Editorial: Unveiling the hidden arsenal: exploring secondary metabolites and fungal development in pathogenic fungi

Editorial on the Research Topic
Unveiling the hidden arsenal: exploring secondary metabolites and fungal development in pathogenic fungi

Pathogenic fungi pose a significant threat to global health and agriculture, contributing to a wide range of infections in both humans and plants. These organisms produce an array of secondary metabolites, which, while not essential for primary growth, play crucial roles in their adaptability, virulence, and interactions with host environments (Yang et al., 2022; Guo et al., 2023). The exploration of these metabolites has uncovered their diverse bioactivities, ranging from antimicrobial and immunosuppressive properties to their involvement in fungal morphogenesis and toxin production (Lara Da Costa et al., 2022). Understanding the biosynthesis, regulation, and functional roles of secondary metabolites in pathogenic fungi is essential for developing novel antifungal strategies and mitigating fungal diseases.

This Research Topic compiles cutting-edge studies that delve into the complex interplay between secondary metabolite biosynthesis, fungal development, and pathogenicity. The contributing articles offer a comprehensive examination of the molecular mechanisms governing secondary metabolite production, their influence on fungal virulence, and their interactions with host immune responses. Additionally, several contributions explore innovative methodologies for characterizing these metabolites and evaluating their potential as targets for antifungal therapies.

In this Research Topic, we highlight four pivotal studies addressing critical aspects in the field:

Jin et al., led by Prof. Jing Si from the Institute of Microbiology, Beijing Forestry University, renowned for advancing fungal genome annotation and natural product discovery, presented a high-quality genome assembly and annotation of Sanghuangporus weigelae. This medicinal fungus is traditionally used in East Asian pharmacopeia for its anti-inflammatory properties. By integrating multi-omics approaches, this study identified key metabolic pathways involved in the biosynthesis of bioactive compounds, such as terpenoids and polysaccharides, offering valuable insights into the medicinal applications of fungal secondary metabolites.

Zhao et al., from Institute of Quality Standard and Monitoring Technology for Agro-product (Guangdong Academy of Agricultural Sciences), specializing in mycotoxin risk assessment in food systems, revealed novel regulatory mechanisms of aflatoxin biosynthesis in Aspergillus flavus. Their work demonstrated that acetohydroxy acid synthase (AHAS) and dihydroxy acid dehydratase, key enzymes in branched-chain amino acid metabolism, directly modulated fungal growth, mycotoxin production, and pathogenicity. These findings provide actionable targets for disrupting toxigenic fungi in agricultural storage.

Ali et al., from Harbin Medical University, whose research focuses on clinical mycology and antifungal resistance epidemiology, featured research on the antifungal susceptibility of Candida species isolated from pregnant women in Yemen, shedding light on the increasing prevalence of Candida infections and the urgent need for effective antifungal treatments in resource-limited settings. The study underscores the growing concern of antifungal resistance and highlights the necessity for tailored therapeutic approaches.

Satterlee et al., from United States Department of Agriculture Toxicology and Mycotoxin Research Unit, pioneers in fungal chemical ecology, examined the chemical interactions between A. flavus and Fusarium verticillioides, two major maize pathogens. The findings reveal the competitive dynamics mediated by mycotoxins such as aflatoxin and fumonisin, offering new perspectives on fungal ecological interactions and potential strategies for controlling mycotoxin contamination in crops.

Collectively, these studies illuminate the dual nature of fungal secondary metabolites—as drivers of pathogenicity and reservoirs of therapeutic potential. They underscore the importance of integrating genomic, ecological, and clinical perspectives to combat fungal threats. As antimicrobial resistance escalates and climate change alters fungal biogeography, such interdisciplinary approaches will be pivotal in safeguarding global health and food security.

We hope that this Research Topic will catalyze innovation in antifungal discovery and inspire collaborative efforts to unravel the hidden complexities of fungal biology.

Author contributions

KY: Writing – original draft, Writing – review & editing. GD: Writing – original draft, Writing – review & editing.

Funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was supported by National Key R&D Program of China (2024YFF1105503), and CAMS Innovation Fund for Medical Sciences (CIFMS) (2023-I2M-2-006).

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Generative AI statement

The author(s) declare that no Generative AI was used in the creation of this manuscript.

Publisher’s note

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References

Guo, Q., Shi, L., Wang, X., Li, D., Yin, Z., Zhang, J., et al. (2023). Structures and biological activities of secondary metabolites from the trichoderma genus (Covering 2018-2022). J. Agric. Food Chem. 71, 13612–13632. doi: 10.1021/acs.jafc.3c04540

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Lara Da Costa, G., Escórcio Ferreira, I., Corrêa-Moreira, D., Marinho, A., Benedito De Almeida, A., Antônio Pereira, S., et al. (2022). Soil samples from sporotrichosis transmission belt area: Searching for fungal species and their antagonistic activity against Sporothrix brasiliensis. Front. Cell Infect. Microbiol. 12. doi: 10.3389/fcimb.2022.1033969

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Yang, K., Tian, J., Keller, N. P. (2022). Post-translational modifications drive secondary metabolite biosynthesis in Aspergillus: a review. Environ. Microbiol. 24, 2857–2881. doi: 10.1111/1462-2920.16034

PubMed Abstract | Crossref Full Text | Google Scholar