Donghong Zhang1*
Rodolfo Negri- 1Department of Pharmacology and Chemical Biology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, United States
- 2School of Basic Medical Sciences, Institute of Cardiovascular Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, China
- 3Center for Molecular and Translational Medicine, Georgia State University, Atlanta, GA, United States
- 4School of Medical Imaging, Tianjin Medical University, Tianjin, China
- 5Department of Biology and Biotechnology “C.Darwin”, Sapienza University of Rome, Rome, Italy
Editorial on the Research Topic
Crosstalk between epigenetics on the development of cancer and cardiovascular disease
Introduction
Chromatin structure is fundamental for transcription regulation (McGinty and Tan, 2015) and genome integrity (Groth et al., 2007; Di Nisio et al., 2021). It can be modified by very complex and variegated machinery with major effects on cell biology. In the last 20 years, several basic epigenetic mechanisms have been described to critically regulate genome expression and preservation while significant advances have been made in identifying and characterizing the complex biochemical machinery involved. These efforts are mainly due to the understanding of the prominent roles of epigenetic modifications in physiological and pathological states. Indeed, an impressive body of experimental evidence has shown the involvement of mutations or dysregulation of epigenetic modifiers in human diseases. While this concept was clear from the beginning in cancer research (Morgan and Shilatifard 2015), it is now rapidly extending to non-cancer diseases such as neurodegenerative syndromes and cardiovascular dysfunctions.
Crosstalk between epigenetics on the development of cancer
All the main epigenetic mechanisms (DNA methylation; histone modification; nucleosome remodeling; mRNA modification and noncoding RNA-mediated processes) seem to be involved in cancer development. Dysfunctions in epigenetic machinery may easily cause genetic instability, which can be inherited from mother to daughter cells, steering cell lineages toward increasingly pathological states. There is consequently great interest in epigenetic drugs, which are potentially capable of counteracting the deleterious effects of the dysfunctions by blocking or supporting the affected modifications. Although very promising, the pharmacological progress in this field is facing great difficulties (Wimalasena et al., 2020; Asano, 2020):
i) epigenetic modifications have typically pleiotropic effects and interfering with them can cause major out-target effects; and
ii) the complexity of the epigenetic machinery makes it very difficult to specifically inhibit single epigenetic actors without affecting structurally similar proteins with distinct or sometimes even opposite functions.
The role of epigenetics in specific cancer diseases
Several excellent reviews have been published on the general role of epigenetic mechanisms in cancer (Dawson and Kouzarides, 2012) while, more recently, the scientific community is focusing on specific cancer diseases with the major goal to identify potential diagnostic biomarkers and/or putative experimental therapy approaches (Xue et al., 2022; Zhang et al., 2022). Testicular cancer is an excellent example of this line of research. Most testicular cancers are testicular germ cell tumors (TGCTs), which can be classified into seminomas (SGCTs) and non-seminoma testicular germ cell tumors (NSGCTs). During their development, primordial germ cells (PGCs) undergo epigenetic modifications and any dysfunctions in their pattern might lead to cancer development. In this special issue, Nicu et al. provide a comprehensive review of the epigenetic mechanisms potentially involved. They include DNA methylation, histone modifications, and non-coding RNAs associated with TGCT susceptibility, initiation, progression, and response to chemotherapy. The authors also review the progresses in the identification and development of epigenetic biomarkers as powerful tools for the diagnostics and prognostics, and the efforts to develop epigenetic-based therapies.
Emerging epigenetic mechanisms
New emerging epigenetic mechanisms involved in cancer development should also be further explored and characterized. Among them, the most interesting one is certainly mRNA N6-adenosine methylation (m6A). One of the most important genes involved in this modification is METTL3 (Wei et al., 2022) which encodes the 70 kDa subunit of MT-A, which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. A very thought-provoking study by Jiang et al. in this special issue provides a comprehensive Pan-Cancer analysis of the prognostic and immunological roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C axis and suggests that this axis can be a prognostic indicator, as well as a promising therapeutic target, for patients with non-small cell lung cancer (NSCLC). In the same issue, Fang et al. present a transcriptome analysis of RNA N6-Methyladenosine modification in adriamycin-resistant Acute Myeloid Leukemia (AML) Cells and suggest that quantitative and qualitative modulation of this modification plays an important role in adriamycin-resistant AML.
The role of epigenetics in the development of cardiovascular disease
In contrast to the intensive research into the roles of epigenetics in cancers, much less progress has been made in non-cancer diseases, while cardiovascular disease has recently become one of the most advanced frontiers. The most intensive crosstalk between various epigenetic modifications has been found in multiple cardiovascular disease. For instance, m6A modification collaborates with specific microRNAs or piRNAs to regulate cardiac development and hypertrophy (Gao et al., 2020; Qian et al., 2021). N6-methyladenine (m6A) DNA-regulated lncRNA myocardial infarction-associated transcript (MIAT) promotes plaque progression in atherosclerosis (Wu et al., 2019). In this special issue, Chen et al., report a comprehensive review on the latest progress on the epigenetic regulation of myocardial infarction, focusing on DNA methylation, histone modifications, and microRNA-dependent mechanisms. The authors also discuss the novel therapies based on epigenetics.
Author contributions
All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
Asano, T. (2020). Drug resistance in cancer therapy and the role of epigenetics. J. Nippon. Med. Sch. 87, 244–251. doi:10.1272/jnms.JNMS.2020_87-508
Dawson, M. A., and Kouzarides, T. (2012). Cancer epigenetics: From mechanism to therapy. Cell 150, 12–27. doi:10.1016/j.cell.2012.06.013
Di Nisio, E., Lupo, G., Licursi, V., and Negri, R. (2021). The role of histone lysine methylation in the response of mammalian cells to ionizing radiation. Front. Genet. 12, 639602. doi:10.3389/fgene.2021.639602
Gao, X. Q., Zhang, Y. H., Liu, F., Ponnusamy, M., Zhao, X. M., Zhou, L. Y., et al. (2020). The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNAChromatin challenges during DNA replication and repair. Nat. Cell BiolCell 22128, 1319721–1331733. doi:10.1038/s41556-020-0576-y10.1016/j.cell.2007.01.030
McGinty, R. K., and Tan, S. (2015). Nucleosome structure and function. Chem. Rev. 115, 2255–2273. doi:10.1021/cr500373h
Morgan, M. A., and Shilatifard, A. (2015). Chromatin signatures of cancer. Genes Dev. 29, 238–249. doi:10.1101/gad.255182.114
Qian, B., Wang, P., Zhang, D., and Wu, L. (2021). m6A modification promotes miR-133a repression during cardiac development and hypertrophy via IGF2BP2. Cell Death Discov. 7, 157. doi:10.1038/s41420-021-00552-7
Wei, X., Huo, Y., Pi, J., Gao, Y., Rao, S., He, M., et al. (2022). METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis. Nat. Cell Biol. 24, 1278–1290. doi:10.1038/s41556-022-00968-y
Wimalasena, V. K., Wang, T., Sigua, L. H., Durbin, A. D., and Qi, J. (2020). Using chemical epigenetics to target. Cancer. Mol. Cell 78, 1086–1095. doi:10.1016/j.molcel.2020.04.023
Wu, L., Pei, Y., Zhu, Y., Jiang, M., Wang, C., Cui, W., et al. (2019). Association of N6-methyladenine DNA with plaque progression in atherosclerosis via myocardial infarction-associated transcripts. Cell Death Dis. 10, 909. doi:10.1038/s41419-019-2152-6
Xue, C., Chu, Q., Zheng, Q., Jiang, S., Bao, Z., Su, Y., et al. (2022). Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine. Signal Transduct. Target. Ther. 7, 142. doi:10.1038/s41392-022-01003-0
Keywords: epigenetics, cancer, cardiovascular disease, epigenetic modification, epigenetic drug
Citation: Zhang D, Wang Y, Ramprasath T, Wang P and Negri R (2022) Editorial: Crosstalk between epigenetics on the development of cancer and cardiovascular disease. Front. Cell Dev. Biol. 10:1027798. doi: 10.3389/fcell.2022.1027798
Received: 25 August 2022; Accepted: 14 September 2022;
Published: 20 October 2022.
Edited and reviewed by:
Michael E. Symonds, University of Nottingham, United KingdomCopyright © 2022 Zhang, Wang, Ramprasath, Wang and Negri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Donghong Zhang, donghong.zhang@emory.edu; Rodolfo Negri, rodolfo.negri@uniroma1.it