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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Biofilms
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1546816
This article is part of the Research Topic Novel Strategies for Caries Control View all articles

The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries

Provisionally accepted
Han Du Han Du 1,2,3,4Zheng Wang Zheng Wang 1,2,3,4Shenglan Long Shenglan Long 1,2,3,4Yiding Li Yiding Li 1,2,3,4Deqin Yang Deqin Yang 1,2,3,4*
  • 1 Department of Endodontics, Stomatological Hospital of Chongqing Medical University, chongqing, China
  • 2 Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Stomatological Hospital of Chongqing Medical University, Chongqing, China
  • 3 Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 404100, China, chongqing, China
  • 4 Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, 426 Songshi North Road, Yubei District, Chongqing 401147, China, chongqing, China

The final, formatted version of the article will be published soon.

    Abstract：The dental caries remains a globally prevalent disease. Although its incidence has decrease due to enhancements in sanitation policies and public health measures, the treatment and prevention of dental caries still pose significant challenges. Within the oral cavity, traditional drug delivery systems suffer from limitation such as inadequate tissue penetration, short duration of action at target site, and low specificity, which minimally affect the prevention and treatment of dental caries. Consequently, nanosystem for drug delivery, offering enhanced drug stability, solubility, and bio-availability while reducing side effects, garnering attention increasing attention in the fight against dental caries. Therefore, this review examines the role of nanosystems for drug delivery in combating dental caries by inhibiting bacteria survival, biofilm formation, demineralization, and promoting remineralization, and exploring their potential to become the mainstream means of prevention and treatment of dental caries in future.

    Keywords: Dental Caries, Biofilm, nanosystems for drug delivery, remineralization, Antibacterial Agents

    Received: 17 Dec 2024; Accepted: 14 Jan 2025.

    Copyright: © 2025 Du, Wang, Long, Li and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Deqin Yang, Department of Endodontics, Stomatological Hospital of Chongqing Medical University, chongqing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.