Innovations in Development, Translational Research and Manufacturing of CAR T cells

Michael Hudecek, Qasim Rafiq, Stephen Goldrick, Ulrike Koehl, Helene Negre, Carmen Sanges

Frontiers Media SA

Immunotherapy with genetically engineered immune cell products is a transformative treatment...

Health Immunology Molecular Innate Immunity

Keywords: ATMPs,­CAR T cells,­TCR-transgenic T cells,­CAR NK cells,­gene transfer,­gene editing,­Automated manufacturing,­machine learning,­artificial intelligence,­Health Technology Assessment,­socioeconomic impact

Biology of C-reactive Protein

Alok Agrawal, Yi Wu

Frontiers Media SA

C-reactive protein (CRP) is a component of the innate immune system. CRP is synthesized by the...

Health Immunology Molecular Innate Immunity

Keywords: C-Reactive Protein,­Inflammation,­innate immunity,­pentraxin,­Pattern-recognition molecule,­complement,­Infection

Myeloid cells in health and liver disease

Evangelos Triantafyllou, Jack Leslie, Carsten Deppermann

Frontiers Media SA

Cells of the myeloid lineage display diverse roles and functions both in tissue homeostatic...

Health Immunology Molecular Innate Immunity

Keywords: innate immunity,­Myeloid Cells,­Liver disease,­Liver Failure,­Acute liver injury,­Chronic liver injury

Insights in Molecular Innate Immunity: 2022

Francesca Granucci, Uday Kishore

Frontiers Media SA

We are now entering the third decade of the 21st Century, and, especially in the last years, the...

Health Immunology Molecular Innate Immunity

Keywords: molecular innate immunity

Delivering Nucleic Acids to Immune and Non-Immune Cells

Francesca Re, Kirill Afonin, Diana Boraschi

Frontiers Media SA

The possibility of inducing or suppressing the expression of specific genes with the targeted...

Health Immunology Molecular Innate Immunity

Transcriptional regulation of macrophage function

Marten A. Hoeksema, Zsolt Czimmerer, Andreas Patsalos

Frontiers Media SA

Health Immunology Molecular Innate Immunity

Keywords: transcription,­enhancers,­Transcription Factors,­Epigenetic regulation,­Chromatin remodeling,­Signaling Pathways,­Cytokines,­environment,­Genetics,­Disease,­macrophage

Current Challenges in Complement Diagnostics

Erik J.M. Toonen, Per Nilsson, Lillemor Skattum

Frontiers Media SA

The complement system is an important innate immune surveillance network that has a key role in...

Health Immunology Molecular Innate Immunity

Keywords: complement diagnostics,­complement system,­assessment of complement components,­Diagnostic Techniques and Procedures,­Complement-mediated diseases

TNFRSF Agonists: Mode of action and therapeutic opportunities

Nataša Obermajer, Harald Wajant, Adam Zwolak

Frontiers Media SA

The receptors of the TNFRSF (TNFRs) are of overwhelming importance in the regulation of the immune...

Health Immunology Molecular Innate Immunity

Keywords: TNFRSF agonists,­Apoptosis,­Cell Death,­TNFRSF,­4-1BB,­CD27,­DR5/TRAILR2,­EDAR,­Fn14,­OX40,­TNFR2 anti-tumor immunity,­Immunotherapy,­Co-stimulation

Effects of cell interactions at the endothelium in leukocyte differentiation and polarization during inflammation

Alain Haziot, Dan Jane-wit, Efstathios G. Stamatiades

Frontiers Media SA

A complex exchange of signals between endothelial cells and tissues occurs during steady-state and...

Health Immunology Molecular Innate Immunity

Keywords: Cell interactions,­Endothelium,­monocyte,­Lymphocytes,­inflamation