Bo Lei
Aldo R. Boccaccini
Xiaofeng Chen- 1Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, China
- 2Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, China
- 3Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, Erlangen, Germany
- 4Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China
Editorial on the Research Topic
Multifunctional Bioactive Nanomaterials for Tissue Regeneration, Volume 2
The development of bioactive biomaterials is an important component in the general field of tissue engineering, specifically for the success of tissue repair and regeneration approaches (Pacelli et al., 2017). Bioactive properties including antibacterial, antiinflammatory, antitumor and antioxidant activities can efficiently regulate cell attachment, proliferation, differentiation, and the immune microenvironment, which are essential cellular functions regulating new tissue formation (Gaharwar et al., 2020). Therefore, the science and technology of bioactive biomaterials continue to be at the center of the interest of researchers in the biomedical area worldwide.
Engineered bioactive materials involve conventional biomaterials, such as bioactive glasses and ceramics, as well as biopolymers based on proteins. Polysaccharides and biomoleculecontaining biomaterials (Zheng et al., 2019). In recent years, the development of nanomaterials has brought new possibilities for tissue regeneration, due their unique surface, small size, and quantum size effects (Wang et al., 2021). Thus, nanoscale bioactive materials have attracted increasing interest in regenerative medicine recently (Chen et al., 2021; Luo et al., 2021). For example, relative to conventional bioactive glass, bioactive nanoscale glasses (BNG) have shown enhanced apatite-forming ability and osteogenic differentiation activity, as well as improved bone regeneration capability (Xue et al., 2017; Westhauser et al., 2021). Additionally, BNG also present controlled release of ions and tailorable degradation, as well as multifunctionalities, being thus interesting for a broad range of biomedical applications (Zheng et al., 2021). Up to now, BNG have demonstrated huge potential for applications in gene delivery, cancer therapy, antiinfection, immunoregulation, bioimaging, and soft tissue regeneration (Yu, et al., 2017; Niu, et al.,2021a; Niu, et al.,2021b; Rivera, et al., 2021; Sharifi, 2022). In addition to BNG, a great number of nanoscale biomaterials, both organic and inorganic nanoparticles, nanofibers and other nanostructures, are being considered for applications in tissue regeneration, usually combined with local drug and growth factor delivery.
This Research Topic is the second part on the “Multifunctional Bioactive Nanomaterials for Tissue Regeneration” series, which includes several papers demonstrating the main advances of multifunctional nanomaterials in tissue engineering. In this topic, Sprio et al. reviewed the application of biomorphic transformations to obtain nanostructured 3-D bioceramics. Yanmei Tang et al. reviewed the advances of polydopamine nanoparticles in tissue engineering applications, including the repair of bone, cartilage, skin, heart, and nerve. Fujian Zhao et al. reported tantalum-gelatin methacryloyl-bioactive glass (Ta-GelMA-BG) scaffolds which could enhance osteointegration at the early stage of implantation. Haiping Lu et al. developed Ag and MSCs-derived exosomes-contained PCL scaffold for regulating immune cells and MSCs proliferation and differentiation. Haiping Lu et al. introduced the broad application of β-TCP in tissue engineering and discussed different approaches to enhance and customize β-TCP scaffolds, including physical modification.
The editors hope that the current topic “Multifunctional Bioactive Nanomaterials for Tissue Regeneration Part 2” will contribute to inspire future developments of advanced bioactive nanomaterials for regenerative medicine to close the gap between research and clinical applications.
Author Contributions
All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s Note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Acknowledgments
We sincerely thank the support from all contributing authors and referes as well as responsible editors at the publisher.
References
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Keywords: bioactive, multifunctional, nanomaterials, tissue engineering, cancer therapy
Citation: Lei B, Boccaccini AR and Chen X (2022) Editorial: Multifunctional Bioactive Nanomaterials for Tissue Regeneration, Volume 2. Front. Chem. 10:848369. doi: 10.3389/fchem.2022.848369
Received: 04 January 2022; Accepted: 06 January 2022;
Published: 25 January 2022.
Edited and Reviewed by:
Xiaomin Li, Fudan University, ChinaCopyright © 2022 Lei, Boccaccini and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Bo Lei, rayboo@xjtu.edu.cn; Aldo R. Boccaccini, aldo.boccaccini@fau.de; Xiaofeng Chen, chenxf@scut.edu.cn