Vasiliki Iliadou1
Christiane Kiese-Himmel2*
Doris-Eva Bamiou3
Helen Grech4
Martin Ptok5Gail D. Chermak6
Hung Thai-Van7
Tone Stokkereit Mattsson8Frank E. Musiek9- 1Clinical Psychoacoustics Lab, Third Department of Psychiatry, Neuroscience Sector, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
- 2Phoniatric and Pediatric Audiological Psychology, University Medical Center Göttingen, Georg-August-University, Göttingen, Germany
- 3Faculty of Brain Sciences, University College London Ear Institute, University College London, London, United Kingdom
- 4Department of Communication Therapy, Faculty of Health Sciences, University of Malta, Msida, Malta
- 5Department of Phoniatrics and Pediatric Audiology, Medizinische Hochschule Hannover, Hanover, Germany
- 6Department of Speech and Hearing Sciences, Elson S. Floyd College of Medicine, Washington State University Health Sciences Spokane, Spokane, WA, United States
- 7Department of Audiology and Otoneurological Evaluation, Hospices Civils de Lyon, Paris Hearing Institute, Centre de l'Institut Pasteur, Inserm U1120, Paris, France
- 8Department of Otorhinolaryngology, Head and Neck Surgery, Ålesund Hospital, Ålesund, Norway
- 9Neuroaudiology Lab, University of Arizona, Tucson, AZ, United States
The opinion article “An Evidence-based Perspective on Misconceptions Regarding Pediatric Auditory Processing Disorder” by Neijenhuis et al. (1) presents a distorted view of the evidence-based approach used in medicine. The authors focus on the amorphous non-diagnostic entity “listening difficulties” not auditory processing disorder (APD) and create confusion that could jeopardize clinical services to individuals with APD. In our perspective article, we rebut Neijenhuis et al. (1), and more importantly, we present a rationale for evidence-based practice founded on the premise that research on APD is only clinically applicable when conducted on clinical populations diagnosed with APD.
What is an Evidence-based Approach to Pediatric APD?
The answer is that it is the same as for any other disease or disorder. According to Sackett et al. (2), the evidence-based approach in medicine includes three elements: (a) clinical expertise, (b) best research available, and (c) the patient's values and preferences. While recognizing the essential role of research in establishing the evidence-base for a disorder, one must not discount the other two pillars. While some might be tempted to prioritize research (even research with methodological and/or design faults) over clinical expertise in one's conceptualization of evidence-based practice, Haynes et al. (3) place clinical expertise at the core of the clinical decision process. A key element for an evidence-based approach to APD is that the approach is informed by research conducted on clinical populations diagnosed with APD (4).
In their opinion paper, Neijenhuis et al. (1) assert that the three “systematic reviews” they cite undermine the evidence-base for APD. In fact, none of these papers is actually a systematic review of primary, peer-reviewed research conducted with participants diagnosed with APD. In the absence of published systematic reviews of participants diagnosed with APD at the present time, the next best evidence-based step is to use current professional association guidelines. European guidelines (5) refer to many countries' guidelines (within and beyond Europe) and these provide analogous and consistent approaches to the diagnosis of APD. This approach is not analogous to the approaches taken in the papers cited as systematic APD reviews by Neijenhuis et al. (1). In fact, they cite a review of clinical practice guidelines (6), in which the authors employed an appraisal method for guidelines using the Agree II tool to rate each guideline's scientific approach. Heine and O'Halloran concluded that all available APD guidelines in the English language (including the American and British Guidelines) scored low in most domains primarily due to “poor methodological reporting” and should not be used in their current form. It should be noted that a systematic search and evaluation of clinical practice guidelines is not a systematic review of primacy research, and, moreover, is limited to clinical trials (7).
The second alleged systematic review cited (8) included research involving participants “suspected of” rather than diagnosed with APD. The third paper they characterized as a systematic review (9) is in fact a report of research in which comparisons were made between a clinical group referred for APD evaluation (but not diagnosed with APD) and a control group of children. The authors reported correlations between auditory processing scores and cognitive scores, concluding that cognitive testing is essential in APD diagnosis. This is, simply put, illogical. Finding correlations between these two variables in undiagnosed participants tells us little about the use of cognitive measures in a test battery designed to diagnose APD. Any conclusions made by reviews of APD that include children suspected of APD or diagnosed with APD on the basis of self-report or informant's report on questionnaires or based on children with general listening difficulties do not provide the best available evidence elucidating APD. Drawing conclusions based on performance of poorly defined participants poses significant threats to the validity of the research. Results of any study that uses the metric “suspected of APD” or “listening difficulties” cannot be relied upon because: (i) One cannot be sure whether the participants in the study presented any type of true auditory deficit, and (ii) the participants may have had a wide range of unidentified issues (10). Efficient (i.e., sensitive and specific) clinical tests of auditory processing must be used to clearly define participants and to identify and describe known comorbidities so that analyses can be conducted and results interpreted accurately (11). The serious limitations of the suspected of APD label (that is not a diagnosis) is corroborated by the finding that many children referred for central auditory processing evaluations because of “listening difficulties” actually perform quite well on central auditory processing measures (12, 13). One would assume that if parent and teacher reports were good predictors of auditory processing difficulties, then the APD hit rate (i.e., true positives) for these referrals would be much higher. The reality is that there are no published, true systematic reviews of appropriately diagnosed individuals with APD. Labeling children suspected APD rather than evaluating and appropriately diagnosing for APD is not evidence-based and is threatening the intervention services provided to APD diagnosed individuals.
The European Consensus APD Clinical Practice Guidelines (5) are predicated on research similar to that underlying the ASHA and AAA Guidelines (14, 15). Neijenhuis et al. (1) attempt to undermine confidence in current guidelines without presenting any alternative, evidence-based approach for the diagnosis of APD. Moreover, they incorrectly assert that APD may be better explained by other developmental disorders, including attention or language-listening deficits. This is an assumption/argument that published research has failed to confirm. Published research shows that a small sub-group of APD diagnosed children present co-morbid attention deficits (16). Moreover, abnormal performance on auditory processing tests often occurs despite sustained attention within normal limits (17). In fact, most auditory processing tests share only a mild to moderate degree of variance with cognition, leading Weihing et al. (18) to conclude that auditory processing performance is not driven by cognition alone. In addition, maturation rates for different auditory tasks are not correlated, as would be expected if a non-sensory factor (e.g., attention) had a uniform influence on performance (19–21). Would Neijenhuis et al. (1) assert that a poor response to an auditory stimulus (in the presence of normal hearing sensitivity) is due to poor attention, but a poor response to a visual stimulus must be due to a visual processing deficit (in the presence of normal peripheral vision)? Grounds to argue either case are lacking. Recent research also shows that although attention is correlated with how well or poorly a typically developing child uses rhythm to perceive speech in babble, this is not true for APD diagnosed children (22). In fact, not surprisingly, there is evidence to suggest that APD (as well as peripheral hearing impairment) can affect measures of cognition (23, 24). Clearly, brain organization and processing underlies bidirectional interactions, as well as comorbidity (25).
What is the APD Clinical Reality in Europe and USA?
APD is diagnosed by appropriately educated otorhinolaryngologists (ENTs) and/or audiologists since few would dispute that an APD assessment begins with a thorough assessment of “peripheral” hearing function. The diagnosing clinician needs to have an in depth understanding of auditory function and related pathologies, so ENTs/audiologists need to be key members of any multidisciplinary team, where such health care personnel are available. However, we must not lose sight of the limited resources in different countries, in which a multidisciplinary approach is advocated, but may not be possible within a formal team setting. Differential diagnosis requires multidisciplinary assessment involving speech-language pathologists, educators, and psychologists (26, 27). This comprehensive evaluation is best practice in APD diagnosis, as well as in formulating individualized intervention. In all cases, research should guide practice, provided that the research is based on the intended population of clinical interest—that is, individuals diagnosed with APD. Auditory processing tests are evaluated for their sensitivity and specificity before they are used for clinical diagnosis (27–30). APD clinical diagnosis reveals the presence of heterogeneity in the specific auditory processing deficits seen in individuals diagnosed with APD. Thus, there is a documented need for further research in this domain implemented in APD diagnosed individuals.
A recent European APD infographic (Figure 1) was designed to raise awareness of the fact that hearing is more than we are currently testing. Emergence of an auditory deficit poses deleterious effects on language, cognition, learning, and communication. We should not forget that tests of attention and memory are often administered through the auditory modality and may be influenced by a hearing impairment—APD included (23, 24, 31, 32). Auditory processing tests included in the graph are the ones used commonly in practice by European clinicians who run specialty APD clinics. The information in the infographic is based on a questionnaire completed by members of the European APD group of 21 countries.
Figure 1. European APD Infographic. The tree at the top is full of the tests of a classical audiology practice on the left side (represented in leaves). These include: the audiogram, pure tone audiometry in quiet, stapedial reflexes, tympanometry (TYMPS), otoacoustic emissions (OAE), and auditory brainstem responses (ABR). The leaves on the right side are tests of auditory processing that are used in specialized APD clinics. These include: speech in noise/babble, pitch pattern sequence (PPS), duration pattern sequence (DPS), dichotic digits (DD), gaps-in-noise (GIN), random gap detection test (RGDT), binaural masking level difference (BMLD), listening in spatialized noise (LISN), otoacoustic emissions suppression (OAE suppression), and complex auditory brainstem response (cABR). On the bottom half of this infographic designed by the European APD Study Group and as part of the European Federation of Audiology Societies (EFAS) APD Working Group the two way pyramid provides a visual of the complex interaction between hearing [hearing sensitivity (HS) + auditory processing (AP)]and cognition. This is an original image, developed by the first author Vasiliki (Vivian) Iliadou.
Is There Place for New Tests or Approaches to APD?
We certainly believe that APD diagnosis will evolve to include more efficient, reliable, and ecologically valid tests (i.e., tests that reflect everyday hearing situations). One such test may be suppression of otoacoustic emissions using contralateral noise (33, 34). In addition, electrophysiological procedures may be used for APD diagnosis. For example, evidence of pre-attentional auditory discrimination deficit was reported in a recent mismatch negativity study in children diagnosed with APD (35). As science and clinical practices advance, however, it is neither ethical, nor practical to simply reject current clinical expertise as formulated in guidelines of audiology societies and consensus groups around the world. There is no evidence base for doing so and undermining clinical services for millions of patients around the world. Neijenhuis et al. (1) criticize the diagnostic criteria for APD because there is no specification of the number of tests or types of tests that are to be used [although that claim is inconsistent with Weihing et al. (30) and Musiek et al. (31)]. In fact, there is no specific number of tests promulgated for most clinical diagnoses. Diagnosing a disease or a disorder is a process that depends on symptoms, test findings, and patterns identified by the diagnosing clinician. Further, it is an iterative process by which clinical hypothesis are formulated on the basis of the patient's presentation and then confirmed, modified or discarded on the basis of the range of findings and additional information (36). This process cannot be successfully defined or replicated on the basis of a strict set of mathematical rules and criteria: most of the current computer-based diagnostic support systems fail to reach expert clinician diagnostic accuracy levels (36). It should be pointed out that emerging technologies give promising results in modeling out both audiometry (37) and complex auditory perception (38) by means of artificial intelligence and machine learning approaches. At this point in time, however, an experienced clinician is still a more accurate diagnostician than a machine. Emerging technologies augment management and treatment of auditory deficits as well (39, 40).
Is the Neijenhuis et al. Opinion Article About APD?
We would argue it is not. It focuses on research using non-diagnosed participants bearing the amorphous, non-diagnostic labels “suspected of” or ‘listening difficulties.'
What Does the Evidence-based Approach to APD Demand?
We must deploy the most efficient (sensitive and specific) available test batteries to diagnose and plan intervention for individuals with APD to minimize the adverse impacts the disorder is causing for communication, education, social integration, and work/livelihoods. APD should be considered within the construct of hearing impairment and should be managed based on diagnosed deficits in central auditory processing.
Author Contributions
This perspective paper is based on the European APD Consensus Iliadou et al. (5). A first draft was prepared by VI. CK-H, D-EB, HG, MP, GC, HT-V, TS, and FM made substantial contributions/edits/modifications to the conception of this paper and were involved in drafting the work and/or revising it critically for important intellectual content. Final approval of the version to be published was provided by all listed authors. All listed authors agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments
We acknowledge support by the German Research Foundation and the Open Access Publication Funds of the Göttingen University.
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Keywords: auditory processing disorder, evidence-based approach, hearing, pediatrics, systematic reviews
Citation: Iliadou V, Kiese-Himmel C, Bamiou D-E, Grech H, Ptok M, Chermak GD, Thai-Van H, Stokkereit Mattsson T and Musiek FE (2019) Clinical Expertise Is Core to an Evidence-Based Approach to Auditory Processing Disorder: A Reply to Neijenhuis et al. 2019. Front. Neurol. 10:1096. doi: 10.3389/fneur.2019.01096
Received: 10 April 2019; Accepted: 30 September 2019;
Published: 18 October 2019.
Edited by:
Jose Antonio Lopez-Escamez, Andalusian Autonomous Government of Genomics and Oncological Research (GENYO), SpainReviewed by:
Katrien Vermeire, Long Island University-Brooklyn, United StatesCaroline Nunes Rocha-Muniz, University of São Paulo, Brazil
Copyright © 2019 Iliadou, Kiese-Himmel, Bamiou, Grech, Ptok, Chermak, Thai-Van, Stokkereit Mattsson and Musiek. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Christiane Kiese-Himmel, ckiese@med.uni-goettingen.de