Learn-Han Lee
Xuefeng Gao
Gang Sun- 1Sunway Microbiome Centre, School of Medical and Life Sciences, Sunway University, Sunway City, Malaysia
- 2Research Center for Life Science and Healthcare, China Beacons of Excellence Research and Innovation Institute (CBI), University of Nottingham Ningbo China, Zhejiang, China
- 3Department of Hematology and Oncology, International Cancer Center, Shenzhen Key Laboratory of Precision Medicine for Hematological Malignancies, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University Health Science Center, Shenzhen, China
- 4Central Laboratory, Shenzhen University General Hospital, Shenzhen, China
- 5Microbiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, China
Editorial on the Research Topic
Roles of microbes in esophageal disease
The human body is home to a vast ecosystem of microorganisms, collectively known as the microbiome, which plays a pivotal role in maintaining our health (Lim et al., 2022b). In recent years, research has shed light on the significance of the microbiome in various aspects of health (Kong et al., 2022), including its involvement in esophageal disease (ED) (Chen et al., 2022; Muszyński et al., 2022). This Research Topic aims to investigate the esophageal microbiota’s role in various EDs, such as gastroesophageal reflux disease (GERD), eosinophilic esophagitis (EoE) and esophageal squamous cell carcinoma (ESCC), shedding light on potential diagnostic and therapeutic avenues.
Two studies investigated the relationship between microbiota and GERD. The first study, focusing on proton pump inhibitors (PPIs), Shi et al. revealed mycobiota dysbiosis in GERD patients, irrespective of PPI use. PPI treatment exacerbated fungal dysbiosis, particularly with increased Candida colonisation, warranting further investigation for a deeper understanding of PPIs effects on fungal dynamics in GERD. The second study, Ye et al. examined gut microbiota in pediatric GERD, identifying imbalances in bacterial phyla and specific metabolic pathways related to arachidonic acid, tyrosine, glutathione, and caffeine. The study suggests potential therapeutic interventions targeting specific bacteria associated with these pathways. Together, these studies provide scientific insights into microbiota dysregulation in GERD, influencing our understanding and potentially reshaping therapeutic approaches for GERD. Meanwhile, in the third study, Zhang et al. scrutinised the intratumoral microbiome in ESCC. The study underscores their potential as prognostic indicators and therapeutic targets by linking higher microbiome diversity and Lactobacillus abundance to forming an immunosuppressive microenvironment. The findings highlight the symbiotic relationship between the intratumoral microbiome and the immune microenvironment, paving the way for innovative ESCC prognosis and treatment approaches.
Zou et al. comprehensively reviewed studies on esophageal microflora in GERD, EoE, ESCC and Barrett’s esophagus, suggesting a bidirectional causal relationship between ED and shifts in esophageal microflora. This implies that pathogenic microflora can reshape the mucosal microenvironment, and alterations in the mucosal microenvironment, in turn, can facilitate changes in the microflora. Meanwhile, Zhang et al. focused on reviewing EoE-related esophageal microbiome research, highlighting key findings such as alterations in microbial composition, the potential role of the microbiota in EoE pathogenesis through interactions with the epithelial barrier and immune system, modulation of the microbiota by EoE treatments, and the emerging therapeutic potential of targeting the esophageal microbiota. Nevertheless, despite the methodological challenges and existing limitations in esophageal microflora research, both Zou et al. and Zhang et al. indicate that the development of genomics and multi-omics approaches holds promise for enhancing our understanding of the esophageal microbiome, identifying molecular biomarkers for more accurate diagnosis, and ultimately contributing to the prevention and treatment of ED.
In conclusion, these studies underscore the oesophagal microbiota’s pivotal role in ED. From unraveling the complexities of EoE to questioning the implications of PPI use and exploring the intricate relationships in ESCC and pediatric GERD, the esophageal microbiota emerges as a dynamic player in the spectrum of ED. As we navigate this fascinating landscape, the call for larger, standardised studies becomes increasingly imperative to investigate the impact of interventions, such as targeted microbiota modulation (Lim et al., 2022a; Lim et al., 2022b; Sim et al., 2023), which holds promise for developing more effective therapeutic strategies in ED.
Author contributions
L-HL: Conceptualization, Writing – original draft, Writing – review & editing. XG: Conceptualization, Writing – review & editing. GS: Conceptualization, Writing – review & editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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References
Chen, X., Xian, B., Wei, J., Chen, Y., Yang, D., Lai, X., et al. (2022). Predictive value of the presence of Prevotella and the ratio of Porphyromonas gingivalis to Prevotella in saliva for esophageal squamous cell carcinoma. Front. Cell. Infect. Microbiol. 12. doi: 10.3389/fcimb.2022.997333
Kong, G. Y.-E., Letchumanan, V., Tan, L. T.-H., Law, J. W.-F. (2022). Gut microbiome in obsessive compulsive disorder: potential of probiotics as an adjuvant therapy. Prog. Microbes Mol. Biol. 5, 1–10. doi: 10.36877/pmmb.a0000272
Lim, J.-M., Letchumanan, V., Tan, L. T.-H., Hong, K.-W., Wong, S.-H., Ab Mutalib, N.-S., et al. (2022a). Ketogenic diet: A dietary intervention via gut microbiome modulation for the treatment of neurological and nutritional disorders (a narrative review). Nutrients 14, 3566. doi: 10.3390/nu14173566
Lim, W. Q., Cheam, J. Y., Law, J. W.-F., Letchumanan, V., Lee, L.-H., Tan, L. T.-H. (2022b). Role of garlic in chronic diseases: focusing on gut microbiota modulation. Prog. Microbes Mol. Biol. 5, 1–12. doi: 10.36877/pmmb.a0000271
Muszyński, D., Kudra, A., Sobocki, B. K., Folwarski, M., Vitale, E., Filetti, V., et al. (2022). Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of view. Front. Cell. Infect. Microbiol. 12. doi: 10.3389/fcimb.2022.1057668
Keywords: microbes, esophageal disease, microbiome, gastroesophageal reflux disease (GERD), eosinophilic esophagitis (EoE), esophageal squamous cell carcinoma (ESCC)
Citation: Lee L-H, Gao X and Sun G (2023) Editorial: Roles of microbes in esophageal disease. Front. Cell. Infect. Microbiol. 13:1339579. doi: 10.3389/fcimb.2023.1339579
Received: 16 November 2023; Accepted: 20 November 2023;
Published: 29 November 2023.
Edited and Reviewed by:
Benoit Chassaing, Institut National de la Santé et de la Recherche Médicale (INSERM), FranceCopyright © 2023 Lee, Gao and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Learn-Han Lee, bGVlbGVhcm5oYW5AeWFob28uY29t; Xuefeng Gao, eGZnYW9Ac211LmVkdS5jbg==; Gang Sun, ZHIuc3VuZ2FuZ0BvdXRsb29rLmNvbQ==