Application and Utility of Continuous Glucose Monitoring in Pregnancy: A Systematic Review

Abstract

Background: In the past decade, continuous glucose monitoring (CGM) has been proven to have similar accuracy to self-monitoring of blood glucose (SMBG) and yet provides better therapy optimization and detects trends in glucose values due to higher frequency of testing. Even though the feasibility and utility of CGM has been proven successfully in Type 1 and 2 diabetes, there is a lack of knowledge of its application and effectiveness in pregnancy, especially in gestational diabetes mellitus (GDM). In this review, we aimed to summarize and evaluate the updated scientific evidence on the application of CGM in pregnancies complicated with GDM.

Methods: A search using keywords related to CGM and GDM on PubMed was conducted and articles were filtered based on full text, year of publication (Jan 1998–Dec 2018), human subject studies, and written in English. Reviews and duplicate articles were removed. A final total of 29 articles were included in this review.

Results: In terms of maternal and fetal outcomes, inconsistent evidence was reported. Among GDM patients using CGM and SMBG, two randomized controlled trials (RCTs) found no significant differences in macrosomia, birth weight (BW), and gestational age (GA) at delivery between these two groups, while one prospective cohort found a lower incidence of cesarean section and macrosomia in CGM use subjects. Furthermore, CGM use was consistently found to have increased detection in dysglycemia and glycemic variability compared to SMBG. In terms of clinical utility, CGM use led to more treatment adjustments and lower gestational weight gain (GWG). Lastly, CGM use showed higher postprandial glucose levels in GDM-complicated pregnancies than in normal pregnancies.

Conclusion: Current updated evidence suggests that CGM is superior to SMBG among GDM pregnancies in terms of detecting hypoglycemic and hyperglycemic episodes, which might result in an improvement of maternal and fetal outcomes. In addition, CGM detects a wider glycemic variability in GDM mothers than non-GDM controls. Further research with larger sample sizes and complete pregnancy coverage is needed to explore the clinical utility such as screening and predictive values of CGM for GDM.

Methods

We conducted a broad search (conducted by QY and verified by L-JL) on PubMed, Scopus, and Web of Science using possible combination of terms from two themes featuring CGM and GDM, as shown in Figure 1. We first filtered full-text articles published between Jan 1st, 1998 and Dec 31st, 2018 that were mainly human studies and written in English. With these inclusion criteria, 560 articles remained. Second, we excluded duplicate articles (n = 191). Third, we removed articles without relevant titles (n = 132). Fourth, we excluded peer-reviews (n = 55) and lastly, we excluded articles without relevant abstracts (n = 105). We included a total of 29 articles in this review.

Figure 1

Results

Table 1 shows the characteristics of the 29 studies included, of which 3 were randomized controlled trials (RCTs), one was a randomized crossover trial, and the remaining 25 were prospective observational cohorts with a small to medium number of subjects (n = 8–340). The majority of studies (n = 20) used Minimed (Medtronic, Dublin, Ireland) with 72 h monitoring. Other studies applied devices including GlucoDay S (GDS) (A.Menarini Diagnostics Ltd, Florence, Italy) (n = 2), Guardian (Medtronic, Dublin, Ireland) (n = 1), Seven and Seven Plus (Dexcom, San Diego, USA) (n = 1), iPro2 (Medtronic, Dublin, Ireland) (n = 4) and Freestyle Libre Flash Glucose Monitoring (FGM) (Abott, Illinois, USA) (n = 1).

We summarize the major findings categorized below:

CGM vs. SMBG in Terms of Feasibility and Acceptability (Table 2)

Two studies which focused on user acceptability found that CGM use was generally well-tolerated by patients. McLachlan et al. demonstrated that CGM was able to provide an additional 62% of information that is missing in patients' self-recorded glucose diaries (18). Most patients felt that CGM is easy to use (44 out of 48, 92%), beneficial for self-glycemic control (43 out of 48, 90%), and that its use outweighed its inconvenience (37 out of 48, 77%) (18). Likewise, Scott et al. demonstrated that CGM had acceptable accuracy (88.1% within Zone A of Consensus Error Grid) with only 11.8% mean difference with SMBG (36).

CGM vs. SMBG and Risk of Adverse Pregnancy Outcomes (Table 3)

Two RCTs and 1 prospective cohort showed no differences in any maternal and fetal outcomes between CGM use and SMBG use among GDM pregnancies, while 3 other studies, including 1 RCT and 2 prospective cohorts, reported otherwise.

Maternal Outcomes

Wei et al. randomly assigned 120 pregnant women with GDM to either CGM (n = 58) or SMBG (n = 62) (31). CGM monitoring was done once for 48–72 h via MiniMed device (Medtronic, Dublin, Ireland) while traditional treatment involved SMBG (4 times daily) and HbA1c levels (every 4 weeks) (31). In this RCT, Wei et al. found no significant differences in cesarean section rates or HbA1c levels between CGM and SMBG users (31). Alfadhli et al. recruited 130 patients with GDM (62 SMBG, 68 CGM) and found no significant differences in cesarean section rates between the groups (29).

In addition, one prospective observational study also found no significant differences in maternal outcomes between CGM and SMBG groups. Kestila et al. enrolled 73 women with GDM and assigned 36 to CGM and 37 to SMBG (19). No differences were found in terms of frequency of pre-eclampsia, pregnancy-induced hypertension, maternal lacerations, and cesarean section rate between the 2 groups (19).

On the contrary, 2 studies found significant differences. Voormolen et al. randomized 109 women with GDM to CGM vs. standard treatment (SMBG 4–8 times daily and HbA1c levels every 4 weeks) (37). Compared with SMBG users, CGM users had a significantly lower incidence of pre-eclampsia [Relative Risk (RR) 0.3; 95%Cl: 0.12–0.8] (37). Yu et al. recruited 340 women with GDM and assigned 190 to routine care (SMBG 7 times daily) and the other 150–72 h CGM (26). Compared with SMBG, CGM users tended to have lower incidence of pre-eclampsia [5 out of 150 (3.3%) vs. 19 out of 190 (10%), P = 0.019], primary cesarean section [51 out of 150 (34.0%) vs. 88 out of 190 (46.3%), P = 0.028], and premature delivery [7 out of 150 (4.7%) vs. 22 out of 190 (11.6%), P = 0.024] (26).

Fetal Outcomes

The same studies also compared fetal outcomes between CGM and SMBG groups and all three RCTs found no significant differences (19, 29, 31, 37). Only one study by Yu et al. reported better fetal outcomes in the CGM group compared to SMBG group, in terms of BW (3,138 vs. 3,345 g, P < 0.001), numbers of macrosomia [6 out of 150 (4%) vs. 20 out of 190 (10.5%), P = 0.025], LGA [20 out of 150 (13.3%) vs. 48 out of 190 (25.3%), P = 0.01], neonatal hypoglycemia [8 out of 150 (5.3%) vs. 26 out of 190 (13.7%), P = 0.011], neonatal hyperbilirubinemia [4 out of 150 (2.7%) vs. 18 out of 190 (9.5%), P = 0.012], and neonatal respiratory distress syndrome (RDS) [2 out of 150 (1.3%) vs. 11 out of 190 (5.8%), P = 0.034] (26).

CGM vs. SMBG and Detection of Dysglycemia (Table 4)

Two prospective observational studies that compared CGM vs. SMBG to detect dysglycemia concluded that CGM detected more hypoglycemia and hyperglycemia incidents. Chen et al. conducted a study in Israel (n = 47) and USA (n = 10) on glucose profiling between CGM and SMBG in women with GDM (13), and found that CGM detected hyperglycemic and hypoglycemic events better than SMBG (13). The other study by McLachlan et al. studied the clinical usefulness of CGM in 36 patients with GDM and had similar conclusions (18). They found that CGM detected postprandial hyperglycemia that was underestimated by SMBG (18).

GDM vs. NDP in Terms of CGM-Derived Glycemic Profiling (Table 4)

Average Daily Glucose Levels

As expected, all three studies focusing on glucose profiling found that women with GDM had higher average glucose levels and that CGM was better than SMBG in detecting subtle glucose changes. Yogev et al. enrolled 117 patients (82 GDM vs. 35 NDP) and identified more asymptomatic hypoglycemic episodes (i.e., no dizziness or sweating due to hypoglycemia) by using CGM in the GDM group compared to the controls (25 vs. 0, P < 0.001) (16). Buhling et al. found similar results when they enrolled 8 non-pregnant healthy women and 56 pregnant women (17 diet-treated GDM, 15 impaired glucose tolerance (IGT) and 24 NDP) (15). The duration of hyperglycemia above 6.7 mmol/L [120 mg/dL] was higher in those with GDM or IGT than NDP (190 vs. 381.8 vs. 138 min; P < 0.05) (15). Colatrella et al. focused on glucose profiles during breastfeeding in two different groups: 18 women with GDM during pregnancy that resolved postpartum and 15 non-diabetic healthy pregnant controls (22). Glycemic levels were significantly higher in those who had GDM than NDP [5.6 mmol/L (101.4 mg/dL) vs. 4.9 mmol/L (87.5 mg/dL), P = 0.002] (22).

Postprandial Glucose Peak Level, Time to Peak, and Time to Resume to Baseline

The majority of research (4 out of 5, 80%) showed that patients with GDM had higher postprandial glucose levels. Naik et al. enrolled 30 women (20 GDM vs. 10 NDP) and found 1 h postprandial glucose levels were higher in women with GDM than NDP [7.21 mmol/L (130 mg/dL) vs. 5.98 mmol/L (108 mg/dL) P = 0.01] (32). Pustozerov et al. recruited 62 patients (49 GDM vs. 13 NDP) and demonstrated higher postprandial peak levels in patients with GDM than NDP [6.6 mmol/L (119 mg/dL) vs. 6.5 mmol/L (117 mg/dL), P = 0.02] (35). Carreiro et al. enrolled 50 patients (36 with GDM, 14 BMI-matched NDP) and found that at both breakfast and dinner times, postprandial glucose levels were consistently higher in the GDM group compared to NDP in both 1- and 2-h time points (i.e., 1 h after breakfast: 6.5 mmol/L [118 mg/dL] vs. 5.5 mmol/L [100 mg/dL]; 1 h after dinner: 6 mmol/L [109 mg/dL] vs. 5.2 mmol/L [94 mg/dL]; 2 h after breakfast: 5.8 mmol/L [105 mg/dL] vs. 4.9 mmol/L [89 mg/dL], 2 h after dinner: 5.8 mmol/L [105 mg/dL] vs. 5.2 mmol/L [93 mg/dL], P < 0.05 for all) (30). Finally, Seshiah et al. enrolled 24 women (12 GDM vs. 12 NDP) and found higher glucose levels 1 h post-meal in women with GDM than NDP, either using CGM [6.8 mmol/L (122.22 mg/dL) vs. 5.7 mmol/L (102.68 mg/dL), P < 0.05] or SMBG [7.2 mmol/L (129.9 mg/dL) vs. 6.5 mmol/L (117.5 mg/dL), P < 0.05] (20).

In terms of postprandial time to peak, there was no consensus among researchers. Buhling et al. conducted two studies focused on postprandial time to peak. Initially, they found that patients with GDM had longer time to peak compared to patients with NDP (54 vs. 47 min, P = 0.008) (15). Subsequently, they enrolled 49 women (13 GDM vs. 36 NDP) but found no significant differences in postprandial time to peak between NDP and diabetic groups (74 vs. 82 min, P > 0.05) (17). Carreiro et al. found similar results to Buhling's first study in that postprandial time to peak was longer in the GDM group than NDP group (56–70 min vs. 33 min, P < 0.02) at breakfast time (30).

For postprandial time to resume, only one study by Ben-Haroush et al. enrolled 45 women with GDM and found that women with diet-treated GDM took a longer time to return to pre-prandial glucose levels than those with insulin-treated GDM (134 vs. 111 min, P = 0.022) (14).

Glycemic Variability

Glycemic variability was consistently found to be increased in patients with GDM compared to NDP. Mazze et al. enrolled 76 patients (51 NDP, 25 GDM) and found significantly higher glucose variability in the GDM group compared to NDP [Interquartile range (IQR): 1.94 mmol/L (35 mg/dL) vs. 1.3 mmol/L (23 mg/dL), P < 0.0001] (21). Su et al. enrolled 70 women (30 GDM, 20 NDP, 20 non-pregnant healthy controls) and found similar results: mean amplitude of glucose excursions (MAGE) values were higher in the GDM group compared to both NDP and non-pregnant healthy controls [3.5 mmol/L (63 mg/dL) vs. 2.3 mmol/L (41 mg/dL) vs. 1.7 mmol/L (30.6 mg/dL); P < 0.01] (24). Other parameters of glycemic variability with significant differences between GDM and NDP included mean of daily differences (MODD) [1.6 mmol/L (29 mg/dL) vs. 1.2 mmol/L (21.6 mg/dL) vs. 1.0 mmol/L (18 mg/dL) P < 0.05], standard deviation of blood glucose (SDBG) [1.5 mmol/L (27 mg/dL) vs. 1.0 mmol/L (18 mg/dL) vs. 0.9 mmol/L (16 mg/dL), P < 0.01], and mean of continuous 24 h blood glucose (MBG) [8.6 mmol/L (155 mg/dL) vs. 6.2 mmol/L (112 mg/dL) vs. 4.8 mmol/L (86 mg/dL), P < 0.01] (24). There were two studies conducted by Dalfra et al. One focused on treatment differences in patients with GDM (insulin vs. diet), and they found patients on insulin had significantly higher glycemic variability compared to those on dietary restriction [MAGE: 3.5 mmol/L (63.3 mg/dL) vs. 2.1 mmol/L (38 mg/dL); P = 0.012] (3). The other study compared 30 patients (20 GDM vs. 10 NDP) and found that GDM had significant correlations between indicators of glycemic variability (MAGE and IQR r = 0.84, P < 0.001; MAGE and continuous overlapping net glycemic action (CONGA) r = 0.54, P = 0.03) (23). Only one study by Alfadhli et al. compared glucose differences between day 1 and day 4 use of CGM device among GDM mothers (29). They found significant reduction of glucose levels after a 4-day's use of CGM [MBG: 1.0 mmol/L (18 mg/dL), P = 0.016; SDBG: 0.25 mmol/L (4.5 mg/dL), P = 0.034] (29).

Interestingly, there was one study which compared mothers of NDP with and without history of GDM. Wang et al. recruited 96 women (48 NDP with prior GDM and 48 without) and found that those with prior GDM had higher MBG [6.5 mmol/L (117 mg/dL) vs. 5.9 mmol/L (106 mg/dL), P = 0.004], SDBG [1.3 mmol/L (23 mg/dL) vs. 0.9 mmol/L (16 mg/dL), P < 0.001], MODD [1.4 mmol/L (25 mg/dL) vs. 1.1 mmol/L (19.8 mg/dL), P = 0.002], MAGE [2.7 mmol/L (48.6 mg/dL) vs. 1.8 mmol/L (32.4 mg/dL), P < 0.001], and AUC [26.8 mmol/L (483 mg/dL) vs. 19.2 mmol/L (346 mg/dL) per hour, P < 0.001] compared to NDP without prior GDM (28).

However, one study did report contrasting results relating to glycemic variability from the findings above. Cypryk et al. enrolled 19 pregnant women (12 GDM, 7 NDP) and found no significant differences between groups for mean 24 h glycaemia, mean glucose level during the night, and duration of glycaemia below 3.3 mmol/L [60 mg/dL] or above 6.7 mmol/L [120 mg/dL], regardless of whether CGM or SMBG was used to measure the parameters (12).

CGM Use in Clinical/Intervention Utility (Table 5)

CGM in Altering Treatment Effect

All four studies focused on using CGM to make medication adjustments in patients with GDM found that CGM led to more treatment changes. Yogev et al. recruited 2 GDM patients and CGM was worn twice (once at baseline and once at 4 weeks after treatment) (39). After adjusting for their insulin regimens, there was a significant decrease in the total time of undetected hyperglycemia (152 vs. 89 min/day, P < 0.03) and in the 24-h mean glucose levels [6.5 mmol/L (117 mg/dL) vs. 5.6 mmol/L (101 mg/dL), P < 0.02] at post-treatment evaluation (39). Kestila et al. found similar results in their study of 73 patients with GDM (36 CGM, 37 SMBG) (19). Those in the CGM group had more patients treated with anti-hyperglycemic medication (31 vs. 8%, P = 0.01) (19). Wei et al. compared CGM use (n = 58) to SMBG use (n = 62) in 120 women with GDM and found that insulin was more commonly used in the CGM group (31.3 vs. 12.7%, P = 0.02), although there was no significant difference in the required dose (31). Yu et al. also found that more women in the CGM group received insulin vs. SMBG [41 out of 150 (27.3%) vs. 23 out of 190 (12.1%), P < 0.001] (26).

One trial conducted by Paramasivam et al. studied CGM vs. SMBG use in preventing HbA1c increases in 50 women with insulin-treated GDM (34). They found that HbA1c had a smaller increase in the CGM group (P = 0.024) and that mean HbA1c was lower in the CGM group at 37 weeks (P < 0.006) (34). The vast majority of patients in the CGM group also achieved an HbA1c <39 mmol/mol (5.8%) at 37 weeks (92 vs. 68%, P = 0.012) (34).

CGM Effect on Gestational Weight Gain (GWG)

Only one RCT studied GWG and found that CGM use lowered the amount of GWG compared to SMBG. Wei et al. recruited 120 women with GDM and randomized them to CGM (n = 58) or SMBG (n = 62), and found a significant difference in GWG (13.56 kg vs. 14.75 kg, P = 0.004) (31). A prospective observational study by Panyakat et al. did find a significant correlation between GWG and BW percentiles using CGM (r = 0.437, P = 0.002) (33).

Other Implications of CGM Use

Postprandial Glucose and HbA1c Levels (Table 4)

Kusunoki et al. enrolled 22 patients with GDM and used CGM to find that postprandial glucose levels were positively correlated with HbA1c levels (r = 0.5, P = 0.03) and patients' BMI (r = 0.55, P = 0.01) (27).

Hyperglycemia and Birth Weight (Table 3)

Sung et al. recruited 53 healthy pregnant women and followed them with gestational diabetes screening (38). They found that the magnitude and duration of hyperglycemia (≥110 mg/dl) had a consistent positive correlation with BW (Area under the curve (AUC) 6.1–7.8 mmol/L [110–140 mg/dl]: all r = 0.29, all P < 0.05) (38).

Diet and Average Glycaemia (Table 5)

Hernandez et al. used CGM to monitor changes in glycaemia in a crossover study using two different diets: a conventional lower carbohydrate and higher fat diet vs. a higher-complex carbohydrate and lower fat diet (25). They found that although the higher-complex diet led to higher levels of average glucose levels, overall the diet still maintained glycaemia below the recommended guidelines (25).

Pregnancy Outcomes (Table 4)

A different study by Panyakat et al. which enrolled 55 women with GDM and investigated the associations between third trimester glucose variability parameters and pregnancy outcomes using CGM (33). They found no associations between the two in terms of LGA, BW, cesarean section rate, and neonatal complications (33).

Discussion

In this systematic review with 29 online published original articles, CGM use has better user acceptability and feedback regarding satisfaction than SMBG use in daily glucose monitoring. Furthermore, most studies showed that CGM use in pregnant women with GDM was more effective in detecting hypoglycemia, hyperglycemia and increased glycemic variability than SMBG use in both GDM subjects and non-GDM subjects. As for treatment effect, CGM use led to more frequent use of insulin, better glycemic control, and reduced GWG in patients with GDM. However, most studies showed inconclusive results regarding CGM use in order to improve maternal and fetal outcomes.

Current research shows that CGM is able to provide more comprehensive glucose data and is convenient for the patient (40). Its clinical utility has been well demonstrated in patients with T1D and T2D by reducing risks of dysglycemia and improving their quality of life (41). However, several questions remain unanswered with regards to CGM use in patients with GDM: (1) Whether CGM can detect early glycemic variability for GDM diagnosis; (2) Whether CGM can subsequently moderate treatment strategies of GDM; (3) Whether CGM can eventually improve maternal and fetal outcomes. Due to these gaps in knowledge, CGM has yet to be adopted widely for use in pregnancies complicated by GDM.

In our review, there are consistent findings on the effect of CGM use on detection of dysglycemia (13, 18), higher glycemic variability (3, 21, 23, 24, 28, 29), higher postprandial glucose peaks in women with GDM (20, 30, 32, 35), and improved treatment effect (19, 25, 31, 34, 39). CGM use contributed positively to treatment effect as clinicians were more aware of patients' hyperglycemic and hypoglycemic episodes, so as to moderate the strategies of their medication (i.e., insulin) by altering dosage and frequency. In general, these findings suggest better clinical utility of CGM use in patients with GDM, compared with traditional SMBG use.

One major gap in clinical knowledge—whether CGM use improves maternal and fetal outcomes—has not been filled with plausible or convincing results. Past findings are still equivocal, as described above (26, 29, 31, 37). The null findings might be due to the lack of study power to detect pregnancy outcomes which are not highly prevalent in relatively small samples (42). Therefore, future studies with larger samples size, longer follow-up, and consistent study design are warranted to detect the practical effect of CGM on maternal and fetal outcomes.

There are a few other aspects of CGM which are worth exploring in future research, such as pregnant users' acceptability and effect on GWG and glycemic control. In our review, only two studies surveyed user acceptability and accuracy of CGM (18, 36), while several studies have been done in patients with T2D with high compliance rates (>90%) (43). Therefore, more should be done on pregnant women, especially on those with GDM, in order to implement universal application of CGM during pregnancy. Future research that tackles the current challenges and difficulties of CGM use in women with or without hyperglycemia during pregnancy could be beneficial for CGM user compliance and glucose control. In addition, one study in our review reported a beneficial effect of CGM on reducing GWG (31). It is worth further investigating whether such self-regulatory effect of CGM use (i.e., reduced GWG and lower glycemic levels during pregnancy) has an impact on improving pregnancy and fetal outcomes.

The strength of this literature review was the novelty of summarizing the clinical utility and treatment effects of CGM use on pregnancies complicated by GDM only, via a set of stringent selection criteria across three reputable medical databases. However, this review is not without limitations. First, there was a possibility of selection bias as we only included articles written in English with full text available and published in the past 2 decades. Second, when filtering articles by title, we might have excluded relevant articles that did not have the keywords (i.e., CGM, pregnancy, GDM) in their title.

In summary, there is sufficient evidence showing that CGM is effective at capturing gestational glucose profiles and improving treatment effect among pregnant women with GDM. The use of CGM provides good user acceptability, detects more dysglycemia than SMBG use, and detects higher glycemic variability in GDM pregnancies than normal pregnancies. Since CGM use is somewhat effective at improving GDM pregnancy outcomes, further research with larger sample sizes, better compliance, and longer monitoring times to detect these effects are warranted.

References

• 1.

  WHO. Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy: a World Health Organization Guideline. Diabetes Res Clin Pract. (2014) 3:341–63. 10.1016/j.diabres.2013.10.012

  • CrossRef
  • Google Scholar

• 2.

  CoustanDRLoweLPMetzgerBEDyerAR. The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: paving the way for new diagnostic criteria for gestational diabetes mellitus. Am J Obstet Gynecol. (2010) 202:654.e1–6. 10.1016/j.ajog.2010.04.006

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 3.

  DalfràMGSartoreGDi CianniGMelloGLencioniCOttanelliSet al. Glucose variability in diabetic pregnancy. Diabetes Technol Ther. (2011) 13:853–9. 10.1089/dia.2010.0145

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 4.

  ZhuYZhangC. Prevalence of gestational diabetes and risk of progression to type 2 diabetes: a global perspective. Curr Diab Rep. (2016) 16:7. 10.1007/s11892-015-0699-x

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 5.

  Excellence N.I.f.H.a.C. Type 2 Diabetes: Prevention in People at High Risk (2012).

  • Google Scholar

• 6.

  ChitayatLZisserHJovanovicL. Continuous glucose monitoring during pregnancy. Diabetes Technol Ther. (2009) 11(Suppl 1):S105–11. 10.1089/dia.2008.0136

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 7.

  CossonEBazBGaryFPharisienINguyenMTSandre-BanonDet al. Poor reliability and poor adherence to self-monitoring of blood glucose are common in women with gestational diabetes mellitus and may be associated with poor pregnancy outcomes. Diabetes Care. (2017) 40:1181–6. 10.2337/dc17-0369

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 8.

  O'KaneMJPickupJ. Self-monitoring of blood glucose in diabetes: is it worth it?Ann Clin Biochem. (2009) 46(Pt 4):273–82. 10.1258/acb.2009.009011

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 9.

  VoormolenDNDeVriesJHEversIMMolBWFranxA. The efficacy and effectiveness of continuous glucose monitoring during pregnancy: a systematic review. Obstet Gynecol Surv. (2013) 68:753–63. 10.1097/OGX.0000000000000002

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 10.

  SlatteryDChoudharyP. Clinical use of continuous glucose monitoring in adults with type 1 diabetes. Diabetes Technol Ther. (2017) 19:S55–S61. 10.1089/dia.2017.0051

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 11.

  CarlsonALMullenDMBergenstalRM. Clinical use of continuous glucose monitoring in adults with type 2 diabetes. Diabetes Technol Ther. (2017) 19:S4–11. 10.1089/dia.2017.0024

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 12.

  CyprykKBartyzelLZurawska-KlisMMlynarskiWSzadkowskaAWilczynskiJet al. Continuous glucose monitoring in type 1 diabetes pregnancy shows that fetal heart rate correlates with maternal glycemia. Diabetes Technol Ther. (2015) 17:619–24. 10.1089/dia.2014.0255

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 13.

  ChenRYogevYBen-HaroushAJovanovicLHodMPhillipM. Continuous glucose monitoring for the evaluation and improved control of gestational diabetes mellitus. J Matern Fetal Neonatal Med. (2003) 14:256–60. 10.1080/713606657

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 14.

  Ben-HaroushAYogevYChenRRosennBHodMLangerO. The postprandial glucose profile in the diabetic pregnancy. Am J Obstet Gynecol. (2004) 191:576–81. 10.1016/j.ajog.2004.01.055

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 15.

  BühlingKJKurzidimBWolfCWohlfarthKMahmoudiMWäscherCet al. Introductory experience with the continuous glucose monitoring system (CGMS; Medtronic Minimed) in detecting hyperglycemia by comparing the self-monitoring of blood glucose (SMBG) in non-pregnant women and in pregnant women with impaired glucose tolerance and gestational diabetes. Exp Clin Endocrinol Diabetes. (2004) 112:556–60. 10.1055/s-2004-830399

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 16.

  YogevYBen-HaroushAChenRRosennBHodMLangerO. Undiagnosed asymptomatic hypoglycemia: diet, insulin, and glyburide for gestational diabetic pregnancy. Obstet Gynecol. (2004) 104:88–93. 10.1097/01.AOG.0000129239.82126.a1

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 17.

  BühlingKJWinkelTWolfCKurzidimBMahmoudiMWohlfarthKet al. Optimal timing for postprandial glucose measurement in pregnant women with diabetes and a non-diabetic pregnant population evaluated by the Continuous Glucose Monitoring System (CGMS). J Perinat Med. (2005) 33:125–31. 10.1515/JPM.2005.024

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 18.

  McLachlanKJenkinsAO'NealD. The role of continuous glucose monitoring in clinical decision-making in diabetes in pregnancy. Aust N Z J Obstet Gynaecol. (2007) 47:186–90. 10.1111/j.1479-828X.2007.00716.x

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 19.

  KestiläKKEkbladUURönnemaaT. Continuous glucose monitoring versus self-monitoring of blood glucose in the treatment of gestational diabetes mellitus. Diabetes Res Clin Pract. (2007) 77:174–9. 10.1016/j.diabres.2006.12.012

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 20.

  SeshiahVChandrasekarABalajiVBalajiMSSrinivasanASuganthiSet al. Glycemic excursions in Indian pregnant women monitored by continuous glucose monitoring system—A pilot study. Diabetes Metabolic Syndrome. (2008) 2:179–84. 10.1016/j.dsx.2008.05.002

  • CrossRef
  • Google Scholar

• 21.

  MazzeRYogevYLangerO. Measuring glucose exposure and variability using continuous glucose monitoring in normal and abnormal glucose metabolism in pregnancy. J Matern Fetal Neonatal Med. (2012) 25:1171–5. 10.3109/14767058.2012.670413

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 22.

  ColatrellaAFramarinoMToscanoVBongiovanniMFestaCMatteiLet al. Continuous glucose monitoring during breastfeeding in women with recent gestational diabetes mellitus. Diabetes Technol Ther. (2012) 14:576–82. 10.1089/dia.2011.0266

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 23.

  DalfràMGChilelliNCDi CianniGMelloGLencioniCBiagioniSet al. Glucose fluctuations during gestation: an additional tool for monitoring pregnancy complicated by diabetes. Int J Endocrinol. (2013) 2013:279021. 10.1155/2013/279021

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 24.

  SuJBWangXQChenJFWuGJinYXuFet al. Glycemic variability in gestational diabetes mellitus and its association with β cell function. Endocrine. (2013) 43:370–5. 10.1007/s12020-012-9753-5

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 25.

  HernandezTLVan PeltREAndersonMADanielsLJWestNADonahooWTet al. A higher-complex carbohydrate diet in gestational diabetes mellitus achieves glucose targets and lowers postprandial lipids: a randomized crossover study. Diabetes Care. (2014) 37:1254–62. 10.2337/dc13-2411

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 26.

  YuFLvLLiangZWangYWenJLinXet al. Continuous glucose monitoring effects on maternal glycemic control and pregnancy outcomes in patients with gestational diabetes mellitus: a prospective cohort study. J Clin Endocrinol Metab. (2014) 99:4674–82. 10.1210/jc.2013-4332

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 27.

  KusunokiYKatsunoTNakaeRWatanabeKOchiFTokudaMet al. Insulin resistance and β-cell function influence postprandial blood glucose levels in Japanese patients with gestational diabetes mellitus. Gynecol Endocrinol. (2015) 31:929–33. 10.3109/09513590.2015.1075498

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 28.

  WangYMZhaoLHSuJBQiaoHFWangXHXuFet al. Glycemic variability in normal glucose tolerance women with the previous gestational diabetes mellitus. Diabetol Metab Syndr. (2015) 7:82. 10.1186/s13098-015-0077-5

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 29.

  AlfadhliEOsmanEBasriT. Use of a real time continuous glucose monitoring system as an educational tool for patients with gestational diabetes. Diabetol Metab Syndr. (2016) 8:48. 10.1186/s13098-016-0161-5

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 30.

  CarreiroMPLauriaMWNavesGNMirandaPALeiteRBRajãoKMet al. Seventy two-hour glucose monitoring profiles in mild gestational diabetes mellitus: differences from healthy pregnancies and influence of diet counseling. Eur J Endocrinol. (2016) 175:201–9. 10.1530/EJE-16-0015

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 31.

  WeiQSunZYangYYuHDingHWangS. Effect of a CGMS and SMBG on maternal and neonatal outcomes in gestational diabetes mellitus: a randomized controlled trial. Sci Rep. (2016) 6:19920. 10.1038/srep19920

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 32.

  NaikDHesarghatta ShyamasunderADoddabelavangala MruthyunjayaMGupta PatilRPaulTVChristinaFet al. Masked hypoglycemia in pregnancy. J Diabetes. (2017) 9:778–86. 10.1111/1753-0407.12485

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 33.

  PanyakatWSPhatihattakornCSriwijitkamolASunsaneevithayakulPPhaophanAPhichitkankaA. Correlation between third trimester glycemic variability in non-insulin-dependent gestational diabetes mellitus and adverse pregnancy and fetal outcomes. J Diabetes Sci Technol. (2018) 12:622–9. 10.1177/1932296817752374

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 34.

  ParamasivamSSChinnaKSinghAKKRatnasingamJIbrahimLLimLLet al. Continuous glucose monitoring results in lower HbA1c in Malaysian women with insulin-treated gestational diabetes: a randomized controlled trial. Diabet Med. (2018) 35:1118–29. 10.1111/dme.13649

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 35.

  PustozerovEPopovaPTkachukABolotkoYYuldashevZGrinevaE. Development and evaluation of a mobile personalized blood glucose prediction system for patients with gestational diabetes mellitus. JMIR Mhealth Uhealth. (2018) 6:e6. 10.2196/mhealth.9236

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 36.

  ScottEMBilousRWKautzky-WillerA. Accuracy, user acceptability, and safety evaluation for the freestyle libre flash glucose monitoring system when used by pregnant women with diabetes. Diabetes Technol Ther. (2018) 20:180–8. 10.1089/dia.2017.0386

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 37.

  VoormolenDNDeVriesJHSansonRMEHeringaMPde ValkHWKokMet al. Continuous glucose monitoring during diabetic pregnancy (GlucoMOMS): a multicentre randomized controlled trial. Diabetes Obes Metab. (2018) 20:1894–902. 10.1111/dom.13310

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 38.

  SungJFKogutEALeeHCMannanJLNavabiKTaslimiMMet al. Correlation of continuous glucose monitoring profiles with pregnancy outcomes in nondiabetic women. Am J Perinatol. (2015) 32:461–8. 10.1055/s-0034-1390344

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 39.

  YogevYChenRKaplanBPhillipMHodM. Continuous glucose monitoring for treatment adjustment in diabetic pregnancies—a pilot study. Diabetic Med. (2003) 20:558–62. 10.1046/j.1464-5491.2003.00959.x

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 40.

  AjjanRACummingsMHJenningsPLeelarathnaLRaymanGWilmotEG. Accuracy of flash glucose monitoring and continuous glucose monitoring technologies: Implications for clinical practice. Diab Vasc Dis Res. (2018) 15:175–84. 10.1177/1479164118756240

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 41.

  RodbardD. Continuous glucose monitoring: a review of recent studies demonstrating improved glycemic outcomes. Diabetes Technol Therapeut. (2017) 19:S25–37. 10.1089/dia.2017.0035

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 42.

  NajafianMCheraghiM. Occurrence of fetal macrosomia rate and its maternal and neonatal complications: a 5-year cohort study. ISRN Obstetr Gynecol. (2012) 2012:353791. 10.5402/2012/353791

  • Pubmed Abstract
  • CrossRef
  • Google Scholar

• 43.

  TaylorPJThompsonCHBrinkworthGD. Effectiveness and acceptability of continuous glucose monitoring for type 2 diabetes management: a narrative review. J Diabetes Invest. (2018) 9:713–25. 10.1111/jdi.12807

  • Pubmed Abstract
  • CrossRef
  • Google Scholar