Coupling Processes between Fractures and Porous Rocks: Experimental and Numerical Investigation View all 11 articles

Analysis of influencing factors on wellbore instability for high-pressure gas well during testing and production

Hailong Jiang,Hailong Jiang1,2Mian Chen
Mian Chen1*Chao HuaChao Hua3Xiao LiXiao Li2Yong ZhangYong Zhang2
  • 1State Key Laboratory of Petroleum Resources and Prospecting, China University of Petroleum, Beijing, China
  • 2College of Mechanical Engineering, Xi’an Shiyou University, Xi’an, Shannxi, China
  • 3Xi’an Qing’an Electrical Control Co., Ltd, Xi’an, Shannxi, China

Unlike normal-pressure gas wells, wellbore instability is more likely to occur during testing for high-pressure gas wells. Gas acceleration effect exists in gas flow during high-pressure gas well testing, which was ignored in previous wellbore instability analysis. In this paper, the developments of effective circumferential stress and effective radial stress are analyzed in the near-wellbore area of high-pressure gas well, considering the influence of in-situ stress non-uniformity and acceleration effect. To analyze the effective circumferential stress and the effective radial stress more accurately, it is established that the fluid-structure coupling stress field of the finite large thick wall cylinder The flow field considers three cases, namely Darcy’s law, Darcy–Forchheimer model and Darcy-Forchheime model considering gas acceleration. The results show that in-situ stress non-uniformity has a similar influence on tensile failure and shear failure. It is observed that the location of occurring shear failure and tensile failure may not be on the wellbore wall. When the formation fluid is under abnormally high pressure, it is more likely to have a tensile failure, while when the formation fluid is under abnormally low pressure, it is more likely to have a shear failure. The Biot parameter has the same effect on tensile failure and shear failure. These results are helpful to control sand production during testing and production for high-pressure gas wells.

1 Introduction

High-pressure gas reservoirs are characterized by natural fractures, high formation pressure and large variation of a production pressure difference which is on account of depletion production. In the process of gas test production, the non-Darcy characteristic of high speed is the prominent characteristic of high-pressure gas flow, which is not only manifested in the inertial resistance, but also in the significant gas acceleration effect induced by the rapid expansion of the gas volume (Jin et al., 2011a; Chen et al., 2011; Jin et al., 2012). The characteristic makes the spatio-temporal evolution of gas pressure more complex (Jin et al., 2019; Zhang et al., 2021; Hou et al., 2022a; Zhang et al., 2022). Traditionally, the inertial effect of near-wellbore gas flow is simply expressed by adding the Forchheimer inertial drag to Darcy’s Law. However, this description of the inertial effects of compressible fluid flows is incomplete. Wooding (1957) might be the first to add an accelerated-inertial term to the gas momentum equation. The model with the accelerated-inertial term has been discussed in detail for a high-speed compressible flow in porous media (Nield, 1994; Levy et al., 1995; Chang and Hou, 2022). Jiang et al. (2015a; 2015b; 2015c; 2016) finds the reason why the gas acceleration effect was ignored in the past literature and analyzes the importance of the gas acceleration effect in detail. Jin et al. (2011b) establishes a plane radial model considering the acceleration effect and presents a method for quantitative evaluation of the gas acceleration effect. Tensile stress is easy to form in the surrounding rock stress of the wellbore wall considering the acceleration effect by analyzing the fluid-structure coupling stress equation in the infinite thick-walled cylinder. The relationship of effective radial stress under different seepage models is not pointed out. Wellbore instability failure is usually divided into two categories, one is a shear failure, and the other is a tension failure. The current research focuses on shear failure (Zhao et al., 2021; Hou et al., 2022b; Hou et al., 2022c; Warsitzka et al., 2022), while the strength of extension is frequently used in analyzing tensile failure for wellbore instability during testing and production (Tan et al., 2021; Hou et al., 2022d; Sun et al., 2022; Hou et al., 2022e; Huang et al., 2023).

In this paper, we investigate the properties of near-wellbore stress using a set of equations that is built in the finite thick-walled cylinder in the non-uniform in-situ stress field. It is proved that the acceleration effect increases the possibility of tensile and shear failure. It is shown that the two types of failure do not necessarily occur on the wellbore wall. It is also shown that when the formation fluid is under abnormally high pressure, it is more likely to have a tensile failure, while when the formation fluid is under abnormally low pressure, it is more likely to have a shear failure. The Biot parameter has the same effect on tensile failure and shear failure.

2 Wellbore stress distributions in the finite large thick wall cylinder model

The stratum is assumed to be a uniform isotropic, linear elastic porous material, and the surrounding rock is considered to be in a plane strain state. σH is the horizontal maximum stress and σh is the horizontal minimum stress. The stress distributions for a radially varying pore pressure given by Eqs. (4.51)–(4.52) in the literature (Fjaer et al., 2008) is under the uniform stress field. The wellbore stress under the non-uniform in-situ stress can be obtained by changing both equations according to the theory of elasticity. The new wellbore stress distributions are:

σr=σH+σh2Re2Re2Rw2Re2Rw2Re2Rw2r2+Rw2Re2r2pwr2Re2Rw2+σHσh2(Re2Re4+Re2Rw2+4Rw4Re2Rw23+3Re4Rw4Re2+Rw2Re2Rw23r44Re2Rw2Re4+Re2Rw2+Rw4Re2Rw23r2)cos2θ+2ηr2RwrrΔprdrr2Rw2Re2Rw2RwRerΔprdrσθ=σH+σh2Re2Re2Rw2+Re2Rw2Re2Rw2r2Rw2Re2+r2pwr2Re2Rw2σHσh2(Re2Re4+Re2Rw2+4Rw4Re2Rw23+3Re4Rw4Re2+Rw2Re2Rw23r412Re2Rw2r2Re2Rw23)cos2θ+2ηΔp(r2ηr2RwrrΔprdr+r2+Rw2Re2Rw2RwRerΔprdr(1)

where η=12vfrαB/21vfr is the poroelastic coefficient, Δpr=prpe, and υfr is the rock frame Poisson ratio.

When σH is equal to σh, Equation 1 will be simplified to Eqs. (4.51)–(4.52) in the literature (Fjaer et al., 2008). The dimensionless stress distributions related to Equation 1 are:

σr=A2Re2Re21Re2Re21r2+Re2r2Dr2Re21+B2Re2Re4+Re2+4Re213+3Re4Re2+1Re213r44Re2Re4+Re2+1Re213r2cos2θ+2ηr21rrΔprdrr21Re211RerΔprdrσθ=A2Re2Re21+Re2Re21r2Re2+r2Dr2Re21B2Re2Re4+Re2+4Re213+3Re4Re2+1Re213r412Re2r2Re213cos2θ+2ηΔpr2ηr21rrΔprdr+r21Re211RerΔprdr(2)

where A=σH+σh/pe, where A>2, B=σH+σh/pe, D=pw/pe, where D<1, and Δpr=pr1.

The dimensionless effective stress distributions are:

σr=σrαBpr=A2re2re21re2re21r2+re2r2Dr2re21+B2re2re4+re2+4re213+3re4re2+1re213r44re2re4+re2+1re213r2cos2θ+2ηr21rrΔprdrr21re211rerΔprdrαBprσθ=σθαBpr=A2re2re21+re2re21r2re2+r2Dr2re21B2re2re4+re2+4re213+3re4re2+1re213r412re2r2re213cos2θ+2ηΔpr2ηr21rrΔprdr+r21re211rerΔprdrαBpr(3)

where αB is the Biot parameter.

3 Analysis of the influence of acceleration effect on the wellbore stress

The traditional Darcy–Forchheimer model is not suitable for characterizing the flow of high-pressure gas into the well, so the acceleration effect of gas should be considered (Jin et al., 2011; Chen et al., 2011; Jin et al., 202). The acceleration effect of near-wellbore gas can be characterized by the dimensionless quantity λ. After considering the acceleration effect, the three characteristics of gas flow in high-pressure gas wells are:

1) With the decrease of bottomhole pressure, there is a maximum mass flow rate of fluid into the well, mmax.

mmax=λD(4)

2) The gas pressure gradient of the three flow models which are Darcy’s law, the Darcy-Forchheime model and the Darcy-Forchheime model considering gas acceleration has the following relation when the mass flow is the same. The subscript AC stands for the Darcy-Forchheime model considering gas acceleration, DF is the Darcy-Forchheime model, and D points to Darcy’s law.

dpdrAC>dpdrDF>dpdrD(5)

3) Under the same mass flow rate, the bottomhole pressure of the three models has the following relationship.

DAC<DDF<DD(6)

3.1 Comparative analysis of effective radial stress

Jin et al. (2011b) believed that the effective radial stress in the near-wellbore zone is more likely to change into tensile stress after considering the acceleration effect, but he did not give the relative size for the effective radial stress of the three flow models. To facilitate the analysis of this relationship, the inhomogeneity of in-situ stress is ignored, i.e., B=0, and the Biot parameter is equal to 1. According to Eq. 3, σr|r=1,αB=1=0 for the three flow models.

The derivative of effective radial stress for Darcy’s law is:

dσrdr|r=1D=dσrdr|r=1dpdr|r=1=re2Are212re2re21ηDD2ηpDmDDD(7)

where pD=2/re211rerprdr.

The derivative of effective radial stress for the Darcy–Forchheimer model can be given by

dσrdr|r=1DF=dσrdr|r=1dpdr|r=1=re2Are212re2re21ηDDF2ηpDF1DDFmDF+δλmDF2(8)

where δ/λ is constant.

The derivative of effective radial stress for the Darcy–Forchheimer model considering gas acceleration becomes

dσrdr|r=1AC=dσrdr|r=1dpdr|r=1=re2Are212re2re21ηDAC2ηpAC1DACmAC+δλmAC2+mAC2/λ1mAC2/λDAC2(9)

The difference in derivative of effective stress on the wellbore between Darcy’s law and Darcy–Forchheimer model with the same mass flow rate is:

dσrdr|r=1Ddσrdr|r=1DF=m1DDF1DD+δλm2DDF2ηpDpDF+2re2re21ηDDDDF(10)

where, 2ηpDpDF+2re2/re21ηDDDDF<2re2/re21ηDDDDF.

We can obtain dσr/dr|r=1Ddσr/dr|r=1DF>0 labeled Equation 11, when m1DD1DDF+1DDF1DD2+8δλDDFre2re21ηDDDDF2δ/λ/DDF=m1.

The given distance ra must exist. σrD>σrDF, when the radius in polar coordinates is between 1 and ra, i.e., 1<r<ra, combining σr|r=1,αB=1=0.

The difference in derivative of effective stress on the wellbore between Darcy–Forchheimer model and Darcy–Forchheimer model considering gas acceleration with the same mass flow rate is:

dσrdr|r=1DFdσrdr|r=1AC=1DACm+δλm2+m2/λ1mAC2/λDAC21DDFm+δλm22ηpDFpAC+2re2re21ηDDFDAC

where 1DACm+δλm2+m2/λ1m2/λDAC21DDFm+δλm2>m+δλm2+m2/λDAC1DDFm+δλm2>m2δλ1DAC1DDF+1λDAC, and 2ηpDFpAC+2re2re21ηDDFDAC<2re2re21ηDDFDAC.

We can find dσrdr|r=1DFdσrdr|r=1AC>0, which is marked as Equation 12 when m2re2/re21ηDDFDACδλ1/DAC1/DDC+1/DλAC=m2.

As well, the given distance rb must exist. σrDF>σrAC, when the radius in polar coordinates is between 1 and rb, i.e., 1<r<rb, combining σr|r=1,αB=1=0.

Combining equation 11 and 12, we can get σrD>σrDF>σrAC, when λDACmmaxm1,m2 and 1<r<minra,rb.

It is quite clear that σrD>σrDF>σrAC even if αB<1.

Effective radial stress near the wellbore must be a negative value when dσrAC/dr|r=1<0. We can find that the effective radial stress is minimal for the Darcy–Forchheimer model considering gas acceleration because σrD>σrDF>σrAC. In other words, the tensile stress is minimal for the Darcy–Forchheimer model considering gas acceleration.

According to Equations 7 and 8 and 9, we can obtain dσr/drD<σr/drDF<σr/drAC and the pore pressure gradient plays a decisive role in the effective radial stress by using Equation 5.

To better observe the variation in tensile stress, a case is presented. The mass flow rate, m, equals 0.0412 which is bigger than the maximum between m1 equal to 0.0232 and m2.given by 0.0245. Set other parameters as follows. re=2000, η=0.5, λ=0.5, δ=50, A=2.2, and B=0. In the above parameters, the distribution of the stress for the three flow models is illustrated in Figure 1. Firstly, for Darcy’s law, the effective radial stress on the wellbore is zero, which is the minimum in the stress distribution. Secondly, for the Darcy-Forchheimer model, the effective radial stress at r=1.0395 equals −0.0105, which is the minimum. Finally, for the Darcy-Forchheimer model, the effective radial stress is equal to −0.0282 at r=1.0568, which is the minimum, i.e., it is 2.82MPA when the formation pressure is 100 MPa.

FIGURE 1
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FIGURE 1. The effective radial stress distribution for the three flow models.

3.2 Difference between effective circumferential stress and effective radial stress

For the convenience of comparative analysis, the inhomogeneity of in-situ stress is not considered here, and the Biot parameter is assumed to be one.

From Equation 2, we can conclude that

σθ|r=1=re2Are2+1Dre21+2ηD1=A11re22η1+1re211re22ηD

where A11re22η>0, and 1+1re211re22η>0.

When the mass flow rates of the three flow models are the same, the wellbore pressure can be written as DAC<DDF<DD. Then, we have σθ|r=1AC>σθ|r=1DF>σθ|r=1D and σθ|r=1AC>σθ|r=1DF>σθ|r=1D.

Because the effective radial stresses on the wellbore for the three flow models are zero, it can be obtained that

σθ|r=1σr|r=1>ACσθ|r=1σr|r=1DF>σθ|r=1σr|r=1D(11)

It is quite clear that Equation 13 is correct, even if αB<1.

When 1<r<re, from Equation 3, we have

σθ=re2r2+1A2r2re21re2+r2r2re21D+2ηαBpr2ηr21rrprdr+r21re211reprdr2ηr2

As long as ηαB/2, σθ and pr are negatively correlated for the same mass flow rate. Then we can conclude that σθAC>σθDF>σθD, where 1r<re. The accelerating flow has the highest difference:

σθσrAC>σθσrDF>σθσrD(12)

To better observe the variation in the difference between effective circumferential stress and effective radial stress, a case is presented. When the other parameters are set to m=0.0412, re=2000, η=0.5, λ=0.5, δ=50, A=2.2, and B=0, the difference is shown in Figure 2. The difference between effective circumferential stress and effective radial stress reaches the maximum at r=1, which is equal to 0.6147, for Darcy’s law. It becomes 1.0004 reaching the maximum at r=1.0584 for Darcy–Forchheimer models. Meanwhile, For the acceleration flow, this difference equals 1.0980 at r=1.0063 which is the maximum in the distribution. When the formation pressure is 100MPa, the maximum for the three flow models is 61.47MPa, 100.04 MPa and 109.80 MPa respectively.

FIGURE 2
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FIGURE 2. Difference between effective circumferential stress and effective radial stress for the three flow models.

4 Analysis of the influence of in situ stress on the wellbore stress

4.1 Comparative analysis of effective radial stress

Since re2/re21re2/re21r2>0, we have dσrdA>0. Thus, the effective radial stress considering the acceleration effect is the monotone-increasing function of A. When the effective radial stress is negative, the smaller A is, the greater the tensile stress is, indicating that the formation fluid is under abnormally high pressure, while the tensile stress is greater.

We plot the effective radial stress for m=0.0412, re=2000, η=0.5, λ=0.5, δ=50 and B=0 in Figure 3. It shows that the effective radial stress is the minimum at r=1.0568, which is −0.0282 when A=2.2. While A=2.4, the effective radial stress is −0.0191 at r=1.0395 which is also minimum. When A=2.6, the mini effective radial stress is −0.0132 at r=1.0253. When 1<r<3+3/re21+1/re2+4/re4 and cos2θ>0, we have re2re4+re2+4re213+3re4re2+1re213r412re2r2re213cos2θ<0.

FIGURE 3
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FIGURE 3. The effective radial stress distribution the acceleration flow for various A

Thus, dσr/dB<0. It can be seen that the effective radial stress considering the acceleration effect is a monotone-decreasing function of B. When the effective radial stress is tensile, the stronger the non-uniformity of in-situ stress is, the smaller the effective radial stress is, that is, the greater the tensile stress is and the maximum tensile stress is obtained in the direction of the maximum horizontal principal stress.

In Figure 4, we plot the effective circumferential stress for m=0.0412, re=2000, η=0.5, λ=0.5, δ=50, A=2.4 and θ=0. In the direction of the maximum horizontal principal stress, the minimum effective radial stress is −0.0359 at r=1.0667 when B=0.2. When B=0.4, the effective radial stress is the minimum at r=1.1010, which is −0.0590. When B=0.6, it is the minimum at r=1.1278, which is −0.0859.

FIGURE 4
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FIGURE 4. The effective radial stress distribution in the acceleration flow for various B

4.2 Difference between effective circumferential stress and effective radial stress

From Equation 3, the difference between effective circumferential stress and effective radial stress in the acceleration flow is given by

σθσr=Are2re21r22Dre21+2ηΔpr4ηr21rrΔprdrBcos2θre2re4+re2+4re213+3re4re2+1re213r46re2r2re213+2re2re4+re2+1re213r2(13)

It is obvious that dσθσr/dA>0, so the value, σθσr, is smaller when the formation pressure is from the normal pressure to the abnormally high pressure.

The parameters in Figure 5 are the same as that in Figure 3. When A=2.0, the maximum stress is 0.9014 at r=1.0142. When A=2.4, when r= 1.0036, the value, σθσr, is 1.2963. When A=2.8, σθσr reaches its maximum value at r=1.004, which is 1.6950.

FIGURE 5
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FIGURE 5. Difference between effective circumferential stress and effective radial stress in the acceleration flow for various A.

It can be written as Fr=re2re4+re2+4re213+3re4re2+1re213r46re2r2re213+2re2re4+re2+1re213r2.

When 1rre, dFrdr<0 and Frre63re4+9re2+5re213>0. Thus, dσθσrdB>0, for cos2θ<0. These imply that the greater the stress non-uniform, the greater the value σθσr.

In Figure 6, we plot the difference between effective circumferential stress and effective radial stress in the acceleration flow for m=0.0412, re=2000, η=0.5, λ=0.5, δ=50, A=2.4 and θ=π/2. When B=0.2, the maximum stress is 1.6947 at r=1.0004. When B=0.4, when r=1.0004, the value, σθσr, is 2.0940. When B=0.6, σθσr reaches its maximum value at r=1, which is 2.4938.

FIGURE 6
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FIGURE 6. Difference between effective circumferential stress and effective radial stress in the acceleration flow for various B.

5 Wellbore stability of uncased hole in the high-pressure gas wells

5.1 Tensile fracture

According to the analysis in section 3.1 of this paper, when the stress of the surrounding rock near the wellbore reaches the tensile strength, the acceleration flow requires less mass flow than the Darcy model and the Darcy-Forhheimer model, that is, the surrounding rock near the wellbore is the first to fail in the s acceleration flow. According to the analysis in section 4.1 of this paper, tensile failure occurs first in the surrounding rock near the wellbore in the direction of maximum horizontal principal stress.

We will assume the Biot parameter αB=1, so σr|r=1,αB=1=0. Thus, the effective tensile stress depends on the positive or negative sign of the effective radial stress derivative at the wellbore. In other words, the condition for the onset of effective tensile stress is dσr/dr|r=1=0. Combining the condition, Equation 9 can be written as

re2*(A2DAre2+2Dre2+4Bcos2θ+2Bre2cos2θ)re2122D2Dre212ηpD1D22Dlnre=0

The critical bottomhole pressure, D, for the onset of tensile stress is determined from the above equation.

5.2 Shear failure

It is assumed that the shear failure of rock follows the weak surface failure criterion (Zeng et al., 2021). The Mohr-Coulomb failure criterion for β<β1 or β>β2 is defined as

σ1σ3=2Cw+tanϕwσ31tanϕwcotβsin2β
β1=ϕw2+12arcsinσ1+σ3+2Cwcotϕwsinϕwσ1σ3
β2=π2+ϕw212arcsinσ1+σ3+2Cwcotϕwsinϕwσ1σ3

where Co is the cohesion of the rock, ϕo is the friction angle of the rock, Cw is the cohesion of the weak plane, ϕw is the friction angle of the weak plane, and β is the angle between maximum principal stress and weak plane normal, related to the failure mode of the anisotropic mudstone with the weak plane.

Only the case is discussed where σθ>σz>σr and weak plane shear failure occurred in the rock. According to the analysis in section 3.2, shear failure occurs first in the surrounding rock of the acceleration flow when the mass flow rate increases and shear failure occurs first in the minimum horizontal direction of the surrounding rock according to the analysis in section 4.2.

Thus, when r=1, Equation 13 can be written as

σθσrr=1=Are2re21B24re2re2+2re212cos2θDre2+2re2112ηD2η(14)

Thus, D=sin2β1μwcotβAre2re212Bre2re2+2re212cos2θ2η+2Cwre2+2re21+12η+2μw1αB.

The critical bottomhole pressure is proportional to the Biot parameter, that is, when the Biot parameter increases, the mass flow required for shear failure decreases. When the Biot parameter increases, the effective radial stress decreases, the tensile stress increases and the required pore pressure gradient decreases. In other words, when the Biot parameter increases, the mass flow rate required for tensile failure decreases. Therefore, the Biot parameter has the same effect on tensile failure and shear failure.

6 Conclusion

Considering the dual effects of non-uniformity of in-situ stress and acceleration effect in the process of seepage, the stress state of surrounding rock suitable for high-pressure gas well and its influence on tensile failure and shear failure in the process of gas test of the high-pressure gas well are analyzed, and the following conclusions are as following.

1) Considering the acceleration effect, the difference between effective circumferential stress and effective radial stress at any flow radius is larger than that in the other two flow models, which is more likely to cause shear failure. The difference between the effective circumferential stress and the effective radial stress does not reach the maximum value at the wellbore wall.

2) The pore pressure gradient plays a decisive role in the effective radial stress. Considering the acceleration effect, the minimum effective radial stress is smaller than that of the other two flow models, which is more likely to lead to tensile failure. The conditional expression of tensile stress generation considering the non-uniformity of in-situ stress is given.

3) The influence of Biot parameter on tensile failure and shear failure is the same.

Data availability statement

The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.

Author contributions

HJ and MC contributed to conception and design of the study. CH organized the database. XL performed the statistical analysis. YZ wrote the first draft of the manuscript. All authors contributed to manuscript revision, read, and approved the submitted version.

Funding

This study is supported by the Open Fund (Program No. PRP/open-2009) of State Key Laboratory of Petroleum Resources and Prospecting, National Natural Science Foundation of China (Grant No. 52104005), Natural Science Basic Research Plan in Shaanxi Province of China (Program No. 2021JM-407), Key Research and Development Program of Shaanxi Province (grant number 2023-YBGY-312).

Conflict of interest

Author CH was employed by the company Xi’an Qing’an Electrical Control Co., Ltd., China.

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

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Keywords: acceleration effect, non-uniform in situ stress, wellbore instability, tensile failure, shear failure

Citation: Jiang H, Chen M, Hua C, Li X and Zhang Y (2023) Analysis of influencing factors on wellbore instability for high-pressure gas well during testing and production. Front. Earth Sci. 11:1119946. doi: 10.3389/feart.2023.1119946

Received: 09 December 2022; Accepted: 10 January 2023;
Published: 25 January 2023.

Edited by:

Peng Tan, CNPC Engineering Technology R & D Company Limited, China

Reviewed by:

Xian Shi, China University of Petroleum, Huadong, China
Hao Yang, China University of Geosciences, China
Zhang Yan, Yangtze University, China

Copyright © 2023 Jiang, Chen, Hua, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Mian Chen, Y2hlbm1AY3VwLmVkdS5jbg==

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