Zhilong Yu
Shanshi Tong
Chenyi Wang
Zizhen Wu
Yingjiang Ye
Shan Wang
Kewei Jiang- 1Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing, China
- 2State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
A Corrigendum on
PPy@Fe3O4 nanoparticles inhibit the proliferation and metastasis of CRC via suppressing the NF-κB signaling pathway and promoting ferroptosis
by Yu Z, Tong S, Wang C, Wu Z, Ye Y, Wang S and Jiang K (2022). Front. Bioeng. Biotechnol. 10:1001994. doi: 10.3389/fbioe.2022.1001994
In the published article, there was an error in the legend for Figure 6 as published. “DLD1” in Figure 6B Legend was incorrectly written as “MGC-803”. The corrected legend appears below.
In the published article, there was an error in Figure 5C and Figure 6B as published. “Invasion” was incorrectly written as “Invation”. The real image in the lower right corner of Figure 5C was incorrect due to a copy error when assembling the images. “NIR” in Figure 6B was incorrectly written as “H2O2”. “Control” in Figure 6F was incorrectly written as “Contol”. The corrected Figure 5 and Figure 6 and its caption appear below.
FIGURE 5. PPy@ Fe3O4 NPs suppress CRC cells metastasis by promoting cell ferroptosis and inhibiting NF-κB signaling pathway. (A) Western blot. Colorectal cancer cell line DLD1 was treated with various groups (Control, H2O2, NPs and NPs +H2O2), and then subjected to Western blot analysis of the key proteins of the NF-κB signaling pathway (Ikk-β, p-Ikk-β, Ikk-α, p-Ikk-α, NF-κB, p-NF-κB, iκB-α, and p-iκB-α). (B) Effects of the ferroptosis inhibitor Ferrostatin-1 on PPy@Fe3O4 NPs-induced metastasis-related proteins expression. (C) Transwell showed that PPy@Fe3O4 NPs induced cell migration and invasion were abolished after addition of the ferroptosis inhibitor Ferrostatin-1 in CRC cells.
FIGURE 6. Anti-tumour activity of PPy@ Fe3O4 NPs in nude mouse tumour cell xenografts. (A) Images of subcutaneous xenograft tumors of DLD1 cells. (B) The final tumor weight of DLD1 cells was shown. (C) The tumor volume and change of different groups. (D) The temperature change and (E) infrared thermal imaging of the mice injected with PBS, NPs under laser irradiation. (F) Ki67 staining of the tumors in the control group and other treated groups. (scale bar: 100 μm). (G) H&E staining of the main organs from the control and treatment groups. (scale bar: 250 μm). **p < 0.01.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: colorectal cancer, nanoparticles, metastasis, NF-κB, ferroptosis
Citation: Yu Z, Tong S, Wang C, Wu Z, Ye Y, Wang S and Jiang K (2022) Corrigendum: Yu et al. PPy@Fe3O4 nanoparticles inhibit the proliferation and metastasis of CRC via suppressing the NF-κB signaling pathway and promoting ferroptosis. Front. Bioeng. Biotechnol. 10:1094064. doi: 10.3389/fbioe.2022.1094064
Received: 09 November 2022; Accepted: 21 November 2022;
Published: 01 December 2022.
Edited and reviewed by:
Yu Luo, Shanghai University of Engineering Sciences, ChinaCopyright © 2022 Yu, Tong, Wang, Wu, Ye, Wang and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Kewei Jiang, dr_jiangkewei@163.com
†These authors have contributed equally to this work