Lei Guo
Haichen Lv
Xiaomeng Yin- Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China
Coronary chronic total occlusion (CTO), which occurs in 18. 4–52% of all patients referred for coronary angiography, represents one of the last barriers in coronary intervention. Approximately half of all patients with prior coronary artery bypass graft (CABG), who undergo coronary angiography, are diagnosed with coronary CTO. In fact, these patients often develop recurrent symptoms and events, necessitating revascularization. Currently, there is neither a consensus nor developed guidelines for the treatment of CTO patients with prior CABG, and the prognosis of these patients remains unknown. In this review, we discuss current evidence and future perspectives on CTO revascularization in patients with prior CABG, with special emphasis on clinical and lesion characteristics, procedural success rates, periprocedural complications, and long-term outcomes.
Introduction
Coronary chronic total occlusion (CTO), which widely occurs in patients who undergo routine invasive coronary angiography with an incidence rate of 18.4–52%, represents one of the last frontiers of coronary interventions (1–4). Successful CTO percutaneous coronary intervention (PCI) has been associated with improved long-term survival, left ventricular function and quality of life, as well as reduced need for coronary artery bypass graft (CABG) surgery (5–10). Despite the significant role played by this strategy in lowering prevalence of adverse events and enhancing outcomes, over the past decades, patients with CTO were often managed conservatively or surgically, rather than with PCI. In fact, according to the National Cardiovascular Disease Registry (NCDR) CathPCI registry, CTO PCI only represents 3.8% of the total 594,510 PCI cases for stable coronary artery disease (CAD) (11). However, recent technological advancements and intervention strategies have contributed to the higher initial success rates and acceptable complication rates at experienced centers (12, 13), and these advancements have increased interest in application of CTO PCI in patients with appropriate indications (14).
Previous studies have shown that CABG has been widely used for treatment of patients with multivessel CAD and left main disease, and proven to significantly improve their long-term clinical outcomes (15, 16). A recent study showed that 54% of patients with prior CABG who underwent coronary angiography were diagnosed with CTO, owing to the fact that coronary bypass is associated with accelerated progression of atherosclerosis of native coronary arteries (1). Notably, patients with saphenous vein graft (SVG) often develop recurrent ischemic symptoms, which necessitates revascularization in this group of patients (17). To date, however, neither recognized guidelines nor accepted consensus have been developed targeting treatment of this group of patients, and the prognosis of these patients remains unknown. Here, we discuss current progress and future perspectives of CTO revascularization in patients with prior CABG, focusing on clinical and lesion characteristics, procedural success rates, periprocedural complications, and long-term outcomes.
Bypass Graft PCI is Avoided in Patients With Prior CABG
Failure of bypass graft or progression of native CAD implies that patients with prior CABG often require additional revascularization, which commonly involves right coronary artery (RCA) or left circumflex coronary artery but less often the left anterior descending (LAD) artery (18). Notably, graft failure, especially for SVGs, can occur early (after CABG surgery) or late (after several months or years following surgical revascularization). Previous studies have reported that 40% of SVGs will be occluded at 1 year, and 50% of SVGs will be diseased or occluded during the first 10 years of follow-up (19–21). Early post-operative graft failure is mainly caused by conduit defects, poor native vessel runoff and anastomotic technical errors, or competitive flow with the native coronary arteries (22). One month after CABG surgery, SVG disease development starts with neointimal hyperplasia, followed by proliferation and migration of smooth muscle cells with deposition of extracellular matrix, which results in luminal loss (23), and the progression of the atherosclerotic plaque leads to bypass graft stenosis or occlusion. There is a remodeling process of SVGs after surgery. During this process, pro-inflammatory factors, cytokines in arterial wall and atherogenic lipoproteins in plasma cause formation of a highly atherogenic substrate, on which atherosclerosis develops (24, 25).
Furthermore, SVG lesions are often degenerated, and are prone to distal embolization and high restenosis. SVG PCI was associated with higher risk of no-reflow and periprocedural myocardial infarction (MI) (26, 27). Accumulating evidences have suggested that embolization of atheromatous material to the distal vasculature, coupled with severe vasospasm induced by microembolization of platelet-rich thrombi that release vasoactive agents resulting in microvascular obstruction, are the possible mechanisms of no reflow (26, 28). To minimize the chance of distal embolization and prevent reflow, several strategies, such as administration of vasodilators, embolic protection devices, direct stenting, and use of undersized stents can be applied (29, 30).
A previous meta-analysis of 6 randomized clinical trials, comprising 1,582 patients, demonstrated that high incidence of procedural complications, such as suture dehiscence and perforation, as well as short and long-term major adverse events, including a 2-fold rate of in-hospital deaths, were more common in bypass graft PCI compared to native coronary PCI (26, 31). The ongoing PROCTOR (Percutaneous Coronary Intervention of Native Coronary Artery vs. Venous Bypass Graft in Patients with Prior Coronary Artery Bypass Graft Surgery) Trial, which plan to enroll 584 patients with a clinical indication for PCI and a dysfunctional graft on the target vesselional venous bypass graft with 3 years follow-up, may give more evidences to us.
Previous study reported that SVG PCIs account for approximately 6% of all PCIs performed in the United States (27). The guidelines of the American College of Cardiology/American Heart Association recommend that class III for PCI of SVG CTOs, and SVG CTOs should generally not be recanalized, due to a high risk of restenosis (32). Similarly, the 2018 ESC/EACTS guidelines for myocardial revascularization recommend that PCI should be considered in the native vessel rather than in an SVG graft (Class IIa, Level of Evidence: C) (33). Notably, these patients are more likely to be predisposed to a higher surgical risk, such as acute coronary syndrome (ACS), serious comorbidities and frailty, which are contraindications to the use of extracorporeal circulation. However, PCI is a safe and effective approach, hence suitable for this group of patients. Furthermore, due to increased age, frailty and multiple comorbid illnesses, repeat CABG has been associated with limited symptomatic improvement, and more adverse events (2 to 4-fold mortality), compared with initial CABG mainly driven by comorbidity (34, 35).
In summary, 50% of SVGs will be diseased or occluded during the first 10 years after CABG surgery. However, SVG PCI typically carries a higher risk of procedural complications, as well as short and long-term major adverse events. Previous studies and guidelines showed, in this case, CTO PCI, rather than CABG, is recommended for revascularization. Therefore, performing CTO PCI in native coronary artery guarantees more favorable outcomes in CTO patients with prior CABG who develop recurrent symptoms.
Characteristics and CTO PCI Success Rates in Patients With Prior CABG
CTO registries indicated that prior CABG is a predictor of procedural failure, and is more frequent in patients with failed CTO PCI procedures (5, 36). A recent study from the REgistry of Crossboss and Hybrid procedures in FrAnce the NetheRlands, BelGium and UnitEd Kingdom (RECHARGE) cohort found a significantly lower success rate (71.9%) in the post-CABG group, relative to no-CABG group (88.7%, p < 0.001) (37). Furthermore, Michael et al. (38) analyzed data for 1,363 subjects from the Multicenter US Registry and found similar results among patients with prior CABG. The low technical success rates of CTO PCI in patients with prior CABG may reflect the enormous difficulty of intervention in this population. We attribute this phenomenon to the following reasons: Firstly, when compared to patients without prior CABG, those with prior CABG who underwent CTO revascularization were older, and exhibited more comorbidities, including hypertension, diabetes, prior MI, previous stroke, chronic kidney insufficiency and left ventricular dysfunction (37, 39–41), which have previously been shown to be independent predictors of CTO PCI failure (11, 42). Secondly, regarding lesion characteristics, patients with prior CABG who underwent CTO intervention often exhibited higher complexity of the CTO lesion and vessel anatomy, mainly because CABG can accelerate development of native coronary artery atherosclerosis due to the competitive flow generated by the grafting process (43). In addition, sternal reentry, pericardial adhesions, in situ arterial grafts, and patent but diseased SVGs all increase the complexity and risk of coronary reoperations. Notably, the above two were also the main reasons why patients with prior CABG were not eligible for redo CABG, according to a study from the Cleveland Clinic (44).
Sakakura et al. (45) reported that CTOs in patients with prior CABG manifested pathological features of accelerated atherosclerosis progression, including moderate/severe calcification, moderate negative remodeling, and more blunt stumps than those without CABG. It is possible that these differences in pathology may negatively impact the success rates of CTO PCI in such patients. In fact, results from a recent meta-analysis comprising 8,131 patients who underwent CTO PCI, of which 2,163 had prior while 5,968 were without CABG, revealed that patients with prior CABG had more calcified and longer lesions, and higher Japanese-chronic total occlusion (J-CTO) score (i.e. more complex lesions) relative to those without prior CABG. Moreover, prior CABG has been associated with longer CTO durations as well as more pronounced calcification, blunt proximal cap and vessel tortuosity, due to the shrinkage of the occluded bypass graft or vessel distortion at the time of bypass grafting (37), which elevate the technical difficulty. The underlying mechanism of native arterial calcification has largely been attributed to blood stasis and low shear stress resulting from competitive flow between the native and bypass graft (46, 47). In addition, PCI on calcified lesion represents a challenge for the interventionalist, and has been associated with lower procedural success rates, relatively higher incidence of procedural complications and increased rates of restenosis, due to insufficient stent expansion (48). Besides, CABG surgery causes distortion, displacement, and deformation of the native coronary arteries, thereby hindering CTO crossing attempts, and making CTO PCI more technically challenging. Additionally, complications during CTO PCI procedures, such as coronary perforation, might negatively impact its success rate (49).
Notably, previous researchers have frequently performed a retrograde approach in CTO patients with prior CABG (38, 41, 50). For example, a previous meta-analysis reported 34.7 and 21.9% success rates in patients with and without prior CABG (p < 0.001), respectively (51). The wide adoption of the retrograde approach in these patients was likely related to complexity of the CTO lesion, which requires application of multiple crossing techniques. Bypass grafts, both SVG and left internal mammary artery (LIMA), can serve as retrograde conduits. For example, Xenogiannis et al. (52) compared retrograde cases via SVGs with other collateral vessels, and found that the former was associated with significantly higher rates of technical (85 vs. 78%; p = 0.04) and procedural success (81 vs. 74%; p = 0.04) than the latter. On the other hand, Dautov et al. (53) examined the feasibility and safety of CTO PCI via SVGs compared to collateral channels or an antegrade-only approach in patients with prior CABG, and found that retrograde cases via SVGs were safe and effective. Notably, use of SVG reduced radiation, contrast volume, fluoroscopic and procedural time, and was further associated with an equally high success and low complications (53). Based on these findings, retrograde approach is recommended for native artery CTO PCI via an occluded or for patients with SVG when the anatomy suggests that the retrograde approach would be more effective. The LIMA is not frequently applied in CTO PCI practice (2%), possibly due to performance of redo CABG in cases of LIMA failure. Besides, the hazard associated with that approach (LIMA is used as a retrograde conduit) should be considered. For example, if an attempt is made to access distal LAD septal collaterals to open a RCA via the LIMA, the risk of kinking the LIMA and inducing ischemia and shock is significant (54). Consequently, this approach should only be used as the last resort. Conversely, retrograde CTO PCI may be safer in patients with prior CABG, because pericardial adhesions may reduce the likelihood of tamponade in CABG case of collateral vessel perforation (37, 51). On the other hand, it should be noticed that if a retrograde approach is attempted, the operator will be forced to use the microchannel via the bypass graft, which may be linked to more complex procedures and a wider area of ischemia (55, 56).
Even though the success rate of CTO-PCI in patients with prior CABG was significantly lower than that in the those without prior CABG, the recent technological advancements and development of novel targeted devices, have made the CTO intervention safe and effective (57). Previous studies showed that prior CABG patients more often had dual injection (71–77%) and femoral access (74–88%) (39, 50). CTO PCIs in prior CABG patients more often required use of antegrade dissection/re-entry (ADR) (35%) and the retrograde (42–53%), whereas the antegrade wire escalation was used less frequently (39, 50). Furthermore, application of the “hybrid approach”, especially the retrograde approach via SVGs, has significantly improved the resulting technical success, from 79.7 to 88.1%, in prior CABG patients (39).
Overall, although the relatively low technical success rates of CTO PCI in patients with prior CABG due to worse baseline risk profiles and higher complexity of the CTO lesion, ADR, retrograde approach via SVGs, even hybrid approach, coupled with a growing operator experience, maintain high success rates. These have enhanced the interest and confidence for application of CTO PCI in these high-risk patients. A summary of recent studies that have evaluated CTO PCI in patients with prior CABG is provided in Table 1, and the corresponding success rates are presented in Figure 1.
Table 1. Recent studies of CTO-PCI in patients with prior CABG.
Figure 1. Successful rates of CTO-PCI in patients with and without prior CABG in recent studies. CABG, coronary artery bypass grafting; CTO, chronic total occlusion; PCI, percutaneous coronary intervention.
Procedural Complications and In-Hospital Outcomes in Patients With Prior CABG
Previous studies have demonstrated that total operating and fluoroscopy times, as well as air kerma radiation doses and volumes of contrast agent administered are higher in CTO patients with prior CABG relative to those without, and these have been attributed to the complexity of CTO lesion (38, 51). Consequently, these patients are predisposed to a high risk for contrast-induced nephropathy (CIN), hemodialysis and dermatitis (37, 38, 53, 60). Dautov et al. (53) found that CTO patients with prior CABG who underwent PCI had approximately 4.6% incidence of CIN, which was significantly higher than that in those without prior CABG (4.6 vs. 1.0%, p = 0.02). Previous studies have also shown that pre-procedural hydration, limiting contrast volume [to < 3.7 × the patients' creatinine clearance is recommended (61)], minimizing the frequency of test injections, and aborting the procedure in cases where CTO crossing has not been achieved before reaching a pre-determined contrast volume limit, as well as using iso-osmolar contrast media, intravascular ultrasound or non-contrast-based optical coherence tomography, microcatheter tip-injections instead of injections via the guiding catheter, may lower the risk for CIN (62–65). In fact, reducing exposure to radiation can be accomplished in several ways, such as using lower frame rate fluoroscopy, limiting the use of cine angiography and using the “fluoro-store” function instead, as well as frequently changing imaging angles. Usually, CTO PCI is stopped after 6–8 Gy air kerma radiation dose is reached, without successful lesion crossing, which is similar to contrast volume administration (61, 64). Additionally, using 7.5 frame per second fluoroscopy, coupled with shielding during CTO PCI can achieve similar effect compared with non-CTO PCI (66).
Notably, coronary perforation is a common complication during CTO PCI procedures in these patients, owing to the complex anatomy of lesions. Previous studies have demonstrated that CTO PCI in patients with prior CABG was associated with a high rate of coronary perforation (6.9–12%) (40, 50), consistent with the report of Megaly et al. (51), who reported comparable results (7.3 vs. 4.9%; odds ratio (OR): 2.07 [95% confidence interval (CI): 1.49–2.86]; p < 0.001). Results of a study from the British cardiovascular intervention society database showed that CTO intervention was an independent factor for perforation (67), and Azzalini et al. (49) found that patients with coronary perforation exhibited higher J-CTO scores, more often required the retrograde approach, and had lower success rates. Although the retrograde approach has been frequently applied in CTO patients with prior CABG, it has been associated with a higher risk of perforation relative to the antegrade approach (50). A recent study also found that a heavier burden of calcification might contribute to the elevated perforation rate (68). Both guidewire passage via the tiny collateral channels during the retrograde approach and result in collateral channel damage, and the aggressive balloon dilation in severely atherosclerotic vessels contributed to the perforation in such high-risk population. According to a recently published global expert consensus for CTO PCI, specific expertise and volume, as well as availability of dedicated equipment, are required to facilitate prevention and management of coronary perforation (69). Notably, covered stents, as effective devices for coronary perforation, are stiff devices that are difficult to navigate through tortuous vessels of CTO lesion in prior CABG patients, suggesting that the operation process may exacerbate the risk of periprocedural complications, including longer procedure time and fluoroscopy time, higher air kerma radiation dose, and larger contrast volume (46). Interestingly, the rate of coronary perforation among these patients is high, whereas the rate of pericardial tamponade is low (0–0.2%) with lesser pericardiocentesis (40, 50). A possible explanation for this phenomenon is existence of potential protective effect of pericardial adhesion in patients with previous CABG, where less free space is evident in the pericardial cavity, which subsequently reduces the risk of cardiac tamponade. However, pericardial effusions and tamponade can occur, and these events can be lethal during CTO PCI in patients with prior CABG (70). According to the OPEN-CTO registry, 4 perforations led to death of 365 patients with prior CABG (1.1%) (71). Therefore, immediate surgery or computed tomography-guided drainage is required for effective treatment when tamponade occurs, because pericardial tamponade may develop loculated hematomas that can compress the atria or the ventricles, potentially progressing to cardiogenic shock in these patients (72).
Although numerous studies have investigated in-hospital outcomes of CTO PCI in patients with prior CABG, the results are inconsistent (37, 41, 50, 54). For example, Megaly et al. (51) performed a meta-analysis, comprising 8,131 patients and found that patients with prior CABG exhibited a higher incidence of in-hospital mortality (0.8 vs. 0.3%; OR: 2.77 [95% CI: 1.43–5.39]; p = 0.003), and MI (1.4 vs. 0.5%; OR: 2.46 [95% CI: 1.46–4.15]; p < 0.001), compared with those without prior CABG. These results were consistent with the findings of Liu et al. (73). However, both groups exhibited similarities with regards to major bleeding (OR, 1.51; 95% CI, 0.90–2.53; p = 0.11), acute cerebrovascular events (0.3 vs. 0.3%; OR: 1.51 [95% CI: 0.49–4.66]; p = 0.47), vascular access complication (OR: 1.50; 95% CI: 0.93–2.41; p = 0.10), and emergency CABG (OR: 0.99; 95% CI: 0.25–3.91; p = 0.99) (51, 73).
Overall, patients with prior CABG exhibit a higher incidence of procedural complications and in-hospital mortality, however, these adverse events are acceptable with a variety of strategies.
Long-Term Clinical Outcomes in Patients With Prior CABG
The findings from a recent cohort study, comprising 123,780 consecutive PCI procedures from the Pan-London (UK) PCI registry, revealed no significant differences in all-cause mortality between patients with or without previous CABG in propensity-matched population, after both unadjusted and adjusted analyses (74). However, CTO is a special subtype of CAD that represents one of the last barriers in coronary intervention. Currently, data on long-term clinical outcomes in patients with previous exposure to CABG are scarce and unclear. Dautov et al. (53) analyzed a cohort of 470 CTO cases, and found that patients with prior CABG exhibited higher incidences of major adverse cardiac events (MACE) (cardiac death, MI, target-vessel revascularization (TVR), or re-occlusion) (hazards ratio (HR) = 2.2; p = 0.02), at 1-year follow up. On the other hand, Azzalini et al. (40) evaluated 2,058 patients who underwent CTO PCI at 7 centers, and found significantly higher 24-month target-vessel failure (cardiac death, target vessel MI, and TVR) rates in patients who had undergone CABG relative to those without prior exposure to CABG (16.1 vs. 9.0%; p < 0.001). More recently, Nikolakopoulos et al. (41) analyzed data from the PROGRESS CTO (Prospective Global Registry for the Study of CTO Intervention) registry, and confirmed that, patients with prior CABG exhibited higher incidence of MACE (21.8 vs. 12.7%) and MI, but had similar mortality and repeat revascularization rates after 1 year. Conversely, Toma et al. (58) retrospectively analyzed 2,002 patients who underwent CTO PCI and found that those exposed to CABG presented with a significantly higher risk of 2.6-year MACE (36 vs. 30%, p = 0.003), including all-cause death, non-fatal MI, and TVR. However, the authors found no significant differences with regards to MACE (adjusted HR 1. 08, 95% CI 0.86–1.35, p = 0.52) after multivariate adjustment. Consistent results were reported in another study, comprising 20,081 patients, from the British Cardiovascular Intervention Society, as evidenced by no significant differences in mortality rates at 1 year (OR 1.02, CI 0.81–1.29, p = 0.87) (59). Table 2 outlines the long-term clinical outcomes in patients with prior CABG in major studies.
Table 2. Major studies comparing long-term outcomes of pCABG vs. nCABG.
The poor follow-up outcomes of patients with prior exposure to CABG are likely to be related to higher risk baseline coronary anatomy and more comorbidities. Notably, long-term dual antiplatelet therapy (DAPT) is recommended for treatment of patients with prior CABG, owing to the fact that they often have extensive, multilevel atherosclerotic disease and high risk for subsequent adverse cardiovascular events (22, 75). A summary of characteristics for CTO patients with and without prior exposure to CABG is presented in Figure 2.
Figure 2. Characteristics of pCABG vs. nCABG. CABG, coronary artery bypass grafting; nCABG, no-CABG; pCABG, post-CABG.
Indication for CTO PCI and Objective Benefits
It is important to assess the patient adequately before undertaking the procedure. The decision-making process leading to revascularization for CTOs should pass through three steps: the evaluation of symptoms, the assessment of ischemic burden, and the demonstration of viability (76). In patients with 12.5% or more ischemic myocardium as assessed by myocardial perfusion imaging (MPI) with single photon emission computed tomography (SPECT) and positron emission tomography (PET), revascularization is recommended. Medical therapy is recommended if there is <6.25% ischemic myocardium, as this was associated with increased ischemia at follow-up. In patients with 6.25–12.5% ischemic myocardium, PCI may be reasonable if medical therapy fails to control symptoms (77). In asymptomatic patients who did not have viability data (which were obtained from stress echocardiography, nuclear imaging, magnetic resonance imaging, or PET) available or in subjects with proved absence of viability, medical therapy was strongly preferred. In symptomatic patients, even without information on viability or in asymptomatic patients with viability, PCI was preferred (78). CTO recanalization is indicated in the presence of objective evidence of viability/ischemia in the territory of the occluded artery of more than 10%, as shown by the guidelines on myocardial revascularization (79). Overall, patients with persistent symptoms despite optimized medical therapy and asymptomatic patients with a high burden of ischemia or evidence of viability are suitable candidates for CTO revascularization. Patients who do not fulfill any of these criteria should be managed medically. In addition, clinical and anatomical factors and operator's experience are also important factors which should be taken into consideration during the assessment of a patient candidate for a CTO revascularization.
The 2012 Appropriate use criteria (AUC) guidelines recommend clinicians in making revascularization decisions for their patients with CTO to take into considerations several factors, including patient's symptoms on maximal medical therapy, clinical presentation, risk profile on non-invasive testing, and angiographic features (79). The 2014 European Society of Cardiology/European Association for Cardio-Thoracic Surgery (ESC/EATCS) guidelines for myocardial revascularization also give a Class IIa (B) recommendation, if an ischemia reduction in the CTO territory and/or the relief of angina symptoms can be expected (80). Similarly, the 2011 American College of Cardiology/American Heart Association PCI guidelines state that “PCI of a CTO in patients with appropriate clinical indications and suitable anatomy is reasonable when performed by operators with appropriate expertise” (class IIa, level of evidence B) (32).
The key objectives of CTO recanalization include symptom relief (not only angina), increase in exercise capacity and improvement of quality of life. Several studies have reported that successful CTO revascularization is associated with symptomatic relief of angina, as well as improved left ventricular function, long-term survival, and quality of life (78, 81). A meta-analysis by Hoebers et al. reported that in 34 studies with 2,243 patients, there was a significant improvement in left ventricular ejection fraction (LVEF) by 4.44% following CTO-PCI compared with preintervention LVEF (82). Recently, the Euro-CTO trial showed that, after 12 months follow-up, a greater improvement of Seattle angina questionnaire (SAQ) subscales was observed with PCI as compared with optimal medical therapy (OMT) for angina frequency and quality of life. However, MACEs were comparable between the two groups (83). The DECISION-CTO trial also reported there was no difference in the incidence of MACEs with CTO PCI vs. no CTO-PCI (84).
However, up to now, there is no widely recognized consensus or guideline on treatment strategy of CTO patients with prior CABG, and the prognosis in this population remains controversial. Well-designed, large randomized clinical trials compared PCI with drug eluting stent (DES), optimal medical therapy, and re-CABG for the management of CTO patients with prior CABG are warranted.
Future Perspectives
Toma et al. (58) reported all-cause mortality (11 vs. 32%; p = 0.005) and MACE (31 vs. 50% p = 0.01) were significantly reduced in those prior CABG patients with procedural success compared with failed procedure. Due to a higher baseline risk of patients with previous CABG, this afforded a substantially higher absolute reduction in mortality and MACE in patients with previous CABG as compared to that in the non-CABG group. This was consistent with the findings of Iglesias and his colleagues (85, 86), who found that higher-risk patients were highly likely to benefit from the “treatment-risk paradox”, which is a common procedure in PCI. Since patients with prior CABG represent a significant proportion (37%) of those undergoing CTO PCI (87, 88), these findings indicate that this procedure has more clinical benefits in patients with prior compared to those in the non-CABG group. Indeed, those patients with prior CABG are older, with many comorbidities, extensive and complex coronary lesions, and they are more likely to present concurrent cardiovascular risk factors. However, application of the technique and equipment, such as dedicated guidewires, microcatheters and the hybrid approach (especially retrograde approach via SVGs), guarantees high success rates (88–90%) of CTO PCI in patients with prior CABG, and this is accompanied by acceptably low complications rates (39, 58). Overall, this gives us more confidence to apply CTO PCI in these high-risk population, especially in cases where graft intervention or repeat CABG result in unsatisfactory outcomes.
In present era of high success and acceptable complication rates, patient selection for CTO PCI should be focused on those expected to benefit from the procedure, instead of concerns about perceived increased procedural complexity and procedural failure by virtue of prior CABG surgery. Given the higher complexity of CTO PCIs in patients with prior exposure to CABG, these procedures should ideally be performed at experienced centers, by seasoned CTO operators who can promptly treat complications should they arise. Considering the safety and efficacy of these procedures, experienced operators as well as high-volume CTO-PCI centers should focus on high-risk patients. Since approximately half of all patients with prior exposure to CABG have CTO and the patients with SVGs often develop recurrent symptoms, coupled with the high necessity to revascularize CTO patients with prior CABG, we anticipate that this patient population will gain remarkable benefits from this intervention.
Conclusion
Accordingly, approximately half of all patients with prior exposure to CABG have CTO, and these CTO patients with prior CABG often develop recurrent symptoms and events. Though these patients are with more comorbidities and complex coronary lesions, with the latest refinements equipment and techniques, high success and acceptable complication rates and good prognosis after intervention can be achieved in these patients. CTO PCI in patients with prior CABG is safe and effective when performed in specialized heart teams and by dedicated and experienced CTO operators, and may be actively considered as a treatment option for these high-risk population to achieve complete myocardial revascularization. There is a need for a well-designed and adequately powered sham-controlled, randomized clinical trial to definitively answer the question of the management of CTO patients with prior CABG.
Author Contributions
LG prepared the manuscript. All authors edited the draft manuscript, and approved the final manuscript.
Funding
This work was supported by the Natural Science Foundation of Liaoning Province (No. 2020-MS-250).
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's Note
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References
1. Fefer P, Knudtson ML, Cheema AN, Galbraith PD, Osherov AB, Yalonetsky S, et al. Current perspectives on coronary chronic total occlusions: the Canadian Multicenter Chronic Total Occlusions registry. J Am Coll Cardiol. (2012) 59:991–7. doi: 10.1016/j.jacc.2011.12.007
2. Christofferson RD, Lehmann KG, Martin GV, Every N, Caldwell JH, Kapadia SR. Effect of chronic total coronary occlusion on treatment strategy. J Am Coll Cardiol. (2005) 95:1088–91. doi: 10.1016/j.amjcard.2004.12.065
3. Guo L, Wu J, Zhong L, Ding H, Xu J, Zhou X, et al. Two-year clinical outcomes of medical therapy vs. revascularization for patients with coronary chronic total occlusion Hellenic. J Cardiol. (2019) 61:264–71. doi: 10.1016/j.hjc.2019.03.006
4. Werner GS, Glaser P, Coenen A, Moehlis H, Tischer KH, Koch M, et al. Reduction of radiation exposure during complex interventions for chronic total coronary occlusions: implementing low dose radiation protocols without affecting procedural success rates. Catheter Cardiovasc Interv. (2017) 89:1005–12. doi: 10.1002/ccd.26886
5. Mehran R, Claessen BE, Godino C, Dangas GD, Obunai K. Long-term outcome of percutaneous coronary intervention for chronic total occlusions. JACC Cardiovasc Interv. (2011) 4:952–61. doi: 10.1016/j.jcin.2011.03.021
6. Guo L, Zhong L, Chen K, Wu J, Huang RC. Long-term clinical outcomes of optimal medical therapy vs. successful percutaneous coronary intervention for patients with coronary chronic total occlusions. Hellenic J Cardiol. (2018) 59:281–7. doi: 10.1016/j.hjc.2018.03.005
7. Sirnes PA, Myreng Y, Mølstad P, Bonarjee V, Golf S. Improvement in left ventricular ejection fraction and wall motion after successful recanalization of chronic coronary occlusions. Eur Heart J. (1998) 19:273–81. doi: 10.1053/euhj.1997.0617
8. Guo L, Meng S, Lv H, Zhong L, Wu J, Ding H, et al. Long-term outcomes of successful recanalization compared with optimal medical therapy for coronary chronic total occlusions in patients with and without left ventricular systolic dysfunction. Front Cardiovasc Med. (2021) 8:654730. doi: 10.3389/fcvm.2021.654730
9. Wijeysundera HC, Norris C, Fefer P, Galbraith PD, Knudtson ML, Wolff R, et al. Relationship between initial treatment strategy and quality of life in patients with coronary chronic total occlusions. EuroIntervention. (2014) 9:1165–72. doi: 10.4244/EIJV9I10A197
10. Guo L, Lv H, Zhong L, Wu J, Ding H, Xu J, et al. Gender differences in long-term outcomes of medical therapy and successful percutaneous coronary intervention for coronary chronic total occlusions. J Interv Cardiol. (2019) 24:484–8. doi: 10.1155/2019/2017958
11. Brilakis ES, Banerjee S, Karmpaliotis D, Lombardi WL, Tsai TT, Shunk KA, et al. Procedural outcomes of chronic total occlusion percutaneous coronary intervention: a report from the NCDR (National CardiovascularData Registry). JACC Cardiovasc Interv. (2015) 8:245–53. doi: 10.1016/j.jcin.2014.08.014
12. Maeremans J, Walsh S, Knaapen P, Spratt JC, Avran A, Hanratty CG, et al. The hybrid algorithm for treating chronic total occlusions in europe: the RECHARGE registry. J Am Coll Cardiol. (2016) 68:1958–70. doi: 10.1016/j.jacc.2016.08.034
13. Tajti P, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, et al. The hybrid approach to chronic total occlusion percutaneous coronary intervention: update from the PROGRESS CTO registry. JACC Cardiovasc Interv. (2018) 11:1325–35. doi: 10.1016/j.jcin.2018.02.036
14. Guo L, Lv H, Zhong L, Wu J, Ding H, Xu J, et al. Comparison of long-term outcomes of medical therapy and successful recanalisation for coronary chronic total occlusions in elderly patients: a report of 1,294 patients. Cardiovasc Diagn Ther. (2019) 9:586–95. doi: 10.21037/cdt.2019.11.01
15. Head SJ, Milojevic M, Daemen J, Ahn JM, Boersma E, Christiansen EH, et al. Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data. Lancet. (2018) 391:939–48. doi: 10.1016/S0140-6736(18)30423-9
16. Mäkikallio T, Holm NR, Lindsay M, Spence MS, Erglis A, Menown IB, et al. Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial. Lancet. (2016) 388:2743–52. doi: 10.1016/S0140-6736(16)32052-9
17. Lee MS, Park SJ, Kandzari DE, Kirtane AJ, Fearon WF, Brilakis ES, et al. Saphenous vein graft intervention. JACC Cardiovasc Interv. (2011) 4:831–43. doi: 10.1016/j.jcin.2011.05.014
18. Yoon SH, Kim YH, Yang DH, Roh JH, Lee EY, Lee PH, et al. Risk of new native-vessel occlusion after coronary artery bypass grafting. Am J Cardiol. (2017) 119:7–13. doi: 10.1016/j.amjcard.2016.09.011
19. Fitzgibbon GM, Kafka HP, Leach AJ, Keon WJ, Hooper GD, Burton JR. Coronary bypass graft fate and patient outcome: angiographic follow-up of 5,065 grafts related to survival and reoperation in 1,388 patients during 25 years. J Am Coll Cardiol. (1996) 28:616–26. doi: 10.1016/0735-1097(96)00206-9
20. Widimsky P, Straka Z, Stros P, Jirasek K, Dvorak J, Votava J, et al. One-year coronary bypass graft patency: a randomized comparison between off-pump and on-pump surgery angiographic results of the PRAGUE-4 trial. Circulation. (2004) 110:3418–23. doi: 10.1161/01.CIR.0000148139.79580.36
21. Tatoulis J, Buxton BF, Fuller JA. Patencies of 2127 arterial to coronary conduits over 15 years. Ann Thorac Surg. (2004) 77:93–101. doi: 10.1016/S0003-4975(03)01331-6
22. Xenogiannis I, Tajti P, Hall AB, Alaswad K, Rinfret S, Nicholson W, et al. Update on cardiac catheterization in patients with prior coronary artery bypass graft surgery. JACC Cardiovasc Interv. (2019) 12:1635–49. doi: 10.1016/j.jcin.2019.04.051
23. Motwani JG, Topol EJ. Aortocoronary saphenous vein graft disease: pathogenesis, predisposition, and prevention. Circulation. (1998) 97:916–31. doi: 10.1161/01.CIR.97.9.916
24. Ribichini F, Pugno F, Ferrero V, Wijns W, Vacca G, Vassanelli C, et al. Long-term histological and immunohistochemical findings in human venous aorto-coronary bypass grafts. Clin Sci (Lond). (2008) 114:211–20. doi: 10.1042/CS20070243
25. Zwolak RM, Adams MC, Clowes AW. Kinetics of vein graft hyperplasia: association with tangential stress. J Vasc Surg. (1987) 5:126–36. doi: 10.1067/mva.1987.avs0050126
26. Brilakis ES, O'Donnell CI, Penny W, Armstrong EJ, Tsai T, Maddox TM, et al. Percutaneous coronary intervention in native coronary arteries versus bypass grafts in patients with prior coronary artery bypass graft surgery: insights from the veterans affairs clinical assessment, reporting, and tracking program. JACC Cardiovasc Interv. (2016) 9:884–93. doi: 10.1016/S0735-1097(16)30177-2
27. Brilakis ES, Rao SV, Banerjee S, Goldman S, Shunk KA, Holmes DR, et al. Percutaneous coronary intervention in native arteries versus bypass grafts in prior coronary artery bypass grafting patients: a report from the National Cardiovascular Data Registry. JACC Cardiovasc Interv. (2011) 4:844–50. doi: 10.1016/j.jcin.2011.03.018
28. Lee KW, Norell MS. Management of 'no-reflow' complicating reperfusion therapy. Acute Card Care. (2008) 10:5–14. doi: 10.1080/17482940701744318
29. Leborgne L, Cheneau E, Pichard A, Ajani A, Pakala R, Yazdi H, et al. Effect of direct stenting on clinical outcome in patients treated with percutaneous coronary intervention on saphenous vein graft. Am Heart J. (2003) 146:501–6. doi: 10.1016/S0002-8703(03)00309-0
30. Hong YJ, Pichard AD, Mintz GS, Kim SW, Lee SY, Kim SY, et al. Outcome of undersized drug-eluting stents for percutaneous coronary intervention of saphenous vein graft lesions. Am J Cardiol. (2010) 105:179–85. doi: 10.1016/j.amjcard.2009.09.006
31. Kheiri B, Osman M, Abdalla A, Ahmed S, Bachuwa G, Hassan M. The short- and long-term outcomes of percutaneous intervention with drug-eluting stent vs bare-metal stent in saphenous vein graft disease: an updated meta-analysis of all randomized clinical trials. Clin Cardiol. (2018) 41:685–92. doi: 10.1002/clc.22908
32. Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, et al. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. J Am Coll Cardiol. (2011) 58:e44–122. doi: 10.1016/j.jacc.2011.08.007
33. Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J. (2019) 40:87–165. doi: 10.1093/eurheartj/ehy855
34. Yap CH, Sposato L, Akowuah E, Theodore S, Dinh DT, Shardey GC, et al. Contemporary results show repeat coronary artery bypass grafting remains a risk factor for operative mortality. Ann Thorac Surg. (2009) 87:1386–91. doi: 10.1016/j.athoracsur.2009.02.006
35. Scarsini R, Zivelonghi C, Pesarini G, Vassanelli C, Ribichini FL. Repeat revascularization: Percutaneous coronary intervention after coronary artery bypass graft surgery. Cardiovasc Revasc Med. (2016) 17:272–8. doi: 10.1016/j.carrev.2016.04.007
36. Jones DA, Weerackody R, Rathod K, Behar J, Gallagher S, Knight CJ, et al. Successful recanalization of chronic total occlusions is associated with improved long-term survival. JACC Cardiovasc Interv. (2012) 5:380–8. doi: 10.1016/j.jcin.2012.01.012
37. Budassi S, Zivelonghi C, Dens J, Bagnall AJ, Knaapen P, Avran A, et al. Impact of prior coronary artery bypass grafting in patients undergoing chronic total occlusion-percutaneous coronary intervention: Procedural and clinical outcomes from the REgistry of Crossboss and Hybrid procedures in FrAnce, the NetheRlands, BelGium, and UnitEd Kingdom (RECHARGE). Catheter Cardiovasc Interv. (2020) 97:E51–60. doi: 10.1002/ccd.28954
38. Michael TT, Karmpaliotis D, Brilakis ES, Abdullah SM, Kirkland BL, Mishoe KL, et al. Impact of prior coronary artery bypass graft surgery on chronic total occlusion revascularisation: insights from a multicentre US registry. Heart. (2013) 99:1515–8. doi: 10.1136/heartjnl-2013-303763
39. Christopoulos G, Menon RV, Karmpaliotis D, Alaswad K, Lombardi W, Grantham JA, et al. Application of the “hybrid approach” to chronic total occlusions in patients with previous coronary artery bypass graft surgery (from a Contemporary Multicenter US registry). Am J Cardiol. (2014) 113:1990–4. doi: 10.1016/j.amjcard.2014.03.039
40. Azzalini L, Ojeda S, Karatasakis A, Maeremans J, Tanabe M, La Manna A, et al. Long-term outcomes of percutaneous coronary intervention for chronic total occlusion in patients who have undergone coronary artery bypass grafting vs those who have not. Can J Cardiol. (2018) 34:310–8. doi: 10.1016/j.cjca.2017.12.016
41. Nikolakopoulos I, Choi JW, Khatri JJ, Alaswad K, Doing AH, Dattilo P, et al. Follow-up outcomes after chronic total occlusion percutaneous coronary intervention in patients with and without prior coronary artery bypass graft surgery: insights from the PROGRESS-CTO registry. J Invasive Cardiol. (2020) 32:315–20. doi: 10.1016/S0735-1097(20)31926-4
42. Galassi AR, Boukhris M, Azzarelli S, Castaing M, Marzà F, Tomasello SD. Percutaneous coronary revascularization for chronic total occlusions: a novel predictive score of technical failure using advanced technologies. JACC Cardiovasc Interv. (2016) 9:911–22. doi: 10.1016/j.jcin.2016.01.036
43. Karthikeyan G. Why is disease progression more rapid in the proximal segments of grafted coronary arteries? Int J Cardiol. (2008) 125:431–2. doi: 10.1016/j.ijcard.2007.01.067
44. Sabik JF. 3rd, Blackstone EH, Houghtaling PL, Walts PA, Lytle BW. Is reoperation still a risk factor in coronary artery bypass surgery? Ann Thorac Surg. (2005) 80:1719–27. doi: 10.1016/j.athoracsur.2005.04.033
45. Sakakura K, Nakano M, Otsuka F, Yahagi K, Kutys R, Ladich E, et al. Comparison of pathology of chronic total occlusion with and without coronary artery bypass graft. Eur Heart J. (2014) 35:1683–93. doi: 10.1093/eurheartj/eht422
46. Batchelor WB, Anstrom KJ, Muhlbaier LH, Grosswald R, Weintraub WS, O'Neill WW, et al. Contemporary outcome trends in the elderly undergoing percutaneous coronary interventions: results in 7,472 octogenarians. J Am Coll Cardiol. (2000) 36:723–30. doi: 10.1016/S0735-1097(00)00777-4
47. Zheng Z, Cheng ZC, Wang SP, Li SY, Wang J, Peng HY, et al. Predictors for new native-vessel occlusion in patients with prior coronary bypass surgery: a single-center retrospective research. Cardiol Res Pract. (2019) 2019:6857232. doi: 10.1155/2019/6857232
48. Newman AB, Naydeck BL, Sutton-Tyrrell K, Feldman A, Edmundowicz D, Kuller LH. Coronary artery calcification in older adults to age 99: prevalence and risk factors. Circulation. (2001) 104:2679–84. doi: 10.1161/hc4601.099464
49. Azzalini L, Poletti E, Ayoub M, Ojeda S, Zivelonghi C, La Manna A, et al. Coronary artery perforation during chronic total occlusion percutaneous coronary intervention: epidemiology, mechanisms, management, and outcomes. EuroIntervention. (2019). doi: 10.4244/EIJ-D-19-00282
50. Tajti P, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, et al. In-hospital outcomes of chronic total occlusion percutaneous coronary interventions in patients with prior coronary artery bypass graft surgery. Circ Cardiovasc Interv. (2019) 12:e007338. doi: 10.1161/CIRCINTERVENTIONS.118.007338
51. Megaly M, Abraham B, Pershad A, Rinfret S, Alaswad K, Garcia S, et al. Outcomes of chronic total occlusion percutaneous coronary intervention in patients with prior bypass surgery. JACC Cardiovasc Interv. (2020) 13:900–2. doi: 10.1016/j.jcin.2019.11.033
52. Xenogiannis I, Gkargkoulas F, Karmpaliotis D, Krestyaninov O, Khelimskii D, Jaffer FA, et al. Retrograde chronic total occlusion percutaneous coronary intervention via saphenous vein graft. JACC Cardiovasc Interv. (2020) 13:517–26. doi: 10.1016/j.jcin.2019.10.028
53. Dautov R, Manh Nguyen C, Altisent O, Gibrat C, Rinfret S. Recanalization of chronic total occlusions in patients with previous coronary bypass surgery and consideration of retrograde access via saphenous vein grafts. Circ Cardiovasc Interv. (2016) 9. doi: 10.1161/CIRCINTERVENTIONS.115.003515
54. Michael TT, Banerjee S, Brilakis ES. Role of internal mammary artery bypass grafts in retrograde chronic total occlusion interventions. J Invasive Cardiol. (2012) 24:359–62.
55. Teramoto T, Tsuchikane E, Matsuo H, Suzuki Y, Ito T, Ito T, et al. Initial success rate of percutaneous coronary intervention for chronic total occlusion in a native coronary artery is decreased in patients who underwent previous coronary artery bypass graft surgery. JACC Cardiovasc Interv. (2014) 7:39–46. doi: 10.1016/j.jcin.2013.08.012
56. Teramoto T, Ito T, Tsuchikane E, Kinoshita Y, Kimura M, Nasu K, et al. Prior coronary artery bypass grafting diminish the initial success rate of percutaneous coronary intervention to the chronic total occlusion in the native coronary artery. J Am Coll Cardiol. (2012) 59. doi: 10.1016/S0735-1097(12)60105-3
57. Galassi AR, Tomasello SD, Reifart N, Werner GS, Sianos G. In-hospital outcomes of percutaneous coronary intervention in patients with chronic total occlusion: insights from the ERCTO (European Registry of Chronic Total Occlusion) registry. EuroIntervention. (2011) 7:472–9. doi: 10.4244/EIJV7I4A77
58. Toma A, Stahli BE, Gick M, Colmsee H, Gebhard C, Mashayekhi K, et al. Long-term follow-up of patients with previous coronary artery bypass grafting undergoing percutaneous coronary intervention for chronic total occlusion. Am J Cardiol. (2016) 118:1641–6. doi: 10.1016/j.amjcard.2016.08.038
59. Shoaib A, Mohamed M, Curzen N, Ludman P, Zaman A, Rashid M, et al. Clinical outcomes of percutaneous coronary intervention for chronic total occlusion in prior coronary artery bypass grafting patients. Catheter Cardiovasc Interv. (2021) 99:7–484. doi: 10.1002/ccd.29691
60. Guo L, Zhang S, Wu J, Zhong L, Ding H, Xu J, et al. Successful recanalisation of coronary chronic total occlusions is not associated with improved cardiovascular survival compared with initial medical therapy. Scand Cardiovasc J. (2019) 53:305–11. doi: 10.1080/14017431.2019.1645351
61. Harding SA, Wu EB, Lo S, Lim ST, Ge L, Chen JY, et al. A new algorithm for crossing chronic total occlusions from the asia pacific chronic total occlusion club. JACC Cardiovasc Interv. (2017) 10:2135–43. doi: 10.1016/j.jcin.2017.06.071
62. Guo L, Lv H, Huang R. Percutaneous coronary intervention in elderly patients with coronary chronic total occlusions: current evidence and future perspectives. Clin Interv Aging. (2020) 15:771–81. doi: 10.2147/CIA.S252318
63. Ali ZA, Karimi Galougahi K, Nazif T, Maehara A, Hardy MA, Cohen DJ, et al. Imaging- and physiology-guided percutaneous coronary intervention without contrast administration in advanced renal failure: a feasibility, safety, and outcome study. Eur Heart J. (2016) 37:3090–5. doi: 10.1093/eurheartj/ehw078
64. Michael TT, Karmpaliotis D, Brilakis ES, Alomar M, Abdullah SM, Kirkland BL, et al. Temporal trends of fluoroscopy time and contrast utilization in coronary chronic total occlusion revascularization: insights from a multicenter United States registry. Catheter Cardiovasc Interv. (2015) 85:393–9. doi: 10.1002/ccd.25359
65. Guo L, Ding H, Lv H, Zhang X, Zhong L, Wu J, et al. Impact of renal function on long-term clinical outcomes in patients with coronary chronic total occlusions: results from an observational single-center cohort study during the last 12 years. Front Cardiovasc Med. (2020) 7:550428. doi: 10.3389/fcvm.2020.550428
66. Tajti P, Xenogiannis I, Karmpaliotis D, Alaswad K, Jaffer FA, Nicholas Burke M, et al. Chronic total occlusion interventions: update on current tips and tricks. Curr Cardiol Rep. (2018) 20:141. doi: 10.1007/s11886-018-1083-7
67. Kinnaird T, Anderson R, Ossei-Gerning N, Cockburn J, Sirker A, Ludman P, et al. Coronary perforation complicating percutaneous coronary intervention in patients with a history of coronary artery bypass surgery: an analysis of 309 perforation cases from the british cardiovascular intervention society database. Circ Cardiovasc Interv. (2017) 10. doi: 10.1161/CIRCINTERVENTIONS.117.005581
68. Cheney A, Kearney KE, Lombardi W. Sex-based differences in chronic total occlusion management. Curr Atheroscler Rep. (2018) 20:60. doi: 10.1007/s11883-018-0760-8
69. Brilakis ES, Mashayekhi K, Tsuchikane E, Abi Rafeh N, Alaswad K, Araya M, et al. Guiding principles for chronic total occlusion percutaneous coronary intervention. Circulation. (2019) 140:420–33. doi: 10.1161/circulationaha.119.039797
70. Marmagkiolis K, Brilakis ES, Hakeem A, Cilingiroglu M, Bilodeau L. Saphenous vein graft perforation during percutaneous coronary intervention: a case series. J Invasive Cardiol. (2013) 25:157–61.
71. Sapontis J, Salisbury AC, Yeh RW, Cohen DJ, Hirai T, Lombardi W, et al. Early procedural and health status outcomes after chronic total occlusion angioplasty: a report from the OPEN-CTO registry (outcomes, patient health status, and efficiency in chronic total occlusion hybrid procedures). JACC Cardiovasc Interv. (2017) 10:1523–34. doi: 10.1016/j.jcin.2017.05.065
72. Wilson WM, Spratt JC, Lombardi WL. Cardiovascular collapse post chronic total occlusion percutaneous coronary intervention due to a compressive left atrial hematoma managed with percutaneous drainage. Catheter Cardiovasc Interv. (2015) 86:407–11. doi: 10.1002/ccd.25571
73. Liu MJ, Chen CF, Gao XF, Liu XH, Xu YZ. In-hospital outcomes of chronic total occlusion percutaneous coronary intervention in patients with and without prior coronary artery bypass graft: a protocol for systematic review and meta analysis. Medicine. (2020) 99:e19977. doi: 10.1097/MD.0000000000019977
74. Rathod KS, Beirne AM, Bogle R, Firoozi S, Lim P, Hill J, et al. Prior coronary artery bypass graft surgery and outcome after percutaneous coronary intervention: an observational study from the pan-london percutaneous coronary intervention registry. J Am Heart Assoc. (2020) 9:e014409. doi: 10.1161/JAHA.119.014409
75. Cardoso R, Knijnik L, Whelton SP, Rivera M, Gluckman TJ, Metkus TS, et al. Dual versus single antiplatelet therapy after coronary artery bypass graft surgery: an updated meta-analysis. Int J Cardiol. (2018) 269:80–8. doi: 10.1016/j.ijcard.2018.07.083
76. Galassi AR, Boukhris M, Tomasello SD, Marza F, Azzarelli S, Giubilato S, et al. Long-term clinical and angiographic outcomes of the mini-STAR technique as a bailout strategy for percutaneous coronary intervention of chronic total occlusion. Can J Cardiol. (2014) 30:1400–6. doi: 10.1016/j.cjca.2014.07.016
77. Safley DM, Koshy S, Grantham JA, Bybee KA, House JA, Kennedy KF, et al. Changes in myocardial ischemic burden following percutaneous coronary intervention of chronic total occlusions. Catheter Cardiovasc Interv. (2011) 78:337–43. doi: 10.1002/ccd.23002
78. Tomasello SD, Boukhris M, Giubilato S, Marza F, Garbo R, Contegiacomo G, et al. Management strategies in patients affected by chronic total occlusions: results from the Italian Registry of Chronic Total Occlusions. Eur Heart J. (2015) 36:3189–98. doi: 10.1093/eurheartj/ehv450
79. Patel MR, Dehmer GJ, Hirshfeld JW, Smith PK, Spertus JA. ACCF/SCAI/STS/AATS/AHA/ASNC/HFSA/SCCT 2012 Appropriate use criteria for coronary revascularization focused update: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, American Association for Thoracic Surgery, American Heart Association, American Society of Nuclear Cardiology, and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol. (2012) 59:857–81. doi: 10.1016/j.jacc.2011.12.001
80. Authors/Task Force m, Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, et al. 2014 ESC/EACTS guidelines on myocardial revascularization: the task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. (2014) 35:2541–619. doi: 10.1093/eurheartj/ehu278
81. George S, Cockburn J, Clayton TC, Ludman P, Cotton J, Spratt J, et al. Long-term follow-up of elective chronic total coronary occlusion angioplasty: analysis from the UK Central Cardiac Audit Database. J Am Coll Cardiol. (2014) 64:235–43. doi: 10.1016/j.jacc.2014.04.040
82. Hoebers LP, Claessen BE, Elias J, Dangas GD, Mehran R, Henriques JP. Meta-analysis on the impact of percutaneous coronary intervention of chronic total occlusions on left ventricular function and clinical outcome. Int J Cardiol. (2015) 187:90–6. doi: 10.1016/j.ijcard.2015.03.164
83. Werner GS, Martin-Yuste V, Hildick-Smith D, Boudou N, Sianos G, Gelev V, et al. A randomized multicentre trial to compare revascularization with optimal medical therapy for the treatment of chronic total coronary occlusions. Eur Heart J. (2018) 39:2484–93. doi: 10.1093/eurheartj/ehy220
84. Lee SW, Lee PH, Ahn JM, Park DW, Yun SC, Han S, et al. Randomized trial evaluating percutaneous coronary intervention for the treatment of chronic total occlusion. Circulation. (2019) 139:1674–83. doi: 10.1161/CIRCULATIONAHA.118.031313
85. Guo L, Wang J, Ding H, Meng S, Zhang X, Lv H, et al. Long-term outcomes of medical therapy versus successful recanalisation for coronary chronic total occlusions in patients with and without type 2 diabetes mellitus. Cardiovasc Diabetol. (2020) 19:100. doi: 10.1186/s12933-020-01087-4
86. Iglesias JF, Degrauwe S, Rigamonti F, Noble S, Roffi M. Percutaneous coronary intervention of chronic total occlusions in patients with diabetes mellitus: a treatment-risk paradox. Curr Cardiol Rep. (2019) 21:9. doi: 10.1007/s11886-019-1091-2
87. Yang L, Guo L, Lv H, Liu X, Zhong L, Ding H, et al. Predictors of adverse events among chronic total occlusion patients undergoing successful percutaneous coronary intervention and medical therapy. Clin Interv Aging. (2021) 16:1847–55. doi: 10.2147/CIA.S337069
Keywords: coronary chronic total occlusions, percutaneous coronary intervention, prior coronary artery bypass graft, characteristics, success rates, complications, outcomes
Citation: Guo L, Lv H and Yin X (2022) Chronic Total Occlusion Percutaneous Coronary Intervention in Patients With Prior Coronary Artery Bypass Graft: Current Evidence and Future Perspectives. Front. Cardiovasc. Med. 9:753250. doi: 10.3389/fcvm.2022.753250
Received: 04 August 2021; Accepted: 21 March 2022;
Published: 11 April 2022.
Edited by:
Diego Arroyo, Fribourg Cantonal Hospital, SwitzerlandReviewed by:
Andrew Ladwiniec, University of Leicester, United KingdomSerban Puricel, Fribourg Cantonal Hospital, Switzerland
Copyright © 2022 Guo, Lv and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Xiaomeng Yin, dr.yinxm@163.com