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BRIEF RESEARCH REPORT article

Front. Cell. Infect. Microbiol.
Sec. Molecular Viral Pathogenesis
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1489936
This article is part of the Research Topic Pathogenesis, Diagnosis, and Treatments of SARS-CoV-2 Co-infection with Influenza Viruses or Other Respiratory Pathogens View all 9 articles

Dynamics of coagulation proteins upon ICU admission and after one year of recovery from COVID-19: a preliminary study

Provisionally accepted
Raquel Behar-Lagares Raquel Behar-Lagares 1Ana Virseda-Berdices Ana Virseda-Berdices 1,2Óscar Martínez- González Óscar Martínez- González 3,4*Rafael Blancas Rafael Blancas 3,4Marcela Homez-Guzmán Marcela Homez-Guzmán 5Eva Manteiga Eva Manteiga 5Juan Churruca-Sarasqueta Juan Churruca-Sarasqueta 6Madian Manso- Álvarez Madian Manso- Álvarez 3Ángela Algaba Ángela Algaba 3Salvador Resino Salvador Resino 1,7Amanda Fernández-Rodríguez Amanda Fernández-Rodríguez 1*María Angeles Jiménez-Sousa María Angeles Jiménez-Sousa 1,7
  • 1 Instituto de Salud Carlos III, Centro Nacional de Microbiología, Majadahonda, Spain
  • 2 2Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
  • 3 Critical Care Department, Hospital Universitario del Tajo, Aranjuez, Spain
  • 4 Alfonso X el Sabio University, Villanueva de la Cañada, Madrid, Spain
  • 5 Critical Care Department, Hospital Universitario Infanta Cristina, Parla, Spain
  • 6 Haematology and Haemostasis Department, University Hospital Infanta Leonor, Madrid, Spain
  • 7 Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain

The final, formatted version of the article will be published soon.

    Objetives: This study aimed to investigate the association of baseline coagulation proteins with hospitalization variables in COVID-19 patients admitted to ICU, as well as coagulation system changes after one-year post-discharge, taking into account gender-specific bias in the coagulation profile.We conducted a prospective longitudinal study on 49 ICU-admitted COVID-19 patients. Proteins were measured using a Luminex 200™. The association between coagulation protein levels and hospitalization variables was carried out by generalized linear models adjusted by the most relevant covariates.Results: At ICU admission, lower factor XII, antithrombin, and protein C levels were linked to the need for invasive mechanical ventilation (IMV) or its duration (p=0.028; p=0.047 and p=0.015, respectively). Likewise, lower factor XII, antithrombin, and prothrombin levels were associated with longer ICU length of stay (ICU LOS) (p=0.045; p=0.022; p=0.036, respectively). From baseline to the end of the follow-up, factor XII, antithrombin, prothrombin, and protein C levels notably increased in patients with longer ICU LOS. One-year post-discharge, differences were found for factor IX, aPTT, and INR. Gender-stratified analysis showed sustained alterations in males.Conclusions: Depleted specific coagulation factors on ICU admission are associated with increased severity in critically ill COVID-19 patients. Most coagulation alterations recover one-year postdischarge, except for factor IX, aPTT and INR, which remain reduced.

    Keywords: SARS-CoV2, COVID-19 severity, biomarkers, coagulation, Hospitalization, ICU

    Received: 02 Sep 2024; Accepted: 13 Dec 2024.

    Copyright: © 2024 Behar-Lagares, Virseda-Berdices, Martínez- González, Blancas, Homez-Guzmán, Manteiga, Churruca-Sarasqueta, Manso- Álvarez, Algaba, Resino, Fernández-Rodríguez and Jiménez-Sousa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Óscar Martínez- González, Critical Care Department, Hospital Universitario del Tajo, Aranjuez, Spain
    Amanda Fernández-Rodríguez, Instituto de Salud Carlos III, Centro Nacional de Microbiología, Majadahonda, Spain

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