Effects of perinatal asphyxia on the neurobehavioral and retinal development of newborn rats
Peter
Kiss1*,
Donat
Szogyi1,
Gabor
Horvath1,
József
Farkas1,
Andrea
Lubics1,
Andrea
Tamas1,
Tamas
Atlasz2,
Krisztina
Szabadfi2,
Norbert
Babai2,
Robert
Gabriel2,
Miklos
Koppan1, 3 and
Dóra
Reglődi1
-
1
Department of Anatomy, University of Pécs, Hungary
-
2
Department of Experimental Zoology and Neurobiology , University of Pécs, Hungary
-
3
Department of Obstetrics and Gynecology, University of Pécs, Hungary
Perinatal asphyxia during delivery produces long-term deficits and represents a major problem in both neonatal and pediatric care. Several morphological, biochemical and behavioral changes have been described in rats exposed to perinatal asphyxia. The aim of the present study was to evaluate how perinatal asphyxia affects the complex early neurobehavioral development and retinal structure of newborn rats. Asphyxia was induced in ready-to-deliver mothers by removing the pups by cesarian section after 15 minutes of asphyxia. Somatic and neurobehavioral development was tested daily during the first 3 weeks, and motor coordination tests were performed on postnatal weeks 3-5. After completion of the testing procedure, retinas were removed for histological analysis. We found that in spite of the fast catch-up-growth of asphyctic pups, nearly all examined reflexes were delayed by 1-4 days: negative geotaxis, sensory reflexes, righting reflexes, development of fore- and hindlimb grasp and placing, gait and auditory startle reflexes. Time to perform negative geotaxis, surface righting and gait reflexes was significantly longer during the first few weeks in asphyctic pups. Among the motor coordination tests, a markedly weaker performance was observed in the grid walking and footfault test and in the walk initiation test. Retinal structure showed severe degeneration in the layer of the photoreceptor and bipolar cell bodies. In summary, our present study provided a detailed description of reflex and motor development following perinatal ashpyxia, showing that asphyxia led to a marked delay in neurobehavioral development and a severe retinal degeneration.
Support:OTKA:K72592;F67830;78480;T061766;Richter
Conference:
12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009.
Presentation Type:
Poster Presentation
Topic:
Pathophysiology and neurology - degenerative disorders
Citation:
Kiss
P,
Szogyi
D,
Horvath
G,
Farkas
J,
Lubics
A,
Tamas
A,
Atlasz
T,
Szabadfi
K,
Babai
N,
Gabriel
R,
Koppan
M and
Reglődi
D
(2009). Effects of perinatal asphyxia on the neurobehavioral and retinal development of newborn rats.
Front. Syst. Neurosci.
Conference Abstract:
12th Meeting of the Hungarian Neuroscience Society.
doi: 10.3389/conf.neuro.01.2009.04.250
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Received:
13 Mar 2009;
Published Online:
13 Mar 2009.
*
Correspondence:
Peter Kiss, Department of Anatomy, University of Pécs, Pecs, Hungary, peter.kiss@aok.pte.hu