New Frontiers in Gene-Modified T Cell Technology

Ignazio Caruana, Francesca Del Bufalo, Rayne Rouce, Shigeki Yagyu, Paul G. Schlegel

Frontiers Media SA

The development, clinical translation and recent efficacy of novel gene therapies targeting...

Health Immunology T Cell Biology

Keywords: CAR Tcells,­CRISPR-Cas Gene,­Pediatric high-grade gliomas,­tcr,­Anti-CD19,­Leukemia

Anti-tumor Activity of Cytotoxic Immune Cells: Basic Research and Clinical Perspectives

Malgorzata Firczuk, Magdalena Winiarska

Frontiers Media SA

Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells are powerful effectors of antitumor...

Health Immunology T Cell Biology

Keywords: Immunotherapy,­T cell,­NK cell,­bites,­Resistance to immunotherapy,­resistance to cytotoxic killing,­Chimeric Antigen Receptor,­monoclonal antibodies

T cell specificity and Cross-reactivity – Implications in Physiology and Pathology

Samuele Notarbartolo, Daniela Latorre, Tomasz Piotr Wypych, Silvia Monticelli, Dominik Aschenbrenner

Frontiers Media SA

Conventional CD8+ and CD4+ T cells recognize antigens, presented by antigen-presenting cells in the...

Health Immunology T Cell Biology

Keywords: T cell,­Human pathology,­microbial infections

Novel therapies for indolent lymphomas in the cellular therapy era

Narendranath Epperla, Sairah Ahmed

Frontiers Media SA

Health Immunology T Cell Biology

Keywords: FL,­MZL,­CAR-T cell therapy,­bispecific antibodies,­Immunotherapies,­Immunoconjugates,­small molecule inhibitors.

CD4 T cells in HIV: A friend or foe?

Sunil Kannanganat Sidharthan, Constantinos Petrovas, Monica Vaccari, Vijayakumar Velu

Frontiers Media SA

Health Immunology T Cell Biology

Keywords: HIV,­CD4+ T cells,­reservoirs,­HIV cure,­follicular T helper cells

Mechanisms of lymphocyte mediated cytotoxicity in health and disease

Cosima T Baldari, Salvatore Valitutti, Michael Loran Dustin

Frontiers Media SA

Health Immunology T Cell Biology

Keywords: CTL,­NK,­Cytotoxicity,­Immune Evasion,­Cancer

Adaptive immunity in local tissues

Yuekang Xu, Xuefeng Wang, Xiao He

Frontiers Media SA

Health Medicine

Keywords: Tissue immunology,­Adaptive Immunity,­T cells,­B cells,­Immune Regulation

Imaging the immune response in inflammatory preclinical in vivo models

Marco Erreni, Nick Devoogdt, Greetje Vande Velde, Roberto Weigert

Frontiers Media SA

Health Immunology T Cell Biology

Keywords: immune response,­preclinical in vivo imaging,­nuclear imaging,­optical imaging,­Magnetic Resonance Imaging,­intravital microscopy,­Mesoscopic imaging

Revisiting the thymus: The origin of T cells

Yayi Gao, Yi Ding, Bin Zhao

Frontiers Media SA

Health Immunology T Cell Biology

Keywords: Thymus,­T cell development and differentiation,­thymic epithelial cells,­MHC,­TCR repertoire,­Cell signaling