Immune-checkpoint Inhibitors in Anti-cancer Armamentarium: a Double-edged Sword in Risk of Developing Autoimmunity and Immune-related Adverse Effects

Maria-Ioanna Christodoulou, Giacomo Cafaro, Yannick Degboé, Flavia Sunzini, Aysin Tulunay Virlan

Frontiers Media SA

Immunotherapy represents a hopeful approach to managing cancer patients, mostly due to its...

Health Oncology Pharmacology of Anti-Cancer Drugs

Keywords: Autoimmunity,­immune-related adverse effect (IrAE:),­immune-checkpoint inhibitors,­cancer immunotherapy,­anti-CTLA4,­anti-PD-1/PD-L1

Genomic Discoveries and Pharmaceutical Development in Urologic Tumors

Jialin Meng, Yin Sun, Xiaolei Sun, Lei Yin, Huan Yang

Frontiers Media SA

Urologic tumors encompass cancers of the prostate, bladder, kidney, testis, and adrenal glands....

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: urologic tumors,­Cancer biomarkers,­drug screen,­drug repurposing,­Genomic sequence

Novel Anti-Cancer Agents Targeting Tumour Metastasis and Stemness

Bo Wang, Zhongrui Li, Jing-Quan Wang, Luping Pang

Frontiers Media SA

Cancer metastasis is the leading cause of cancer-related deaths. Despite the development of...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: Tumor metastasis,­tumor stemness,­novel anti-cancer strategy

Gliomas microenvironment: new drug entities, mechanisms of action, molecular biomarkers and drug delivery strategies

Célia Cabral, Mariana Magalhães, Diana Matias, Claudia Carbone

Frontiers Media SA

Gliomas are neoplasms originating in glial cells, the most malignant and frequent primary tumors of...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: Nanotechnology,­drug repurposing,­Glioblastoma,­gliomas,­Tumor Microenvironment,­Drug delivery,­biomarkers

Recent advances in the treatment of epilepsy

Khojasteh Malekmohammad, Mahmoud Rafieian-Kopaei, Antonella Riva

Frontiers Media SA

Epilepsy is one of the most common neurological chronic disorders characterized by unpredictable...

Science Pharmacology Analytical and Experimental Pharmacology

Keywords: Epilepsy,­Drug Development,­pharmacokinetics,­Pharmacodynamics,­Drug Discovery,­Pharmacological Targets

New progress in the treatment of bone and soft tissue tumors

Zhiyu Zhang, Xiaomeng You, Yingqi Hua, Xiaoyu Xu, Duoyi Zhao

Frontiers Media SA

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: chemotherapy,­Immunotherapy,­nanomaterials,­translational medicine,­clinical research

Disputes and Challenges of Immune Checkpoint Inhibitors in Gastrointestinal Cancers

Hongwei Yao, Wen G. Jiang, Zhi-Chun Gu, Lin Zhao, Zhengyang Yang

Frontiers Media SA

Recently, immune checkpoint inhibitors (ICIs) have received a lot of attention to treat...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: immune checkpoint inhibitors,­Gastrointestinal cancers,­Immune-related adverse events

Tumour microenvironment in cancer research and drug discovery

Syed Mahmood, Nur Akmarina Mohd Said, Kenneth K. W. To

Frontiers Media SA

The implication of tumour microenvironment (TME) on cancer progression and therapeutic response has...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: tumour microenvironment,­Cancer,­cancer-associated fibroblasts,­Nanotherapeutics,­Drug Discovery,­drug repurposing