SENSORY HAIR CELL DEATH AND REGENERATION, 2nd Edition

Sensory hair cells are the mechanosensory receptors of the auditory and vestibular systems in all vertebrates and of the lateral line system of some aquatic vertebrates. Hair cells can be damaged and lost due to such factors as aging, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of these hair cells lead to deficits in hearing and balance, and in mammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells. Researchers have been examining the process of hair cell death and regeneration in animal models in an attempt to find ways of either preventing hair cell loss or stimulating the production of new hair cells in mammals, with the ultimate goal of finding new therapeutics for human sensorineural hearing and balance deficits. This has led to a wide array of research on hair cells- such as understanding the factors that cause hair cell loss and finding agents that protect them from damage, elucidating the apoptotic pathways activated during hair cell death, examining the genes and cellular pathways that are regulated during the process of hair cell death and regeneration, and characterizing the functional sensory loss and recovery following hair cell death and regeneration. This research has involved cell and developmental biologists, physiologists, geneticists, bioinformaticians, and otolaryngologists. In this Research Topic, we wish to summarize and review recent progress of hair cell regeneration research and collate original articles advancing sensory hair cell death and regeneration research into the future.