Myc as a Disease Target Beyond Cancer

Jonathan R. Whitfield, Mariano F. Zacarias-Fluck, John Sedivy, Yulia A. Nevzorova, Jastrinjan Kaur

Frontiers Media SA

Myc is a pleiotropic transcription factor fundamental for many cellular processes. It is an...

Science Cell and Developmental Biology Signaling

Keywords: MYC,­therapy,­disease target,­non-cancerous conditions,­non-oncological pathologies,­Myc-related pathologies

Network-based Mathematical Modeling in Cell and Developmental Biology

Susan Mertins, Michael Blinov

Frontiers Media SA

The vast amount of knowledge in Cell Signaling gathered through reductionist efforts and omics...

Science Cell and Developmental Biology Signaling

Keywords: cellular reaction networks,­mathematical modelling,­math biology,­differential equations,­graph theory,­Boolean models,­whole cell modelling

Mitochondrial Plasticity and Quality Control in Health and Disease

Milena Rizzo, Francesca Forini, Emilia Bramanti, Elena Levantini, Filippo M. Santorelli, Azhar Ali, Vincenzo Lionetti

Frontiers Media SA

Mitochondria are essential cytosolic organelles that meet the rapidly-changing metabolic needs of...

Science Cell and Developmental Biology Cellular Biochemistry

Keywords: Mitochondrial plasticity,­Oxidative Stress,­mitochondria dysfunctions

In Celebration of Women in Molecular and Cellular Reproduction

Dolores Busso, Vanina Gabriela Da Ros, Patricia S. Cuasnicu

Frontiers Media SA

At present, less than 30% of researchers worldwide are women. Long-standing biases and gender...

Science Cell and Developmental Biology Molecular and Cellular Reproduction

Keywords: molecular reproduction,­cellular reproduction,­women in science,­Gender Equality

Artificial Intelligence Applications in Chronic Ocular Diseases

Wei Chi, Weihua Yang, Peirong Lu, Yanwu Xu, Huiying Liu

Frontiers Media SA

With the acceleration of urbanization and aging processes, chronic ocular diseases have become a...

Science Cell and Developmental Biology Molecular and Cellular Pathology

Keywords: Artificial intelligence applications,­ocular diseases,­chronic diseases,­big data analyses; disease screening and diagnosis

Epithelial Barrier Dysfunction in Disease

Carlos Pardo-Pastor, Rocío López Posadas, Elena Ortiz Zapater

Frontiers Media SA

The epithelium plays a central and critical role in development, physiology and immunity, both...

Health Medicine Gastroenterology

Metabolic Modulation of Cellular Function

Or Kakhlon, Ann Saada, Pablo Vicente Escriba

Frontiers Media SA

Metabolic pathways and their metabolites are gaining recognition as both sensitive biomarkers for...

Science Cell and Developmental Biology Cellular Biochemistry

Keywords: Metabolites,­metabolic pathway,­Metabolic modulation,­Metabolomics,­cell fate

New Advancement in Tumor Microenvironment Remodeling and Cancer Therapy

Xiangsheng Zuo, Ying Shen, Yi Yao, Jiayan Chen

Frontiers Media SA

Tumor microenvironment (TME) refers to the area with non-malignant cells, signaling molecules and...

Science Cell and Developmental Biology Cancer Cell Biology

Keywords: tumour microenvironment (TME),­Remodel,­tumor therapy,­Mechanism

Molecular Architecture and Dynamics of Meiotic Chromosomes

Ricardo Benavente, Mónica Pradillo, Pedro A. San-Segundo

Frontiers Media SA

Meiosis is a special type of cell division that allows the generation of haploid gametes and is a...

Science Cell and Developmental Biology Nuclear Organization and Dynamics

Keywords: Meiosis,­chromosome,­pairing,­synapsis,­meiotic recombination,­Checkpoints,­Nuclear Envelope