Gliomas microenvironment: new drug entities, mechanisms of action, molecular biomarkers and drug delivery strategies

Célia Cabral, Mariana Magalhães, Diana Matias, Claudia Carbone

Frontiers Media SA

Gliomas are neoplasms originating in glial cells, the most malignant and frequent primary tumors of...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: Nanotechnology,­drug repurposing,­Glioblastoma,­gliomas,­Tumor Microenvironment,­Drug delivery,­biomarkers

Recent advances in the treatment of epilepsy

Khojasteh Malekmohammad, Mahmoud Rafieian-Kopaei, Antonella Riva

Frontiers Media SA

Epilepsy is one of the most common neurological chronic disorders characterized by unpredictable...

Science Pharmacology Analytical and Experimental Pharmacology

Keywords: Epilepsy,­Drug Development,­pharmacokinetics,­Pharmacodynamics,­Drug Discovery,­Pharmacological Targets

New progress in the treatment of bone and soft tissue tumors

Zhiyu Zhang, Xiaomeng You, Yingqi Hua, Xiaoyu Xu, Duoyi Zhao

Frontiers Media SA

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: chemotherapy,­Immunotherapy,­nanomaterials,­translational medicine,­clinical research

Disputes and Challenges of Immune Checkpoint Inhibitors in Gastrointestinal Cancers

Hongwei Yao, Wen G. Jiang, Zhi-Chun Gu, Lin Zhao, Zhengyang Yang

Frontiers Media SA

Recently, immune checkpoint inhibitors (ICIs) have received a lot of attention to treat...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: immune checkpoint inhibitors,­Gastrointestinal cancers,­Immune-related adverse events

Tumour microenvironment in cancer research and drug discovery

Syed Mahmood, Nur Akmarina Mohd Said, Kenneth K. W. To

Frontiers Media SA

The implication of tumour microenvironment (TME) on cancer progression and therapeutic response has...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: tumour microenvironment,­Cancer,­cancer-associated fibroblasts,­Nanotherapeutics,­Drug Discovery,­drug repurposing

New Strategies for Reversing Cancer Therapy Resistance

Yue Du, Shengxi Chen, Xiujun Liu, Lulu Wang

Frontiers Media SA

Amazing anticancer therapy advancements have been made in the last decade due to tremendous...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: Drug Resistance,­cancer therapy,­Mechanism,­Reverse strategy,­Novel drug

New Mechanisms for Anti-Cancer Drugs

Ayaz Shahid, Pranav Kumar Prabhakar, Ajit Prakash, Saad Mustafa

Frontiers Media SA

Cancer is the second leading cause of death. Every year, many anticancer drug candidates are...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: anti-cancer,­biomarkers,­Drug Discovery,­Immunotherapy,­Gene Therapy,­Phytomedicine,­Cell signaling,­Cell Cycle,­Oncogenes,­Protooncogenes,­Cyclins,­Cyclin dependent kinases

Advances in Molecular and Pharmacological Mechanisms of Novel Targeted Therapies for Melanoma

Luana Mota Ferreira, Marcel Henrique Marcondes Sari, Juliana Hofstatter Azambuja

Frontiers Media SA

Malignant melanoma is the most aggressive type of skin cancer with invasive growth patterns. Recent...

Health Oncology Pharmacology of Anti-Cancer Drugs

Keywords: Skin Cancer,­Melanoma,­immunology,­Nanotechnology,­Cancer biomarkers,­Drug repositining,­Immunotherapy

Oncogenic PI3KT/Akt/mTOR Pathway Alterations, ROS Homeostasis, Targeted Cancertherapy and drug resistance

Rozangela Curi Pedrosa, Karina Felipe, Danilo Wilhelm Filho

Frontiers Media SA

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin...

Health Oncology Pharmacology of Anti-Cancer Drugs

Keywords: PI3KT/Akt/mTOR Pathway,­Metabolism,­Reactive Oxygen Species