Wen Zhou
Xiaojing Huang- Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China
Editrorial on the Research Topic
Control of biofilms to control caries
Dental caries, a disease caused by bacterial biofilms, is one of the most prevalent chronic diseases in humans globally. A dysbiotic shift at the interface of the biofilm–tooth surface leads to a prolonged low-pH environment at the interface, resulting in net mineral loss from the teeth (Zheng et al., 2023). For the prevention and treatment of caries, biofilm control is of critical importance (Comeau et al., 2022). To develop novel and effective strategies for the control of biofilms and caries, it is necessary to investigate biofilms in greater depth. Accordingly, their pathogenic mechanisms and interactions among microorganisms should be explored along with new biofilm control strategies. Herein, we discuss the issues related to biofilm control in detail.
The cariogenic mechanism of specific bacteria is an important topic in caries research. Protein lysine malonylation (Kmal) is a novel post-translational modification that is crucial for regulating metabolism and virulence expression in Streptococcus mutans (S. mutans). However, the Kmal of S. mutans remains poorly understood. Li et al. revealed that approximately 50% of the total malonyl lysine sites in S. mutans were identified as Kmal sites. It provides a multidimensional comprehension of the bacterial virulence and physiological functions of S. mutans. In addition, the cross-kingdom interactions of S. mutans and Candida albicans (C. albicans) have been found to promote the cariogenicity of S. mutans (Katrak et al., 2023). In this Research Topic, Li et al. reported that inhibiting the activity of glycosyl transferases (Gtfs) or glucans to hinder extracellular polysaccharide production may weaken the co-adhesion between the two species. Lu et al. summarized the coexistence and synergistic or antagonistic interactions of the two species, aiding in understanding the interactions of S. mutans and C. albicans.
There is an urgent need for developing novel and effective antibacterial agents. As part of the present Research Topic, Liu et al. revealed that areca nut essential oils reduce the cariogenicity of S. mutans through the targeted inhibition of Gtfs. Fang et al. explored mesoporous silica nanoparticles, which are a promising drug delivery vehicle for antibacterial agents. Furthermore, Zhao et al. reported a cold atmospheric plasma device that could easily produce plasma through a double-ring discharge structure with quartz tubes. This device was demonstrated to have a stronger bactericidal effect on caries-related biofilms than ultraviolet radiation under the same test conditions.
Achieving antibiofilm activity in a pH-sensitive way is another research hotspot. For example, Wang et al. developed a novel resin infiltrant containing a smart monomer, dodecylmethylaminoethyl methacrylate, which showed stronger antibacterial effectiveness at lower pH. Their findings shed light on the promising future of pH-sensitive anti-caries agents. In addition, Huang et al. summarized the state-of-the-art pH-activated antibiofilm strategies for the control of dental caries, focusing on their effects, mechanisms of action, and biocompatibility. The limitations of previous studies have also been discussed, thus highlighting aspects for future study.
Currently, drug-resistant strains of oral bacteria are often detected. Shen et al. reported that the fluoride-resistant strains of S. mutans can significantly increase the diversity of the oral microbial community. To better cope with potential drug resistance challenges in the future, there is a critical need for novel antimicrobial approaches. Based on in silico screening and computational methods, Zhang et al. used computer-aided drug design to identify compounds with optimal interactions with the target. Synthetic antimicrobial peptides obtained through rational design, computational design, or high-throughput screening have demonstrated increased selectivity for both single-species and multispecies biofilms, making the development of new antimicrobial modalities a crucial challenge for researchers in this field.
In future research, the mechanism by which S. mutans causes dental caries requires further exploration. For example, C. albicans synergistically promotes the pathogenicity of S. mutans through the bacterial quorum-sensing system. The use of natural products as drugs and pH-responsive antibacterial agents has great potential and is an important future Research Topic. Furthermore, there is a need to develop prevention and treatment strategies for oral cariogenic bacteria. The emergence of antibiotic resistance has necessitated the search for novel antibacterial agents that target specific oral bacterial pathogens or can be delivered through targeted drug delivery systems. Through rational design, computational design, and high-throughput screening, computer-aided drug design has led to the identification of potential therapeutic agents that can promote the targeted control of oral microbial biofilms in the near future.
Author contributions
WZ: Formal Analysis, Writing – original draft. XH: Funding acquisition, Project administration, Supervision, Writing – review & editing.
Funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (Grant No. 30500564).
Acknowledgments
We sincerely thank all authors and reviewers who participated in this Research Topic. We would also like to thank all researchers who have contributed to the research on biofilms and diseases.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
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References
Comeau, P., Panariello, B., Duarte, S., Manso, A. (2022). Impact of curcumin loading on the physicochemical, mechanical and antimicrobial properties of a methacrylate-based experimental dental resin. Sci. Rep. 4, 12(1),18691. doi: 10.1038/s41598-022-21363-5
Katrak, C., Garcia, B. A., Dornelas-Figueira, L. M., Nguyen, M., Williams, R. B., Lorenz, M. C., et al. (2023). Catalase produced by Candida albicans protects Streptococcus mutans from H2O2 stress-one more piece in the cross-kingdom synergism puzzle. mSphere 8 (5), e0029523. doi: 10.1128/msphere.00295-23
Keywords: caires, biofilm, antibacterial, cross-kingdom interactions, Streptococcus mutans
Citation: Zhou W and Huang X (2023) Editorial: Control of biofilms to control caries. Front. Cell. Infect. Microbiol. 13:1332907. doi: 10.3389/fcimb.2023.1332907
Received: 03 November 2023; Accepted: 23 November 2023;
Published: 30 November 2023.
Edited and Reviewed by:
Diane McDougald, University of Technology Sydney, AustraliaCopyright © 2023 Zhou and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Xiaojing Huang, aHhpYW9qQDE2My5jb20=